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ASCO 2025: Key Highlights in Prostate Cancer

ASCO 2025: Key Highlights in Prostate Cancer

Medscape06-06-2025
Dr Petros Grivas surveys several exciting developments in prostate cancer research, including AI-driven biomarker analysis from the STAMPEDE trial, to identify high-risk patients who may benefit from abiraterone. He also discusses positive results from the AMPLITUDE trial, where adding niraparib to standard therapy improved radiographic progression-free survival, especially in patients with BRCA1 or BRCA2 mutations, reinforcing the need for comprehensive genomic testing.
Emerging treatments such as bispecific antibodies and radioligand theranostics, including the impact of lutetium-PSMA and updates from the PSMAddition study, showed promise, though practice-changing data are still forthcoming. He emphasizes the importance of leveraging technology and community collaboration to drive progress and improve outcomes in cancer care.
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The Future Of Porsche's Racing Tech Transfer to Street Cars? Software.
The Future Of Porsche's Racing Tech Transfer to Street Cars? Software.

Motor Trend

time7 minutes ago

  • Motor Trend

The Future Of Porsche's Racing Tech Transfer to Street Cars? Software.

On April 12, 2025, Porsche made history, becoming the first automaker to win three classes of professional motorsports with three different powertrains on the same day. In California, a 963 hybrid won the LMDh class and took the overall win at the IMSA Long Beach Grand Prix while a 911 GT3 R won the GTD Pro class in the same race with pure combustion engine. Across the country, the 99X Electric won the Miami e-prix in Formula E on pure battery power. Different as they may be, each shares a common link with the Porsche road cars you can buy today and in the future. Porsche uses motorsport to drive tech innovation, focusing on software as the key to improving road cars. Software impacts drivability and efficiency, with lessons from racing series shared across projects. This approach is cost-effective and enhances both performance and development. This summary was generated by AI using content from this MotorTrend article Read Next Racing Technology for the Street 'We have a philosophy that, yes, motorsport is part of our DNA,' Porsche vice president of motorsport, Thomas Laudenbach, told MotorTrend , 'and I cannot imagine Porsche without motorsport, but we are not doing motorsport for the sake of its own. We do motorsport to give a contribution to the company, and this is exactly what we are talking about.' In the past, tech transfer from racing to the road consisted mostly of more power and better aerodynamics, but as everything on a car has become linked and controlled by computers, the next frontier is in the software that controls them. Hard parts like engines, suspension, and aerodynamics are fairly mature technologies, but automotive software is still in its relative infancy. 'It is still a very steep curve,' Laudenbach said. 'It's growing so fast, it's changing so fast…I mean, if you look at the combustion engine, obviously development [today] is slower like this because you know, it is more and more difficult to make the [next] step. If you look at the software, not only software itself, how we approach it, the tools…I would say [it is] still very steep, the curve, how fast it changes.' It's All in the Software In all three racing series, physical parts on the cars are heavily regulated, particularly when it comes to batteries and electric motors. Software, though, isn't and has become the most important factor in improving lap times and efficiency. 'Everything you can do on the software has a much bigger impact and a much bigger effect in the drivability,' Porsche Formula E driver and reigning champion, Pascal Wehrlein, told MotorTrend , 'because yeah, there's also software things in in a combustion engine, but the effect is just smaller than an electric car. We pay a lot of attention to the software and I would say that is our biggest toolbox for setting up the car and getting quicker and so on. And there's just so many more things you can do on the software compared to a combustion engine. 'How much we are going into the details,' he continued, 'into the smallest details, I would say on the software side is even more than what I did when I was in Formula One, just because there are so many different options on, you know, the four-wheel drive, how to set up the four-wheel drive. How much work do you want to have at the front? At which point in time in the corner you want to have more front torque or less? What you can do on the braking side, on the [energy] recuperation, setting it up for different corners? In certain corners, where it's high speed, you need something different than in the low-speed corner, but then also when the track is bumpy, or not bumpy. We are going so much into the details.' Lauderbach agrees. 'It's absolutely right. We always love about talking about hardware. And I did develop combustion engines for 18 years, so I'm a real mechanical guy, and it's absolutely right, probably the bigger part is software. And but this is the good thing about it because some things [physical] we are not allowed to touch [under the regulations]. But we have a big freedom of software, and I think that's good because racing should give freedom where it is beneficial also for your brand. And that's certainly in software and I think this is probably also the biggest change between the projects.' Because the applications are so different, it's not as simple as just sharing code between teams in different series or with the engineers working on the road cars. Instead, it's the exchange of knowledge and ideas which brings this tech to cars like the 911 GTS T-hybrid. 'It's for sure not a carryover part,' Laudenbach said, 'but it's from learning about the difficulties, about the weak points, about the solutions, for sure they benefit from each other. 'When you have more than one project,' he said, 'you just work it on in a wider range and then you always find synergy. These two programs (Formula E and LMDh) benefit from each other in various areas. And at the same time, this is linked so close to our road car development. We work a lot on road cars as well in the motorsport department and do benefit from each other. If you tell your engineers, oh, please sit together with these guys from this program, then you know what they do? They sit together for an hour, they chat, and they go to it. If you sit side by side, if you meet each other with a coffee, this is the best way to benefit from each other. These two programs benefit, but also this is very beneficial to what we do on road cars, even inside the motorsport department.' It's not just about making the cars faster, either. Power makes heat, and heat needs to be dealt with before it breaks things, on a race car or a road car. Efficiency matters in racing because using less fuel or electricity allows you to go farther between pit stops, and it matters for the same reason on the street. 'Look at Formula E,' Laudenbach said. 'It's not our battery, but we control the thermal system [and] energy management. That's a lot of control systems. That's a lot of software. I mean, if we work with AI in the meantime and there you can learn a lot of the one side and transfer it to the other. Sometimes then you figure out that, okay, I can only take this because this [other technology] is not allowed. It's never carry over one to one. 'But you still learn a lot about how to handle it. It's software functions, it's control systems, it's sometimes also just the tools that we use, the approach that you take is not always [about] the final product. In the end, you have the product, there, no matter if it's software, hardware, but it's also, how do you approach it, because you're always looking for being most efficient. Especially Formula E, [where] we have a cost cap. It's a factor to say, okay, can I reach a certain goal with the smallest amount of money? These kind of things we always exchange because it's in the background.' Cheaper and Easier Not only are software learnings easier to transfer between programs, software is also easier to iterate on and less expensive to develop. 'Compared to hardware,' he said, 'it's not that cost intensive. Yes, you have you have the labor. But you know, you' not always having to change your bits and pieces. And don't forget, if you talk about bits and pieces, you always have to stop and throw parts away. So it's a lot more, let's say, cost efficient.' Whether in the office or trackside, the way data is managed and analyzed has changed a lot in the past decade. 'If we would do it like 10 years ago,' Lauderbach said, 'where the engineer himself goes through all the raw data, that doesn't work anymore. You got to feed your data through automatic analysis. It's just more [a question of], how do you analyze? How do you get something out in order to make the car quicker? This is a lot more or this is high sophisticated, a lot more automation and algorithms, than 10 years ago. 'It's a software basically to calculate what the car's doing because you got sensors. Obviously, you want to calculate some figures, you see what the car's doing in order to feature simulations. The simulation then gives you back again in which direction you have to go.'

Rivian Is Integrating Google Maps Into Its Native Navigation Software
Rivian Is Integrating Google Maps Into Its Native Navigation Software

Motor Trend

time7 minutes ago

  • Motor Trend

Rivian Is Integrating Google Maps Into Its Native Navigation Software

Fresh off major upgrades to its R1S SUV and R1T pickup, Rivian is now set to launch a software update of its onboard navigation system to include Google Maps data—both for the new vehicles it's producing and its existing customer cars. This isn't simply Google Maps like the app on your phone, however. Leveraging Google's Automotive SDK, Rivian has, in effect, overlaid its existing navigation experience over that of Google Maps, taking advantage of the internet giant's superior "routing, estimated time of arrivals, traffic updates, search capabilities, and satellite imagery," as Rivian put it, in order to further augment its own in-house "EV-friendly navigation features." Rivian is updating its R1S SUV and R1T pickup navigation systems to integrate Google Maps, blending Google's routing, traffic, and imagery with Rivian's EV-specific features. The update includes a new interface and extends to the Rivian Mobile App, rolling out starting tomorrow. This summary was generated by AI using content from this MotorTrend article Read Next In other words, Rivian's navigation system will now blend Google's superior mapping capabilities with its proprietary charging information, including estimated range and battery capacity remaining at your destination, route planning, real-time charging info, and more. In addition, Rivian skins the whole interface in its own design, a new version of which will also debut with the Google Maps update. Even better, Rivian says the update will extend to its Rivian Mobile App (a 2025 MotorTrend Best Tech award winner), which benefits from Google-like photos and descriptions of searched destinations, as well as satellite map views and real-time traffic data. As before, users can send trips and navigation destinations from the app to their Rivians, and now they'll be able to use the "share" function via Google Maps to do the same. The rollout of the new Google-augmented system is imminent—Rivian says it'll begin doing so as soon as tomorrow via an over-the-air update for every all-electric R1S SUV and R1T pickup it has sold to date, and it will come already equipped with every new model it sells.

The Perseids Meteor Shower Brings Bright Fireballs to the Skies, Starting This Week
The Perseids Meteor Shower Brings Bright Fireballs to the Skies, Starting This Week

CNET

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The Perseids Meteor Shower Brings Bright Fireballs to the Skies, Starting This Week

Skygazers have a lot to look forward to over the next month. A couple of dueling meteor showers are gracing the skies later in July, and they will be joined by perhaps the most popular meteor shower of the year. Perseids are known for their bright fireballs and plentiful meteors. The show starts on July 17 and will run through Aug. 23. The reason the Perseids meteor shower is so popular is twofold. First, it takes place in the summer, so going outside and watching it is less uncomfortable than other large meteor showers like Quadrantids, which takes place in wintery January. The other reason is that it's one of the most active meteor showers of the year. During its peak, the meteor shower is known to spit as many as 100 meteors on average, according to the American Meteor Society. These not only include your typical shooting stars, but also a higher chance for fireballs, which are meteors that explode as they enter orbit. Per NASA, fireballs tend to last longer than standard shooting stars and can come in a variety of different colors. Perseids come to Earth courtesy of the 109P/Swift-Tuttle comet. Earth's orbit around the sun brings it through Swift-Tuttle's tail every year. The comet itself takes 133 years to orbit the sun. Its last perihelion -- the point at which it's the closest to the sun -- was in 1992. It won't be back until the year 2125. Until then, it leaves behind an excellent tail of dust and debris to feed us yearly meteor showers. How to watch the Perseids meteor shower The best time to view the Perseids is during its peak, which occurs on the evenings of Aug. 12 and 13. During this time, the shower will produce anywhere from 25 to 100 meteors per hour on average. However, since the shower officially lasts for over a month, you have a chance to see a shooting star on any given evening, provided that you are far enough away from light pollution. Thus, if you're planning on watching this year's Perseids during their peak, you'll want to get out of the city and suburbs as much as possible. According to Bill Cooke, lead of NASA's Meteoroid Environments Office, folks in the city might see one or two meteors from the meteor shower per hour, which is pocket change compared to what folks outside city limits might see. Regardless, once you've arrived at wherever you want to watch the meteors, you'll want to direct your attention to the radiant, or the point at which the meteors will appear to originate. Like all meteors, Perseids are named after the constellation from which they appear. In this case, it's Perseus. Per Stellarium's free sky map, Perseus will rise from the northeastern horizon across the continental US on the evenings of Aug. 12 and 13. It'll then rise into the eastern sky, where it'll remain until after sunrise. So, in short, point yourself due east and you should be OK. Binoculars may help, but we recommend against telescopes since they'll restrict your view of the sky to a very small portion, which may hinder your meteor-sighting efforts. The American Meteor Society also notes that the moon may give viewers some difficulty. Perseids' peak occurs just three days after August's full moon, so the moon will still be mostly full. Thus, it is highly probable that light pollution from the moon may reduce the number of visible meteors by a hefty margin, depending on how things go.

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