Congruence Therapeutics Announces Oral Presentation on Novel GCase Activators and Correctors for Parkinson's Disease with GBA1 Mutations at the GBA1 Meeting 2025
, June 3, 2025 /CNW/ -- Congruence Therapeutics, a computationally-driven biotechnology company building a unique pipeline of correctors for diseases of protein misfolding, including MC4R-deficient genetic obesity, GBA-driven Parkinson's disease and Alpha-1 antitrypsin deficiency, announced today its participation at the GBA1 Meeting 2025, being held June 5-7, 2025 in Montreal, Canada. Congruence is also a sponsor of the meeting.
"We are pleased to present our science on novel GCase activators and correctors for GBA1 Parkinson's Disease at this important scientific congress," said Sharath Hegde, Ph.D., Chief Scientific Officer of Congruence. "We are developing small molecules discovered leveraging our Revenir ™ platform that are designed to correct biological deficits resulting from mutations in the GBA1 gene. We look forward to advancing the most potent orally active and brain-penetrant allosteric GCase activator and corrector molecules for future evaluation in people living with Parkinson's disease."
Oral presentation details:
Title:" Discovery of Small Molecule Therapeutics for GBA1-PD"
Session: 2- Small Molecules Targeting GBA1
Session Date and Time: Thursday, June 5 th, 2025, 11:40am-12:00pm
Presenting Author: Indranath Ghosh, PhD, Director, Medicinal Chemistry, Congruence Therapeutics
About Congruence Therapeutics
Congruence is a computationally-driven biotechnology company building a unique pipeline of transformative small molecule correctors rationally designed to rescue aberrant protein function. Our proprietary scalable platform, Revenir™, captures the biophysical features of proteins across their conformational ensembles, in order to identify novel allosteric and cryptic pockets which are virtually screened to generate novel chemical matter. Congruence has leveraged its proprietary discovery engine to launch a pipeline of wholly owned drugs directed to high-value, genetically validated, difficult-to-drug targets spanning a variety of indications including genetic obesity, GBA Parkinson's Disease, and α1-Antitrypsin Deficiency. Congruence is further deploying its discovery platform to support two recently executed multi-target research collaborations with large pharmaceutical companies focused on the discovery of small molecule correctors for the treatment of solid tumors and metabolic diseases.
For more information, please visit www.congruencetx.com.
Media Contact
Amy Conrad
Juniper Point
[email protected]
858-366-3243
SOURCE Congruence Therapeutics
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Cision Canada
36 minutes ago
- Cision Canada
LOGISTEC Appoints New Chief Financial Officer Texas Howard to Advance Growth and International Expansion
MONTREAL, Aug. 4, 2025 /CNW/ - LOGISTEC, a leading marine and logistics services provider, is pleased to announce the appointment of Texas E. Howard IV (Tex) as Chief Financial Officer, as part of its commitment to accelerate international growth and further strengthen its position in the global logistics and supply chain industry. "Tex's deep expertise in financial leadership and logistics will be a great asset for LOGISTEC," said Sean Pierce, CEO of LOGISTEC. "Tex has a strong track record of optimizing complex operations and driving financial performance. As we focus on expanding our portfolio, Tex's experience in strategic planning and execution will support our growth initiatives and strengthen our market position." "LOGISTEC is entering an exciting period of international expansion," said Tex Howard. "It's a tremendous opportunity to be a part of a highly experienced team and a dynamic business with a solid reputation. I am truly looking forward to building upon LOGISTEC's legacy of operational excellence and continued success." With twenty years in the industry, spanning manufacturing, rail equipment leasing and repair, and transportation, Tex brings unparalleled insight into leading high-performing teams across multi-national operations. He has successfully lead integrations and growth strategies in North American markets, which will be instrumental in delivering results to create value for all stakeholders. About LOGISTEC LOGISTEC is based in Montréal (QC) and provides specialized bulk, break-bulk and container cargo handling services, as well as logistics solutions, to marine and industrial companies across its North American network of 62 ports and 85 terminals. LOGISTEC also offers marine transportation services in the Arctic and marine agency services for shipowners and operators.
Cision Canada
2 hours ago
- Cision Canada
BST Global Receives Frost & Sullivan's 2025 Global AEC Project Management Company of the Year Award for Excellence in Market Leadership and Digital Transformation
Market-leading innovation, AI-enabled project intelligence ™, and a customer-first approach are transforming the AEC project management industry. SAN ANTONIO, Aug. 4, 2025 /CNW/ -- Frost & Sullivan is pleased to announce that BST Global has received the 2025 Global Company of the Year Award in the architecture, engineering, and consulting (AEC) project management industry for its outstanding achievements in innovation, performance, and customer impact. This top honor recognizes BST Global's leadership in transforming the AEC project management landscape through cutting-edge technology and a customer-centric business model. Frost & Sullivan evaluates companies through a rigorous benchmarking process across two core dimensions: strategy effectiveness and strategy execution. BST Global excelled in both, demonstrating its ability to align strategic initiatives with emerging AEC market demands—such as increasing project complexity and skilled workforce shortages—while executing them with scale and precision. Guided by a long-term strategy focused on digital transformation and customer satisfaction, BST Global has reshaped how AEC firms manage project performance. With AEC companies facing industry-wide challenges—from rising material costs and labor shortages to increasingly remote operations and outdated legacy systems—BST Global delivers intuitive, AI-powered solutions that reduce complexity, improve decision making, and increase productivity. Innovation remains at the core of BST Global's approach. The company's AI-enabled project intelligence platform includes BST Insights, which leverages more than 35 discrete digital signals to provide real-time visibility into project health using net labor multiplier (NLM) as a predictive KPI. "BST Insights predicts outcomes with a 95% or higher accuracy rate for qualified projects, enabling project managers and project directors to make meaningful changes to how their projects are resourced in real time, for example, identifying roles that can be staffed more cost effectively to better align with the economic footprint of the project," said Lynda Stadtmueller, Associate Partner, Information & Communications Technology, Frost & Sullivan. BST Global also introduced BST Connect ™, a cloud-based iPaaS launched in 2024. It integrates seamlessly with systems such as Oracle CX and Microsoft Dynamics, enabling enterprise-wide connectivity. "Earning this honor from Frost & Sullivan reflects the transformative work our team and our clients are doing together to redefine project management in the AEC industry," said Eileen M. Canady, Chief Marketing Officer at BST Global. "We're proud to lead with innovation—infusing AI and real‑time insights into project delivery—while never losing sight of what matters most: enabling our clients to thrive in an increasingly complex and competitive environment." BST Global's consumer-grade mobile applications and Waze-inspired user interface reduce training time and accelerate user adoption. Whether clients are migrating from on-premises solutions or embracing BST Global's latest cloud-native platforms, the company supports them with tailored implementation, data migration, and ongoing reporting services to ensure a smooth, effective transition. Frost & Sullivan commends BST Global for setting the standard in market responsiveness, ecosystem collaboration, and customer experience. The company's launch of the AI + Data Consortium in October 2024 further demonstrates its commitment to advancing the AEC industry through collective benchmarking and standard setting. Each year, Frost & Sullivan presents the Company of the Year Award to a company that demonstrates outstanding strategy development and implementation, resulting in measurable improvements in market share, customer satisfaction, and competitive positioning. The honor recognizes forward-thinking organizations that are reshaping their industries through innovation and growth excellence. Frost & Sullivan Best Practices Awards Frost & Sullivan's Best Practices Awards honor companies across regional and global markets that exhibit exceptional achievement and consistent excellence in areas such as leadership, technological innovation, customer experience, and strategic product development. Each recognition is the result of a rigorous analytical process in which Frost & Sullivan industry experts benchmark performance through comprehensive interviews, deep-dive analysis, and extensive secondary research. The goal is to identify true best-in-class organizations that are driving transformative growth and setting new industry standards. Contact us: Start the discussion. Contact: E: About BST Global BST Global designs, develops and deploys the AEC industry's first suite of AI-powered project intelligence ™ solutions. Beyond our flagship ERP offering, we provide work management, predictive insights and resource management solutions to complement a firm's existing ERP. More than 120,000 architects, engineers and consultants in 65 countries across six continents rely on BST Global's solutions each day to successfully manage their projects, resources, finances and client relationships. With unrivaled industry knowledge, BST Global serves as a trusted partner to its loyal clients and remains at the forefront of innovation. For more information, visit
Cision Canada
3 hours ago
- Cision Canada
SatSure and KALRO Partner to Leverage Satellite Data for Agricultural Transformation in Kenya
BANGALORE, India, Aug. 4, 2025 /CNW/ -- SatSure Analytics India Pvt. Ltd., one of the leading Earth Observation (EO) data refinery platforms, has partnered with Kenya Agricultural and Livestock Research Organisation (KALRO) to revolutionize agricultural productivity and resilience in Kenya through the use of advanced satellite data and analytics. This strategic collaboration aims to integrate SatSure's expertise in Earth observation and artificial intelligence with KALRO's extensive research capabilities to drive data-driven decision-making in the agriculture sector. The partnership will focus on leveraging satellite imagery, remote sensing, and advanced analytics to provide actionable insights for crop monitoring, yield forecasting, soil health assessment, and climate resilience strategies. Speaking on the partnership, Dhruva Rajan, Chief Revenue Officer at SatSure, stated, "We're thrilled to collaborate with KALRO in bringing cutting-edge geospatial intelligence to Kenya's agricultural landscape. This strategic partnership marks a significant step toward enabling data-driven policymaking, strengthening food security, and empowering smallholder farmers with near real-time insights into crop health, weather variability, and sustainable practices." KALRO, a premier institution in agricultural research, is committed to improving agricultural productivity and sustainability in Kenya. Salim Kinyimu, ICT Director at KALRO, commented, "Our partnership with SatSure aligns with our vision of integrating technology into agricultural research and extension services. By harnessing satellite-based analytics, we can better understand climate impacts, optimize resource utilization, and empower farmers with precise, timely information." Paving the Way for Innovation The MoU between SatSure and KALRO will pave the way for pilot projects, joint research initiatives, and the development of digital tools that support agricultural stakeholders, including government agencies, agribusinesses, and farmers. By combining SatSure's geospatial intelligence capabilities with KALRO's on-ground expertise, the collaboration is set to enhance Kenya's agricultural resilience and contribute to the country's food security goals. About SatSure SatSure is one of the world's leading Earth Intelligence companies, delivering analytics-ready data products that enable contextual, industry-specific Earth Observation (EO) solutions at a global scale. It is an end-to-end EO data refinery platform—transforming EO data into decision intelligence—designed to address global challenges across sectors such as Agriculture, Banking, Aviation, Utilities and Critical Infrastructure, and Natural Resources, including Water and Forestry. About KALRO The Kenya Agricultural and Livestock Research Organization (KALRO) is a premier research institution dedicated to enhancing agricultural productivity and rural development in Kenya. KALRO conducts cutting-edge research in crop sciences, livestock management, and sustainable farming practices to support the country's agricultural sector.
