Plus Therapeutics reports Q1 EPS ($1.19) vs. (75c) last year
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Associated Press
4 days ago
- Associated Press
Pulmotect Initiates Landmark Phase 2 Clinical Trial in Immunosuppressed Cancer Patients
Leading oncology centers in the United States engaged to conduct the Phase 2 Antiviral Trial and further advance the development of PUL-042 HOUSTON, TX, UNITED STATES, July 8, 2025 / / -- Pulmotect, Inc., a privately held clinical-stage biotechnology company, today announced that it has begun dosing in their 100 patient Phase 2, double-blind, placebo controlled, clinical trial in immunosuppressed patients with hematologic malignancies. The trial is funded in part by an $8.9 million Product Development Research grant awarded by the Cancer Prevention and Research Institute of Texas ( CPRIT, ID#DP230066). 'This clinical trial is a key stepping stone in our development program with PUL-042. The three viruses that we are targeting have no effective treatments and are the most serious and potentially lethal viruses that cause pneumonia in this patient population. It is unheard of for an agent to be clinically effective against multiple different viruses however, PUL-042 activates lung surface immunity to fight off infection and is effective in multiple preclinical models against viruses, bacteria and fungi. The prospect of viral resistance to treatment is non-exsitent due to PUL-042 being a host directed therapy which makes this an exciting and potentially paradigm changing therapeutic. ' said Dr. Colin Broom, CEO of Pulmotect. 'This trial is an example of bringing private and public resources together to address a significant problem facing cancer patients. With funding support from the state of Texas, Fannin Partners and other investors we are able to conduct this trial with the participation of leading cancer centers across the country and their patients.' said Leo Linbeck III, Chairman, Pulmotect Board of Directors and Chairman, Fannin Partners. The Phase 2 antiviral trial is entitled 'A Phase 2 Multiple Dose Study to Evaluate the Efficacy and Safety of PUL-042 Inhalation Solution in Reducing Lower Respiratory Tract Complications in Patients with Hematologic Malignancies and Recipients of Hematopoietic Stem Cell Transplantation (HSCT) with Documented Viral Infections with Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV).' (NCT06665100). The design of the trial builds upon the experience and results from Pulmotect's previous Phase 2 trials that demonstrated activity of inhaled PUL-042 against SARS-CoV-2 when administered by nebulization following diagnosis of viral infection. About PUL-042 PUL-042, a first-in-class, synergistic combination of two toll-like receptor agonists, activates the lungs' surface innate immune system to inhibit and kill a wide range of respiratory pathogens. As microbes land on the epithelial cells of the lung lining, they are destroyed on contact by antimicrobial peptides and reactive oxygen species (ROS) that are released by epithelial cells. Activation of the innate immune system also triggers a response from the adaptive immune system. PUL-042 has demonstrated protection against a broad range of viral, bacterial and fungal respiratory pathogens in pre-clinical models, including models with immunocompromised animals. Phase 1 and 2 trials to date have demonstrated favorable tolerability in more than 200 subjects that included healthy individuals, COPD patients and subjects infected with SARS-CoV-2 with evidence of antiviral activity. PUL-042 may provide potentially life saving therapy for immunocompromised patients and also offer a broad-spectrum therapy for multiple other populations such as patients with COPD, asthma, seasonal infections and potential utility in future pandemics. About Pulmotect Pulmotect has an immunomodulatory platform technology and is developing PUL-042, a clinical-stage, first-in-class, inhaled, immunomodulatory agent. This synergistic agonist amplifies the innate immune defenses of the lung epithelial mucosa to provide broad-spectrum, pathogen-agnostic protection against respiratory infections. Invented at UT MD Anderson Cancer Center/Texas A&M University, PUL-042 has patents issued in 28 countries, both as a stand-alone composition of matter product and in combination with antivirals. PUL-042 R&D has been supported by the Department of Defense (DoD), National Institutes of Health (NIAID, NIGMS), CPRIT, other funding agencies, and private investors including Houston based Fannin Partners, LLC, a life sciences product development company. For more information, visit Brenton Scott Pulmotect, Inc. +1 713-579-9226 email us here Legal Disclaimer: EIN Presswire provides this news content 'as is' without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.
Business Insider
26-06-2025
- Business Insider
Why Is Plus Therapeutics Stock (PSTV) Up 100% Today?
Plus Therapeutics (PSTV) stock saw a huge rally on Wednesday as the clinical-stage pharmaceutical company received approval from the Food and Drug Administration (FDA) for its Investigational New Drug (IND) application for REYOBIQ. Confident Investing Starts Here: Easily unpack a company's performance with TipRanks' new KPI Data for smart investment decisions Receive undervalued, market resilient stocks right to your inbox with TipRanks' Smart Value Newsletter This approval covers the use of REYOBIQ as a potential treatment for pediatric patients with supratentorial recurrent, refractory, or progressive high-grade glioma (HGG) and ependymoma. The company will conduct a clinical trial of this, with the U.S. Department of Defense providing a $3 million grant to fund the study. PSTV stock was up 103.69% in pre-market trading on Wednesday, following a 1.47% rally yesterday. However, the shares are down 83.74% year-to-date and have seen much volatility in 2025. This makes the stock a dangerous gambit not fit for risk-averse traders. Is Plus Therapeutics Stock a Buy, Sell, or Hold? Turning to Wall Street, the analysts' consensus rating for Plus Therapeutics is Strong Buy, based on three Buy and one Hold rating over the past three months. With that comes an average PSTV stock price target of $10, representing a potential 5,247.59% upside for the shares.
Yahoo
25-06-2025
- Yahoo
Plus Therapeutics to Provide Business Update and Host Conference Call on Thursday, June 26, 2025 at 9:00 A.M. ET
HOUSTON, June 25, 2025 (GLOBE NEWSWIRE) -- Plus Therapeutics, Inc. (Nasdaq: PSTV) (the 'Company'), a clinical-stage pharmaceutical company developing targeted radiotherapeutics with advanced platform technologies for central nervous system (CNS) cancers, today announces that the Company will provide a business update on Thursday, June 26, 2025 before the market open. Plus Therapeutics' management team will then host a conference call and webcast at 9:00 a.m. ET to discuss and provide additional details. Webcast and Conference Call Date/Time: Thursday, June 26, 2025 @ 9:00 AM ET Webcast: Dial-in Link: Participants are encouraged to pre-register any time before the call through the dial-in link. Once registration is completed, participants will be provided a dial-in number with a personalized conference code to access the call. Please dial in 15 minutes prior to the start time. Following the live call, a replay will be available on the Company's website under the 'For Investors' section. The webcast will be available on the Company's website for 90 days following the live call. About Plus TherapeuticsHeadquartered in Houston, Texas, Plus Therapeutics, Inc. is a clinical-stage pharmaceutical company developing targeted radiotherapeutics for difficult-to-treat cancers of the central nervous system with the potential to enhance clinical outcomes. Combining image-guided local beta radiation and targeted drug delivery approaches, the Company is advancing a pipeline of product candidates with lead programs in leptomeningeal metastases (LM) and recurrent glioblastoma (GBM). The Company has built a supply chain through strategic partnerships that enable the development, manufacturing, and future potential commercialization of its products. For more information, visit Investor ContactCORE IRinvestor@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
