AstraZeneca drug lowers high blood pressure in late-stage study
said on Monday its experimental drug
baxdrostat
significantly lowered blood pressure in a late-stage trial of patients with treatment-resistant hypertension.
The news sent shares of the Anglo-Swedish drugmaker up by almost 2%.
The company said it expects peak annual sales for the drug to exceed $5 billion, driven by its use as a standalone therapy and in combination with
Farxiga
, its blockbuster treatment - one that generates $1 billion or more in annual sales - for type 2 diabetes, heart failure and chronic
kidney disease
.
by Taboola
by Taboola
Sponsored Links
Sponsored Links
Promoted Links
Promoted Links
You May Like
15 Most Beautiful Female Athletes in the World
WomenSportOnline.com
Click Here
Undo
Baxdrostat met the main and secondary goals of the study, showing a statistically significant and clinically meaningful reduction in systolic blood pressure at 12 weeks when added to standard treatment at two doses, and compared with placebo, AstraZeneca said.
It acquired baxdrostat through its 2023 purchase of CinCor Pharma as part of efforts to expand its pipeline in heart and kidney disease.
Live Events
The drug targets aldosterone, a hormone that raises blood pressure, offering a new approach distinct from older treatments like
ACE inhibitors
that do not address hormonal drivers, AstraZeneca says.
High blood pressure
affects more than 1 billion people worldwide, according to the World Health Organization.
AstraZeneca is testing baxdrostat in four indications, including chronic kidney disease and prevention of heart failure, in a clinical programme involving more than 20,000 patients.
Shares in London's biggest listed company by market value were up 1.9% at 0834 GMT and among the top gainers on the FTSE 100 index in early trading.
Mineralys Therapeutics is developing a similar drug, lorundrostat, and expects to submit data to the U.S. Food and Drug Administration by the end of the year.
AstraZeneca said it will present full trial results at a medical conference in August but did not say when it will seek U.S. approval.
Its shares are flat this year to date though they have outperformed Europe's benchmark healthcare index by about 5.5%, Barclays analysts said in a note on Monday.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Time of India
34 minutes ago
- Time of India
14-Samdani-CM-FIber-Net-Revival
Vijayawada: Chief minister Chandrababu Naidu directed officials to take swift action to restore and revitalize the AP Fiber Net project. He charged that the previous government had completely derailed the AP Fiber Net project, a visionary initiative launched between 2014 and 2019. Reviewing the progress of AP Fibernet activities here on Monday, the chief minister asked the officials to assess the challenges, financial constraints, necessary corrective steps, and new policy directions. He said that the system, designed to benefit the public, students, and government departments, was exploited for political purposes by the previous govt. He pointed out that while there were 8.70 lakh connections before 2019, was dropped to 4.50 lakh during the YSRCP regime. "We managed the organization effectively with just 130 employees and provided over 8 lakh connections. But the YSRCP government created unauthorized posts to accommodate its party workers, expanding the workforce from 130 to 1,350 and misusing public funds. This was a new form of corruption where party affiliates were placed in government roles and used for political work. The fiber network was no exception. Those responsible must be held accountable. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Providers are furious: Internet access without a subscription! Techno Mag Learn More Undo A thorough investigation should be conducted into those appointments, and full transparency must be ensured," directed chief minister. He, however, said that steps must be taken to rectify past mistakes and ensure a better future. He instructed that the current 4,53,525 connections be increased to at least 8–10 lakh. The chief minister approved the integration of AP Fiber Net with the BharatNet (Amended BharatNet Programme – ABP). Under this scheme, the Centre will allocate Rs. 1,900 crore to AP Fiber Net from 2025 to 2035. He also approved the transition of fiber networks in 1692 gram panchayats across Chittoor and Visakhapatnam districts from linear to ring architecture. Additionally, 480 new gram panchayats will be connected using the ring model. The Centre will provide Rs. 430 crore for this phase. GFX *A Special Purpose Vehicle (SPV), jointly managed by the Central and State Governments, to oversee these projects should be created: CM *The selection process for set-top box suppliers be completed immediately and that a revenue-sharing model be developed with Local Cable Operators (LCOs) using new set-top boxes: CM *Reintroduce services like virtual classrooms *Andhra Pradesh currently leads the nation in village panchayat connectivity. *Fiber net services have been extended to 12,946 panchayats so far. *The government aims to expand the network to a total of two lakh km. *Andhra Pradesh leads all Indian states in fiber optic network coverage with 78355km, followed by Maharashtra (50,481 km), Tamil Nadu (49,616 km), Gujarat (35,246 km), and Telangana (29,143 km).
Time of India
an hour ago
- Time of India
Cancer Daily Horoscope Today (Aaj Ka Kark Rashifal), July 15, 2025: Peace arrives when you stop forcing
Today teaches you that forcing something to happen is not always the answer. You may have been pushing too hard in one area of life, but now, when you step back, things begin to settle. Let life flow without trying to control every detail. When you stop struggling, a new solution may appear clearly in front of you. What clicks into place now will feel smooth and natural. Trust that rest and surrender can often do more than pressure ever could. Cancer Love Horoscope Today In love, stop trying to shape every moment or control the outcome. If in a relationship, your partner might respond better when you stop pushing for answers. Let the conversation flow softly and let love grow slowly. If single, step back from chasing or overthinking. When you release the need to control, the right connection will find you with ease. Emotional peace is the true sign of love. Let your heart breathe today and give space for real closeness. Cancer Career Horoscope Today Career life may feel less tense if you allow things to unfold naturally. A delay or confusion you were stressing over might start resolving itself. You don't have to fix every problem in one day. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like An engineer reveals: One simple trick to get internet without a subscription Techno Mag Learn More Undo Focus on doing your part well, then leave space for results to come. Sometimes, people work better when you stop managing them too closely. Step back, and solutions will appear more clearly. Trust your own efforts and give the rest to time and patience. Cancer Money Horoscope Today Money matters become more manageable when you stop trying to do everything perfectly. If your financial plans were feeling too heavy or strict, lighten them today. A simple, clear approach will help more than complex planning. Allow space in your budget for breathing room. Do not pressure yourself to meet every financial target immediately. Trust that your calm and consistent mindset will bring more peace. Let abundance come in its own time, not through force or stress. Cancer Health Horoscope Today Health feels better when your emotional body is relaxed. Forcing strict routines or pushing your body too much can create tension. Today, allow yourself to slow down and notice how your body feels. Gentle exercise, peaceful music, and light food will help. Avoid trying to fix every discomfort quickly. Sometimes, just resting deeply or drinking warm water is enough. Your body will guide you to what it needs when you listen calmly. Stop forcing healing, and it will begin naturally. Discover everything about astrology at the Times of India , including daily horoscopes for Aries , Taurus , Gemini , Cancer , Leo , Virgo , Libra , Scorpio , Sagittarius , Capricorn , Aquarius , and Pisces .
Time of India
an hour ago
- Time of India
Silver outshines gold, hits 1.12L/kg
Ahmedabad: Silver outpaced gold in returns this year, with prices in Ahmedabad climbing 30% since Jan 1 to touch a record Rs 1.125 lakh per kilogram on Monday. In comparison, gold gained 28% during the same period, rising from Rs 79,200 for 10g at the start of the year to reach the current Rs 1.015 lakh. The latest spike saw silver prices rise by Rs 2,500 in a single session to go up from Saturday's Rs 1.10 lakh. The white metal's stronger performance is backed by surging industrial demand and tight global supplies. "Silver's outperformance is largely due to increased consumption in sectors like solar energy and electronics. Last week, US President Donald Trump imposed a 50% tariff on copper imports, which will take effect on Aug 1. Since silver and copper are both widely used in industrial applications, especially in electronics and clean energy sectors, if copper becomes more expensive due to tariffs, manufacturers are likely to look for cheaper alternatives like silver," said Haresh Acharya, director of Indian Bullion and Jewellers Association (IBJA). Nearly 60% of silver's global demand now comes from industrial applications, particularly green technologies. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like This Could Be the Best Time to Trade Gold in 5 Years IC Markets Learn More Undo "With India's bullish push for green energy through solarisation, silver consumption has sizeably increased in the country. With international prices hovering around $39 an ounce, silver is clearly emerging as a safe-haven investment and an essential input for industry," Acharya added. You Can Also Check: Ahmedabad AQI | Weather in Ahmedabad | Bank Holidays in Ahmedabad | Public Holidays in Ahmedabad Meanwhile, gold price also increased to Rs 1.015 lakh per 10g on Monday. The increasing price of the yellow metal has impacted retail demand for gold. According to jewellers, both gold and silver are gradually getting out of reach of common customers. "A combination of industrial use and investment demand has fuelled the sharp rise, with silver ETFs attracting increasing investor interest as the metal gains attention for its growth potential. Gold and silver are clearly out of reach of customers. Exchange transactions have gone up substantially to 80% over the past six months, since when gold and silver prices increased. People come with old jewellery for repairing it or exchanging it for new. Jewellery trade is clearly muted," said Manoj Soni, member of the Jewellers' Association Ahmedabad (JAA).
