
Prep Now: 25 Of The Smartest Summer Problem-Solvers
A pair of sockless shoe liners so your feet don't overheat in actual socks. A summer without sweaty, smelly socks? Sounds like a win to me. These no-slip and no-show liners are also washable!
A pack of 10 DEET-free mosquito-repellent bracelets that use essential oils to keep bloodsuckers away. Some reviewers suggest wearing one on your wrist and one on your ankle if you're in mosquito-dense areas.
An SPF 30 scalp sunscreen mist because you probably forget that the top of your head needs sun protection, too. Formulated with plant-based antioxidants, this spray will also help nourish your hair and prevent UV-related hair color fading.
A Shark Tank-famous bug bite suction tool for mosquito bite relief because you're excited about tank tops and short shorts but not the fact that you'll be exposed to some nasty bloodsuckers. It pretty much sucks the irritant out from under your skin so you can live an itch-free life.
A ceiling fan carbon air filter to catch dust, pollen, pet dander, and smoke. These self-adhesive filters are made from coconut shells whose lightweight structure traps particles and contaminants. Turn your ceiling fan into an air purifier!
A crack weeder tool if weeds think they're being clever by growing in the cracks of your patio or sidewalk. This L-shaped tool can remove the entire root without you needing to literally dig around for it. It's also got a soft grip handle because taking care of your home's outward appearance shouldn't be physically taxing.
A set of stackable stick-shaped ice molds so you can easily toss a few pieces of ice into your bottle without having to literally force a square into a circle. Staying cool and hydrated just got a little easier.
A sleek 3-in-1 handheld fan because it's also a portable charger and flashlight, so if you're caught in the dark, and it's hot and your phone is on 1%, you'll be glad to have this gadget in your back pocket.
A pre-swim hair cream since it'll help protect your hair from dryness and chlorine damage. Enriched with aloe, this cream can create a barrier to prevent your hair from absorbing chlorine and salt. No green hair and no frizz!
A hot tub cleaner scientifically engineered to remove all the gunk hiding in the plumbing. So all the dirt, grime, oil, and sweat will go bye-bye in exchange for improved water clarity and filtration.
A set of stackable starfish-shaped sand cup holders so you don't have to fight to keep your bottle of water upright in the sand. It's also great for holding your phone, sunscreen, or keys — anything you don't want getting lost or covered in sand.
A set of electrolyte-rich Liquid I.V. hydration packets because sometimes you get so caught up in having fun on a scorching hot summer day that you forget to drink water and start to feel a little...not good. These can help hydrate you lickety-split!
An easy-to-install smart sprinkler controller since it monitors your local weather and will skip watering if the forecast calls for rain. It'll always provide the right amount of water, making sure your greens stay green AND your water bill stays low.
A pack of SPF-sensing stickers that change color to alert you as to when to apply more sunscreen. And because they're hypoallergenic, latex-free, and pain-free to take off, they're great for the whole family.
A portable electric mosquito repellent — this DEET-free and scent-free shield works to keep mosquitoes up to 15 feet away. Each repellent mat lasts up to four hours, and they change color to let you know it's time to replace them. So bring this out to your backyard and have some worry-free fun!
A sand-removal powder bag because you love the beach, in theory, but in practice? You hate getting sand all over your body. This talc-free and reef-friendly bag easily removes sand and leaves you feeling clean.
A stick-on shade since the sun plans to tag along on your travel adventures so some protection from its rays might be nice. This is great especially if you have kids in the backseat.
A windproof beach tent so you don't have to lie directly under the sun when all you want is to feel a cool breeze and hear the waves crash down. This spacious tent offers UPF 50+ protection, meaning the material can block 98% of harmful UV rays!
And a foldable baby tent for trips to the beach or backyard! Covered in a breathable mesh, this playpen allows you to keep an eye on your little one while also providing them some shelter from UV rays since it comes with a UPF 50+ canopy.
A laptop shade because it'll not only give you privacy while you work by the crowded pool but it'll also help protect your laptop from the heat of the sun.
A pack of towel bands so you don't have to curse the winds for carrying your towel away from the chair you claimed at the pool. These durable latex bands won't rust, break, or lose strength over time like towel clips.
A refillable roll-on sponge sunscreen applicator that's easy enough for your kids to use (with supervision, of course)! Just fill it with your sunscreen of choice, and let the fun in the sun begin! Plus? There'll be less mess on your hands.
A set of heel caps because it's stiletto weather but you shouldn't have to risk sinking into dirt, gravel, and grass just to look sharp.
A waterproof baby carrier with adjustable straps so you can take your little one into the pool with you and they can safely splash around. It features adjustable, padded straps for the wearer's comfort.
A long-reaching lotion applicator — moisturize your back without trying (and failing) to force your arms to bend in ways they simply don't. You can also use this to apply self-tanner or sunscreen on your back. No more sunburns in places you normally can't reach!

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Yahoo
3 hours ago
- Yahoo
UVBrite Smart Water Bottle Reinforces Market Leadership in UV-C LED Water Purification and Intelligent Hydration Trends
UV-C Self-Cleaning Technology Gains Momentum as UVBrite Enhances Sustainable, Filter-Free Hydration for Health-Conscious and On-the-Go Consumers Kearny, June 28, 2025 (GLOBE NEWSWIRE) -- UVBrite, a pioneer in personal wellness technology, has reaffirmed the critical role of its flagship UVBrite Smart Water Bottle in the expanding global movement toward intelligent hydration, personal sanitation, and sustainable living. The company's 2025 update contextualizes the growing adoption of UV-C LED-based self-cleaning hydration systems, highlighting the UVBrite bottle's practical features, automation cycles, and eco-friendly design as consumer behavior continues to evolve toward reusable, low-maintenance wellness tools. With increased awareness of microbial contamination, public tap water variability, and the high environmental cost of bottled water, demand for UV-enabled smart bottles has surged across key demographics, including health-conscious commuters, global travelers, outdoor enthusiasts, and eco-conscious households. The UVBrite Smart Water Bottle meets this demand through a combination of rechargeable UV-C purification, thermal insulation, and self-cleaning automation that operates passively throughout the day. What You'll Learn in This Release The UV-C LED water purification system is the key behind UVBrite's clever design. The shift in consumer expectations around self-cleaning hydration systems Industry trends in wellness technology and personal sanitation Practical use scenarios spanning travel, home, work, and recreation Scientific context and performance benchmarks for UV-based disinfection. Sustainability comparisons versus filtered or single-use bottle models Expanded Q&A addressing standard safety, usage, and performance topics. UVBrite's mission is to support eco-responsible, intelligent hydration. Intelligent Hydration Meets Portable Safety The UVBrite Smart Water Bottle represents a new generation of hydration tools designed for both convenience and control. Engineered to disinfect water using ultraviolet light, the bottle neutralizes common waterborne pathogens at the molecular level—providing peace of mind in uncertain environments, from unfamiliar airport taps to mountain trailhead refills. Its user-friendly design, easy operation, and unique features, such as the self-cleaning automation mode and long-lasting rechargeable battery, ensure that you can enjoy safe, clean water without any hassle. This trend toward "intelligent hydration" reflects broader consumer preferences for self-sufficient, automated products that reduce friction in everyday wellness. UVBrite's approach aligns closely with this shift, offering a system that eliminates the need for chemicals, scrubbing, or filter replacements—features that traditional water purification models often rely on. We understand your needs and have designed our product to meet them. Inside the Bottle: UVBrite's Core Technology At the heart of UVBrite's system is a state-of-the-art UV-C LED module housed within the bottle's cap. This module emits light in the 260–280 nanometer germicidal range, initiating a DNA-disrupting purification cycle at the push of a button. This process effectively deactivates a wide range of microorganisms, including E. coli, Giardia, and certain viruses, without altering the water's taste or composition. The UV-C LED water purification system is the key behind UVBrite's clever design, providing a powerful and efficient way to ensure the safety and cleanliness of your drinking water. The bottle offers two cycle options: Standard Mode: A 180-second cycle designed for municipally treated tap water Enhanced Mode: A longer cycle suitable for untreated sources like fountains or rivers In addition to its on-demand disinfection feature, UVBrite includes a self-cleaning automation mode that activates every six hours. This internal sanitization cycle helps prevent the development of biofilm, odors, and microbial residue buildup—issues common in conventional reusable bottles. The rechargeable battery supports over 60 disinfection cycles per full charge, and the body is constructed from 304-grade stainless steel, providing double-walled insulation to maintain both hot and cold beverage temperatures. Why UV-C Is the New Standard in Portable Purification UV-C light disinfection has been trusted for decades in clinical and laboratory environments for sterilizing surfaces, instruments, and water. Now adapted for personal hydration, it offers several advantages over traditional filtration or chemical water treatment methods: No filter replacements required: Unlike carbon-based filters that require routine changes and can clog over time, UV-C purification uses a maintenance-free LED system that eliminates microbes without any consumable parts. No chemical taste or residue: While iodine tablets and chlorine drops leave a distinct aftertaste, UV-C disinfection neutralizes pathogens without altering the water's flavor or clarity. Instant operation on demand: The UVBrite Smart Water Bottle purifies water in just 180 seconds. There's no need to boil water, wait for tablets to dissolve, or pressurize a filter system. Low-maintenance hygiene: Built-in auto-cleaning cycles activate every six hours, helping to maintain a sanitized interior and reduce bacterial buildup with no manual scrubbing required. Portable and energy-efficient: The rechargeable battery provides over 60 purification cycles per charge, making UVBrite ideal for travel, the office, or outdoor settings where reliability is crucial. This combination of features has made UV-C technology the go-to solution for users who value hygienic autonomy, sustainability, and ease of use—whether purifying tap water in a city or collecting fresh water on a remote trail. From Airports to Campsites: A Versatile Everyday Tool The UVBrite Smart Water Bottle is not just for outdoor survival scenarios or specialty use cases. It is designed to integrate into everyday life, adapting to your urban routines, fitness regimens, travel habits, and workplace hydration needs. Its versatility ensures that it can meet your needs, regardless of where you are or what you're doing, providing you with the assurance that the UVBrite Smart Water Bottle is a versatile solution for all your hydration needs. For example: Remote workers and digital nomads utilize UV-enabled bottles to ensure safe hydration when using unfamiliar water systems. Healthcare professionals working long shifts rely on auto-cleaning features to maintain hygiene passively. Fitness enthusiasts value the zero-maintenance sanitation cycle during workouts or commutes. Families and students appreciate the child-safe design and freedom from filters or chemicals. This broad application spectrum helps explain the product's steady rise in relevance—not as a gadget but as a new hygiene norm. The Broader Wellness Tech Ecosystem UVBrite is not alone in this wave of automation-enabled wellness devices. Today's consumers routinely integrate: UV-based toothbrushes or phone sterilizers Smart water pitchers with sensors Self-cleaning appliances (e.g., vacuums, fridges) Wearables that passively monitor health metrics These tools are defined by their hands-off operation, data-driven logic, and seamless integration into daily habits. UVBrite fits squarely within this ecosystem, reinforcing the demand for gear that offers passive protection, not additional chores. The bottle's success is not just about hydration—it's about portable safety without friction. Environmental and Economic Impact of Reusable UV Bottles In the push to reduce single-use plastic waste, reusable smart bottles offer a dual benefit: sustainability and cost savings. A person drinking three bottled waters daily generates: ~1,095 bottles/year ~140–$180/year in bottled water costs Hundreds of pounds of plastic waste per household In contrast, UVBrite users: Avoid plastic accumulation Eliminate filter replacement expenses Gain long-term usage with no recurring consumables This model also supports corporate sustainability goals. Offices adopting reusable smart bottles can reduce company-wide plastic use while promoting access to hygienic hydration for staff—without increasing the janitorial burden. Frequently Asked Questions Q: How does UV-C water purification work? UV-C light breaks down the genetic material of bacteria, viruses, and protozoa, preventing them from reproducing. The process is chemical-free and leaves no taste or residue. Q: Can this bottle purify water from a stream or river? Yes, using the Enhanced Mode. However, UVBrite is intended for relatively clear water. It does not filter out debris or heavy sediment. Q: How often does the bottle clean itself? Every 6 hours, the auto-cleaning cycle activates, running a complete sanitization of the interior to prevent microbial buildup and odor. Q: Is the bottle dishwasher-safe? The UVBrite Smart Water Bottle is not dishwasher-safe. Hand washing is recommended for exterior components, though the interior is sanitized via UV automation. Q: What kind of battery does it use, and how is it charged? It utilizes a rechargeable lithium battery, which is charged via USB. A full charge provides over 60 cycles. Q: Is UVBrite safe for children or seniors? Yes, it's suitable for users of all ages when used as directed. The UV light is sealed within the lid and never exposed to external elements. Q: How long does the UV-C cycle take? Standard Mode takes 180 seconds. Enhanced Mode runs slightly longer and is used for less predictable water sources. Q: What are the maintenance requirements? Virtually none. No filter changes, no chemical additives, and no deep scrubbing. Occasional exterior cleaning is the only recommendation. Scientific Support and Regulatory Context UV-C disinfection is widely supported in scientific literature. According to the World Health Organization (WHO) and U.S. Environmental Protection Agency (EPA), UV-C is an effective non-chemical method for inactivating waterborne microorganisms. Peer-reviewed studies have demonstrated that UV-C light can neutralize over 99.9% of bacteria and viruses under controlled exposure conditions. While results depend on turbidity and exposure time, the method is recognized globally as a valid means of sanitation. UVBrite's product operates within this accepted scientific framework, repurposing lab-grade safety protocols into a handheld format for the modern consumer. Availability and Transparency The UVBrite Smart Water Bottle is available for purchase on the official website at The site provides access to: Technical specs Water disinfection explanations Usage recommendations Frequently asked safety questions UVBrite emphasizes transparency in materials and technology. While designed to enhance wellness and sanitation, the Smart Water Bottle is not a medical device and should not be considered a substitute for local water safety regulations. About UVBrite UVBrite is a wellness-focused consumer technology company specializing in intelligent, reusable hydration systems. By merging UV-C disinfection with ergonomic product design, UVBrite supports health-conscious lifestyles through convenience, automation, and sustainability. The company's mission is to eliminate dependence on single-use plastics, improve access to everyday water quality, and empower users with low-maintenance tools that align with modern mobility. UVBrite products are intended for general wellness purposes and do not serve diagnostic or therapeutic functions. Contact UVBrite Email: info@ Website: CONTACT: UVBrite Email: info@ Website: in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data


Buzz Feed
14 hours ago
- Buzz Feed
34 Reviewer-Loved Products To Nail Your Beauty Routine
A lightweight gel cream from Nivea so shockingly effective, you might trick people into thinking you have a filter on your skin. No, really — it actually happened for one reviewer! This uses the miracle-working abilities of an ingredient called ~Q10~ to deliver plumper, firmer-looking, more moisturized skin. A cult-classic Clinique Almost Lipstick Tinted Lip Balm in Black Honey if you want to keep dry, chapped lips AWAY. This bb is lightweight, slightly glossy, and has a little dash of magic. I mean, I'm guessing it's magic — because the way this glosses you up and complements all different skin tones so beautifully is beyond anything ordinary. A moisturizing hair serum here to breathe some life back into your locks and rescue them from eternal dryness. This delightful blend is derived from seven incredible oils: argan, olive, coconut, apricot, marula, jojoba, and camellia. This reviewer says it gives you gloss without the grease, and that the scent alone makes them want to keep using it! Medicube's "Zero Pore" Pads that do their job so well, they turned this skeptical reviewer into a believer. They contain lactic acid, salicylic acid, and a dual-textured surface to help control excess sebum while exfoliating dead skin and refining pores, all while keeping you looking like a true ~glow-getter~. A pore-clearing cleansing oil because it uses the calming powers of heartleaf oil to soothe irritated skin and eliminate makeup residue, blackheads, and sebum while preventing pore congestion. It's also hypoallergenic and works wonders for sensitive, acne-prone skin. A reviewer-beloved teeth-whitening pen — you'll see the difference almost immediately, and it'll help you avoid having to go get it done by a pro. It's painless, minty fresh, and helps whiten your teeth after years of drinking coffee, tea, wine, and basically anything that isn't water. 🙃 A satin-finish TirTir cushion foundation, which has had the whole TikTok beauty community in a chokehold. This all-star gem lets you enjoy 72-hour flawless coverage and offers effortless blending to hide redness, blemishes, and under-eye bags. Plus, it comes in 40 shades and is *packed* with hibiscus and red propolis extracts for a boost in skin elasticity. Perfect for beauty enthusiasts who love effortless applications anytime, anywhere. A gentle LilyAna Naturals retinol cream that this reviewer (an esthetician of over 13 years) has deemed "The BEST hidden gem!!" This magical cream supports natural collagen production, combats uneven skin tone, and smooths rough texture. How, you ask? It comes jam-packed with all the goods, including botanical hyaluronic acid, shea butter, organic green tea, organic jojoba oil, and vitamins A and E. A TikTok-famous VieBeauti eyelash growth serum to help with upkeep when you can't make it to the esthetician for extensions. Apply to your lashes daily to help them become longer and stronger within just a few weeks! You'll be resisting the urge to flutter your lashes like a cartoon character every time your S.O. walks by in no time. A surprisingly effective instant foot peeling spray that'll make your footsies so baby-soft and pretty, they'll be a good uh... backup plan. (You know, in case your current career doesn't pan out. 👀) This not only helps gently remove dead skin, but also moisturizes dry and cracked heels, so you'll really get some refreshing bang for your buck. For an ~extra~ peeling effect, use an exfoliating mitt! A bottle of Elizavecca Hair Treatment some reviewers say is even BETTER than Olaplex, which is over three times the price! It's infused with collagen, ceramides, and protein extracts to help repair your hair if it is damaged, over-processed, or has just spent too much time with that flat iron. Simply apply it on wet hair after shampooing, wait five minutes, and rinse it out. A SeoulCeuticals toner mist — a powerful potion that not only hydrates and plumps your skin but is also a *miracle* worker on blemishes, helping keep those pesky breakouts at bay. It's made with 98% naturally derived ingredients like refreshing cucumber, antioxidant-rich green tea, tamarind, soothing aloe, and rejuvenating marine minerals for a perfect dose of dewy radiance. Good Molecules Yerba Mate Wake Up Eye Gel, which is like treating your face to a morning espresso shot. It uses the power of yerba mate, caffeine, and peptides to soothe the delicate skin under your eyes, and also contains three forms of hyaluronic acid to moisturize. And here I was thinking there was only one type of hyaluronic acid — the more ya know! And a cruelty-free under-eye brightener to help balance out the bluish tones of under-eye shadows and dark circles. And bonus! It's infused with hyaluronic acid and shea butter to nourish your skin and give you a radiant glow. Wear it by itself or under your concealer for a more full-coverage look! A paraben-free self-tanner with a dreamy mousse formula that glides over your skin smoothly, ensuring an even application without those pesky streaks. In just one hour, you'll be glowing like you just got back from an exotic, tropical getaway — and you didn't even have to step a foot outside. Dermora's foot exfoliation mask — you apply the two bootie-shaped masks on your feet for an hour, wash your feet, and then, over the next five to seven days, enjoy the disgustingly satisfying experience of watching all of your dead skin fall away to reveal baby-soft feet. Reviewers swear by this for calluses and rough, cracked skin! A travel-friendly SPF 50 Airy Sunstick Smoothing Bar — ya know, because K-beauty doesn't have ENOUGH wins. This genius product is designed with a curved stick that makes it super easy to apply, and a non-sticky, white cast-free formula that blends ridiculously well with your makeup. (Seriously, what kind of sorcery is in this thing?) Top that off with its lightweight "soft matte" finish, and you've got yourself a new summer staple. A light, silky Touch in Sol No Poreblem primer to banish the flaky patches and dryness that dare to mess with your glam. This ultra-hydrating primer will create a base for your makeup that's so satisfyingly smooth, you'll be singin' 🎶smooth operatorrr. 🎶 It also works *chef's kiss* wonders when it comes to minimizing the appearance of spots, blemishes, and pores! And a tube of Elizabeth Mott Thank Me Later eye primer because it'll make the eyeshadow look you created 10 hours ago look like it's only been 10 minutes. It helps keep your eyeshadow from wearing off, smudging, or creasing, and enhances your eyeshadow's color and vibrance! A bestselling Sol De Janeiro firming cream if you want to be known for smelling like a walking Italian bakery, leaving the enchanting scent of salted caramel, pistachio, and vanilla everywhere you go. Enriched with caffeine, guarana extract, and coconut oil, this miraculous little jar of cream will help smooth, firm, and add a glow to your skin. But may I just highlight again its intoxicating scent? According to the reviewers, you might just get a little obsessed. And a Gold Bond neck and chest firming cream, because our décolletage is too often forgotten when it comes to skincare needs. This elixir is a pro at improving your skin's firmness, texture, *and* elasticity. Its salicylic acid gently exfoliates dead skin cells while its stress response proteins boost your skin's moisture retention to help improve smoothness and suppleness. It also contains glycerin and aloe, which adds some extra hydration. Iconic, truly. A lash-extending E.l.f. Cosmetics tubing mascara that reviewers are saying is a great alternative to the pricier one from Thrive Causemetics. This quite literally wraps your lashes with lengthening tubes for a fuller appearance. A unique benefit of this? It makes it SO easy to remove at the end of the day — no mindless scrubbing needed! It's even enriched with a dash of jojoba seed oil to condition your lashes while providing that striking length. A Naturium cooling gel body wash — you might literally hear your skin breathe a sigh of relief once you lather this on after a *hot*, sweaty day. It's infused with citrus essential oils and mandelic acid, a gentle AHA that helps neutralize body odor, keeping you fresher for way longer than you'd ever expect. Bring it on, summer. Or a Baccarat Rouge 540-inspired Cremo moisturizing body wash enriched with white jasmine, red currant, and sweet amber so you can smell ~expensive~ (cue the lip bite 🫦) without affecting the weight of your wallet too much. This reviewer even calls it "life-changing" and says they'll be buying this for the rest of their life! A pack of two dark-spot corrector soap bars, which you can use on your face as well as your hands, neck, bikini area, inner thighs, and underarms. Its wonderful mix of shea butter, olive oil, turmeric, hyaluronic acid, and retinol will give hyper-pigmented areas an even glow by helping to reduce scars and restore moisture. An easy-to-apply fungal nail renewal formula if you wanna get those toes lookin' healthy and sandal-ready for the sunny season. Apply this fast-acting formula, and you can start seeing visual improvements in as little as two days! The TikTok-famous Medicube Turmeric Overnight Wrapping Peel Off Mask that this esthetician reviewer says is great for a special occasion and makes their skin feel hydrated and smooth the next day. What better way to get a nice, fresh start to your morning than to literally ~shed~ your skin as soon as you wake up? This mask features hydrolyzed collagen, vitamin C, and turmeric that work together to help even your skin tone and improve elasticity. Put it on before bed and peel off the old you in the morning! A Briotech spray because it might even give the pricier Tower 28 spray a run for its money. Packed with the same key ingredient, hypochlorous acid, this skincare gem will quickly become one of your staples as it helps to soothe inflammation, calm angry red patches, and fortify your skin's barrier. A benzene-free mattifying dry shampoo powder to trick people into thinking it most definitely has not been a week since you last washed your hair. This is infused with biotin, black ginseng, and root-boosting powder and comes with a conveniently attached puff so that you can dab, dab, dab away all that excess oil and grease to instantly add some volume back into your hair. Retinol body lotion that'll enhance your already beautiful skin. It's overflowing with powerful ingredients like vitamins A and E, ferulic acid, shea butter, and green tea to help diminish the look of deep wrinkles, fine lines, sagging skin, crepey skin, and even sun damage — all while giving your collagen production a *major* boost to help with firming. An illuminating L'Oreal moisturizer because it'll have you looking glowy, sun-kissed, and ready for that lunchtime walk you planned your whole day around. The glycerin and shea butter in it also give it a mega hydrating factor. It's a lotion, glowy foundation base, and highlighter all in one bottle. Oh, and it has over 33,000 5-star ratings! A set of antimicrobial toothbrushes that have thin "floss" bristles, which help naturally eliminate the buildup and debris that tend to linger on other toothbrushes. The tip of each flossing bristle is as thick as a single human hair and is formulated with nano-silver, which may help kill off microbes left on the bristles. And if you have sensitive teeth, no worries — reviewers say these bristles are super soft. A Wonderskin lip stain, which reviewers rave about because of how true it is to its long-lasting, transfer-resistant reputation! It glides on as a vibrant blue hue that you can peel off to reveal an adorable, rosy lip stain. So treat yourself, and ~kiss~ those constant lipstick re-applications goodbye. 💋 An *iconic* Revlon one-step hair dryer and volumizer (with over 400,000 5-star ratings!!!) that will save you more than double the time it takes you to style your hair with a traditional blow-dryer and round brush — it'll give you soft, smooth waves with just a few passes!


Business Upturn
a day ago
- Business Upturn
Pliant Therapeutics Provides Update on BEACON-IPF
Bexotegrast development in IPF discontinued Clinical oncology program and early-stage programs continue Recent workforce and operational changes align with next steps SOUTH SAN FRANCISCO, Calif., June 27, 2025 (GLOBE NEWSWIRE) — Pliant Therapeutics, Inc. (Nasdaq: PLRX) today announced that following the review of data from the recently terminated BEACON-IPF Phase 2b/3 clinical trial, the Company has discontinued development of bexotegrast in idiopathic pulmonary fibrosis (IPF). BEACON-IPF Trial Update BEACON-IPF was a randomized, double-blind, placebo-controlled, global Phase 2b/3 clinical trial evaluating patients with IPF. In March of this year, Pliant announced the voluntary discontinuation of BEACON-IPF following a prespecified data review and recommendation by the trial's independent Data Safety Monitoring Board (DSMB), as well as a secondary review and recommendation by an outside expert panel, citing an imbalance in IPF-related adverse events. Following an analysis of the full safety and efficacy data from the BEACON-IPF trial, the Company is discontinuing development of bexotegrast in IPF. Results showed that at doses of 160 mg and 320 mg, bexotegrast demonstrated an unfavorable risk-benefit profile. Compared to placebo, bexotegrast-treated participants showed an increased risk of experiencing adverse events associated with IPF disease progression, defined as events of worsening of IPF and acute IPF exacerbation, respiratory-related hospitalization, and/or all-cause mortality. The average time to disease progression for bexotegrast-treated participants was 33 weeks, suggesting that the safety risk may not be apparent with shorter dosing duration as was the case in the prior INTEGRIS-IPF Phase 2a trial. At Week 12, bexotegrast 160 mg and 320 mg treatment groups demonstrated improvements in forced vital capacity (FVC) decline of 72 mL (p<0.05) and 46 mL (p>0.05), respectively, compared to placebo. At Week 24, bexotegrast 160 mg and 320 mg treatment groups demonstrated improvements in FVC decline of 58 mL (p>0.05) and 8 mL (p>0.05), respectively, compared to placebo. The full results from BEACON-IPF will be submitted for future publication. 'Although the decision to discontinue bexotegrast in IPF is disappointing for us and the many patients in need of new treatment options, we believe it is the right decision to protect patient safety,' said Bernard Coulie, M.D., Ph.D., President and Chief Executive Officer of Pliant. 'We sincerely thank all patients, their caregivers, the study investigators and their research teams who were part of the BEACON-IPF clinical program for their extensive efforts.' Oncology Phase 1 Enrollment Continues PLN-101095 is an oral, small molecule, dual selective inhibitor of αvβ8 and αvβ1 integrins, designed to block TGF-β activation in the tumor microenvironment. PLN-101095 is currently undergoing a Phase 1 open-label trial as monotherapy and in combination with pembrolizumab in patients with solid tumors that are resistant to immune checkpoint inhibitors. In March, the Company announced interim results from this trial showing that PLN-101095 was generally well tolerated with confirmed partial responses in 50% of patients at highest dose tested to date, across multiple tumor types. The trial is currently enrolling the fifth of five planned dose cohorts. Early Programs Supported by Proprietary Platform The Company's drug discovery platform consists of a proprietary library of over 15,000 integrin binding molecules, a comprehensive screening assay system (binding, integrin confirmation, ligand-induced internalization) and an advanced live human tissue program. The Company believes in the broad applicability of the platform across multiple disease areas including delivery of drug payloads to cells utilizing integrin receptor-binding molecules as tissue-specific delivery and internalization mechanisms. About Pliant Therapeutics, Inc. Pliant Therapeutics is a clinical-stage biopharmaceutical company and leader in the discovery and development of integrin-based therapeutics. Pliant is conducting a Phase 1 study for PLN-101095, a small molecule, dual-selective inhibitor of α v ß 8 and α v ß 1 integrins, that is being developed for the treatment of solid tumors. In addition, Pliant has received regulatory clearance for the conduct of a Phase 1 study of PLN-101325, a monoclonal antibody agonist of integrin α 7 β 1 targeting muscular dystrophies. Pliant's early-stage platform includes preclinical research focused on tissue-specific delivery and internalization of drug payloads utilizing integrin receptor-binding molecules. For additional information, please visit: Follow us on social media X, LinkedIn and Facebook. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are 'forward-looking statements' within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as 'may,' 'will,' 'expect,' 'anticipate,' 'estimate,' 'intend,' and similar expressions (as well as other words or expressions referencing future events, conditions, or circumstances) are intended to identify forward-looking statements. These statements include those regarding development plans for PLN-101095, PLN-101325 and the Company's proprietary platform; and the Company's efforts to align its workforce and operations for its next steps. Because such statements deal with future events and are based on our current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Pliant Therapeutics could differ materially from those described in or implied by the statements in this press release. These forward-looking statements are subject to risks and uncertainties, including those related to the development and commercialization of our product candidates, including any delays in our ongoing or planned preclinical or clinical trials, the impact of current macroeconomic, geopolitical and marketplace conditions on our business, operations, clinical supply and plans, our reliance on single-source third parties located in foreign jurisdictions, including China, for critical aspects of our development operations, the risks inherent in the drug development process, the risks regarding the accuracy of our estimates of expenses and timing of development, our capital requirements and the need for additional financing, including the availability of additional term loans under our loan facility, and our ability to obtain and maintain intellectual property protection for our product candidates. These and additional risks are discussed in the sections titled 'Risk Factors' and 'Management's Discussion and Analysis of Financial Condition and Results of Operations' in our Quarterly Report on Form 10-Q for the period ended March 31, 2025 which are available on the SEC's website at Unless otherwise noted, Pliant is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. Investor and Media Contact: Christopher KeenanVice President, Investor Relations and Corporate CommunicationsPliant Therapeutics, Inc. [email protected]