
The experts: neurologists on 17 simple ways to look after your brain
'All of the sensible things that apply to bodily health apply to brain health,' says Dr Suzanne O'Sullivan, a consultant in neurology at the National Hospital for Neurology and Neurosurgery in London, and the author of The Age of Diagnosis. 'When you're 20, you can get away with absolute murder. You can not sleep for nights at a time and stuff like that. But you get away with nothing when you hit middle age. With every year that I get older, my lifestyle gets healthier.'
All of her consultations will focus to some degree on lifestyle choices, she says: 'I work with a lot of people with degenerative brain diseases, and they are not caused by lifestyle. But everything is made better by having a moderate degree of exercise, eating healthily and sleeping well, whether it be bodily disease, brain disease or mental health.'
'If you want to damage your brain, smoke a lot,' says Tom Solomon, professor of neurology at the University of Liverpool. Likewise, 'a lot of alcohol is not good for you. A bit of alcohol seems to be OK. There is some soft data suggesting one to two units might reduce risks of cardiac disease in the elderly, but the evidence overall is that alcohol is harmful, especially to the brain.'
Dr Faye Begeti, a neurologist and neuroscientist at Oxford University hospitals, takes a hard line: 'I find that people who are not alcoholics, but drink a small amount of alcohol every day over many decades, can still run into problems. With alcohol I have two rules for my patients: not out of habit, so only when celebrating; and not drinking daily.'
There is a well-established link between physical activity and brain health, says Dr Richard Davenport, a consultant neurologist in Edinburgh and the outgoing president of the Association of British Neurologists: 'It works on many levels: psychological, metabolic, physiological.'
'Things that are good for your blood vessels are good for your brain,' Solomon says. 'A lot of dementia is because of damaged blood vessels. Physical activity is good for blood vessels as it keeps blood pressure down.'
Solomon got a Guinness world record for running the fastest marathon dressed as a doctor in 2010, raising money for Encephalitis International, a brain inflammation charity. But you don't need to run marathons to keep your brain healthy, he says. Although, 'there is not much hard data telling you exactly how much exercise to do – in our headache clinics we say do 20-30 minutes of something that gets you at least a little bit short of breath two or three times a week, so running, swimming, cycling. They are very good for de-stressing, too,' he adds – another bonus for the brain.
'There are studies that show being active in every decade really helps with brain longevity,' says Begeti. 'I advise people to include single-leg exercises in their routine, because walking relies heavily on single-leg balance, and maintaining this becomes crucial as we get older. Aerobic exercise releases a brain-nourishing chemical called brain-derived neurotrophic factor that supports our neurons. A combination of that with resistance exercises that build up muscle is very important, as numerous studies have found greater muscle mass reduces cognitive decline, even in those who have already been diagnosed with dementia.'
Opt for 'antioxidants and unsaturated fats, and not too much red meat', says Solomon.
'The biggest evidence is for the Mediterranean diet,' says Begeti, adding: 'I was born in Greece, so maybe I am biased.' She says the advice she often gives on this is simple: 'When you cook, your primary source of fat should be olive oil rather than butter. This is what I do and it is a really easy transition to make. You can have cakes with olive oil in; everything you fry should be in olive oil, rather than butter. I'm not saying you would never eat butter again, but that the primary source of fat is olive oil. And having some omega-3 with oily fish has really good evidence for brain health as well.' She says it is important for vegans and vegetarians to take vitamin B12 supplements.
'We see people who have simple or chronic headaches,' says Solomon. 'The things that reduce the risk of headaches are all very much the same. Regular exercise. Staying hydrated by drinking at least two litres of water a day. Stopping all caffeine. Not skipping meals. Getting to bed at a sensible time. We usually say to people: if you do this religiously for three months, headaches will reduce or come under control. And most of those things are also good for your general brain health, as far as we know.'
'Good sleep starts at the beginning of the day,' says Begeti, 'rather than at night when you are stressing about not getting good sleep. Anchor your morning by getting up at roughly the same time each day. If you need more sleep at the weekends, then catch up with 60 to 90 minutes, or one sleep cycle extra. Don't make it too erratic, because then your brain doesn't know when to produce the right hormones.'
'We still don't exactly know what sleep is all about,' says Davenport, 'but increasingly, there is good evidence that sleep is allowing the brain some downtime to do a bit of tidying up, and in particular, tidying some of these dodgy proteins that ultimately may do bad things in terms of degenerative disease. In other words, getting decent sleep matters.'
'With insomnia, there can be a lot of worry when we hear that reduced sleep can give rise to disease,' says Begeti. 'I think it is about being able to do good things for your brain, but not being really stressed if you're not doing everything perfectly, because stress has really negative effects as well.' But, she concedes: 'It's easier said than done to say to somebody, 'Don't be stressed!''
'There is evidence that people with perceived long-term stress are at increased risk of cognitive decline and dementia,' Solomon agrees.
We are in the midst of a panic about what technology is doing to our brains, but as Begeti explains in her book The Phone Fix, the science does not confirm that we are addicted to our phones. That said, she limits checking her Instagram account to twice a day and mutes all WhatsApp groups. 'I suggest people try to develop a routine or a schedule of connection and disconnection that works for them. Distraction is a big thing when it comes to technology. I prefer people to use technology intentionally because they want to, rather than to avoid doing some difficult work or dealing with something, and instead using technology to fill that gap. When people use it as an avoidance tactic, I think that is when it can make them feel bad.'
Does having so much information readily available online mean we are losing memory capacity? 'You may not be able to remember a phone number, but the brain is very adaptable,' says Begeti. 'It remembers things that you use and sidelines things that you don't. If you don't remember phone numbers daily, then your brain might not be accustomed to remembering them. It doesn't mean this ability has disappeared. It is more the brain is prioritising certain things that you do.'
Maintaining social connections is crucial in helping to avoid dementia. 'Of course, there are problems associated with technology,' says O'Sullivan. 'There is some awful content on there. But I think we often forget the positive things it brings to our lives. For older people, who may not have great mobility, it is creating incredible connectedness.' Begeti adds: 'There are early studies with preliminary findings that show if middle-aged adults engage in social media, they have reduced incidence of dementia.'
'Brain and mind health is all about having ambitions and interests outside of yourself,' says O'Sullivan. 'I have so much work to do that my mind is kept well occupied, but my plan going forward is to do all the things I wish I had time to do now: go back to university, do art appreciation courses, and challenge myself in settings where I'll be mixing with lots of different people.'
Find a 'magnificent obsession', says Dr Richard Restak, a professor of neurology at George Washington University hospital in the US and author of How To Prevent Dementia: An Expert's Guide to Long-Term Brain Health. 'Take up an interest, the earlier in life the better, and do a lot of mental work trying to learn more stuff. You can link it to social interaction, which is very important.'
'You need to exercise the brain every day, particularly with memory,' says Restak. At 83, he is still writing books. What is his secret? 'I think, in my case, it is mostly training the brain. I walk and have a sensible diet, but I'm not cultish about it. If my wife brings back some pastries, I will certainly have one.'
What's his training? 'Every day I try to learn a new word,' says Restak. 'The word today is turveydrop – based on a character in [Charles Dickens's] Bleak House – and is someone who is just interested in looking important. If somebody calls you that, it's not a compliment.' He keeps lists of all his daily words to refer back to, if his memory fails him.
But don't narrow your training too much, he adds. 'Remembering particular things is only good for the area in which they are applied, so that you become a good crossword puzzler or a great Scrabble player. I lose at Scrabble all the time. I think I've got a pretty good vocabulary, but Scrabble is its own world.'
'Learning is harder when you are older,' says Solomon, 'but it helps as you mature.' He played piano as a child, then took it up again 10 years ago. 'People who play musical instruments are less likely to have cognitive impairment because it is all about using the brain.' The same goes for learning languages. With both, 'You're using very different parts of your brain. If you don't do any of those things, there are whole chunks of your brain that are not really being used.'
'Deafness is one of the characteristics that the Lancet Commission has identified as being an important risk factor for dementia,' says Davenport. 'It's the same for vision. Anything that leads you to less interaction with the outside world is likely to be detrimental.' There is less evidence on the effects of reduced vision, he says, 'but if your vision deteriorates, you're going to stop driving, you may stop going out so much, and all of those things start to lead to social isolation, like deafness. Keep on top of your senses; make sure you can hear and see.'
Interestingly, Davenport adds, 'sense of smell is often an early symptom of some of the degenerative diseases. No one is suggesting losing your sense of smell leads to them. It is probably just an early symptom, particularly in Parkinson's disease.'
Davenport is a keen cyclist. Does he wear a helmet? 'Absolutely. There is good evidence that helmets do protect you.' He refers to the debate around the effect of repeated head injuries in sports such as rugby and football, and their role in neurodegenerative disease: 'There is still quite a lot to be unravelled about that, but it makes sense to try to protect your head from unnecessary injury. Where you need to be careful, of course, is that we know that physical exercise is very good for people, and therefore you don't want to stop kids playing football. But maybe easing up on heading the ball, which is already happening.'
O'Sullivan points out that memory decline starts in your 30s. 'We all are increasingly forgetful over time,' Solomon agrees. Don't worry, he says, if, for example: 'You go upstairs for a jumper, and then you get upstairs and you can't remember what you've gone up there for. That's not a reason to see the doctor.' He says that the difference is obvious between patients who have dementia and those who are experiencing normal forgetfulness: 'When I say to these patients, 'Why have you come to see me?', they turn their head to look at the relative who is with them, because they have no idea why they are there.'
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Reuters
4 days ago
- Reuters
Three-person IVF technique spared children from inherited diseases, scientists say
July 16 (Reuters) - Eight children in the UK have been spared from devastating genetic diseases thanks to a new three-person in vitro fertilization technique, scientists from Newcastle University reported on Wednesday. The technique, which is banned in the United States, transfers pieces from inside the mother's fertilized egg - its nucleus, plus the nucleus of the father's sperm - into a healthy egg provided by an anonymous donor. The procedure prevents the transfer of mutated genes from inside the mother's mitochondria - the cells' energy factories - that could cause incurable and potentially fatal disorders. Mutations in mitochondrial DNA can affect multiple organs, particularly those that require high energy, such as the brain, liver, heart, muscles and kidneys. One of the eight children is now 2 years old, two are between ages 1 and 2, and five are infants. All were healthy at birth, with blood tests showing no or low levels of mitochondrial gene mutations, the scientists reported in the New England Journal of Medicine, opens new tab. All have made normal developmental progress, they said. The results "are the culmination of decades of work," not just on the scientific/technical challenges but also in ethical inquiry, public and patient engagement, law-making, drafting and execution of regulations, and establishing a system for monitoring and caring for the mothers and infants, reproductive medicine specialist Dr. Andy Greenfield of the University of Oxford, who was not involved in the research, said in a statement. The researchers' "treasure trove of data" is likely to be the starting point of new avenues of investigation, Greenfield said. Often during IVF screening procedures, doctors can identify some low-risk eggs with very few mitochondrial gene mutations that are suitable for implantation. But sometimes all of the eggs' mitochondrial DNA carries mutations. In those cases, using the new technique, the UK doctors first fertilize the mother's egg with the father's sperm. Then they remove the fertilized egg's 'pronuclei' – that is, the nuclei of the egg and the sperm, which carry the DNA instructions from both parents for the baby's development, survival and reproduction. Next, they transfer the egg and sperm nuclei into a donated fertilized egg that has had its pronuclei removed. The donor egg will now begin to divide and develop with its healthy mitochondria and the nuclear DNA from the mother's egg and the father's sperm. This process, detailed in a second paper in the journal, opens new tab, 'essentially replaces the faulty mitochondrial DNA (mtDNA) with healthy mtDNA from the donor,' senior researcher Mary Herbert, professor of reproductive biology at Newcastle, said at a press briefing. Blood levels of mtDNA mutations were 95% to 100% lower in six newborns, and 77% to 88% lower in two others, compared to levels of the same variants in their mothers, the researchers reported in a second paper. "These data indicate that pronuclear transfer was effective in reducing transmission of mtDNA disease," they said. The procedure was tested in 22 women whose babies were likely to inherit such genes. In addition to the eight women who delivered the children described in this report, another one of the 22 is currently pregnant. Seven of the eight pregnancies were uneventful; in one case, a pregnant woman had blood tests showing high lipid levels. There have been no miscarriages. The authors of the current reports have also tried transplanting the nucleus of a mother's unfertilized egg into a donor egg and then fertilizing the donor egg afterward, but they believe their new approach may more reliably prevent transmission of the genetic disorders. In 2015, the UK became the first country in the world to legalize research into mitochondrial donation treatment in humans. That same year in the United States, pronuclear transfer was effectively banned for human use by a congressional appropriations bill that prohibited the Food and Drug Administration from using funds to consider the use of "heritable genetic modification".


Telegraph
4 days ago
- Telegraph
Can ADHD really be diagnosed with a simple 18-question test? We ask the experts
There are now 2.6 million people in the UK with ADHD – and diagnoses are on the rise. Looking at 18 years of anonymised NHS patient records, researchers at University College London noted a 20-fold increase in the diagnosis of ADHD in adult men, and 15-fold in women. Meanwhile, demand for a diagnosis has soared by more than 400 per cent since the pandemic, according to figures from the ADHD Foundation. As those looking for an ADHD diagnosis face a wait as long as eight years on the NHS, the two-minute Adult ADHD Self-Report Scale (ASRS), which asks individuals to answer 18 questions themselves, has become widely used. But when Oxford University made the decision to use it to grant extra exam time to almost all students who got a positive result, it called to question the efficacy of the quick test. The students underwent a 90-minute assessment by an unqualified expert after the initial screening but still, it opened a heated discussion about whether the ASRS test was fit for purpose. There are two main concerns surrounding this test: One being that the ease at which people are accessing it is contributing to the fact that doctors are being inundated with diagnosis requests from people who believe they have ADHD. And secondly, if people know that a positive result on the ASRS test could lead to extra time in exams, or to being eligible for benefits, then there could be incentives to answer a certain way. What exactly is the ASRS test? Written in 2005, the self-reporting test was devised by the World Health Organisation (WHO) and experts from Harvard Medical School. It is generally used as an initial screening for ADHD and is widely used by the NHS and private clinicians. The test is only meant to be used as an initial screening and to assess whether a further assessment by a specialist clinician is necessary. 'It was designed to screen for what we call ADHD traits. The main purpose is to flag those patients to primary care providers like GPs, who might want to refer them to secondary care where a more thorough assessment can be done. It's not meant to be used alone for a diagnosis,' says Dr Alessio Bellato, clinical psychologist and lecturer in neurodiversity and mental health at the University of Southampton. With no blood test or objective criteria, ADHD is tricky to diagnose – and sometimes open to abuse. 'ADHD is a constellation of behaviours, but there's no specific gene or signal in the brain that we know about, so we have to rely on observations,' says Dr Bellato. 'The presence of symptoms alone is not enough for a clinical diagnosis; they must have negative consequences that are clinically impactful in everyday life, like maybe the person can't hold down a job or perform at university.' Ideally, a diagnosis should include extensive clinical interviews and evidence of impairment across more than one area of life, according to NICE (National Institute for Health and Care Excellence). So what's the theory behind this two-minute test for ADHD and is there still a place for it? Concerns over diagnosing ADHD with a two-minute test Dr Bellato believes the ASRS test, provided it's used correctly, is a useful tool for initial screening and referrals. 'As of today, it's the best screening tool we have – it's supported by the WHO and designed and developed by researchers from reputable institutions. We have to be realistic about the time GPs have, and ADHD assessment is not their job,' he says. But it isn't perfect. Since ADHD is being widely talked about amongst friends and on social media, most people now understand what boxes to tick on the test, and in some older versions of the test, the answers with the highest scores are also obvious because they're shaded grey. Dr Marios Adamou is a consultant psychiatrist with the adult ADHD and Autism Service, South West Yorkshire Partnership Foundation Trust. He's concerned that too many people are referred by GPs for an assessment after completing the test and are adding to already lengthy waiting lists. 'It used to be useful in the UK, but I don't think it's useful now. People are coming in and demanding a diagnosis because they have already diagnosed themselves,' he says. In his trust, they've recently started to trial a new system. 'GPs contact us and we complete a one-hour face-to-face interview for a referral,' he says, saying that the trial has significantly reduced referrals. Although some clinicians and politicians have claimed that ADHD is being over diagnosed, experts rightly point to the fact that, although it is estimated that around 2.8 per cent of adults have ADHD in the UK, only around 0.32 per cent currently have an ADHD diagnosis, although numbers are rising. How the ASRS test works The test has 18 questions linked to the criteria for diagnosing ADHD, which is set out in the Diagnostic and Statistical Manual of Mental Disorders, also known as DSM-5. The manual classifies ADHD into three types: predominantly inattentive, hyperactive-impulsive and combined. None of these types are inherently more severe; it simply depends on how ADHD shows up in each individual. People with predominantly inattentive ADHD may struggle with focus, forgetfulness, procrastination, concentration and following through on tasks. Those with the hyperactive-impulsive type are more likely to experience restlessness, impulsivity and difficulty sitting still. The combined type includes significant symptoms from both categories. The ASRS test asks questions that help to identify traits of each type of ADHD outlined in the DSM-5. So part A of the test contains six questions that cover both symptoms of inattentiveness and hyperactivity-impulsivity. Part B has a further 12 questions that provide additional clues for clinicians and asks a broader set of questions about how severe the symptoms are and the impact on people's lives. Experts think that the criteria – and the questions – are due an update though, in light of how much researchers are beginning to understand about ADHD. 'The DSM was created decades ago and is constantly updated by clinicians who also involve the public. Right now, signs of emotional dysregulation are not part of the diagnostic criteria, but when we move to DSM-6, I expect we might see that change,' says Dr Bellato. Questions about inattentiveness With ADHD, inattentiveness looks like difficulties focusing on details, organisation, remembering appointments, procrastination, making mistakes, losing things and struggling with concentration. So the ASRS also asks several questions about those things as well as their impact on life, like staying focused at work when doing a boring task, having difficulty concentrating on what people are saying to you or being distracted by noise or activity. 'Attention is a cognitive function, so what we are looking for here is someone with impaired function. If you're honest when you fill it out these questions could signal an attention problem. Of course, there could be other causes like depression, anxiety, alcohol disorder and trauma,' says Dr Adamou. For an ADHD diagnosis, inattention would usually need to have been present since childhood and be pervasive across multiple areas, like work and home. When it comes to ADHD, inattention and procrastination are often linked to the demands of the task; if it's boring, it can be impossible to get started, but if it's stimulating, ADHD people can hyperfocus for a long time. 'There are theories that say that lack of motivation in people with ADHD is due to altered neurotransmitters, including dopamine. This means that doing things that are not really engaging or exciting are much more challenging than they should be, then if something is exciting, they over focus, which is a trait that overlaps with autism,' says Dr Bellato. Questions about hyperactivity and impulsivity 'Hyperactivity is mostly applicable to children,' says Dr Bellato. 'It's the child with ADHD who can't sit still, who is always active, in a way that is excessive for their age. Impulsivity, on the other hand, is related to difficulties in inhibiting a response – for example, let's say, you provoke me and I will react immediately in an inappropriate way. ADHD is very closely related to aggression, and people often struggle with inhibiting their responses which aren't socially acceptable.' So the test also includes several questions that speak to the hyperactive and impulsive nature of ADHD. For adults, these can be physical hyperactive symptoms like difficulties sitting still or staying seated in meetings, feeling constantly restless or fidgety, unable to unwind or relax, or being overly compelled to do things as if being 'driven by a motor'. The questions also aim to measure how the impulsive behaviours relate to inner difficulties, asking whether people often interrupt others and finish their sentences, talk too much and find it difficult to wait their turn. Scoring the test A score between zero to nine indicates a low likelihood of ADHD, between 10-13; a moderate likelihood, 14-17; a high likelihood and 18-24; a very high likelihood. The questions that score highly can also indicate the ADHD subtype, which could be hyperactivity-impulsivity, inattentive or combined. Only the first six questions in Part A of the test are scored, and in 2024, the scoring system was updated to provide more nuance. Each question has a multiple-choice answer of Never/Sometimes/Often and Very Often, with a score ranging from zero to four points for each. Questions seven to 18 are answered in the same way but they're not included in the total score. They're simply used by clinicians to get a more detailed picture of how much of an impact the traits are having on an individual's life. Researchers are continuing to work on better diagnosis methods for ADHD, but in the meantime, Dr Bellato believes the ASRS can be helpful, provided it's used correctly as a first step and not a standalone diagnostic tool. As Dr. Bellato puts it, 'It's not the tool that's the problem, it's how the tool is used.' Where can I find the ADHD Self-Report Scale test? The updated ASRS test is freely available online. You can find a user-friendly version on the website of the charity ADHD UK, the updated version on the Psychology Tools website, and the original version on the ADD website. Experts advise answering the questions honestly and without overthinking your answers. A positive score is a sign to seek further clinical assessment, not a diagnosis of ADHD. Experts recommend sharing your results with a GP, who can refer you for a formal ADHD assessment if appropriate. The test can be a useful tool and a helpful first step if you have a history of symptoms, a family history or other mental health symptoms. But he emphasises that people shouldn't forget 'this is a self-reporting tool, so any non-honest reply will affect the final results, and each individual might have different opinions about how to define something occurring 'rarely' or 'sometimes'. It is always important to talk to your GP or clinical practitioner and only an expert and trained clinician can diagnose ADHD and it might be that follow up assessments rule out ADHD,' says Dr Bellato.


Scottish Sun
12-07-2025
- Scottish Sun
From mushrooms to magnesium and Gaba – we test three booze-free drinks for Alcohol Awareness Week
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