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Medscape
26 minutes ago
- Medscape
Ovarian Cancer Risk Rises Soon After IBS Diagnosis
TOPLINE: Women with a new diagnosis of irritable bowel syndrome (IBS) have a significantly higher risk for ovarian cancer at 3 months and 6 months post-diagnosis, but this risk is no longer elevated beyond 8 months. METHODOLOGY: Ovarian cancer often presents with nonspecific symptoms overlapping those of IBS. The frequency of misdiagnosis remains unknown, and not all IBS guidelines recommend screening for ovarian cancer. Researchers conducted a retrospective cohort study using US administrative claims data to compare ovarian cancer incidence in adult women with and without a new IBS diagnosis. Diagnostic codes were used to identify cases of IBS and ovarian cancer. TAKEAWAY: The cohort comprised 9804 women with IBS and 79,804 women without IBS, identified between January 2017 and December 2020. Women with IBS had a significantly higher risk for ovarian cancer at 3 months (hazard ratio [HR], 1.71; P = .02) and 6 months (HR, 1.43; P = .02), but not beyond 8 months post-diagnosis. Women with both IBS and endometriosis had an even greater risk for ovarian cancer at 3 months (HR, 4.20; P = .01), 6 months (HR, 3.52; P = .01), and after 1 year (HR, 2.67; P = .04). Increasing age was significantly associated with higher ovarian cancer incidence only in women younger than 50 years (HR, 1.07; P < .01), regardless of IBS status. IN PRACTICE: 'Identifying patient-specific risk factors, such as chronic pelvic pain or endometriosis, could help develop tailored risk profiles and improve the approach to personalized care in women with IBS-type symptoms,' the authors wrote. SOURCE: This study was led by Andrea Shin, Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles. It was published online in Alimentary Pharmacology & Therapeutics. LIMITATIONS: The use of diagnostic codes for identifying IBS may have led to misclassification or reflected symptoms rather than confirmed and validated diagnosis. DISCLOSURES: This study received support from the National Institutes of Health. Some authors reported serving as consultants, advisors, and/or receiving research support from pharmaceutical and healthcare companies; one author reported having stock options. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Fox News
27 minutes ago
- Fox News
Christina Applegate explains 'I don't enjoy living' comments after worried fans react
This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255). Christina Applegate is clarifying recent comments that she made about struggling with her mental health amid her battle with multiple sclerosis (MS). During the June 4 episode of her "MeSsy" podcast, which she co-hosts with Jamie-Lynn Sigler, the 52-year-old "Dead to Me" actress shared that she was "in a depression." "Like a real, f--- it all depression where it's kind of scaring me a little bit because it feels really fatalistic. I'm trapped in this darkness right now that I haven't felt like... I don't even know how long, probably 20 something years," said Applegate, who first revealed her diagnosis with the chronic disease in 2021. "This is being really honest... I don't enjoy living. I don't enjoy it. I don't enjoy things anymore," she added. In the latest episode of the "MeSsy" podcast, Applegate reassured fans who were concerned about her well-being and said she was "very disturbed" by the "clickbait" about her remarks. CHRISTINA APPLEGATE ADDRESSES FUTURE AS AN ACTRESS AMID MS DIAGNOSIS "I'm good. Does that take a little bit of the pressure off of all of you? I'm good," Applegate said. "Let's address it," said Sigler, who is also battling MS. "We are going to address it," Applegate said. "I was talking about some dark stuff I was thinking and feeling." "This is our safe place to get those things out," she continued. "Because I feel that when we hold things in, we give them power. I also think that there's so much shame that a lot of people feel when they're going through mental health issues, and they call them issues." "I hate that," the actress added. "It's not mental issues. It's not a problem. It's a moment. It's a thought. It's a feeling. And when people hold those in because they're so afraid to say how they truly feel, we give it immense power." The "Married… with Children" alum said she believes "society has told us that we're supposed to be just f------ fine." "And I am not into that," Applegate said. "I am not a proponent of that kind of thing. I think that it's incredibly healing and important to be able to express the thoughts, whether that makes someone uncomfortable or not, to be able to say it." LIKE WHAT YOU'RE READING? CLICK HERE FOR MORE ENTERTAINMENT NEWS Following her remarks, the Emmy Award winner said she began receiving text messages from people who were worried about her and had to reassure them that she has "beautiful people around me and beautiful support systems." However, Applegate expressed her fear that the outpouring of concern might make others more reluctant to express their feelings. "By making such a big deal about it you're making other people think, 'Oh, s---, I can't talk about this.' And that is not OK with me," she said. "It's important to be able to say these things. And, no, I'm not sitting here on suicide watch, OK? I am not. Nor have I ever been." "I dare anyone to be diagnosed with MS or any kind of chronic illness that has taken who you were prior to that moment and go, 'This is great,'" she continued. "You know? No, you have moments of feeling, 'This is tiring and I don't wanna do this.' But you do it, and by having friends like you and my beautiful friends that I have saying this s--- out loud, it releases the pressure in the balloon." Applegate revealed her diagnosis on X, formerly Twitter, in 2021. CLICK HERE TO SIGN UP FOR THE ENTERTAINMENT NEWSLETTER "Hi friends. A few months ago I was diagnosed with MS," she wrote. "It's been a strange journey. But I have been so supported by people that I know who also have this condition," Applegate continued. "It's been a tough road. But as we all know, the road keeps going. Unless some a--hole blocks it." In a separate post, she added, "As one of my friends that has MS said, 'We wake up and take the indicated action.' And that's what I do." In her first lengthy in-person interview since she found out about the illness, Applegate opened up about the "hell" she has been living in. "I live kind of in hell," she said during a "Good Morning America" interview in March. "I'm not out a lot, so this is a little difficult, just for my system. But of course, the support is wonderful, and I'm really grateful." CLICK HERE TO GET THE FOX NEWS APP Fox News Digital's Lauryn Overhultz contributed to this report.
New York Times
an hour ago
- New York Times
U.S. Opens Antitrust Investigation Into NewYork-Presbyterian
The Justice Department is investigating whether the renowned NewYork-Presbyterian health system violated antitrust laws through hidden deals with insurance companies that kept hospital prices high, according to a subpoena reviewed by The New York Times. The civil investigation is examining whether NewYork-Presbyterian persuaded insurance companies to agree to conditions that insulated the hospital system from competition — which would enable it to charge more for common procedures with little worry about losing patients. The federal investigation is likely to send a jolt through some of the city's biggest hospitals and the health insurance companies that negotiate with them. The administrative subpoena states that the review seeks to determine if there has been 'potential unlawful agreement between NewYork Presbyterian Health Care System and health insurance companies relating to steering restrictions and contracting conduct.' The investigation is examining a corner of the health industry that has received little attention from antitrust investigators, outside of cases in North Carolina and California in recent years: the negotiations between hospitals and insurers to build a network of providers. NewYork-Presbyterian includes two of the city's most storied medical institutions: Columbia University Medical Center and Weill Cornell Medical Center. The hospitals are affiliated with the medical schools of Columbia and Cornell. The inquiry could lead to more spirited competition among New York City's leading hospital systems, which might translate into lower prices for childbirth, knee replacements, colonoscopies and other common medical care. Want all of The Times? Subscribe.
