Avvio Medical's Microbubble Technology Reduces Complications and Shows Promise for Enhancing Laser Lithotripsy: AEROLITH Trial Results Published in
Study highlights include:
The AEROLITH study demonstrated that in the ureteral stone subgroup, a key clinical population, efficacy was comparable between URS-LL with microbubbles and URS-LL alone. However, the use of microbubbles demonstrated a significant safety advantage, including a 42% relative reduction in adverse events. 'This study demonstrates that conventional URS-LL, which currently is the most common surgical procedure to treat stones, yields disappointing results. More than 50% of patients will still have stones after the procedure, with residual fragments large enough to have a high chance for future problems,' stated Wesley Mayer, MD, lead author of the study. 'It is also poorly tolerated, with > 40% of patients reporting adverse events. AEROLITH showed that patients undergoing URS-LL augmented with microbubbles had significantly fewer adverse events, suggesting improved safety and tolerability compared to conventional laser lithotripsy.'
These clinical findings further strengthen the growing body of evidence supporting Avvio's proprietary technology. Avvio Medical is also currently evaluating, in a pivotal multi-center clinical trial, the safety and effectiveness of Acoustic Enhancer Microbubbles delivered with its breakthrough Enhanced Lithotripsy System (ELS) utilizing low-intensity therapeutic ultrasound.
For more information, visit www.avviomedical.com.
About the Enhanced Lithotripsy System (ELS)
The AVVIO ELS introduces microbubble enhanced acoustic cavitation lithotripsy, enabling kidney stone treatments outside the traditional operating room and into more accessible outpatient settings like ambulatory surgery centers (ASCs), office-based labs (OBLs), and cystoscopy suites. The system delivers a single, minimally invasive therapy without the need for general anesthesia, fluoroscopy, intra-operative imaging, or costly capital equipment. By reducing procedural complexity and resource requirements, ELS supports wider patient access, improves care delivery efficiency, and offers meaningful clinical, economic, and health equity benefits.
About Avvio Medical
Avvio Medical is a privately held medical technology company based in San Francisco committed to expanding access to safer, more effective urinary stone treatments. By developing minimally invasive solutions that lower costs, reduce reliance on hospital-based care, and remove barriers like general anesthesia and advanced imaging, Avvio aims to improve patient outcomes, drive health system efficiencies, and close gaps in care access across diverse healthcare settings.
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