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How 5 days of eating ultra-processed food can impact your brain

How 5 days of eating ultra-processed food can impact your brain

Yahoo02-03-2025
This just in: Junk food is not good for your health.
We jest, but recent research reveals just how damaging ultra-processed foods can be.
Research shows that 60% of Americans' daily caloric intake typically comes from ultra-processed foods, which often contain high levels of sodium, refined sugars, cholesterol-spiking fats and other lab-based ingredients.
What's more, a recent study linked exposure to these foods to 32 poor health outcomes, such as a higher risk of cardiovascular disease, cancer, metabolic syndrome, obesity, non-alcoholic fatty liver disease, Type 2 diabetes and premature death.
In yet another new study, it gets worse.
Researchers at the Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center in Munich and the University of Tubingen in Germany found that those adverse effects might be dangerously easy to acquire, and long-lasting, too.
Researchers found that even in the short-term, consuming a high-calorie diet rich in ultra-processed foods impairs brain insulin responsiveness and increases liver fat in healthy men.
These effects linger long after the eating period, according to the researchers.
Insulin regulates appetite and metabolism, and insulin resistance such as the kind triggered by ultra-processed foods compromises this regulation and contributes to obesity, Type 2 diabetes and cognitive dysfunction.
The German team also found a link between ultra-processed food consumption and disruption in the brain's reward learning response. This suggests that as little as five days of overeating can condition the brain for unhealthy eating patterns.
As part of the study, 29 healthy male participants between 19 and 27 were divided into a high-caloric diet (HCD) group and a control group.
Over five days, the HCD group was asked to eat additional daily calories from ultra-processed snack foods. The control group, meanwhile, maintained their regular diet.
The aim of the study was to assess insulin-induced brain activity during three moments: Before the high-caloric diet, during it and one week after subjects returned to eating normally.
The HCD group increased their daily caloric intake by 1,200 calories on average, and liver fat content in that group increased dramatically, while brain insulin responsiveness also increased.
One week after resuming a regular diet, insulin activity was significantly lower in the brain.
Researchers were surprised at the effect short-term HCD had on reward learning, which is the process by which the brain learns to associate behaviours or stimuli with a positive or negative outcome and modify accordingly.
After five days of eating ultra-processed foods, the HCD group showed decreased reward sensitivity and increased punishment sensitivity.
Ultra-processed foods associated with cognitive impairment: Study
Junk food, processed meat paving way for rise of cancer?
After a week of normal eating, this trend let up but didn't fully reverse itself.
'Data suggest that a short-term HCD, rich in sugar and saturated fat, has prolonged effects on the brain that outlast the time frame of its consumption,' according to the research team.
'Habitual daily intake of sweet and fatty snacks has been shown to increase neural responses to food, while decreasing the preference for low-fat food independent of changes in body weight and metabolism.'
The study is gender specific and more research is required, but the team said, 'the brain response to insulin adapts to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.
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Press Release: Sanofi's Sarclisa approved in the EU for the treatment of transplant-eligible newly diagnosed multiple myeloma
Press Release: Sanofi's Sarclisa approved in the EU for the treatment of transplant-eligible newly diagnosed multiple myeloma

Yahoo

time3 hours ago

  • Yahoo

Press Release: Sanofi's Sarclisa approved in the EU for the treatment of transplant-eligible newly diagnosed multiple myeloma

Sanofi's Sarclisa approved in the EU for the treatment of transplant-eligible newly diagnosed multiple myeloma Approval based on GMMG-HD7 phase 3 study demonstrating that Sarclisa with VRd induction treatment significantly improved MRD negativity benefit and prolonged PFS compared to VRd alone With the first global approval in TE NDMM, Sarclisa is now approved in the EU across all lines of therapy, regardless of transplant eligibility Paris, July 25, 2025. Following the positive opinion by the European Medicines Agency's Committee for Medicinal Products for Human Use on June 19, 2025, the European Commission has approved Sarclisa in combination with bortezomib, lenalidomide, and dexamethasone (VRd) for the induction treatment of adult patients with newly diagnosed multiple myeloma (NDMM) who are eligible for autologous stem cell transplant. 'We have been on a mission to accelerate Sarclisa's clinical development program with the hope to bring this important medicine to as many people as possible living with multiple myeloma,' said , Global Head of Oncology at Sanofi. 'Today's decision represents a prime example of those efforts, and most importantly, paves the way for Sarclisa to potentially become accessible to even more patients in the EU, regardless of transplant eligibility or line of therapy.' The approval is based on results from part one of the two-part, double-randomized, German-speaking Myeloma Multicenter Group (GMMG)-HD7 phase 3 study (clinical study identifier: NCT03617731), which was designed to independently assess the effects of Sarclisa during the induction and maintenance phases. Sarclisa-VRd demonstrated a deep and rapid response in transplant-eligible (TE) NDMM patients compared to VRd alone, reflected by a statistically significant minimal residual disease (MRD) negativity benefit at the end of the 18-week induction period, which was the primary endpoint of part one. These MRD results were supported by the final progression-free survival (PFS) analysis of part one (induction and transplant), which demonstrated a statistically significant and clinically meaningful improvement in PFS in patients treated with Sarclisa-VRd during induction, regardless of the maintenance therapy received. Additionally, the majority (53.1%) of patients receiving Sarclisa-VRd experienced continued MRD negativity (compared to 38% in the control arm), defined as MRD negativity persisting from post-induction to post-transplant, which was consistent with the prolonged PFS benefit. 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Planned Parenthood closes 5 Northern California clinics, citing Trump budget bill
Planned Parenthood closes 5 Northern California clinics, citing Trump budget bill

San Francisco Chronicle​

time6 hours ago

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Planned Parenthood closes 5 Northern California clinics, citing Trump budget bill

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Eating This Food Could Add Years to Your Life, According to Dietitians
Eating This Food Could Add Years to Your Life, According to Dietitians

Yahoo

time7 hours ago

  • Yahoo

Eating This Food Could Add Years to Your Life, According to Dietitians

Reviewed by Dietitian Karen Ansel, M.S., RDN Who doesn't wish for a long, healthy life? The foods you eat can help, especially nuts. 'Nuts are little powerhouses of nutrition!' says Lauren Manaker, M.S., RDN, LDN. 'They're packed with healthy fats, fiber, protein, vitamins and minerals that can help reduce inflammation, improve heart health and even lower the risk of chronic diseases like diabetes and certain cancers.' They are so promising that one study found that switching from an unhealthy eating pattern to a healthy pattern rich in foods like nuts was linked to a 10-year increase in life expectancy among 40-year-olds. No wonder dietitians are huge fans! Read on to learn how nuts support longevity, tips to enjoy them, plus other foods that may help you live longer. How Nuts May Add Years to Your Life May Promote Brain Health A sharp brain can help you stay vital and active as you age. Conversely, cognitive decline can substantially reduce your quality of life and even shorten your lifespan. In fact, dementia and Alzheimer's disease are leading causes of death worldwide. But what if there were foods that might keep your brain spry, like nuts? 'Studies so far suggest that nuts could help maintain brain health and possibly prevent cognitive decline, especially in older adults or those at higher risk for conditions like dementia,' says Manaker. This may be due to their cocktail of brain-healthy unsaturated fats, fiber, B vitamins, polyphenols and minerals. While studies have found benefits from eating nuts in general, walnuts may be especially advantageous. 'Among nuts, walnuts stand out because they're rich in a plant-based omega-3 fat called alpha-linolenic acid, which is thought to be especially good for the brain,' says Manaker. Can Support Heart Health Heart disease is the No. 1 killer of Americans. Eating more nuts may help protect against this all-too-common cause of death. One large review study found that a nut-rich eating pattern may reduce the risk of cardiovascular disease by as much as 25%. What makes them so effective? 'Nuts provide unsaturated fats that support vascular health and reduce risk of cardiovascular diseases that lead to heart attack and stroke,' says Ayanna Smart, RD. That's not all, though. Nuts also boast a cocktail of heart-healthy fiber, antioxidants, minerals and plant protein. May Protect Against Chronic Disease 'Nuts are a key part of the healthiest dietary patterns linked to longer life, including Mediterranean and plant-based diets,' says Sapna Peruvemba, M.S., RDN. In addition to protecting against heart disease, research shows regular nut consumption lowers the risk of death from other chronic diseases, such as diabetes and cancer, she says. A nut-rich eating pattern has even been linked to lower all-cause mortality, she adds. For instance, one large review study found people who ate roughly 1 ounce of nuts per day were 11% less likely to die from cancer and 22% less likely to die from any cause. Might Preserve Muscle Mass As we age, it's common to lose muscle mass and strength. That doesn't just make it harder to lift the heavy box that just dropped on your doorstep or carry a giant bag of groceries. Advanced muscle loss, known as sarcopenia, also increases the risk of falls and fractures. In older folks, it may also raise the risk of infection, postoperative complications and mortality. A small yet encouraging body of research has found that nuts may help preserve muscle mass and prevent sarcopenia. While the mechanisms have yet to be determined, one review study suggests that nuts' combination of vitamins, minerals, unsaturated fats, antioxidants and protein may work together synergistically to protect against age-related muscle loss. Tips to Enjoy Nuts While nuts are a tasty, convenient snack on their own, there are loads of ways to add more of these healthy treats to your meals and snacks. These dietitian-approved tips can get you started. Toss them into trail mix. Whether you're at your desk or on a long hike, trail mix makes a satisfying snack. Make your own by combining nuts with dark chocolate, no-sugar-added dried fruit and seeds. Blend them into smoothies. Nuts are an easy way to add protein and healthy fats to your smoothie. Softer nuts like pecans and walnuts work particularly well. But almond, cashew and peanut butters are also fantastic ways to add creamy, nutty goodness to your smoothie. Add them to your snack plate. Think charcuterie board with crunch! For a tasty, well-balanced snack plate, arrange nuts, cheese, whole-wheat crackers and fruit on a platter and enjoy! Sprinkle them on cereal and yogurt. Enhance a bowl of yogurt, cereal or overnight oats with a sprinkling of chopped or sliced nuts. In addition to adding extra crunch and flavor to your bowl, they'll help you stay full longer. Mix them up! All nuts are great for you. But if you always go for the same kind, try switching things up. 'The key is variety,' says Manaker. 'Mixing up your nut choices ensures you get a range of nutrients.' Other Foods That May Improve Longevity Whole grains. There's a reason nutrition experts recommend making at least half of your grains whole grains. Research has found that whole grains are strongly linked to a longer lifespan. Oats, barley, corn, quinoa, farro, brown rice and whole-wheat bread and pasta are all outstanding choices. Leafy greens. 'Leafy greens are linked with a reduction in cognitive decline,' says Lisa Andrews, RD, LD. Dark, leafy greens, like spinach, kale and chard, are loaded with antioxidants that may reduce inflammation in the brain. They may also indirectly support brain health by enhancing gut health. Your gut is in constant communication with your brain via an internal superhighway called the brain-gut axis. So, when your gut is healthier, your brain thrives, too. Legumes. 'Beans, lentils and chickpeas are high in fiber and plant-based protein, which can help lower cholesterol and support gut health,' says Manaker., They're also central to eating patterns linked to longevity, like the Mediterranean diet. Berries. 'Blueberries and other berries are beneficial, as they provide antioxidants to prevent cellular damage and aging and are associated with a stronger gut microbiome,' says Andrews. One study found that frequent berry eaters were less likely to die from any cause compared to people who rarely consumed berries. Our Expert Take Nuts have loads of health benefits and may add years to your life. They've been linked to brain and heart health, less muscle loss, fewer chronic diseases and a longer lifespan overall. Don't just save them for snacks, though. Crunchy, tasty nuts are a fantastic addition to trail mix, yogurt, smoothies, cereal or overnight oats. As healthful as nuts are, it's important to remember that one food alone won't make or break your health. 'Think of nuts as a small but mighty part of a much larger lifestyle approach to wellness,' says Manaker. For even more benefits, include them in an eating plan rich in other foods linked to longevity, like whole grains, leafy greens, legumes and berries. Read the original article on EATINGWELL

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