Cubs at White Sox Prediction: Odds, expert picks, starting pitchers, betting trends, and stats for July 25
The Cubs are 1-3 in the past four games and coming off a series loss to the Royals where they dropped two of three.
On the other hand, White Sox are one of the hottest teams in the second half with a 5-1 record and series wins over Tampa Bay and Pittsburgh.
Let's dive into the matchup and find a sweat or two. We've got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.
Game details & how to watch Cubs at White Sox
Date: Friday, July 25, 2025
Time: 7:40PM EST
Site: Rate Field
City: Chicago, IL
Network/Streaming: MARQ, CHSN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Cubs at the White Sox
The latest odds as of Friday:
Moneyline: Cubs (-187), White Sox (+154)
Spread: Cubs -1.5
Total: 8.0 runs
Probable starting pitchers for Cubs at White Sox
Pitching matchup for July 25, 2025: Shota Imanaga vs. Adrian Houser
Cubs: Shota Imanaga, (7-3, 2.40 ERA)Last outing: 0.00 ERA, 0 Earned Runs Allowed, 5 Hits Allowed, 1 Walks, and 5 Strikeouts
White Sox: Adrian Houser, (5-2, 1.89 ERA)Last outing: 6.23 ERA, 3 Earned Runs Allowed, 10 Hits Allowed, 1 Walks, and 5 Strikeouts
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Expert picks & predictions for tonight's game between the Cubs and the White Sox
Rotoworld Best Bet
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Friday's game between the Cubs and the White Sox:
Moneyline: NBC Sports Bet is recommending a play on the Chicago Cubs on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Chicago White Sox at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Cubs at White Sox
Chicago is 4-1 in Imanga's last five starts
The Cubs are on a 4-game win streak at the White Sox
The Under is 7-3 in the Cubs' last 10 road games
The Cubs have covered in their last 4 games against the White Sox
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Follow our experts on socials to keep up with all the latest content from the staff:
Jay Croucher (@croucherJD)
Drew Dinsick (@whale_capper)
Vaughn Dalzell (@VmoneySports)
Trysta Krick (@Trysta_Krick)
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