OS Therapies' OST-HER2 Immunotherapy for Osteosarcoma Featured in Upcoming Movie Shelter Me: The Cancer Pioneers
'Our team is dedicated to advancing a treatment for osteosarcoma and are proud to see our immunotherapy in Shelter Me: The Cancer Pioneers,' stated OS Therapies' CEO Paul Romness. 'Comparative oncology is an important area of research for us because of the striking genetic homology of over 96% between human and canine osteosarcoma.' OST-HER2 is an investigational drug and is not currently approved to treat osteosarcoma or any other disease.
Shelter Me: The Cancer Pioneers also features leading scientists at the National Cancer Institute / National Institutes of Health, the University of Pennsylvania, the University of Illinois, the University of Wisconsin, and Colorado State University. It is part of an Emmy Award-winning PBS series, Shelter Me, that celebrates the life-changing relationships between people and animals.
A trailer of the movie can be viewed here.
About OS Therapies
OS Therapies is a clinical stage oncology company focused on the identification, development, and commercialization of treatments for Osteosarcoma (OS) and other solid tumors. OST-HER2, the Company's lead asset, is an immunotherapy leveraging the immune-stimulatory effects of Listeria bacteria to initiate a strong immune response targeting the HER2 protein. OST-HER2 has received Rare Pediatric Disease Designation (RPDD) from the US Food & Drug Administration and Fast-Track and Orphan Drug designations from the US FDA and European Medicines Agency. The Company positive data in its Phase 2b clinical trial of OST-HER2 in recurrent, fully resected, lung metastatic osteosarcoma demonstrating statistically significant benefit in the 12-month event free survival (EFS) primary endpoint of the study. The Company anticipates submitting a Biologics Licensing Application (BLA) to the US FDA for OST-HER2 in osteosarcoma in 2025 and, if approved, would become eligible to receive a Priority Review Voucher that it could then sell. OST-HER2 has completed a Phase 1 clinical study primarily in breast cancer patients, in addition to showing preclinical efficacy data in various models of breast cancer. OST-HER2 has been conditionally approved by the U.S. Department of Agriculture for the treatment of canines with osteosarcoma.
In addition, OS Therapies is advancing its next-generation Antibody Drug Conjugate (ADC) and Drug Conjugates (DC), known as tunable ADC (tADC), which features tunable, tailored antibody-linker-payload candidates. This platform leverages the Company's proprietary silicone Si-Linker and Conditionally Active Payload (CAP) technology, enabling the delivery of multiple payloads per linker. For more information, please visit www.ostherapies.com.
Forward-Looking Statements
Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute forward-looking statements within the meaning of the federal securities laws. These forward-looking statements and terms such as 'anticipate,' 'expect,' 'intend,' 'may,' 'will,' 'should' or other comparable terms involve risks and uncertainties because they relate to events and depend on circumstances that will occur in the future. Those statements include statements regarding the intent, belief or current expectations of OS Therapies and members of its management, as well as the assumptions on which such statements are based. OS Therapies cautions readers that forward-looking statements are based on management's expectations and assumptions as of the date of this news release and are subject to certain risks and uncertainties that could cause actual results to differ materially, including, but not limited to the approval of OST-HER2 by the US FDA and grant of a priority review voucher and other risks and uncertainties described in 'Risk Factors' and 'Management's Discussion and Analysis of Financial Condition and Results of Operations' in the Company's registration statement on Form S-1 filed with the Securities and Exchange Commission (the 'SEC') on November 12, 2024, as amended on November 27, 2024, and other subsequent documents we file with the SEC, including but not limited to our Quarterly Reports on Form 10-Q. Any forward-looking statements contained in this press release speak only as of the date hereof, and, except as required by the federal securities laws, OS Therapies specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.
Jack Doll
571.243.9455
[email protected]://x.com/OSTherapies
https://www.instagram.com/ostherapies/
https://www.facebook.com/OSTherapies/
https://www.linkedin.com/company/os-therapies/
SOURCE: OS Therapies
Copyright Business Wire 2025.
PUB: 03/25/2025 07:40 AM/DISC: 03/25/2025 07:39 AM
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- 273 - - (273 ) (100.0 ) Net write down on premises and equipment no longer in use - (356 ) - 356 (100.0 ) - - Payment processing income 2,079 2,192 1,798 (113 ) (5.2 ) 281 15.6 Income on bank-owned life insurance 289 279 195 10 3.6 94 48.2 Mortgage banking income 162 16 408 146 912.5 (246 ) (60.3 ) Investment commissions 312 350 352 (38 ) (10.9 ) (40 ) (11.4 ) Debit card income 793 525 573 268 51.0 220 38.4 Credit card income 58 49 335 9 18.4 (277 ) (82.7 ) Other 747 312 115 435 139.4 632 549.6 Total non-interest income 5,246 3,727 3,445 1,519 40.8 1,801 52.3 Non-interest expense: Salaries and employee benefits 8,909 11,566 8,701 (2,657 ) (23.0 ) 208 2.4 Occupancy and equipment 2,042 2,018 2,384 24 1.2 (342 ) (14.3 ) Data processing 2,994 3,378 2,218 (384 ) (11.4 ) 776 35.0 Professional fees 1,088 661 739 427 64.6 349 47.2 Payment processing 932 1,043 992 (111 ) (10.6 ) (60 ) (6.0 ) Deposit insurance 780 632 687 148 23.4 93 13.5 Advertising 310 265 334 45 17.0 (24 ) (7.2 ) Telecommunications 96 92 101 4 4.3 (5 ) (5.0 ) Problem loan and foreclosed real estate, net 194 112 100 82 73.2 94 94.0 Other general and administrative 2,418 2,064 2,707 354 17.2 (289 ) (10.7 ) Total non-interest expense 19,763 21,831 18,963 (2,068 ) (9.5 ) 800 4.2 Income (loss) before income tax expense 5,030 (16,509 ) 3,110 21,539 (130.5 ) 1,920 61.7 Income tax expense (benefit) 1,158 (4,922 ) 759 6,080 (123.5 ) 399 52.6 Net income (loss) $ 3,872 $ (11,587 ) $ 2,351 $ 15,459 (133.4 ) % $ 1,521 64.7 % Expand Assabet Valley Bancorp Consolidated Statements of Operations YTD (Unaudited) Six Months Ended Six Months Ended June 30, 2025 Change (In thousands) June 30, 2025 June 30, 2024 From Six Months Ended June 30, 2024 Interest and dividend income: Loans, including fees $ 57,067 $ 54,750 $ 2,317 4.2 % Securities 5,206 4,953 253 5.1 Other 636 1,038 (402 ) (38.7 ) Total interest and dividend income 62,909 60,741 2,168 3.6 Interest expense: Deposits 14,973 15,872 (899 ) (5.7 ) Federal Home Loan Bank advances 7,439 8,344 (905 ) (10.8 ) Subordinated debt 667 630 37 5.9 Total interest expense 23,079 24,846 (1,767 ) (7.1 ) Net interest income: 39,830 35,895 3,935 11.0 Provision expense (reversal) for credit losses 18,687 310 18,377 5,928.1 Net interest income, after provision expense for credit losses 21,143 35,585 (14,442 ) (40.6 ) Non-interest income: Customer service fees 1,785 1,620 165 10.2 Net (loss) on sale of securities available for sale (619 ) (1,366 ) 747 (54.7 ) Net recognized gain on equity securities - 1,637 (1,637 ) (100.0 ) Net write down on premises and equipment no longer in use (356 ) - (356 ) (100.0 ) Payment processing income 4,271 3,660 611 16.7 Income on bank-owned life insurance 568 407 161 39.6 Mortgage banking income 178 858 (680 ) (79.3 ) Investment commissions 662 660 2 - Debit card income 1,318 1,109 209 18.8 Credit card income 107 566 (459 ) (81.1 ) Other 1,060 193 867 449.2 Total non-interest income 8,974 9,344 (370 ) (4.0 ) Non-interest expense: Salaries and employee benefits 20,475 17,308 3,167 18.3 Occupancy and equipment 4,060 4,468 (408 ) (9.1 ) Data processing 6,372 4,423 1,949 44.1 Professional fees 1,749 1,254 495 39.5 Payment processing 1,975 2,012 (37 ) (1.8 ) Deposit insurance 1,412 1,396 16 1.1 Advertising 575 779 (204 ) (26.2 ) Telecommunications 188 205 (17 ) (8.3 ) Problem loan and foreclosed real estate, net 306 184 122 66.3 Other general and administrative 4,484 5,031 (547 ) (10.9 ) Total non-interest expense 41,596 37,060 4,536 12.2 Income (loss) before income tax expense (11,479 ) 7,869 (19,348 ) (245.9 ) Income tax expense (benefit) (3,764 ) 1,973 (5,737 ) (290.8 ) Net income (loss) $ (7,715 ) $ 5,896 $ (13,611 ) (230.9 ) % Expand Assabet Valley Bancorp Average Balances and Average Yields And Costs (Unaudited) For the Quarters Ended June 30, 2025 March 31, 2025 June 30, 2024 (Dollars in thousands) Average Outstanding Balance Interest Average Yield/ Rate Average Outstanding Balance Interest Average Yield/Rate Average Outstanding Balance Interest Average Yield/ Rate Interest-earning assets: Short-term investments $ 67,357 $ 421 2.51 % $ 37,105 $ 215 2.35 % $ 49,032 $ 568 4.66 % Securities 296,321 2,555 3.46 309,608 2,651 3.47 352,204 2,833 3.24 Loans 2,229,893 28,883 5.20 2,214,952 28,183 5.16 2,015,649 27,492 5.49 Total interest-earning assets 2,593,571 31,859 4.93 2,561,665 31,049 4.92 2,416,885 30,893 5.14 Noninterest-earning assets 122,176 105,220 104,623 Total assets $ 2,715,747 $ 2,666,885 $ 2,521,508 Interest-bearing liabilities: NOW accounts $ 697,452 $ 700 0.40 % $ 690,014 $ 813 0.48 % $ 605,633 $ 737 0.49 % Money market accounts 270,969 848 1.26 260,430 842 1.31 299,203 1,117 1.50 Regular and other savings accounts 401,215 2,278 2.28 383,017 2,098 2.22 348,440 2,231 2.58 Certificates of deposit 347,419 3,416 3.94 387,556 3,978 4.16 246,367 4,200 6.86 Total interest-bearing deposits 1,717,055 7,242 1.69 1,721,017 7,731 1.82 1,499,643 8,285 2.22 FHLB advances and other borrowings (1) 333,834 3,647 4.38 339,814 3,792 4.53 362,083 3,985 4.43 Subordinated debt 27,782 352 5.08 27,691 315 4.61 27,592 315 4.59 Total interest-bearing liabilities 2,078,671 11,241 2.17 2,088,522 11,838 2.30 1,889,319 12,585 2.68 Noninterest-bearing demand deposits 415,035 336,000 388,359 Other noninterest-bearing liabilities 33,242 45,439 43,526 Total liabilities 2,526,948 2,469,961 2,321,203 Total capital 188,799 196,924 200,305 Total liabilities and capital $ 2,715,747 $ 2,666,885 $ 2,521,508 Net interest income $ 20,618 $ 19,211 $ 18,308 Net interest rate spread (2) 2.76 % 2.62 % 2.46 % Net interest-earning assets (3) $ 514,900 $ 473,143 $ 527,566 Net interest margin (4) 3.19 % 3.04 % 3.05 % Average interest-earning assets to interest-bearing liabilities 124.77 % 122.65 % 127.92 % (1) Average balances for borrowings includes the financing lease obligation which is presented under other liabilities on the consolidated balance sheet. 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