Invivoscribe Expands Flow Cytometry Services to Accelerate CAR-T Immunotherapy Development and Regulatory Readiness with the Initiation of CERo Therapeutics Phase 1 Clinical Trial
Through this collaboration, LabPMM (Invivoscribe's global reference laboratories) have customized their multiparametric flow cytometry (MFC) services and implemented their sensitive MFC AML MRD assay to support CERo's clinical trial of its lead compound, CER-1236. The trial targets Acute Myeloid Leukemia (AML) in patients who are relapsed/refractory, in remission with MRD, or newly diagnosed with TP53-mutated MDS/AML.
AML is an aggressive blood cancer characterized by the rapid accumulation of abnormal myeloid cells in the bone marrow and blood, disrupting normal hematopoiesis. 1 Treating AML is especially complex due to its genetic heterogeneity and the high risk of relapse. CAR-T (chimeric antigen receptor T-cells) and Chimeric Engulfment Receptor T-cells ('CER-T') therapies, which involve engineering a patient's own T-cells to recognize and attack cancer cells, have shown promise in other hematologic malignancies and are now being explored for AML. However, because these therapies are manufactured from patient-derived cells, it's critical to confirm that leukemic blasts are not inadvertently included in the final therapeutic product – underscoring the need for sensitive, validated assays like those offered by Invivoscribe and its global accredited regional laboratories, LabPMM.
LabPMM's CAP/CLIA-Validated AML MRD MFC assay, which was designed to quantify residual leukemic cells in patients undergoing treatment, was customized to meet two critical needs in CERo's drug development program: (1) assessing the purity of the manufactured T-cell product by detecting residual AML blasts prior to infusion, and (2) evaluating therapeutic response to CER-1236 during the trial.
Kristen Pierce, Ph.D., CERo Chief Development Officer, commented, 'Invivoscribe has played an integral role in the execution of this clinical trial. Its technology and expertise have facilitated our advancement into the clinic by helping to ensure the purity of our investigational product, and now we are reaping the benefits of our collaboration as the trial is underway and we seek to assess therapeutic response.'
This collaborative effort was instrumental in advancing CER-1236, which recently received FDA Orphan Drug Designation for the treatment of AML 2. The designation highlights the growing urgency of integrated diagnostic support in the advancement of personalized immunotherapies and reflects Invivoscribe's commitment to driving innovation and standardization across the oncology treatment landscape – now helping bring immunotherapies to patients faster.
For more information about LabPMM's flow cytometry and molecular testing services, please visit https://invivoscribe.com/clinical-lab-services/ or contact us at inquiry@invivoscribe.com and follow us on LinkedIn.
About Invivoscribe Inc.
Invivoscribe ® is a global, vertically integrated biotechnology company dedicated to Improving Lives with Precision Diagnostics ®. For thirty years, Invivoscribe has improved the quality of healthcare worldwide by providing high quality standardized reagents, tests, and bioinformatics tools to advance the field of precision medicine. Invivoscribe has a successful track record of partnerships with pharmaceutical companies interested in clinical trial testing via our global lab network located in the U.S., Germany, Japan and China, and in developing and commercializing companion diagnostics, with our rigorous expertise in both regulatory and laboratory services. Providing distributable kits, as well as clinical trial services through its globally located clinical lab subsidiaries (LabPMM ®), Invivoscribe is an ideal partner from diagnostic development, through clinical trials, regulatory submissions, and commercialization.
About CERo Therapeutics Holdings, Inc.
CERo is an innovative immunotherapy company advancing the development of next generation engineered T cell therapeutics for the treatment of cancer. Its proprietary approach to T cell engineering, which enables it to integrate certain desirable characteristics of both innate and adaptive immunity into a single therapeutic construct, is designed to engage the body's full immune repertoire to achieve optimized cancer therapy. This novel cellular immunotherapy platform is expected to redirect patient-derived T cells to eliminate tumors by building in engulfment pathways that employ phagocytic mechanisms to destroy cancer cells, creating what CERo refers to as Chimeric Engulfment Receptor T cells ('CER-T'). CERo believes the differentiated activity of CER-T cells will afford them greater therapeutic application than currently approved chimeric antigen receptor ('CAR-T') cell therapy, as the use of CER-T may potentially span both hematological malignancies and solid tumors. CERo has commenced clinical trials for its lead product candidate CER-1236 for hematological malignancies.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Business Wire
3 days ago
- Business Wire
Ant Group Recognized for Best AML Technology Initiative in Asia Pacific and Best GRC Implementation in China
HANGZHOU, China--(BUSINESS WIRE)--Ant Group has been recognized by The Asian Banker as the Best Anti-Money Laundering (AML) Technology Initiative in Asia Pacific for its advanced AML system, and as having the Best Enterprise Governance, Risk, and Compliance (GRC) Implementation in China for its unified indicator management platform, RiskKey. Ant Group has implemented a unified AML framework by integrating AI, image computing and large language model technologies, and has applied it to its global operations across multiple industries. By standardizing risk indicators and automating suspicious transaction reporting, Ant Group has reduced compliance preparation time by nearly 30% and increased the speed of strategic decision-making by 90%. Using intelligent tools such as RiskKey and iGuardian, Ant Group has enhanced the accuracy of anti-money laundering detection and operational efficiency, enabling the swift generation of reports compliant with regulatory standards. The RiskKey platform addresses core challenges in AML, such as indicator governance through semantic research and development and intelligent services. It has increased indicator development efficiency by 40%, achieved 99.99% data availability, and saved over RMB 10 million ($1.4 million) in annual costs. About Ant Group Ant Group is a global digital technology provider and the operator of Alipay, a leading internet services platform in China, connecting over one billion users to more than 10,000 types of consumer services from partners. Through innovative products and solutions powered by AI, blockchain and other technologies, Ant Group supports partners across industries to thrive through digital transformation in an ecosystem for inclusive and sustainable development. For more information, visit
Business Insider
4 days ago
- Business Insider
PUM Exchange Advances European Compliance with Newly Granted Virtual Asset License
California, United States, July 9th, 2025, Chainwire PUM Exchange, a leading global digital asset trading platform. PUM Exchange's unwavering commitment to operating within robust legal frameworks, enhancing user protection, and fostering sustainable growth in the rapidly evolving crypto market. Strategic Commitment to Regulatory Excellence In the face of increasingly stringent global regulations, PUM Exchange has proactively prioritized compliance, embedding regulatory best practices across its operations. Bolstering User Trust and Institutional Confidence Regulatory certification enhances the platform's ability to implement comprehensive Anti-Money Laundering (AML) and Know Your Customer (KYC) protocols, which are crucial for safeguarding users and preventing illicit activities. This compliance milestone enables PUM Exchange to expand its service offerings within the European market, including fiat on-ramps, derivatives, and token listings, thereby providing greater access and convenience to traders. Driving Sustainable Global Expansion 'Our vision extends beyond compliance — it's about building a responsible and future-ready trading ecosystem,' said by founder Allen Oliver. 'By integrating regulation with innovation, PUM Exchange aims to be a reliable partner for users at all levels.' PUM Exchange is a global digital asset platform focused on innovation, transparency, and user empowerment. With products spanning spot trading, derivatives, fiat integration, and community governance, PUM is building the future of digital finance.
Yahoo
4 days ago
- Yahoo
Inside Million Dollar Sellers, a community of 700 Amazon sellers doing 7-figures in annual revenue
Million Dollar Sellers is a community of high-performing e-commerce entrepreneurs. MDS started as a Facebook group for sellers with $10,000 monthly revenue. The threshold is now $1 million annually. There are 700 vetted members worldwide who must complete an application and interview to join. Walking into a Million Dollar Sellers event is like stepping into the pit of a rock concert. It's loud, it's electric, and it's a little chaotic. "Think of it like a family reunion, where you're actually excited to see everybody there," the COO of the community, Eugene Khayman, told Business Insider. "It's very high-energy." Million Dollar Sellers, or MDS, consists of Amazon sellers and e-commerce entrepreneurs who bring in at least $1 million in annual revenue. Events — in which community members connect in person, trade ideas, and swap strategies — are just one aspect of the community. "At the center of it is still a Facebook group," said Khayman. "It's your collective 24/7 brain trust so, at any point in time, you can drop a question." Khayman came across the group in 2016, a few years after he started selling kitchen products on Amazon. At the time, it was a Facebook group for private label sellers doing at least $10,000 in monthly revenue. The threshold grew to $50,000 a month and, eventually, $1 million a year. He said that joining the group made business more fun while helping him stay competitive. His brand, eparé, had hit the seven-figure annual revenue mark, but sales started dropping as e-commerce grew and new sellers burst onto the scene. "There were a lot of strategies that people were using that were destroying me," he said. "I wasn't keeping up with the information fast enough." It was his idea to bring the MDS Facebook group to life through in-person events. He organized the first one at an all-inclusive resort in Cancún. "I charged people $99 for a ticket — and I lost money on it because I thought all-inclusive meant that you didn't have to pay for anything," said Khayman, adding that the bill was worth it. "It was amazing energy." As live events took off, so did the community. As of 2025, there are about 700 MDS members who pay $7,497 a year to be a part of the group. Khayman still runs two e-commerce brands, but said he prefers to direct more of his time and energy to growing MDS: "As I did all of these events, I saw people coming together and I saw how much was being created from those relationships. I was getting a lot more fulfillment from that." The application process has evolved as the MDS community has grown. "In the very, very beginning, it was quite simple," said Khayman. Prospective members would email the MDS founder a copy of their photo ID and a screenshot of their sales. However, as the group gained more exposure and applications started flowing in, the process became more rigorous, primarily so that MDS could maintain its core identity. "No community ever wants to get bigger. That's always a thing, like, it's going to lose its charm if it gets too big. And everybody wanted to really preserve that." The interview is meant to screen for a type of person, not necessarily a type of business. "They need to have the mindset that they're coming in here to help and share and become a member of the community," said Khayman. "Sometimes people come in with some kind of agenda to sell some other product or service, so it's meant to filter for that." One of the group's core values is: Give more, get more. "That's a big thing we try to instill in everybody, so there's not really much judgment or flash," said Khayman. "It's just people that are really deep in their businesses and just wanting to help one another." Once the interview is complete and the application is approved, members gain access to exclusive events, a network of high-level sellers, and online groups that share insights, experiences, and resources. Despite the challenges of growing, Khayman recognizes the immense benefits of having more members. It allows specific sub-groups to form, so sellers in the kitchen space or supplement space, for example, can discuss their industry-specific challenges. "There's enough members in each of these specific domains to give each other value," he said. Selling on Amazon has never been more complex and competitive. When Khayman started in the early 2010s, "my first year of selling on Amazon, I sold $150,000 worth of pepper grinders," he said. "These were pepper grinders that I was buying for $5 and selling for $50 on Amazon. I took home 80% of that as profit." Today, it's much harder to run a profitable Amazon business. The fees are higher, the competition is stiffer, and the strategies are constantly evolving. Tariffs added an entirely new level of complexity at the start of 2025. "For a long time, we were a very Amazon-focused community, and we've been trying to break away from that overall stigma and just be a general community for e-commerce founders," said Khayman. "It's been nice to see over the past few years that people coming into the group have a wider understanding of e-commerce. Amazon is just a part of their business, rather than their whole business, and I think that aligns with the future. If people are treating Amazon as their whole business, they're definitely more at risk." There's a big selling opportunity right now on TikTok, for example. He said the current TikTok marketplace reminds him of Amazon in the early years. Being a member of a group like MDS helps entrepreneurs spot these trends, adapt, and stay ahead of the curve. It can also help with morale, which is inevitably going to be low at times for every entrepreneur. "We get a lot of members saying that their team or significant others want them to go to these events because they come back very excited with high energy," said Khayman. "Business is always raining. Business always gets you down, so it's like a pick me up." Perhaps the biggest perk of all, though, is the network. "I truly think the best way to succeed is to surround yourself with people that have already succeeded," he said. "You're going to make mistakes and mistakes are always great, but why learn from your own mistakes when you can learn from other people's?" Read the original article on Business Insider Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
