logo
Bicara Therapeutics publishes updated data from Phase 1/1b trial of Ficerafusp

Bicara Therapeutics publishes updated data from Phase 1/1b trial of Ficerafusp

The company states: 'Bicara Therapeutics (BCAX) announced the publication of an abstract with updated interim data from the company's Phase 1/1b clinical trial of ficerafusp alfa in combination with pembrolizumab in patients with first line recurrent/metastatic head and neck squamous cell carcinoma on the 2025 American Society of Clinical Oncology Annual Meeting website. The company will host a conference call on Sunday, June 1, 2025 at 3:00 p.m. CT / 4:00 p.m. ET to present the fulsome dataset, including overall survival and duration of response data, following an oral presentation of the data at the ASCO Annual Meeting. Ficerafusp alfa is a first-in-class bifunctional antibody designed to enhance tumor penetration by breaking barriers within the tumor microenvironment that have challenged the treatment of multiple solid tumor cancers. Specifically, ficerafusp alfa combines two clinically validated targets: an epidermal growth factor receptor directed monoclonal antibody with a domain that binds to human transforming growth factor beta.' 'We are pleased to present the fulsome dataset from our Phase 1/1b trial of ficerafusp alfa in patients with recurrent/metastatic head and neck squamous cell carcinoma during our upcoming oral presentation at ASCO,' said David Raben, MD, Chief Medical Officer of Bicara Therapeutics. 'The interim data featured in the ASCO abstract demonstrate encouraging signals that represent a meaningful improvement over historical benchmarks in patients with HPV-negative disease, a population with high unmet need and worse survival outcomes than those with HPV-positive disease. Notably, we're encouraged to see how ficerafusp alfa, specifically designed to drive tumor penetration within the tumor microenvironment, is leading to deep, and now, durable responses that appear to be translating to prolonged overall survival.'
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

'Eclipse of the century': Lengthy 6-minute solar eclipse is coming Aug. 2, 2027
'Eclipse of the century': Lengthy 6-minute solar eclipse is coming Aug. 2, 2027

Indianapolis Star

time2 hours ago

  • Indianapolis Star

'Eclipse of the century': Lengthy 6-minute solar eclipse is coming Aug. 2, 2027

No, the world will not go dark this weekend. Rumors about a lengthy total solar eclipse may have been circulating online, but the so-called "eclipse of the century" isn't for another two years. A total solar eclipse lasting up to 6 minutes and 23 seconds, at its peak, is expected to occur on Aug. 2, 2027, according to NASA. The total solar eclipse, in which the moon moves perfectly between the sun and Earth and casts a shadow on Earth, will be one of the longest in several decades. For a time comparison, the total solar eclipse that occured on April 8, 2024, lasted 4 minutes and 28 seconds at its peak. The solar eclipse of 1991, however, lasted 6 minutes and 53 seconds. reports the Aug. 2, 2027 eclipse will be the longest eclipse totality until 2114. The eclipse will be visible in parts of Africa, Europe and the Middle East. Unfortunately for American skywatchers, the vast majority of the U.S. won't have a view of it. The Aug. 2, 2027 solar eclipse isn't actually the next total solar eclipse though. That one, on Aug. 12, 2026, will be visible in Greenland, Iceland, Spain, Russia and parts of Portugal, according to NASA. Here's what to know about the solar eclipse on Aug. 2, 2027. The solar eclipse's path of totality will cross over parts of Africa, Europe and the Middle East, according to National Eclipse and NASA. Parts of the following countries are within the path of totality. Other countries in Africa, Europe and the Middle East will have a partial view of the eclipse. A partial solar eclipse will be visible in parts of Maine between 5:14 and 5:19 a.m. ET on Aug. 2, 2027, according to Time and Date.

Sky Harbour to Report Its Second Quarter 2025 Financial Results and Host Webcast Investor Call on August 12th, 2025
Sky Harbour to Report Its Second Quarter 2025 Financial Results and Host Webcast Investor Call on August 12th, 2025

Business Wire

time6 hours ago

  • Business Wire

Sky Harbour to Report Its Second Quarter 2025 Financial Results and Host Webcast Investor Call on August 12th, 2025

WEST HARRISON, N.Y.--(BUSINESS WIRE)--Sky Harbour Group Corporation (NYSE: SKYH, SKYH WS) ('SHG' or the 'Company'), an aviation infrastructure company building the first nationwide network of Home-Basing campuses for business aircraft, today announced that it will release its Second Quarter 2025 financial results and file its quarterly report on Form 10-Q with the SEC after market close on Tuesday, August 12th, 2025, and that it will host an investor webcast at 5:00 pm ET the same day. On the call, Sky Harbour will review quarterly financial results and provide a general business update. A question-and-answer session with Sky Harbour leadership will follow. Both the call and webcast are open to the general public. The webcast will be publicly available in the UPCOMING EVENTS section of the Company's investor relations website, A replay of the webcast will be available on the Company's website following the event. To join the webcast, please use the following link: For the audio-only conference call, please use the following participant details: North America Toll-Free: (888) 660-6739 North America Toll: (929) 203-0875 International Toll: +1(929) 203-0875 Conference ID: 3259957 If you have any questions or are interested in connecting with Sky Harbour leadership, please contact Investor Relations at investors@ About Sky Harbour Group Corporation Sky Harbour Group Corporation is an aviation infrastructure company developing the first nationwide network of Home-Basing campuses for business aircraft. The Company develops, leases and manages general aviation hangars across the United States. Sky Harbour's Home-Basing offering aims to provide private and corporate customers with the best physical infrastructure in business aviation, coupled with dedicated service tailored to based aircraft, offering the shortest time to wheels-up in business aviation. To learn more, visit Forward Looking Statements Certain statements made in this release are "forward looking statements" within the meaning of the "safe harbor" provisions of the United States Private Securities Litigation Reform Act of 1995, including statements about the expectations regarding future operations at Sky Harbour Corporation and its subsidiaries. When used in this press release, the words 'plan,' 'believe,' 'expect,' 'anticipate,' 'intend,' 'outlook,' 'estimate,' 'forecast,' 'project,' 'continue,' 'could,' 'may,' 'might,' 'possible,' 'potential,' 'predict,' 'should,' 'would' and other similar words and expressions (or the negative versions of such words or expressions) are intended to identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. The forward-looking statements are based on the current expectations of the management of Sky Harbour Group Corporation (the 'Company') as applicable and are inherently subject to uncertainties and changes in circumstances. These forward-looking statements involve a number of risks, uncertainties or other assumptions that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements. For more information about risks facing the Company, see the Company's annual report on Form 10-K for the year ended December 31, 2024, and other filings the Company makes with the SEC from time to time. The Company's statements herein speak only as of the date hereof, and the Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

Don't Just Clean It—Leverage It: The Business Case for Extinguishing Remediation Liability
Don't Just Clean It—Leverage It: The Business Case for Extinguishing Remediation Liability

Associated Press

time6 hours ago

  • Associated Press

Don't Just Clean It—Leverage It: The Business Case for Extinguishing Remediation Liability

Live date: Tuesday, August 19th at 12pm CT Register here! Organizations have been managing legacy remediation liability around the world since the 1960s and have experienced a multitude of challenges to reduce or remove these financial liabilities from their organizations. The stories range from 'these sites just never go away' to 'why is there so much variability in the future cost estimate?' along with everyone's favorite, 'why does the estimated cost to close these sites keep going up with no end in sight?'We face hard questions from business leadership, so it is important to: Understanding complex technical issues, managing 'technically righteous' consultants, keeping regulators happy, and engaging with your operations and finance team can be a struggle. Most people live in a world of constant change orders, complex stakeholder engagement, and regulatory remediation programs that seem to go on forever. These liabilities are a burden to the balance sheet and finding the pathway to manage them to zero is a business-driven goal for your organizational stakeholders. That business driver can be used as a vehicle to close sites and quickly extinguish those legacy remediation liabilities. Rest assured; you found the help you've been looking for. This webinar will teach you how to present strategies to your leadership in business terms that will help reduce or extinguish your legacy liability and keep you out of hot water with regulators, your finance group, and the C-suite. Please join us on Tuesday, August 19th at 12pm CT. If you can't attend live, registrants will receive on-demand access shortly after the event. Visit 3BL Media to see more multimedia and stories from Antea Group

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store