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There is no safe amount of processed meat to eat, according to new research

There is no safe amount of processed meat to eat, according to new research

CTV Newsa day ago
The equivalent of one medium-size hot dog was associated with an increased risk of colorectal cancer and Type 2 diabetes in a new study. (RiverRockPhotos/iStockphoto/Getty Images via CNN Newsource)
There is strong evidence that there is 'no safe amount' of processed meat to eat, nutrition experts say in response to a new study on the connection between diet and the risk of major diseases, including cancer, Type 2 diabetes and heart disease. The researchers also found elevated risks from the consumption of sugar-sweetened beverages and trans fatty acids.
Researchers analyzed data from more than 60 previous studies on the relationship between processed meats, sugar-sweetened beverages and trans fatty acids in a person's diet and their risk of Type 2 diabetes, colorectal cancer and ischemic heart disease, which reduces blood supply to the heart and cuts off oxygen and nutrients, according to the study published Monday in the journal Nature Medicine.
'Habitual consumption of even small amounts of processed meat, sugary drinks, and trans fatty acids is linked to increased risk of developing Type 2 diabetes, ischemic heart disease and colorectal cancer,' said lead author of the study, Dr. Demewoz Haile, a research scientist at the Institute for Health Metrics and Evaluation in Seattle.
The data showed that people who ate as little as one hot dog a day when it comes to processed meats had an 11% greater risk of Type 2 diabetes and a 7% increased risk of colorectal cancer than those who didn't eat any. And drinking the equivalent of about a 12-ounce soda per day was associated with an 8% increase in Type 2 diabetes risk and a 2% increased risk of ischemic heart disease.
'This current research has shown, yet again and consistent with prior research … that to achieve health gains it is best to avoid or minimize the habitual consumption of each of processed meat, sugar-sweetened beverages (SSBs) and industrially produced trans fatty acids (TFAs),' said Dr. Nita Forouhi, head of nutritional epidemiology at the University of Cambridge in the United Kingdom. She was not involved in the research.
The risk increased as consumption increased; and for processed meat consumption, the data showed that there is no 'safe amount,' she added in an email.
A stronger association than it may appear
At first glance, the increase in risk seems modest and might look like the association is weak, said Dr. Mingyang Song, associate professor of clinical epidemiology and nutrition at the Harvard T.H. Chan School of Public Health. He was not involved in the research.
'When we look at the actual data there, it's really remarkably consistent and remarkably strong, and even in the lower dose of consumption, we can still see an increased risk of disease,' he said.
The researchers examined dozens of earlier findings on diet and disease using a burden-of-proof method: a newer form of meta-analysis that not only tries to quantify an association across multiple studies but also accounts for the quality of each, Song said. 'One caveat is it tends to give very conservative results,' he added.
It's also important to note that the studies included in the analysis were observational, meaning that the data can only show an association between eating habits and disease –– not prove that what people ate caused the disease. They also relied on people recalling their dietary patterns, which can leave room for misremembering or misreporting, said Dr. Gunter Kuhnle, professor of nutrition and food science at the University of Reading in the United Kingdom. He was not involved in the study.
Utilizing even 'the most sophisticated techniques does not really solve the problem that the information about diet is rather limited – which is obviously a big problem in nutritional epidemiology in general,' he said.
Why meats, drinks and fats are linked to disease
There are many reasons why such foods could be associated with health problems. Sugar-sweetened beverages and processed meat –– such as sausages, bacon, salami and burgers –– can increase inflammation, which plays a big part in a variety of chronic diseases, Song said.
Processed meats are also often cured with nitrite, which is converted to carcinogenic nitrosamines in the stomach, Kuhnle said.
The problem with sugary drinks is that they are a quick way to consume large amounts of sugar, he added. Not only can that cause weight gain, but it also influences metabolic pathways that affect heart disease and diabetes risk, Kuhnle said.
Trans fatty acids reduce levels of good cholesterol and increase the bad, which is known to increase the risk of plaque buildup in arteries and heart disease, he added.
Other potential connections to consider are that people who are more likely to eat processed meats, sugar-sweetened beverages and trans-fats are often also at a higher risk of diseases because of 'lifestyle factors (smoking, lack of exercise), but also social factors such as education and income, chronic stress and limited access to health care,' Kuhnle said. 'It is very difficult to take these apart.'
What to avoid and what to add
Although the data can't say reducing your consumption of these foods and drinks will cause a lower risk of the diseases, it does suggest that a reduction is a good idea, Song said.
A sensible approach is to follow a varied and balanced diet that avoids excess, Kuhnle said.
That means people who drink a lot of sugary drinks should cut back, he said. It can also be helpful to avoid excess amounts of processed meats and avoid hydrogenated fats where possible –– although they are no longer as common as they used to be, he said.
'The goal shouldn't be perfection but rather a healthy and sensible dietary pattern that allows room for enjoyment,' Kuhnle said.
A good diet isn't just about what to avoid. It's also important to get good nutrients, Forouhi said. 'Wider research has shown us that overall dietary patterns that include higher consumption of fruit and vegetables, whole grains, legumes, nuts and fermented dairy products like yogurt are good for health and longevity,' she said.
'My general advice: don't panic,' Kuhnle said in an email. 'Food is not just (a) source of nutrients –– it plays a central role in culture, pleasure, family life, and social connection. Reducing it solely to a list of health risks misses the bigger picture.'
By Madeline Holcombe, CNN
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Why I Think Viking Therapeutics Is an Asymmetric Growth Opportunity
Why I Think Viking Therapeutics Is an Asymmetric Growth Opportunity

Globe and Mail

time3 hours ago

  • Globe and Mail

Why I Think Viking Therapeutics Is an Asymmetric Growth Opportunity

Key Points Wall Street's smartest money has quietly amassed over $150 million in bullish positions, with Goldman Sachs eliminating all downside hedges. Despite trading near 52-week lows due to biotech industry headwinds, Viking's oral GLP-1 drug shows unprecedented tolerability that could revolutionize obesity treatment. Upcoming phase 2 oral data expected in October or November 2025 represents a rare binary event where the market significantly undervalues the upside potential. Most investors have written off biotech stocks as a graveyard of broken dreams. While artificial intelligence (AI) captures Wall Street's imagination, the biotech industry -- once the crown jewel of innovation -- has been left for dead. But beneath the wreckage, Wall Street's sharpest funds are quietly positioning for what could be the most significant metabolic breakthrough in a generation. A differentiated player in the GLP-1 gold rush Viking Therapeutics (NASDAQ: VKTX) is developing VK2735, a dual GLP-1/GIP receptor agonist for obesity treatment. The company reported stellar phase 2 results in February 2024, showing 14.7% weight loss at 13 weeks with the injectable formulation. But here's what makes Viking different: Its drug demonstrated unprecedented tolerability with a 13% discontinuation rate that was no higher than placebo -- a stark contrast to competing GLP-1 drugs. In obesity treatment, tolerability isn't a luxury -- it's key to real-world adoption. Viking's breakthrough with VK2735 isn't just efficacy; it's safety. The drug's 13% discontinuation rate matched placebo -- unlike Wegovy and Zepbound, which see discontinuation rates typically five to 10 percentage points higher than their placebo groups. Tolerability indistinguishable from placebo could expand the entire obesity market -- not just capture share. 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The numbers tell a compelling story: Viking showed a near-perfect dose-response relationship, with tolerability no different than placebo -- something no other GLP-1 developer has achieved. Every major pharma has tried and failed to create an effective oral GLP-1, with Pfizer discontinuing its program due to safety issues and an exceptionally high discontinuation rate (> 50%). Viking appears to have cracked the code based on the early data, and Wall Street seems to know it (more on that later). Why is the stock trading near 52-week lows? Viking's stock has plummeted 64% from its 52-week high of $81.73 to around $27 as of July 2. This devastation reflects broader structural damage in the biotech space rather than company-specific issues. Since interest rates have flipped higher, biotech as a whole has been crushed, leaving a bad taste in investors' mouths. The 2022 biotech collapse has created a vicious cycle. Great opportunities are no longer getting flagged for investors, as AI stocks dominate headlines and capture imaginations. Meanwhile, GLP-1 drugs have shown a mixed bag in clinical trials lately, suggesting to some that a top in efficacy and safety is near. But I believe that's shortsighted thinking. VK2735 has shown a differentiated clinical profile, with tolerability nearly indistinguishable from placebo in early studies -- something no other GLP-1 has achieved. While it's far too early to declare victory, the data suggests Viking may have solved one of the key challenges that has plagued obesity drugs. This widespread biotech pessimism has created the kind of mispricing sophisticated funds live for: quality assets trading at distressed valuations. It's the very definition of an asymmetric opportunity. The institutional positioning tells a different story While retail investors panic, institutional behavior reveals extreme confidence. 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In March 2025, the company inked a $150 million manufacturing deal with CordenPharma -- one of the world's premier peptide contract development and manufacturing organizations (CDMOs) -- giving Viking turnkey capacity for 100 million autoinjectors and 1 billion tablets annually, without dilution or costly infrastructure builds. This agreement removes a major overhang that has plagued other clinical-stage biotechs, as well as serves as a clear green flag that the broader market has curiously decided to ignore. After all, such an agreement would not have been signed without deep due diligence and extreme confidence in VK2735's clinical profile. Why? There is a tsunami of demand for GLP-1 manufacturing capacity right now. The asymmetric setup ahead of oral data The phase 2 oral data release expected in the fourth quarter of 2025 represents a rare asymmetric opportunity. 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Meet the U.S. climate resistance
Meet the U.S. climate resistance

CBC

time5 hours ago

  • CBC

Meet the U.S. climate resistance

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