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DOGE Needs a Different Playbook for Science

DOGE Needs a Different Playbook for Science

New York Times19-03-2025
In the early 1990s, Katalin Karikó was obsessed with an idea most of her fellow scientists dismissed: Could messenger RNA, or mRNA, a genetic molecule that helps cells synthesize proteins, be harnessed to create new kinds of treatments?
She believed that if used correctly, mRNA could instruct cells to produce their own medicines, transforming how we fight diseases. But grant after grant was rejected. Reviewers at the National Institutes of Health were skeptical of her work. Her career stalled. She was demoted. Yet she kept going through sheer grit and some timely lifelines from colleagues. Her research changed the course of the Covid-19 pandemic — and she won a Nobel Prize — but only after being delayed by a decade because our system was so risk-averse.
Scientists have been complaining for years that the way we fund science is flawed. Researchers are too often waiting up to 20 months for grant funding, an eternity in fast-moving fields like genetic engineering. Project leaders report that nearly 50 percent of their time is spent doing paperwork and other administrative tasks. The average age at which scientists receive their first traditional N.I.H. grant is 43.
Earlier this month, thousands of scientists marched on Washington to defend science from Elon Musk's Department of Government Efficiency, as staff reductions at the N.I.H. and National Science Foundation and steep cuts to biomedical funding roiled the scientific establishment. But it's difficult to fully defend the status quo, which made it hard for a scientist like Karikó to pursue her visionary work.
At the same time, I fear this administration's current approach will make things worse. The N.I.H.'s new policy to cap what it pays universities to cover 'indirect costs' on grants (for things like utility bills, research facilities and administrative staff) to 15 percent will amount to a $4 billion cut in biomedical funding per year if it holds up in court. It could force universities to lay off researchers and shutter labs. Some universities have already frozen hiring, and important long-term studies have been cut short.
Right now, DOGE is treating efficiency as a simple cost-cutting exercise. But science isn't a procurement process; it's an investment portfolio. If a venture capital firm measured efficiency purely by how little money it spent, rather than by the returns it generated, it wouldn't last long. We invest in scientific research because we want returns — in knowledge, in lifesaving drugs, in technological capability. Generating those returns sometimes requires spending money on things that don't fit neatly into a single grant proposal.
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