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Indigenous people less likely to be waitlisted for a kidney transplant

Indigenous people less likely to be waitlisted for a kidney transplant

There's a gap in the number of Aboriginal and Torres Strait Islander people who are waitlisted for a kidney transplant.
A study has found while eight per cent of non-Indigenous dialysis patients were waitlisted, just two per cent of Aboriginal and Torres Strait Islander patients were.
In most cases it was because of an incomplete work‐up, because they were awaiting transplant assessment or because their eligibility had not yet been assessed.
Guest/s
Professor Jacqui Hughes, a kidney specialist at Flinders University and one of the leaders of the National Indigenous Kidney Transplantation Taskforce
Professor Jacqui Hughes, a kidney specialist at Flinders University and one of the leaders of the National Indigenous Kidney Transplantation Taskforce
Professor Stephen McDonald, a specialist in the epidemiology of kidney disease at The University of Adelaide
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Eight babies have been born via a new IVF technique called mitochondrial donation. What is it?
Eight babies have been born via a new IVF technique called mitochondrial donation. What is it?

ABC News

time34 minutes ago

  • ABC News

Eight babies have been born via a new IVF technique called mitochondrial donation. What is it?

Researchers in the United Kingdom have announced the successful birth of eight babies after a clinical trial of an IVF technique known as mitochondrial donation. The pioneering technique — which some in the media have dubbed "three-person IVF" — has been developed to prevent the sometimes fatal and incurable mitochondrial (mito) disease. Researchers hope clinical trials using this technique could be held in Australia within years. Here's how it works. Mitochondria are parts of a cell that break down food and turn it into energy. They're found in almost every cell of the human body. When they don't work properly, they can drain the body of energy, which can result in a rare condition called mitochondrial disease. Mild cases cause problems like weak muscles, diabetes, deafness, vision loss, and heart disease, but at its worst, children can die before birth or soon after from widespread organ failure. In Australia, about 60 babies born each year will develop a serious or fatal case of mitochondrial disease, and only mothers can pass it on to their children. As there is no cure, scientists have focused on IVF technologies to reduce the likelihood of mothers passing this genome onto their children. This is where "pronuclear transfer", or mitochondrial donation, comes in. It involves a technique where a woman's disease-causing mitochondria are replaced with those from another woman's egg. An egg with disease-causing mitochondrial DNA is fertilised with sperm via IVF. The resulting "pronucleus" — which contains the couple's genetic material — is removed from the egg and then transferred to the donor egg. This donor egg has healthy mitochondria and has already had its genetic material removed. The resulting embryo inherits the parent's DNA, but the mitochondrial DNA comes from the donor egg. This process greatly reduces the baby's chance of developing mitochondrial disease. A research team at Newcastle University in the UK tested this method with 25 women who were at a high risk of passing on disease-causing mitochondrial DNA. It found undetectable or low levels of the DNA in eight babies, while another pregnancy is ongoing. Professor John Carroll, director of Monash's Biomedicine Discovery Institute and head of mitoHOPE — which aims to pilot this technology in Australia — said he was excited about the outcome, which had been decades in the making. "For families that would have very likely had children with high levels of mitochondrial genetic disease, they've been able to prevent that," he said. Professor Carroll said it was the first scientific study of this technique and therefore was "early days". "We have to proceed with care, with caution, step by step to make sure it's as safe as it possibly can be," he said. "We really have to monitor those babies and children as they grow up and make sure that none of the disease-causing mitochondria come back. "That's a really important part of this whole process." But he said the research was "remarkable" so far. "[We have] eight babies born to families who would've normally had very ill children," Professor Carroll said. Swinburne University bioethicist Evie Kendal also said this technology was different to the process which could lead to gene-edited or "designer babies". "Mitochondrial donation is only really targeting those specific mitochondrial diseases that are impacted by mutations in that mitochondrial DNA," she said. "So it's not something that we could manipulate to change the traits of offspring, and most genetic conditions are of course related to mutations in the nuclear DNA." Some in the media have dubbed the technique "three-person IVF", because it uses two eggs and sperm to make a baby. But Professor Carroll said this wasn't technically correct. Instead, he said it should be thought about as a couple and an egg donor. This is because the genome — which determines the physical attributes of a person — comes from the parents, while the donor egg carries the mitochondrial DNA. 'All of the genes that make us who we are … they are all from the parents,' he said. In March 2022, the federal government passed legislation, known as Maeve's Law, to allow the use of mitochondrial donation to prevent the transmission of severe disease under strict regulatory conditions. While a clinical trial using this technology hasn't been approved yet in Australia, it's not far off. A program called mitoHOPE has been set up to pilot mitochondrial donation in Australia. It's a collaboration between Monash IVF, Monash University and the Murdoch Children's Research Institute, which received $15 million in funding from the federal government in 2023. Professor Carroll, who is the president of the program, said they were in the process of applying for the licence required to start a clinical trial. He also said one of the lead researchers involved in the UK research, Professor Mary Herbert, was now working at Monash University with mitoHOPE. "For the first time, we have now an evidence base and experience of mitochondrial donation in a clinical setting," he said. "That really gives the ethics committees who are looking at the work, the regulators who are looking at the work, some real reassurance that this technique works." Professor Carroll said he hoped a clinical trial would be underway in the second half of next year, and encouraged willing participants to get in contact. Monash IVF, which has had two high-profile incidents of incorrect embryo transfers in recent months, said the mitoHOPE Program was subject to "strict regulatory oversight". "[It] is being conducted in full compliance with Australian legislation and the required licensing framework," a spokesperson said.

Koala Polar+ Mattress review: For the ultimate cool night's sleep
Koala Polar+ Mattress review: For the ultimate cool night's sleep

News.com.au

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Koala Polar+ Mattress review: For the ultimate cool night's sleep

These products are hand-picked by our team to help make shopping easier. We may receive payments from third parties for sharing this content and when you purchase through links in this article. Product prices and offer details are not assured, and should be confirmed independently with the retailer. Learn more When it comes to getting the perfect night's sleep there's one factor that can make or break it: Temperature. If your bed is too hot you'll easily find yourself frustrated in sweaty sheets. Too cold and you'll suffer through a night of broken sleep. While your bedding can make a difference, a good base is key. Enter Koala's Polar+ Mattress *. Dubbed Koala 's 'coolest mattress ever' it features trademarked PolarBands technology that helps to remove body heat and keep hot sleepers cool. As someone who has struggled with night sweats since giving birth, I was excited to put the Polar+ Mattress to the test. But as I soon learnt to call this simply a cooling mattress would be reductive — the Polar+ comes also with two firmness options, plus a winter side of the topper to keep you cosy when the temperature drops. Read on for my honest review. WHAT IS THE KOALA POLAR+ MATTRESS? The Koala Polar+ has all the features of the Koala Plus mattress but with two extras the company claims will keep you up to five degrees cooler. Found in the top layer of the Polar+ mattress, PolarBands work to conduct body heat away from you. CoolThread fabric, a blend of cooling yarn, helps wick away sweat and feel comfortably cool on your skin. The Polar+ comes with a zippable seasonal topper which has a summer or winter side. You can choose between two flippable levels of firmness: firm or medium firm. It also has all the features Koala are known for in their mattresses — an eight centimetre Kloudcell layer and five-zone support core zero disturbance technology designed to keep bed movement to a minimum. KOALA POLAR+ MATTRESS: FIRST IMPRESSIONS The Polar+ was delivered to my apartment door in three boxes. First impressions were that it was much heavier and bigger than my current mattress, the Koala SE. But despite it being bulkier it was still easy enough to get unboxed and on my bed frame, although it doesn't hurt to have another person to help. Next I waited a few hours for the mattress to expand. While Koala says it can take up to 72 hours for the mattress to fully expand and for the foam to firm up, I found it was perfect to sleep on that night after unboxing it at 2pm that day. DOES IT KEEP YOU COOL? I tested this mattress in June-July, so I can't attest (yet) to how well it keeps you cool during summer. However the Polar+ has helped me regulate my body temperature and sleep more soundly as a result. I don't wake up feeling overheated anymore, but nor do I feel like I am too cold. Instead the mattress offers a level of breathability that I've never experienced with a mattress before, it's a true game changer. My husband also remarked that his sleep has improved drastically. Not too hot, not too cold, it's the Goldilocks of mattresses. WHAT'S IT LIKE TO SLEEP ON? It's always hard to believe that Koala's mattresses don't have springs because they're so supportive and the Polar+ is no different. I prefer a softer mattress and opted for the medium firm setting and while it's firmer than other mattresses from a box I've tried, it still has that dreamy, cloud-like support. This mattress helps me sleep like a baby and I can't recommend it enough.

‘Get vaccinated': Hospitals under pressure as elective surgeries remain on hold
‘Get vaccinated': Hospitals under pressure as elective surgeries remain on hold

ABC News

time3 hours ago

  • ABC News

‘Get vaccinated': Hospitals under pressure as elective surgeries remain on hold

Elective surgeries remain on hold at several major Queensland hospitals, with state leaders calling the influx of flu and COVID-19 patients taking up valuable beds "overwhelming" and "startling". The State Government announced on Wednesday that non-urgent surgeries were postponed for two days at the Royal Brisbane and Women's Hospital, Prince Charles Hospital, Redcliffe Hospital, and Caboolture Hospital. The delay affects around 185 patients. While urgent category one procedures will go ahead, category two and three surgeries, like knee or hip surgeries, have been paused to free up resources. Health Minister Tim Nicholls said elective surgeries were expected to resume Monday, depending on whether case numbers remained steady. "When our beds get full, that restricts the amount of people who can come through emergency departments so we've had to free up beds by pausing elective surgery so we've got capacity in the system," he said. "I've got an overnight report that the situation has steadied, and we haven't had a huge surge. The night before we had 106 people at Redcliffe Hospital and 102 at Caboolture at 9.30pm — there was a big surge Wednesday evening that led to that decision. "Anyone in an emergency should call Triple 0 and our emergency departments will provide quality care." Mr Nicholls said the department was keeping a "watching brief" on numbers, which would determine whether further elective surgery cancellations occurred this flu season. "We're seeing similar presentations in Rockhampton, Gladstone and Ipswich where we're seeing big surges of winter flu and that's why the vaccination is so important," he said. "Last week, more than 250 people were hospitalised with flu and on average, 169 patients are currently in hospital with flu and about 150 with COVID." Staff shortages are also adding to the strain, as more frontline workers fall ill. "Our nurses and doctors are being exposed and our rosters are getting affected by clinicians coming down with the flu, so that's adding to the challenge and our hospitals are doing a mighty job," Mr Nicholls said. He warned this year's winter surge had been one of the most challenging in recent times. "This year it's been worse, there's been a 16 per cent increase in the number of people presenting and 90 per cent presenting with flu are unvaccinated," he said. Patients and health workers have voiced concerns over the system's capacity during flu season. Lou, a patient at the Royal Brisbane and Women's Hospital, said she believed the surgery suspension should be extended because "it's crowded and ramping is up to six, seven hours. "It's choc-a-block," she said. "I was in the Emergency [Department] for seven hours. It should be extended for a lot more than 48 hours. There's not enough staff and the nurses just work and get no recognition." Nursing students, Sarah and Gina, currently on placement at RBWH, said they feared the delays would impact their training. "We're just a bit sad we might not get to experience some learning opportunities in some areas," Sarah said. "We've selected this placement for surgical at RBWH as one of the biggest hospitals in South East Queensland, so we're hopeful we can care for people in surgery as well as those with cold and flu. "For us, it means it makes it difficult from a learning perspective. Everyone should get vaccinated, it really does help. It's preventable," Gina added. Since the end of 2021, there has been a pattern for COVID-19 where there are two peaks of deaths - one between November and January and the other between May and August. Nationally, there were 581 deaths due to COVID-19 and 180 deaths due to influenza in the first four months of 2025. Mr Nicholls said low vaccination rates were contributing to hospital pressure and strongly urged Queenslanders to get the flu shot. "The government put $25 million into free flu vaccines so my real call to Queenslanders is to make sure you get the vaccine - it's safe, it's tested and it may prevent you from coming to hospital," he said. "Queensland Health have been pushing people to get the flu vaccine that's been available since May 1 for free, but unfortunately sometimes it does take these sorts of circumstances to bring it to people's minds. "It's not too late, don't think the season is half way through. Get the vaccination. There's no good reason not to get it. It's the best thing you can do for yourself, your family and your community." Queensland Health is contacting patients whose surgeries have been delayed.

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