World's First Large-Scale, Multicenter Prospective Study in Single-Reading Mammography Confirms Lunit AI Boosts Cancer Detection
SEOUL, South Korea, March 10, 2025 /PRNewswire/ -- Lunit (KRX:328130.KQ), a leading provider of AI-powered solutions for cancer diagnostics and therapeutics, today announced the publication of a groundbreaking prospective study in Nature Communications validating the real-world effectiveness of AI-powered mammography screening in South Korea's national breast cancer screening program. Conducted as the world's first large-scale, multicenter prospective study in a single-reading setting, the research underscores how AI-assisted mammography interpretation significantly improves breast cancer detection rates without increasing recall rates.
The study was led by Professor Yun-Woo Chang from Soonchunhyang University Seoul Hospital, in collaboration with both breast and general radiologists from six leading academic hospitals in South Korea. The study analyzed 24,543 women aged 40 and above who underwent routine biennial mammography (2D full-field digital mammogram) between February 2021 and December 2022 as part of Korea's national breast cancer screening program.
The study compared the performance of breast radiologists interpreting screening mammograms with and without Lunit's AI-based computer-aided detection, Lunit INSIGHT MMG. The results revealed that AI-assisted breast radiologists detected 13.8% more screen-detected breast cancers than those relying solely on conventional interpretation methods, or without AI assistance. The cancer detection rate (CDR) increased from 5.01 (per 1,000) to 5.70 with AI assistance, while recall rates (RRs) remained statistically unchanged, ensuring improved clinical effectiveness and minimizing unnecessary additional recalls. Moreover, AI assistance led to a significant improvement in detecting small-sized tumors and node-negative cancers, key indicators of improved early detection.
Additionally, the study evaluated Lunit INSIGHT MMG's impact on general radiologists who do not specialize in breast imaging through a simulated retrospective study. The results demonstrated that AI assistance led to an even greater improvement in CDRs for general radiologists, with an increase of 26.4% (3.87 to 4.89 per 1,000), underscoring AI's potential to support radiologists with varying levels of expertise.
"This prospective study offers compelling real-world evidence that AI can improve early cancer detection while maintaining effectiveness and reducing unnecessary patient anxiety caused by false positives in a single-reading setting," said Professor Chang, the lead and corresponding author of the study.
A Proven Solution for Single and Double-Reading Screening Systems
The publication further builds upon Lunit INSIGHT MMG's well-established track record in improving breast cancer detection. In Sweden, Capio St. Göran Hospital conducted a prospective clinical trial to assess Lunit AI's effectiveness in breast cancer screening when replacing one reader within a double-reading setting. Following positive trial results, Capio St. Göran Hospital became the world's first to replace one of two radiologists in its double-reading workflow with AI, marking a paradigm shift in breast cancer screening.
"This latest prospective study in South Korea further solidifies Lunit INSIGHT MMG's potential as an indispensable tool in breast cancer screening," said Brandon Suh, CEO of Lunit. "Whether in a single-reader or double-reader setting, AI can serve as a powerful force multiplier, assisting radiologists in detecting cancer earlier and more accurately."
Shaping the Future of National Breast Cancer Screening Programs
With mounting evidence supporting AI's role in breast cancer screening, Lunit is driving its global adoption. Lunit INSIGHT MMG has already been deployed in national breast screening programs in Australia, Sweden, Iceland, Singapore, Saudi Arabia, and Qatar, helping healthcare systems enhance efficiency and optimize diagnostic accuracy.
The study's findings are expected to influence global breast cancer screening protocols, particularly in countries where single-reading mammography interpretation is widely practiced. By demonstrating AI's ability to enhance radiologists' accuracy without increasing RRs, the study provides critical data supporting AI's role in optimizing cancer detection while reducing the workload burden on radiologists. This is particularly relevant as many countries face a shortage of specialized breast imaging professionals, making AI an important tool to improve efficiency and maintain high diagnostic standards.
"As AI adoption accelerates, we remain committed to driving innovation and making AI-powered cancer screening the new standard of care," added Suh. "By working closely with healthcare providers worldwide, we aim to ensure that AI benefits as many patients as possible."
About Lunit
Founded in 2013, Lunit (KRX:328130.KQ) is a medical AI company on a mission to conquer cancer. Lunit harnesses AI-powered medical image analytics and biomarker analysis to ensure accurate diagnosis and optimal treatment for each cancer patient. The FDA-cleared Lunit INSIGHT suite for cancer screening serves over 4,800 medical institutions across 55+ countries.
Lunit clinical studies have been published in top journals, including the Journal of Clinical Oncology and the Lancet Digital Health, and presented at global conferences such as the ASCO and RSNA. Headquartered in Seoul, South Korea, with a network of offices worldwide, Lunit leads the global fight against cancer. Discover more at lunit.io.
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Destination & Delivery is $1,420 for Crosstrek and may vary in the following states: CT, HI, MA, ME, NH, NJ, NY, RI and VT. D&D is $1,570 for retailers in Alaska. About Subaru of America, of America, Inc. (SOA) is an indirect wholly owned subsidiary of Subaru Corporation of Japan. Headquartered in Camden, N.J., the company markets and distributes Subaru vehicles, parts, and accessories through a network of about 640 retailers across the United States. All Subaru products are manufactured in zero-landfill plants, including Subaru of Indiana Automotive, Inc., the only U.S. automobile manufacturing plant designated a backyard wildlife habitat by the National Wildlife Federation. SOA is guided by the Subaru Love Promise, which is the company's vision to show love and respect to everyone and to support its communities and customers nationwide. Over the past 20 years, SOA and the SOA Foundation have donated more than $340 million to causes the Subaru family cares about, and its employees have logged over 115,000 volunteer hours. Subaru is dedicated to being More Than a Car Company® and to making the world a better place. For additional information, visit Follow us on Facebook, Instagram, LinkedIn, TikTok, and YouTube. Dominick Infante Director, Corporate Communications 856.488.8615 dinfante@ Aaron Cole Product Communications Manager 856.488.3697 acole1@ Miranda Jimenez Product Communications Specialist 856.438.2820 mjimen@ Karley Dowdy Product Communications Specialist 856.488.8527 Kdowdy@ View original content to download multimedia: SOURCE Subaru of America, Inc.
