
25 Target Skin Care Products You'll Want To Use Daily
Some reviewers have emphasized that if they're wearing makeup, this is only step one in their routine, followed by a cleanser, to double-down on a dirty face.Promising reviews: "Once you use this you will realize it's a staple In a skincare routine. Was my face even clean before this ?" —Care"The ONLY product I will ever use to take off my make up!!! This is the holy grail And will clean your skin like no other. It makes my skin feel soo soft and supple. I use it twice a day with little pads. Buy!" —Joelle_rachelPrice: $3.99+ (available in three sizes)
Neutrogena Makeup Remover does what it says, which is why some reviewers have called these their go-to FOR YEARS. And you can scratch off "cotton rounds" from your shopping list if you use these plant-based ultra-soft cleansing wipes instead.
Designed to be gentle on the skin, they're still tough enough to free your face of makeup, dirt, oil, and sunscreen without following with a rinse. Just be sure to close the package properly to keep the wipes ~moist~.Promising review: "These makeup remover wipes are some of the best I've tried—effective and gentle on my skin. They're not the cheapest, but they actually remove stubborn makeup without leaving me red-faced. They don't leave a greasy film, which is a huge plus. Perfect for lazy nights when washing my face feels like a marathon. If you wear heavy makeup, these are a must-have in your routine." —romamaPrice: $1.99+ (available in three counts)
La Roche-Posay Toleriane Purifying Foaming Cleanser leaves your face feeling so fresh and so clean, clean (thank you, Outkast). Made for everyday use for normal to oily and sensitive skin, it boasts an ingredient list of ceramide-3 for maintaining moisture and a healthy skin barrier, niacinamide for its soothing and restoring abilities, and thermal spring water high in antioxidants sourced from the French town the brand is named after. (Fancy!)
If your skin is on the drier side, the brand offers another cleanser in their Toleriane line for dry skin—the Hydrating Gentle Cleanser, which has a creamy texture as opposed to foaming.Promising reviews: "Been using this everyday for the past two weeks and so far it's good. Hasn't dried my skin out and does an excellent job at removing dirt and makeup! If you don't like using makeup remover and rather wash it off, this is the product for you. La Roche-Posay Purifying foaming Cleanser washes all my makeup off with one full plunge and leaves my face feeling cleaner than many of the other products on the market. This is exactly what I've been searching for!" —Rachel"My skin is very temperamental. Normal to dry, depending on the season. It also sprouts some pretty aggressive cystic acne whenever it dang well pleases. I've tried many different products of different price points and this is the only one that has visibly and internally transformed my skin. The texture is smoother and appears brighter. ZERO cystic acne breakouts since I began using the cleanser." —Target_Customer22613579Price: $7.99+ (available in three sizes and one refill pack)
Thayers Unscented Facial Toner preps your skin in a multitude of ways while the alcohol-free witch hazel and aloe vera work BTS to reduce pores, hydrate your skin, and smooth texture. Sweep it across your face twice a day after cleansing to prep your skin for the rest of your routine. You can even use it to soothe your skin after shaving and waxing, prepare your face for makeup, clean your nails before a manicure, or calm irritation from sunburns, bug bites, and new tattoos.
Promising review: "This toner has been a game-changer for my skincare routine! I love that it's gentle on my skin yet still effectively removes impurities and balances my complexion. Since it's alcohol free, it doesn't dry out my skin or cause any irritation, which is a big plus. The unscented formula is perfect for anyone with sensitive skin or those who prefer a more neutral experience. I've noticed my skin feels smoother, hydrated, and refreshed after each use. The packaging is simple and easy to use, and a little goes a long way. This toner has quickly become a staple in my daily skincare regimen, and I highly recommend it for anyone looking for a gentle, non-drying toner." —A complete set Price: $10.99 (also available in rose petal, lavender, and cucumber scents)
The Ordinary Glycolic Acid 7% Exfoliating Toner — aka "miracle in a bottle" or "magic" according to some reviewers — tackles texture, skin tone, radiance, and dryness. While the brand doesn't recommend this for sensitive, peeling, or compromised skin, the solution is designed for mild exfoliation (and for areas beyond your face!) so you can use it after cleansing on the reg.
If your skin tends to be reactive or you're new to acids, patch test and work your way up to incorporating it into your daily routine. The brand recommends this for your evening routine, though if you're going to use it during the day, follow with an SPF. The formula also includes a Tasmanian Pepperberry derivative — a plant extract for soothing skin and reducing irritation during exfoliation. You can even use this toning solution on your scalp a few times a week to combat dryness or on small areas of the body for rough and bumpy skin.Some reviewers have also applied this to their arms and legs to address strawberry skin — or keratosis pilaris — while others have used it as a deodorant, armpit brightener, and heel exfoliant. You know what that means: more bang for your buck!Promising review: "I've never seen such immediate results from a product before!!! After one use, I noticed my skin was plumper and smoother. I've been using it for about 5 days now and my pores appear smaller and my skin has never felt so smooth and moisturized." —HannahPromising review: "Really good product! it can be used for a multitude of things and it's fairly unscented. i use it for odor reduction, hyperpigmentation, body acne scars, childhood scars, and strawberry legs and it works very well with lightening and fading. i don't even have to use deodorant anymore. my only issue is that it's mildly irritating. if you have sensitive skin take this into consideration." —kofiPrice: $8.70+ (available in two sizes)
Grace & Stella Energizing Eye Masks give your under-eyes a luxe boost when you've had a late night, the tossing and turning kind of sleep, an early morning when all you want is to hit snooze (a daily struggle for me), or just because you want to pamper yourself. Hyaluronic acid, chondrus crispus (which the brand says works against the visible effects of blue light exposure, aka purple tones), and glycerin work to hydrate, brighten, and plump the skin.
Hack: Store the masks in the fridge (like I and many reviewers have done) to give them a cooling effect — like cucumbers for your eyes! Use these masks any time of day, as much as you'd like, and keep them on for 15–20 minutes. That means a quick little spa treatment at home or on the go — whenever you want! While some reviewers mention using these in their morning routine, others have noted that they use it at night, even going to bed with them!Promising reviews: "The first thing I do when I wake up is put on a pair of these eye patches. Then I do wordle and go about the rest of getting ready for the day. They cool and tighten the skin around my eyes so I feel bright and more awake. Give them a try." —ELIZ"These patches actually stay on when doing activities! I have a 30 min commute to work and I wear them driving and they don't slip off my face. Also they really do energize under the eye!" —JenPrice: $9.99+ (for six pairs; also available in 24 and 48 pairs)A few people have also said that there is enough juice in the package to reuse a set of masks — so you can double the amount of times you use them.
RoC Retinol Correxion Line Smoothing Eye Cream is a 3-in-1 targeting wrinkles, puffiness, and dark circles. So whether you're a night owl, a crybaby, or simply seeing the normal signs of aging, the cream is gentle enough to use once or twice a day. Just work your way up to frequent use if you have sensitive skin.
Promising review: "⭐️⭐️⭐️⭐️⭐️⭐️I wish i could give it 6 stars. I've had dark circles/lines since I was a kid(genetics). I've tried everything from home remedies to very expensive eye creams and nothing has worked! Until I tried ROC eye cream! I was shocked the first time I used it, I noticed results with my fine lines. I'm in love with this eye cream! I use it twice a day sometimes. It's been a month since I started and my fine lines/ dark circles are disappearing!" —melinaPrice: $12.99+ (available in two sizes)
Pacifica Crystal Wand Secret Weapon Rose Quartz Facial Roller can be used on your face and neck to massage the skin and relieve pressure. Use it with a serum or stick it in the fridge to give your face a cooling wake-up call in the mornings. Rose quartz is known as the "love stone" so it's a pretty-in-pink way to show yourself some love. One reviewer even said they feel like Beyoncé when they use it, aka "feelin' myself!"
It has a small and large end, depending on what part of your face you're rolling.Promising reviews: "This is the first roller I've ever bought. I'm skeptical of it leading to any noticeable changes to my skin, but it is very calming and nice to use. I love using it in the morning out of the fridge to wake me up. It is nice for headaches as well. The only issue I've had with it is occasionally the small roller gets stuck and doesn't roll." —Julia"I bought this because i have significant acne scarring and read that these rollers can help break up scar tissue and over time fade scars. i can't speak to the long-term efficacy, but using the roller is such a relaxing experience. the quartz is cooling on my skin, and it does feel like it's making my skin a bit brighter." —tayPrice: $18.99
Timeless Skin Care 20% Vitamin C Serum gives your skin a big ol' drink of L-ascorbic acid, ferulic acid, and vitamin E for brighter, more even skin, protection against environmental ~stressors~ like pollutants, and boosts collagen production. So if you have discoloration, dullness, stressed skin, or uneven skin tone and texture, add this to your morning (follow with SPF!) or evening routine. Reviewers have even said it's similar to a popular, more $$$ option. Tip: Stick it in the fridge so it lasts longer!
A handful of reviewers have complained that it is a little too runny for them or that it smells like hot dogs, while some have said other vitamin C options smell much worse. But if you notice those traits, the cons could be outweighed by praise for the results, from a noticeable glow to fading post-acne marks and sun spots.Promising reviews: "I've been using this serum daily for about three months now and I am very pleased with the results. I suffer from hyperpigmentation and dark sun spots, I wouldn't say they've completely disappeared but they have faded quite noticeably. Ever since using this product, my skin is so smooth, no texture or enlarged pores. Also, I used to struggle with scars. I don't break out a lot, but when I do, I'd always have a scar from the pimple for weeks after it was gone. Since using this, there have been no marks or scars. I just can't say enough good things about this vitamin C. I buy the big 4 oz bottle and it lasts me for a few months and that's using it everyday." —Sarah R"I've used a few vitamin c serums that mimic the skinceuticals ferulic version and they all work well (including this serum) but what puts this one above all others is the packaging. Vitamin C oxidizes and this bottle prevents that. All others come in a dropper and you're stuck with an expensive oxidized serum after a few weeks. This has stayed fresh since I purchased it a few months ago. Highly recommend!!" —PPPrice: $25.99+ (available in two sizes)
E.l.f. Holy Hydration Face Cream has some reviewers saying "holy grail!" not just because it's in the name but because of its ability to hydrate, brighten and even skin tone, and improve moisture balance and elasticity. Filled with squalane, hyaluronic acid, niacinamide, and a peptide complex, this moisturizer is designed for all skin types but especially for sensitive skin.
Promising reviews: "It's been a while I have found such a hydrating clean fragrance free facial cream. I wear it every day during the day and night. It's been a week and I've already seen improvement in my skin. I have smoother skin without getting greasy." —Jessgh"This has been my go-to for a year now. I use it as the final step after my serums. The price is great, so I don't hesitate to apply it to my neck and chest as well. It's also excellent under SPF and makeup in the morning. My skin feels moisturized, but not oily or heavy." —MarPrice: $13
Honest Beauty Hydrogel Cream puts the *hydro* in hydration. This award-winning, fragrance-free, lightweight "water cream" — made with hyaluronic acid, jojoba, and squalane — refreshes and cools thirsty skin while locking in moisture to encourage supple, plump, and soft skin. For twice-daily use on your face and neck, it's formulated to reduce the appearance of fine lines while also being super gentle.
Promising review: "This cream absorbs quickly and leaves my skin feeling soft and refreshed without any greasiness. Great for daily use, especially under makeup. The hyaluronic acid provides lasting moisture. Would recommend for normal to dry skin types!" —Amandatwilight"This product has been effective for me, especially since I have oily skin. I apply every morning and it doesn't get greasy by noon like the other moisturizer. I haven't experienced any new cystic acne or breakouts, which is a plus. I'll continue using it at night also since it absorbs easily." —LongPrice: $19.99
Olay Regenerist Retinol 24 Night Moisturizer works the late shift to promote surface skin cell turnover and regeneration so you can rise and shine to a face that feels AND looks smoother, firmer, and brighter. With extra ingredients of niacinamide and amino peptides, the face cream aims to address dark spots, pores, fine lines, wrinkles, and moisture retention.
While Target reviewers have left over 2,400 reviews totaling 4.5 stars, some reviewers have noted the moisturizer can create pilling if applied too generously or an uncomfortable sensation when applied on eyelids — so know that a little goes a long way, and you should avoid your eyes.It's also important to remember that because this cream contains retinol, your skin may take some time to get used to it before you can use it daily. That means patch testing and using it every other day first. Because retinol can make your skin more sensitive to UV rays, you'll also want to put on SPF in the morning (which you may already be doing anyway!).Promising review: "Leaves my skin feeling supple and hydrated and somehow when I wake up, I look refreshed and my skin is so calm. If I skip an application before bed, the difference is noticeable. Love this product that works better than those with higher price points and buzzy followings." —JPrice: $29.99
Up&up Oil Absorbing Sheets let you pat, pat, pat your face to remove excess oil and shine throughout the day, without leaving a powdery finish like other brands do and without ruining your makeup. They're unscented, hypoallergenic, and especially recommended for oily complexions.
Promising reviews: "I have been purchasing these for years and will never be without them! They absorb oil so well without ruining makeup." —Mec"They work wonderfully, they absorb oil and leave you with a fresh looking face! No need to powder your face all day and get a cakey look by the end of the day." —TeachingKindersPrice: $4.99 (for 100 sheets)
Hero Mighty Patch Duo comes to the rescue when you get a zit, and this pack contains BOTH the original version for nighttime use and an invisible, barely-there option for daytime. So if a pesky pimple is starting to form a whitehead — or you've already popped it — what feels like every day, then slap on one of these hydrocolloid patches and watch it absorb your gunk in 6–8 hours. Derm-tested and suitable for sensitive skin, the patch also stops you from picking and popping (and when I say "you," I mean "me" because I use these on my face AND my back as soon as I see a whitehead starting to form).
Just clean and dry the pimple area before patching it up. Then peel it off when the patch turns white. Some reviewers noted that they had to use a few consecutive patches on one pimple to keep the healing and gunk-sucking going but that it still worked wonders by the end of it, especially compared to similar products from other well-known brands. Keep in mind that these don't address cysts or blackheads or the big bumpy zits that are still underground, so you'll need something else to manage those.Promising reviews: "Love love love love! I don't have a ton of acne, but when I get a pimple they are deep, and painful, and can be ugly. I put one of these on each night when they start to form a head and it seriously pulls out all the bacteria (and whatever else is in there). They've helped reduce the number of days my pesky pimples stick around. Must have!" —aliiiiiiiii"These were amazing for my daughter. She had a zit and nothing was working, and it was getting noticeably worse. We tried band aids, neosporin, toothpaste, nothing - nothing worked. These also were the perfect size for her to wear to school and be marginaly noticeable. Would absolutely buy these again." —Allie FPrice: $6.99 (for a 12 count; also available in a 36 count)If you know you only want The Original, those are available in a 24- and 72- count. Packs of only the Invisible are available in a 24- and 72- count as well as mini ones in a 30 count. The brand also offers patches specifically for your chin, forehead, nose, surface, and more.
Megababe Thigh Rescue Anti-Friction Stick creates a friction-free glide anywhere on your body that chafing happens —between your legs, your toes, along your arm, and beyond! If you chafe when you run or when you're wearing shorts or skirts, apply this to your thighs to help you move on with your day pain- and irritation free. The award-winning (and derm- and gyno-approved) stick is also filled with ingredients including pomegranate extract, ginger root, vitamin E, and grapeseed oil, so your skin can stay hydrated and protected while feeling comfy.
Promising review: "I've been using this on a daily basis for a few years now. I had fully stopped wearing dresses prior to trying it because of inner thigh chafing. I can't believe how well it works and how long-lasting a single application is. Even through the muggiest days on the beach in the Caribbean or extensive walking in D.C. summers, my thighs stay chafe-free! Not having friction between my thighs has also improved my skin there- way fewer issues with ingrown hairs and uneven skin tone. I also use it along the front band line of sports bras if I'm going to be wearing one for several hours." —DisappointedPromising review: "This stick? Literal magic. I used to dread the chafe struggle, but not anymore. Megababe glides on smoother than any of the competitors, no sticky mess, and keeps my thighs happy all day. No heat rash, no irritation, just soft comfort. As a plus-size girl, I'm telling you: this is a game changer. Sundress season? Bring it on." —BathorybearPrice: $13.99 (also available in .81 oz)
Eos Shea Better 24H Moisture Body Lotion soothes and protects skin for — you guessed it — 24 hours with seven nourishing oils and butters, including 100% natural shea butter. This Vanilla Cashmere version has notes of whipped vanilla, soft musk, and cozy caramel, so you can smell sweetly delicious head to toe all day, every day.
While Vanilla Cashmere is the most-reviewed scent on Target, the derm-tested 24H Moisture Body Lotion line comes in eight other scents. Some reviewers noted that Vanilla Cashmere was a little too sweet for them, so if this isn't your vibe, you've got options: fragrance-free, créme de pistachio, strawberry dream, fresh + cozy, coconut waters, pink champagne, pomegranate raspberry, and jasmine peach (which, unfortunately, isn't available at Target right now).Promising reviews: "OMG!!! This smells so good. I use it everyday and it is very effective for irritated, dry skin." —Makayla"The smell is amazing but it's also a great moisturizer! I LOVE this lotion. It has a perfect balance to be very hydrating but not greasy at all. If I wait about five minutes after application I don't have to put on socks to keep my floors from getting coated by my lotion feet." —Boba FettPrice: $9.99
CeraVe Moisturizing Cream is for those who want a more basic, no-frills body lotion — and it even works on your face. For normal to dry skin, this fragrance-free, oil-free, hypoallergenic moisturizer helps restore the skin's protective barrier with three essential ceramides and retain moisture with hyaluronic acid. And the brand's patented delivery system continually releases moisturizing ingredients for 24 hours, which means all-day hydration.
Promising reviews: "I am a habitual hand washer. Constantly dry skin, random sensitive rashes, eczema, dry patches, rough cuticles. I used to have to apply lotion after each hand washing, and the moment I stepped out of the shower. I am so glad that I can afford to buy this cream now! I can use this one to two times a day and not feel like my skin is going to rip apart from dryness after washing! It is absolute bliss! It works amazingly well." —Emily"I know a lot of reviews say it's pretty basic but that is perfect for us with sensitive skin. It's not too greasy and it is a great moisturizer for your face and body. I always feel really nice after using it and like I mentioned before, it's nice to have a run of the mill, basic, lotion to use when your skin needs it that doesn't cause breakouts." —MereBearPrice: $5.99+ (available in four sizes)
Neutrogena Beach Defense Sunscreen Spray helps protect your face and body (or your kid's, since it's safe for them, too!) from the sun with broad spectrum SPF 70 and the brand's Helioplex technology, which fights UVA and UVB rays. It's water-resistant, so even if you're slick from sweating or swimming (hello, summer!), you won't need to reapply it for up to 80 minutes. And when you DO re-apply it — because you definitely should — you won't need an extra set of hands to get your back thanks to the convenient spray bottle.
Promising review: "We go to SoCal water parks and beaches constantly. Any time we go somewhere like this, we are taking this particular sunscreen. It's easy to spray on two squirmy kids and most importantly it lasts between the sand and surf. I go through a dozen cans over the summer. It's simply the best. And it doesn't irritate my contacts, which is my eternal struggle." —SoCalPrice: $9.89The Beach Defense sunscreen also comes in lotion form, if you prefer slathering that all over yourself instead.
Black Girl Sunscreen Broad Spectrum SPF 30 — infused with natural ingredients such as avocado, jojoba, cacao, carrot juice, and sunflower oil — protects you from the sun with skin tone in mind. Made for and by women of color, many reviewers say this doesn't leave a white cast and that it's part of their daily routine, with one reviewer saying it's universal for all skin tones and types. No more walking around looking like a ghost in the sun.
However, some have noted it may not be ideal for oily or acne-prone skin, though others have noted it's lightweight and doesn't irritate sensitive skin or cause breakouts. As always with new skincare, patch test, especially if using it on your face.Promising reviews: "Love the formula of the product. It makes it so much easier for me not to forgo my use of daily sunscreen now that I'm 50 y/o. I'm actually forever sold on the product. A little pricey for me; but I'm at the age where you got to spend a lil more for quality products." —KatI have had a troubled history with sunscreens. Of all of the ones that I've tried, they either leave a white cast, sensitize my skin, dry me out, or make me itchy. This is the only one that I've used that feels nice on my skin, gives me a nice glow on no-makeup days, and wears well under makeup. As someone with combo-normal skin, it can make me feel greasy sometimes, especially in really hot weather. Personally, I would proceed with caution if you have really oily skin, especially if you live in a hot environment. Aside from that, I quite enjoy it, and have used it faithfully for the past several years. I may try others in the future, but this is my staple for the time being." —Allyg90Price: $15.99
Carmex Weather Guard Lip Balm with SPF 30 is enriched with cocoa butter to moisturize and protect your yapper against wind and UVA and UVB rays while being water-resistant for up to 80 minutes. That means more time swimming, sweating, and soaking up the sun and less time spent reapplying your lip balm.
Some reviewers have noted that they're not huge fans of the taste, but it comes as a two-pack, so if you're looking for budget protection, it might be worth the risk.Promising review: "This is the only lip balm I've found that actually cures the dryness so that I don't have to use it constantly. And it's one of the few that doesn't have mint or menthol which are irritating for me. I wear it under lipstick every day and love that it has sunscreen." —CarriePrice: $4.99
Essie On A Roll Apricot Cuticle Oil makes cuticle care less boring and tedious and more fruity and easy. Hydrate and condition your nail beds and cuticles so you can have a quick salon-level manicure on the go, whenever when you want, while smelling like a juicy apricot.
Promising review: "I have had weak nails which have been further damaged by an aggressive nail tech and medications. My nails were so weak and damaged that they couldn't grow past the bed and were frequently splitting vertically which was painful. I've used just two products to repair them, a nail bonding repair serum and this Essie nail oil. This doesn't just moisturize your cuticles, it also sets the foundation for healthier and stronger nails. I love how portable it is. I can sneak in an application on a quick break at work. It soaks in quickly. They aren't perfect, but they look healthy and I can actually do manicures now. I will keep getting this product." —Tableless in MNPrice: $14.99
Duke Cannon Bloody Knuckles Hand Repair Balm provides deep hydration to cracked and chapped skin. It's made out of lanolin — wax from sheep wool, which might sound gross, but stay with me — to moisturize your hands (or feet) without a greasy residue. While it's designed for ~the working man~ I, a woman, have used it nightly before bed without the worry of it sticking to my sheets.
Promising reviews: "Being a massage therapist for 23 years my hands are always rough and cracked because of the amount of handwashing I do, this is hands-down, the best hand lotion I have ever ever ever tried. But get the tube, because then you don't have to dig into the tub of it…. Then when people want to borrow it they aren't digging their dirty little hands in your lotion. Also works very well on feet and cracked heels." —AMLT"I am OBSESSED with this stuff. I'm a woman but use this exclusively as my hand cream. Love that it's unscented and not greasy at all! It soaks right up and my hands are never dry afterwards. I keep a big jar of it in my nightstand and recently bought this travel size for my purse. I recommend it to everyone!" —RachelPrice: $6.99
Aquaphor Healing Ointment is a multitasking MVP for everyday needs — including (but not limited to) dry hands, chapped lips, ashy elbows, scraggly looking cuticles, cracked heels, blistering and irritated skin, taming eyebrows, and even minor cuts and burns. I've used it after day one of a new tattoo in addition to most of the other reasons on this list. Name a daily problem, and this water-free, fragrance-free, derm-recommended, clinically proven ointment just might fix it.
Promising reviews: "I always keep at least 2 tubes of aquaphor in the house because it helps with dryness and it doesn't have the smell of straight up petroleum jelly. It is also less sticky and I find that it absorbs easier. I use it on my lips before bed and always wake up with nice moisturized lips - minus the gross smell of petroleum jelly. A must have!" —Erica7"I have used this for over 30 years and have never been disappointed. Aquaphor is amazing and will heal super fast. I use it on cuts, burns, chapped lips, sunburn, you name it. I always have a tube of this on hand." —NHPrice: $6.29While the above is a 1.75-ounce squeeze bottle, the ointment comes in various other sizes and packaging, including a jar in 2.8 and 14 ounces, an on-the-go version, and a lip balm with SPF 30 and without SPF.
Scotch Porter Beard Wash isn't just for facial hair — it's for the skin underneath, too! Vegan and free of harmful ingredients, with natural ingredients like burdock root, nettle leaf, and aloe vera, the wash cleans, strengthens, and hydrates your beard, mustache, what have you, while preventing the skin underneath from being dry and itchy. Wash out the smell of that burrito you had earlier AND moisturize at the same time.
Promising review: "Other beard wash products left my beard dry and my skin under my beard was almost always itchy. I've been using this brand for months, and I no longer have that problem. Since using this wash, my beard is easier to comb and feels softer. Don't need much of it to get a good lather. Every few days, I use this company's conditioner too. Both products have a nice, clean, masculine scent." —Azure37Price: $11.99
Every Man Jack Sandalwood Beard Oil helps soften and nourish facial hair and the skin below it, thanks to argan and borage oils, shea oil, and vitamin E. The brand says you'll "smell like fresh cut lumber" aka sandalwood, vetiver, and amber, if that's your thing — though not in an overwhelming way like other beard oils, according to some reviewers. Some also say their beard stays shiny without looking too oily. Time for kisses (it's partner-approved), chin-rubbing-level pondering, or generally tamed and not-itchy facial hair. Just rub it into your face fur and comb through.
Promising reviews: "Great beard oil. Smells very good and stopped my beard itchiness. Most beard oils don't have shea butter and argan oil. Second purchase of this great product. It has high quality ingredients and is vegan at a great price. Tried other beard oils but the scents have been too strong. Plus it lasts a long time—roughly six months with daily use—and is very high quality for a reasonable price." —Jl"Saw this at Target and thought my husband would like it since he has a long and thick beard. His beard was getting a little rough so I thought this might help soften it. He's been using it for a month now and OMG. The smell is addicting and his beard is softer than before. I would literally buy this for him again just so that I can selfishly smell it on him everyday." —happywifePrice: $9.99
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- Scientific American
Doctors Discover a Woman With Her Own Unique Blood Type
The following essay is reprinted with permission from The Conversation, an online publication covering the latest research. In a routine blood test that turned extraordinary, French scientists have identified the world's newest and rarest blood group. The sole known carrier is a woman from Guadeloupe whose blood is so unique that doctors couldn't find a single compatible donor. The discovery of the 48th recognised blood group, called 'Gwada-negative', began when the woman's blood plasma reacted against every potential donor sample tested, including those from her own siblings. Consequently, it was impossible to find a suitable blood donor for her. On supporting science journalism If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today. Many people know their blood type – A, B, AB or O – along with whether they are Rh-positive or negative. But these familiar categories (those letters plus 'positive' or 'negative') represent just two of several dozens of blood group systems that determine compatibility for transfusions. Each system reflects subtle but crucial differences in the proteins and sugars coating our red blood cells. To solve the mystery of the Guadeloupian woman's incompatible blood, scientists turned to cutting-edge genetic analysis. Using whole exome sequencing – a technique that examines all 20,000-plus human genes – they discovered a mutation in a gene called PIGZ. This gene produces an enzyme responsible for adding a specific sugar to an important molecule on cell membranes. The missing sugar changes the structure of a molecule on the surface of red blood cells. This change creates a new antigen – a key feature that defines a blood group – resulting in an entirely new classification: Gwada-positive (having the antigen) or -negative (lacking it). Using gene editing technology, the team confirmed their discovery by recreating the mutation in a lab. So red blood cells from all blood donors tested are Gwada-positive and the Guadeloupean patient is the only known Gwada-negative person on the planet. The implications of the discovery extend beyond blood transfusions. The patient suffers from mild intellectual disability, and tragically, she lost two babies at birth – outcomes that may be connected to her rare genetic mutation. The enzyme produced by the PIGZ gene operates at the final stage of building a complex molecule called GPI (glycosylphosphatidylinositol). Previous research has shown that people with defects in other enzymes needed for GPI assembly can experience neurological problems ranging from developmental delays to seizures. Stillbirths are also common among women with these inherited disorders. Although the Caribbean patient is the only person in the world so far with this rare blood type, neurological conditions including developmental delay, intellectual disability and seizures have been noted in other people with defects in enzymes needed earlier in the GPI assembly line. The Gwada discovery highlights both the marvels and challenges of human genetic diversity. Blood groups evolved partly as protection against infectious diseases (many bacteria, viruses and parasites use blood group molecules as entry points into cells). This means your blood type can influence your susceptibility to certain diseases. But extreme rarity creates medical dilemmas. The French researchers acknowledge they cannot predict what would happen if Gwada-incompatible blood were transfused into the Guadeloupian woman. Even if other Gwada-negative people exist, they would be extremely difficult to locate. It is also unclear if they can become blood donors. This reality points towards a futuristic solution: lab-grown blood cells. Scientists are already working on growing red blood cells from stem cells that could be genetically modified to match ultra-rare blood types. In the case of Gwada, researchers could artificially create Gwada-negative red blood cells by mutating the PIGZ gene. A growing field Gwada joins 47 other blood group systems recognised by the International Society of Blood Transfusion. Like most of these blood-group systems, it was discovered in a hospital lab where technicians were trying to find compatible blood for a patient. The name reflects the case's Caribbean roots: Gwada is slang for someone from Guadeloupe, giving this blood group both scientific relevance and cultural resonance. As genetic sequencing becomes more advanced and widely used, researchers expect to uncover more rare blood types. Each discovery expands our understanding of human variation and raises fresh challenges for transfusion and other types of personalised medicine.


Medscape
16 hours ago
- Medscape
A 67-Year-Old Woman With an Incidental Rectal Mass
Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians, but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case that you would like to suggest for a future Case Challenge, please email us at ccsuggestions@ with the subject line "Case Challenge Suggestion." We look forward to hearing from you. Background and Presentation A 67-year-old woman initially presented to the hospital more than 4 years ago and was admitted for management of a hypertensive emergency and acute kidney injury. Her course was complicated by atrial fibrillation, acute cerebrovascular accident, and worsening constipation. She was subsequently transferred to the long-term care ward because it was determined that she is incapacitated and unable to make healthcare decisions without assisted consultation; thus, she was deemed unsafe for discharge. She is under a conservatorship through a probate court. The patient has been receiving routine screenings that would typically be completed as an outpatient, such as mammograms and DEXA, during her very prolonged hospital stay. Interpretation of a recent CT scan for evaluation of abdominal pain revealed an extensive stool burden and incidentally noted a questionable 1.3-cm round density in the rectum, possibly representing a stool ball, although an underlying lesion could not be excluded (Figure 1). The inpatient gastroenterology team was consulted for further recommendations. Figure 1. Round density within the rectum (white arrow) measuring 1.3 cm. The patient had no complaints, although she had difficulty providing an accurate history. Per the nursing staff, she can go 4-5 days without having a bowel movement and she often has hard stool. She was taking laxatives, including polyethylene glycol 17 g twice daily and senna glycoside, two tablets twice daily. She occasionally also has loose stool. Upon further chart review, her last colonoscopy was 4 years ago and revealed stool throughout the colon. There were no colonic polyps or mass noted. She reported not having any unintentional weight loss, rectal bleeding, dysphagia, heartburn, nausea, or vomiting. Physical Examination and Workup The patient has a temperature of 98.6 °F, blood pressure of 123/65 mm Hg, heart rate of 77 beats/min, and respiratory rate of 18 breaths/min. She is alert and cooperative. Her eyes are nonicteric. Her abdomen is soft, nontender, and nondistended. No supraclavicular lymphadenopathy is noted. She has no temporal or clavicular muscle wasting and no lower-extremity edema. Laboratory testing results are: Hemoglobin: 12.5 g/dL (reference range, 12-16 g/dL) Mean cell volume: 80 fL (reference range, 80-100 fL) Alkaline phosphatase: 50 U/L (reference range, 39-113 U/L) Aspartate aminotransferase: 19 U/L (reference range, 17-35 U/L) Alanine aminotransferase: 20 U/L (reference range, 8-39 U/L) Total bilirubin: 1.0 mg/dL (reference range, 0.1-1.2 mg/dL) Albumin: 3.8 g/dL (reference range, 3.8-5.3 g/dL) Blood urea nitrogen: 20 mg/dL (reference range, 8-24 mg/dL) Creatinine: 1.50 mg/dL (reference range, 0.60-1.20 mg/dL) Next Steps to Consider The most appropriate next step in management would be a colonoscopy for further evaluation and possible biopsy of the suspected rectal mass. 64Cu-dotatate PET is an imaging technique that provides high-quality images for detection of neuroendocrine tumors (NETs). This is an excellent imaging tool with high sensitivity (90.9%) and specificity (96.6%) for detecting NETs.[1] However, a colonoscopy would be the preferred next step in this situation, given the location of the mass in the rectum and the opportunity to obtain definitive biopsy specimens. Rectal NETs typically are associated with an excellent prognosis, although the rate of metastasis depends on tumor size. For example,[2] lesions ≤ 1 cm have only a 3% rate of metastasis, while tumors 11-19 mm have a 66% rate of metastasis. This rate further increases to 73% for tumors ≥ 2 cm. Rectal NETs are typically resected. The resection technique depends on tumor size. For lesions ≤ 1 cm, endoscopic mucosal resection (EMR) is typically the preferred method. Given the submucosal nature of the tumor, a standard cold snare or hot snare polypectomy would not be sufficient. Band ligation and underwater EMR are the preferred EMR methods per the 2023 American College of Gastroenterology guidelines on subepithelial lesions.[2] For lesions > 1 cm, a surgery referral is warranted. Endoscopic submucosal dissection also may be considered for these cases.[2] Gastrointestinal NETs (GI-NETs) can occur anywhere along the digestive tract, from the esophagus to the rectum, but they more commonly occur in the midgut (ileum, appendix).[3] They are also known as carcinoid tumors. GI-NETs are typically diagnosed in individuals in their seventh decade, but they can occur at any age and incidence is similar between males and females. Symptoms can include abdominal pain or cramping, diarrhea, rectal bleeding or blood in the stool, and flushing, among others. Carcinoid syndrome occurs when GI-NETs release excessive amounts of bioactive hormones and is associated with metastasis, particularly to the liver.[3] Carcinoid syndrome is characterized by systemic symptoms such as flushing, diarrhea, and wheezing. Serum chromogranin A (CgA) is a nonspecific biomarker that may be useful during the investigation for gastroenteropancreatic NETs, although it has limited use in the evaluation of colorectal NETs because it is rarely elevated and does not accurately reflect tumor burden. CgA elevations have been noted with various gastrointestinal and nongastrointestinal comorbidities, ranging from atrophic gastritis and pancreatitis to renal insufficiency, chronic bronchitis, and hyperthyroidism. Certain medications can increase chromogranin levels as well, including proton pump inhibitors (which should be held 7 days prior to CgA testing) and histamine-2 receptor antagonists (which should be held 24 hours prior to CgA testing). Strenuous exercise or food intake prior to testing also can affect levels. These factors explain the low specificity of CgA testing for NETs.[4] This would not be the best next step for evaluation of an incidentally noted rectal mass on CT. CT-guided biopsy also would not be the best next step in management for this patient. Given the finding of a possible rectal mass, the patient should undergo colonoscopy for further evaluation and possible sampling of this mass. The patient was scheduled for a colonoscopy. She underwent a 2-day bowel preparation given her significant history of constipation and extensive stool burden noted on CT. The colonoscopy revealed a dilated colon and brown pigmentation of the colonic mucosa, consistent with melanosis coli (Figure 2). She had a redundant colon, prone to extensive looping of the colonoscope. Figure 2. Colonoscopy showing a dilated colon and brown pigmentation of the colonic mucosa, consistent with melanosis coli. Additionally, a round, subepithelial lesion was found in the rectum, with a dimpled appearance and a central erosion (Figure 3). Figure 3. Colonoscopy showing a round, subepithelial lesion in the rectum with a dimpled appearance and central erosion (yellow arrow). Establishing the Diagnosis The most appropriate next step to establish the diagnosis would be a tunneled "bite-on-bite" forceps biopsy. Given the subepithelial nature of the tumor, a standard mucosal cold forceps biopsy would not provide tumor tissue for diagnosis. Thus, an endoscopist would have to take a forceps biopsy and then take several additional samples in the same location to obtain deeper levels of tissue. NETs are typically found in the submucosa. A cold snare polypectomy would not be appropriate because this is typically done for standard colon polyps, which are mucosal lesions. Given the submucosal nature of a rectal NET, endoscopic removal should be done via EMR or endoscopic submucosal dissection. Typically, endoscopic resection of rectal NETs is suggested for small (< 1 cm) tumors, whereas larger tumors > 1 cm should undergo endoscopic submucosal dissection or surgical resection.[2] Similarly, hot snare polypectomy would not be appropriate because this is typically done for standard colon polyps, which, again, are mucosal lesions. A tunneled 'bite-on-bite' biopsy was obtained. Pathology revealed multiple fragments of unremarkable rectal mucosa, with the exception of two fragments in which a submucosal proliferation of small, uniform glands were positive for synaptophysin, chromogranin, and insulinoma-associated protein 1 (INSM1). The proliferative activity index by MIB-1 (Molecular Immunology Borstel 1) is less than 1%. Explanation Pathology revealing a submucosal proliferation of small, uniform glands positive for synaptophysin, chromogranin, and INSM1, with a proliferative activity index by MIB-1 of less than 1%, is consistent with a well-differentiated NET. A poorly differentiated NET typically has a proliferative activity index of 20% or greater.[5] Common immunohistochemical markers for a schwannoma include S100 protein and glial fibrillary acidic protein.[6] Common immunohistochemical markers for a gastrointestinal stromal tumor include CD117 (c-KIT) and discovered on GIST-1 (DOG-1).[7] Because of its high sensitivity (90.9%) and specificity (96.6%) for detecting NETs,[1] a 64Cu-dotatate PET scan was performed to confirm diagnosis. PET findings did not show any metastatic disease. Management Decisions A surgery referral would be the best next step in management. Rectal NETs typically have an excellent prognosis, although the rate of metastasis depends on tumor size, with rates ranging from 3% (≤ 1 cm) to 66% (11-19 mm) to 73% (≥ 2 cm).[2] Rectal NETs are typically resected. The resection technique depends on tumor size. For lesions ≤ 1 cm, EMR is typically the preferred method of resection. Given the submucosal nature of the tumor, a standard cold snare or hot snare polypectomy would not be sufficient. As discussed, American College of Gastroenterology guidelines recommend band ligation and underwater EMR as the preferred EMR methods for subepithelial lesions.[2] For lesions > 1 cm, a surgery referral is warranted. Endoscopic submucosal dissection also may be considered for these cases.[2] 64Cu-dotatate PET scanning is useful for assessing for metastatic disease, which was not seen in this patient. Clinical/imaging surveillance would not be the best next step in management, as rectal NETs > 1 cm have a rate of metastasis of greater than 60%. Thus, resection is indicated if the patient is deemed to be a procedural candidate and if this is within the patient's goals of care. Underwater EMR is an excellent option for rectal NETs < 1 cm, but this patient's tumor is > 1 cm. Starting a somatostatin analog (octreotide or lanreotide) would not be the best next step of management for this patient with a solitary, nonmetastatic rectal NET. These medications are certainly a consideration in patients with NETs, particularly those with metastatic disease, and octreotide is used in carcinoid syndrome. The decision to start octreotide or lanreotide is typically made by the hematology-oncology service. Data suggest an antiproliferative effect; for example, the CLARINET trial (2014) — a randomized, double-blind study comparing lanreotide with placebo — suggested significantly prolonged progression-free survival among patients with metastatic enteropancreatic NETs grade 1-2 (Ki-67 < 10%).[8] One caveat is that the hazard ratios had wide confidence intervals for patients with hindgut tumors (which include rectal NETs), possibly attributed to the smaller sample size of this subgroup. In consultation with her conservatorship, the patient discussed resection options with both the surgery team and the advanced gastroenterology team. Owing to the size of her lesion (1-2 cm) and lack of metastasis, the decision was made to perform an endoscopic mucosal dissection procedure, which went well, without any complications. Explanation Type 1 gastric NETs are associated with atrophic gastritis, which is commonly seen in states of chronic inflammation such as chronic Helicobacter pylori gastritis or autoimmune gastritis. Patients with autoimmune gastritis have antibodies against intrinsic factor and/or parietal cells. Patients with atrophic gastritis typically have achlorhydria (an absence of hydrochloric acid secretion in the stomach). This leads to hypergastrinemia as a physiologic response, which, in turn, leads to enterochromaffin-like cell hyperplasia and can progress to type 1 gastric NET formation. These tumors typically are small, multiple, and have low metastatic potential. Type 2 gastric NETs are seen in patients with multiple endocrine neoplasia type 1 syndrome. Patients with this syndrome often have a pancreatic tumor that can secrete insulin, vasoactive intestinal peptide, glucagon, or gastrin. When a pancreatic neuroendocrine tumor secretes excessive gastrin, this is known as Zollinger-Ellison syndrome. Patients with type 2 gastric NETs typically have high gastrin levels, which lead to high levels of gastric acid secretion (as opposed to the achlorhydria seen in those with type 1 gastric NETs). Type 3 gastric NETs are sporadic and are more likely to be metastatic. Unlike type 1 and 2 gastric NETs, type 3 gastric NETs are not associated with hypergastrinemia. Rectal NETs are thought to have the best prognosis among NETs, especially small (< 1 cm) rectal NETs, which have a low (3%) rate of metastasis and can be endoscopically resected.


San Francisco Chronicle
18 hours ago
- San Francisco Chronicle
The White House praised In-N-Out for switching to beef tallow. It hasn't
The White House touted in a Monday press release examples of prominent food companies that had made changes aligned with President Donald Trump's promises to 'Make America Healthy Again' — including California's In-N-Out Burger, which, the announcement claimed, had switched to only using beef tallow. But in fact, the burger chain continues to use sunflower oil to cook its French fries, the company's customer service line confirmed. The White House press release linked to a viral April 1 X post appearing to announce the company was 'transitioning to 100% pure beef tallow.' The post was from a In-N-Out fan account that quickly clarified it was an April Fool's joke. 'Just delete it bruh,' responded political commentator Dominic Michael Tripi. 'Everyone thinks it's real.' In-N-Out did not immediately respond to a request for comment on the confusion. The burger chain did announce last month that it would remove artificial dyes from two of its drinks and change to a ketchup made with real sugar rather than high-fructose corn syrup. In-N-Out president Lynsi Snyder said in a May 15 Facebook post that the company is 'researching an even better-quality oil for our fries' but did not mention beef tallow. Cardiologists believe that vegetable oils are healthier than animal fats, citing decades of research. Still, Health and Human Services Secretary Robert F. Kennedy Jr. has championed tallow over seed oils, and some Bay Area restaurants have made the switch. Critics claim without medical evidence that seed oils like canola, soybean and sunflower oil cause inflammation and worsen health problems such as obesity and heart disease. Steak 'n Shake, a burger chain in the Midwest, has announced it's moving away from seed oils, and is now cooking fries, onion rings and chicken tenders in beef tallow. In-N-Out operates more than 400 locations in California and beyond. A privately held company, its family-owners have drawn criticism from some customers in liberal-leaning California for their donations to Republicans. And on social media, some customers have indeed pressed In-N-Out to move to beef tallow. But as of now, In-N-Out's website confirms its fries are cooked in 100% sunflower oil.