logo
Ancient DNA shows genetic link between Egypt and Mesopotamia

Ancient DNA shows genetic link between Egypt and Mesopotamia

Yahooa day ago
WASHINGTON (AP) — Ancient DNA has revealed a genetic link between the cultures of ancient Egypt and Mesopotamia, according to research published Wednesday in the journal Nature.
Researchers sequenced whole genomes from the teeth of a remarkably well-preserved skeleton found in a sealed funeral pot in an Egyptian tomb site dating to between 4,495 and 4,880 years ago.
Four-fifths of the genome showed links to North Africa and the region around Egypt. But a fifth of the genome showed links to the area in the Middle East between the Tigris and Euphrates Rivers, known as the Fertile Crescent, where Mesopotamian civilization flourished.
'The finding is highly significant" because it 'is the first direct evidence of what has been hinted at' in prior work,' said Daniel Antoine, curator of Egypt and Sudan at the British Museum.
Earlier archeological evidence has shown trade links between Egypt and Mesopotamia, as well as similarities in pottery-making techniques and pictorial writing systems. While resemblances in dental structures suggested possible ancestral links, the new study clarifies the genetic ties.
The Nile River is 'likely to have acted as an ancient superhighway, facilitating the movement of not only cultures and ideas, but people,' said Antoine, who was not involved in the study.
The skeleton was found in an Egyptian tomb complex at the archaeological site of Nuwayrat, inside a chamber carved out from a rocky hillside. An analysis of wear and tear on the skeleton — and the presence of arthritis in specific joints — indicates the man was likely in his 60s and may have worked as a potter, said co-author and bioarchaeologist Joel Irish of Liverpool John Moores University.
The man lived just before or near the start of ancient Egypt's Old Kingdom, when Upper and Lower Egypt were unified as one state, leading to a period of relative political stability and cultural innovation — including the construction of the Giza pyramids.
'This is the time that centralized power allowed the formation of ancient Egypt as we know it,' said co-author Linus Girdland-Flink, a paleogeneticist at the University of Aberdeen.
At approximately the same time, Sumerian city-states took root in Mesopotamia and cuneiform emerged as a writing system.
Researchers said analysis of other ancient DNA samples is needed to obtain a clearer picture of the extent and timing of movements between the two cultural centers.
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Science and Educational Media Group and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

First Human Genome from Ancient Egypt Sequenced from 4,800-Year-Old Teeth
First Human Genome from Ancient Egypt Sequenced from 4,800-Year-Old Teeth

Yahoo

timean hour ago

  • Yahoo

First Human Genome from Ancient Egypt Sequenced from 4,800-Year-Old Teeth

Teeth from an elderly man who lived around the time that the earliest pyramids were built have yielded the first full human genome sequence from ancient Egypt. The remains are 4,800 to 4,500 years old, overlapping with a period in Egyptian history known as the Old Kingdom or the Age of Pyramids. They harbour signs of ancestry similar to that of other ancient North Africans, as well as of people from the Middle East, researchers report today in Nature. 'It's incredibly exciting and important,' says David Reich, a population geneticist at Harvard Medical School in Boston, Massachusetts, who was not involved in the study. 'We always hoped we would get our first ancient DNA from mummies.' [Sign up for Today in Science, a free daily newsletter] Numerous labs have tried to extract DNA from ancient Egyptian remains. In 1985, evolutionary geneticist Svante Pääbo reported the first ancient DNA sequences from any human: several thousand DNA letters from a 2,400-year-old Egyptian mummy of a child. But Pääbo, who won a Nobel prize in 2022 for other work, later realized that the sequences were contaminated with modern DNA — possibly his own. A 2017 study generated limited genome data from three Egyptian mummies that lived between 3,600 and 2,000 years ago. The hot North African climate speeds up the breakdown of DNA, and the mummification process might also accelerate it, said Pontus Skoglund, a palaeogeneticist at the Francis Crick Institute in London who co-led the Nature study, at a press briefing. 'Mummified individuals are probably not a great way to preserve DNA.' The remains that Skoglund's team sequenced pre-date widespread mummification: the person was interred instead in a ceramic pot, a sign of high, but not elite, status. The remains were found at an archaeological site called Nuwayrat, 265 kilometres south of Cairo along the Nile river. The teeth and bones were discovered in 1902, when Egypt was under British colonial rule. They were donated to institutions in Liverpool, UK, where they have been ever since, even surviving German bombing during the Second World War. Skoglund says his expectations were low when his team extracted DNA from several teeth from the Nuwayrat individual. But two samples contained enough authentic ancient DNA to generate a full genome sequence. Y-chromosome sequences indicated that the remains belonged to a male. The majority of his DNA resembled that of early farmers from the Neolithic period of North Africa around 6,000 years ago. The rest most closely matched people in Mesopotamia, a historical Middle Eastern region that was home to the ancient Sumerian civilization, and was where some of the first writing systems emerged. It's not clear whether this implies a genetic direct link between members of Mesopotamian cultures and people in ancient Egypt — also hinted at by similarities in some cultural artefacts — or whether the man's Mesopotamian ancestry arrived through other unsampled populations, the researchers say. The rest of the ancient Egyptian man's bones revealed more details about his life. Evidence of arthritis and osteoporosis suggest he died at an advanced age for the time, possibly in his sixties. Other signs of wear indicate a life of physical toil, sitting hunched over on hard surfaces. On the basis of this and imagery from other tombs from this period, he might have been a potter, said co-author Joel Irish, a bioarchaeologist at Liverpool John Moores University, at the press briefing. 'The publication of a whole-genome data set of an ancient Egyptian constitutes a significant achievement in the field of molecular Egyptology,' says Yehia Gad, a geneticist at Egypt's National Research Centre in Cairo, who praises the researchers for presenting the provenance of the remains clearly. But he points out that the genome is from one individual and might not fully represent ancient Egypt's gene pool, which was probably a melting pot of different ancestries. For this reason, researchers are eager for more ancient Egyptian genome data — perhaps even from a mummy. Advances in ancient-genomics technology and local capacity — Gad supervises an ancient DNA lab at the National Museum of Egyptian Civilization in Cairo — means it hopefully won't take another 40 years. This article is reproduced with permission and was first published on July 2, 2025.

'Curse of Tutankhamun' Could Hide a Secret Cancer-Fighting Compound
'Curse of Tutankhamun' Could Hide a Secret Cancer-Fighting Compound

Yahoo

time11 hours ago

  • Yahoo

'Curse of Tutankhamun' Could Hide a Secret Cancer-Fighting Compound

A mold speculated to have been behind the deaths of a few who dared breach the tomb of Tutankhamun may be hiding a hopeful secret. The species, called Aspergillus flavus, is not actually a Pharaoh's curse, but it may be a medical blessing. A new study, led by molecular engineers at the University of Pennsylvania (Upenn), has now found that this particular fungus possesses cancer-fighting compounds. In the lab, when its natural products were mixed with human leukemia cancer cells, they showed potent effects. When modified, they even performed as well as some chemotherapy drugs. The compounds are called RiPPs for short (ribosomally synthesized and post-translationally modified peptides), and they are made by a variety of organisms, including plants and bacteria. In recent years, plant-derived RiPPS have shown great potential in fighting off some types of cancer, but fungal RiPPS are not as well researched and can be misidentified because of their unique structures. "Even though only a few have been found, almost all of them have strong bioactivity," says lead author and biomolecular engineer Qiuyue Nie from UPenn. "This is an unexplored region with tremendous potential." A. flavus is found around the world in decayed organic material, and its yellow-green spores can infect crops as well as the lungs of mammals. In humans, an aspergillosis infection can lead to chronic lung conditions that may be fatal if left untreated. In 1973, some of the scientists who opened the tomb of a Polish King ended up dying prematurely. A microbiologist at the time found evidence of A. flavus in the tomb, which led to the assumption that this is what had killed the researchers. This logic was then applied to the curious fates of workers and an earl who attended the opening of Egyptian pharaoh Tutankhamun's tomb in the early 20th century, only to famously die of illness days (or in the cases of the workers, years) later. Aspergillus's role in these deaths has fuelled imaginations. But its rise to fame in the history books has brought the fungus scientific attention in the modern era. Inspired by other studies which have linked A. flavus to anticancer activity, Nie and colleagues scanned a dozen different Aspergillus strains for RiPPs. Using metabolic and genetic techniques, they zoomed in on four different purified compounds with similar, complex structures. They named them asperigimycins. In lab experiments, two out of the the four asperigimycins exhibited high potency against leukemia cells, although none worked on breast, liver, or lung cancer cells. When researchers modified one RiPP and added a fatty molecule (a lipid), the compound showed enhanced anti-cancer activity on several different leukemia cell lines and a breast cancer cell line. In fact, this altered RiPP performed on par with two chemotherapy drugs approved by the FDA for leukemia: cytarabine and daunorubicin. The authors of the study, who hail from a variety of institutions around the United States and Portugal, suspect that their lipid substitution affects how the activity of a specific gene allows the drug to better infiltrate and remain inside cancer cells, disrupting replication. "Knowing that lipids can affect how this gene transports chemicals into cells gives us another tool for drug development," says Nie. Nearly a century after fungi gave us penicillin, these curious lifeforms are pointing us in the direction of yet another potential advancement. The study was published in Nature Chemical Biology. Common Vitamin Could Be The Secret to Younger-Looking Skin Scans Reveal What The Brains of Psychopaths Have in Common First Step Towards an Artificial Human Genome Now Underway

Oldest Egyptian DNA Reveals Secrets of Elite Potter From Pyramid Era
Oldest Egyptian DNA Reveals Secrets of Elite Potter From Pyramid Era

Yahoo

time20 hours ago

  • Yahoo

Oldest Egyptian DNA Reveals Secrets of Elite Potter From Pyramid Era

For the very first time, scientists have sequenced DNA from the entire genome of an individual who lived in ancient Egypt up to 4,800 years ago – right when the first pyramids were being built. The ancient genome belongs to an older male individual who was probably part of an elite social class and who, based on his ancestry, likely had brown hair, brown eyes, and dark skin. About 80 percent of the man's genome is linked to lineages in North Africa, while the remaining 20 percent is linked to lineages in West Asia. Related: The findings suggest that early Egyptians once lived in a melting pot of cultures, with migrants and traders arriving from other parts of Africa and Mesopotamia – an ancient region that now encompasses parts of Iraq, Türkiye, and Iran. Previous archaeological evidence has also indicated trade and cultural connections between Egypt and other parts of the Fertile Crescent, primarily through the exchange of domesticated plants and animals, writing systems, and technology such as the pottery wheel. But actual human DNA is not as easily preserved in the hot and dry region. This newest discovery is the oldest DNA ever recovered from ancient Egypt, and scientists say the remains provide "direct evidence of genetic ancestry" from Mesopotamia. "Ancient Egypt is a place of extraordinary written history and archaeology, but challenging DNA preservation has meant that no genomic record of ancestry in early Egypt has been available for comparison," says geneticist Pontus Skoglund, who founded the first high-throughput ancient DNA laboratory in the United Kingdom at the Francis Crick Institute. "Building on this past research, new and powerful genetic techniques have allowed us to cross these technical boundaries and rule out contaminating DNA, providing the first genetic evidence for potential movements of people in Egypt at this time." The ancient man's remains were recovered from a necropolis in the ancient city of Nuwayrat, 265 kilometers (165 miles) south of Cairo, where he was buried in a large pottery vessel inside a rock-cut tomb. He died sometime between 2855 and 2570 BCE. In life, the individual was approximately 160 centimeters (5.2 feet) tall, and judging by his heavily worn teeth and severe arthritis, he was likely between 44 and 64 years old – an advanced age for the time. His form of burial suggests he had a high social status, but unexpectedly, his body holds signs of routine physical labor. "His seat bones are expanded in size, his arms showed evidence of extensive movement back and forth, and there's substantial arthritis in just the right foot. Though circumstantial, these clues point towards pottery, including use of a pottery wheel," suggests bioarchaeologist Joel Irish from Liverpool John Moores University. "That said, his higher-class burial is not expected for a potter, who would not normally receive such treatment. Perhaps he was exceptionally skilled or successful to advance his social status." When scientists analyzed the mix of isotopes in the ancient man's second molar, they found evidence that he grew up in the hot and dry Nile Valley, eating animal protein and plants like wheat and barley. This was typical for early Egyptians. "This individual has been on an extraordinary journey. He lived and died during a critical period of change in ancient Egypt, and his skeleton was excavated in 1902 and donated to World Museum Liverpool, where it then survived bombings during the Blitz that destroyed most of the human remains in their collection," says archaeogeneticist Linus Girdland Flink from the University of Aberdeen. "We've now been able to tell part of the individual's story." One individual's story can't tell us everything we would like to know about ancient Egypt, but the findings are an intriguing start. Researchers hope that their technique will allow for a "more detailed and nuanced understanding of ancient Egyptian civilization and its inhabitants" in the future. The study was published in Nature. Zapping Volunteers' Brains With Electricity Boosted Their Maths Skills Ruins of Ancient Temple Belonged to Mysterious Pre-Inca Civilization Does Using Artificial Intelligence Ruin Your Actual Intelligence? Scientists Investigated

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store