Scientists issue urgent warning to festivalgoers over terrifying new drug that's 500 TIMES stronger than heroin – as two people die from suspected overdoses in Britain

Daily Mail​

08-06-2025

Scientists have issued an urgent warning to festivalgoers over a terrifying new drug that is sweeping the country.
Nitazenes are ultra-powerful synthetic opioids, similar to fentanyl, which can be up to 500 times stronger than heroin.
Even a tiny dose can be enough to trigger fatal overdoses - with two people killed in the UK this week alone.
Now, ahead of the summer festival season, experts warn that the deadly drug poses a 'huge public health risk'.
Originally used by criminals to supercharge weak heroin, nitazenes are now being cut into common party drugs and even pharmaceuticals.
Speaking to MailOnline, experts have raised concerns that musical festivals will be unable to keep attendees from accidentally taking these deadly drugs.
Dr Adam Holland, co-chair of the Faculty of Public Health Drugs Special Interest Group, told MailOnline: 'We haven't been able to keep drugs out of prisons, so we're certainly not going to be able to keep drugs out of festivals.
'If you're going to take unregulated drugs, we strongly recommend testing them to ensure you're taking what you think you're taking.'
What are nitazenes?
Nitazenes are a group of chemicals originally developed as painkillers in the 1950s that were never licenced to be used as medicines.
They are a type of drug called 'synthetic opioids' which means they were made in a lab but work on the same receptors in the brain as natural drugs like heroin and opium.
However, the big difference between nitazenes and heroin is that the synthetic variants are significantly stronger and much more deadly.
Even the weakest type of nitazene is about as strong as fentanyl, with the most potent being about 100 times stronger.
This is a major problem for drug users because they have no way of knowing which types of nitazenes are in their drugs, making accidental overdoses much more likely.
Dr Holland says: 'Most nitazenes are extremely dangerous. You only need to consume a tiny amount of these drugs to fatally overdose, and they could be found in a range of substances.'
This week, a man, 28, and a woman, 20, allegedly overdosed after taking pills containing nitazenes after visiting a nightclub in south London.
What are nitazenes?
Nitazenes are a group of chemicals called synthetic opioids.
This means they are not found in nature but act on the same parts of the brain as drugs like heroin and opium.
Nitazenes were originally developed to be painkillers but were never licenced since they were too dangerous and unpredictable.
They can range from 50 to 500 times stronger than heroin and cause overdoses in very small amounts.
In the last two years alone they have already caused over 400 deaths in the UK.
Authorities believe that the pills were sold as 'oxycodone', a powerful prescription painkiller often used by clubbers to help fall asleep after taking other drugs.
Recently, nitazenes have spread wildly through the UK drug market, leading some experts to warn of a 'second wave for the UK drug-related death crisis '.
In the last two years, 485 people have died after using nitazenes and the official figures show a rapid increase.
Of those deaths, 333 took place in 2024 alone - a 166 per cent increase on previous years.
Additionally, Dr Holland says this is 'certainly an underestimate' of the true figure as monitoring systems try to catch up with new drugs.
What should festivalgoers look out for?
With major festivals such as Glastonbury and Download rapidly approaching, there are now serious concerns that nitazenes could lead to a spike in deaths.
The problem is that nitazenes are increasingly being cut into common party drugs and sold to unsuspecting users.
Fake pills sold online, such as this counterfeit diazepam (Valium) tablet, have been found to contain the super-strength drug
Which drugs are most likely to contain nitazenes?
Oxycontin
Oxycodone
Valium
Xanax
Heroin
Even more worryingly, dealers are increasingly selling products containing nitazenes which have been repackaged in blister packs to look like prescription medication.
Dr Holland says: 'In terms of nitazenes, most people using drugs in festivals and nightlife settings would be at the greatest risk from drugs purchased as benzodiazepines - like Valium or Xanax - or opioids, which they might be taking at the end of the night to come down, or to help them sleep.'
MailOnline analysis of data from the UK's only drug testing facility WEDINOS has revealed that two-thirds of samples that contained nitazenes were supposed to be legal medications that could be purchased legally.
Two-thirds of those 'legal' drugs containing nitazenes were purchased by people trying to buy Valium.
Why are festivals more dangerous this year?
This public health risk may be even higher this year because the government is still restricting access to testing services.
Currently, the Home Office is allowing licenced 'back-of-house' testing at festivals.
This means drug-testing services such as The Loop, the only licenced festival drug testing service, can test surrendered or confiscated drugs and issue warnings if anything dangerous is found.
What to do if someone overdoses on opioids
Keep calm and follow these steps:
Make sure that you're not in any danger first
Keeping yourself safe is important. Call 999 and ask for an ambulance
Check to see if there is anything obstructing their airways
Place the person in the recovery position
You can find out how to do this here
If you have Prenoxad, inject it into their thigh or upper arm muscle
If you have Nyxoid, place the spray in their nose and press the plunger
Wait with the person until the ambulance arrives, and give the used naloxone kit to the paramedics
Source: changegrowlive.org
Katy Porter, CEO at The Loop, told MailOnline: 'The deaths in London, following a night out clubbing, have demonstrated the increasing and wider risk of exposure to nitazenes.
'Drug checking, accessible to the public, can identify substances of concern in circulation alongside purchase intent, and importantly communicate risk directly to an individual, and assisting in the prevention of overdose.'
However, experts say the Government is putting lives at risk by maintaining a ban on 'front-of-house' drug checking.
These services would allow users to hand over a sample of their drugs to be tested and receive information about what it contains and in what purity.
This service was entirely legal until 2023 when the Conservative-led Home Office suddenly moved to block festivals from testing drugs.
In light of this, experts warn that authorities should be ready to deal with a higher number of potentially fatal overdoses.
Dr Holland says: 'Whatever you think about drugs, a significant proportion of the population is always going to use them - evidence suggests that drug checking prevents the use of dangerous drugs like nitazenes.
'The Government is currently preventing drug checking services from being offered in festivals, which is counterproductive, and likely to increase the risk of incidents in the coming festival season.'
How to tell if someone has overdosed
Keep an eye out for these signs that someone is having an overdose:
Deep snoring/gurgling noises
You can't wake the person up, and they don't respond if you shake their shoulders or call their name
A blue tinge to the lips, nail beds or other extremities
They have stopped breathing
You should always call 999 if you think someone is having an overdose.
Don't be scared that you'll get in trouble. The ambulance will not bring the police with them except in very particular cases.
Source: changegrowlive.org
Likewise, Dr Kars de Bruijne, senior research fellow at the Clingendael Institute, told MailOnline: 'Whether there is a festival or not, Nitazenes are available on the streets and pose huge public health risks.
'It is advisable that there is general preparedness by authorities to respond to cases of overdosing and support with proper treatment.'
A Government spokesperson told MailOnline: 'The Policing Minister and Minister for Public Health and Prevention have already written to festival organisers highlighting the serious threat posed by synthetic opioids and other drugs.
'They urged festival organisers and Police Crime Commissioners to work closely with health partners to ensure naloxone, which reverses the effect of an opioid overdose, is readily available.
The spokesperson added that 'confiscated and surrendered drugs will continue to be tested at music festivals to identify toxic substances in circulation, and help prevent drug-related overdoses.'
However, the Government maintains that it will not licence a testing service that offers 'personalised results' to users and adds that offering testing without a licence may be considered an offence.
Why are nitazenes now such a problem for the UK?
The sudden rise in popularity is largely down to nitazenes' low cost and high strength.
Coming in either a liquid or powder form they are easy to bulk out with other substances to create low-cost drugs with an extremely high profit margin.
Dr de Bruijne says: 'The reason that dealers could try nitazenes - despite them being extremely dangerous - is that they are highly addictive and thus generate demand and in very tiny amounts can be consumed without leading to an overdose.'
However, the real boost for nitazenes came after the Taliban regained control in Afghanistan following the removal of American troops.
The Taliban have cracked down on farmers growing opium poppies - the precursor for heroin - crippling the world's supply of the drug.
Prior to the pandemic a kilo of heroin sold for roughly £16,000, but that has now jumped to around £26,000 per kilo, according to anecdotal reports.
Meanwhile, the average purity of heroin on the streets has dropped to between 10 and 20 per cent in 2024 compared to 45 per cent in 2022.
Dr de Bruijne says this has pushed organised crime groups to seek out synthetic alternatives such as nitazenes.
Being so potent, nitazenes can also be moved across borders in smaller volumes before being diluted for sale which has made it hard to stop their spread.
Current research suggests that the nitazene-containing drug 'kush' is being imported to West Africa via the UK and Europe in large quantities.
However, it isn't yet clear where the nitazenes in the UK are coming from.
Dr de Bruijne says: 'The simple answer is that we don't know if they are produced in the UK or Europe
'There is known production of Nitazenes in China. But there are indications that some of the mixture might happen in Western Europe or the UK and there are rumours about potential production of Nitazenes in Western Europe too.'