Cubs at Astros prediction: Odds, expert picks, starting pitchers, betting trends, and stats for June 27
The Cubs are 3-5 over the past eight games and coming off a 2-2 series tie with the Cardinals. Houston is hot at 12-3 in the last 15 games and a series sweep over the Phillies, The Astros are winners four straight and five of the past six over the Phillies and Angels.
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Let's dive into the matchup and find a sweat or two. We've got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Cubs at Astros
Date: Friday, June 27, 2025
Time: 8:10PM EST
Site: Minute Maid Park
City: Houston, TX
Network/Streaming: MARQ, SCHN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Cubs at the Astros
The latest odds as of Friday:
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Moneyline: Cubs (-107), Astros (-112)
Spread: Astros 1.5
Total: 8.0 runs
Probable starting pitchers for Cubs at Astros
Pitching matchup for June 27, 2025: Cade Horton vs. Brandon Walter
Cubs: Cade Horton, (3-1, 3.73 ERA)
Last outing: 4.2 Innings Pitched, 3 Earned Runs Allowed, 7 Hits Allowed, 2 Walks, and 2 Strikeouts Astros: Brandon Walter, (0-1, 3.80 ERA)
Last outing: 6.0 Innings Pitched, 7 Earned Runs Allowed, 9 Hits Allowed, 1 Walks, and 6 Strikeouts
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Expert picks & predictions for tonight's game between the Cubs and the Astros
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
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Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Friday's game between the Cubs and the Astros:
Moneyline: NBC Sports Bet is recommending a play on the Houston Astros on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Chicago Cubs at +1.5.
Total: NBC Sports Bet is leaning towards a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Cubs at Astros
The Astros have won 3 straight home games against the Cubs
The Astros' last 5 home games have stayed under the Total
Houston is 1-3 when Brandon Walter pitches this season
Chicago is 6-2 when Cade Horton pitches this season
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
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