
Orogen Therapeutics and Chemspace/Enamine Announce a Strategic Collaboration to Enable Unique REAL-Driven DNA Encoded Small Molecule Libraries
Enamine's REAL compounds are the world's largest collection of make-on-demand small molecules that represents a significant fraction of the synthetically accessible chemical space. Its member molecules are REadily AccessibLe through validated parallel synthesis protocols using qualified in-stock building blocks. Orogen's DEL- and AI-enabled platform, including FocusDEL™ technology, enables rapid, efficient drug screening of billions of chemically diverse compounds to effectively home in on small drug-like molecules against specific targets from a wide range of therapeutic areas and clinical indications.
'We are thrilled to engage in this strategic collaboration to drive new horizons for DEL-based drug development that brings together this powerful combination of technologies – Chemspace-Enamine's vast REAL Space of innovative chemical matter and Orogen's AI- and DEL-enabled small molecule drug discovery platform - to advance a new generation in DEL capability,' stated Mark Pykett, Orogen CEO. 'We are excited by the potential synergy of the two platforms to enhance and accelerate small molecule drug discovery.'
"DNA-encoded library (DEL) screening offers a proven valuable alternative for sampling large chemical space for efficient small molecule drug discovery,' stated Sven Wagner, PhD, Vice President of Partnerships at Enamine. 'We are pleased to bring our large and rapidly synthesizable Chemspace/Enamine chemical space into this collaboration with Orogen, a pioneer in DEL-based drug discovery, leveraging AI-enabled DELs. Our dovetailing joint effort will enrich DEL-based drug R&D with a critical component and a large part of chemical space, ready to be mined by researchers around the world, ultimately to enable sooner than later treatments for patients with high unmet needs across therapeutic areas, such as immuno-inflammatory disorders."
Under the terms of the collaboration, Chemspace and Orogen will design novel DELs in alignment with the REAL Space foundational principles; Chemspace and Enamine will synthesize and analytically validate these REAL-driven DELs, and Orogen will screen pilot DELs against multiple biological targets. Chemspace and Enamine anticipate the opportunity to provide these libraries to enhance their array of product and service offerings, while Orogen envisions opportunities for multiple novel small molecule candidates aligned with its areas of focus in immuno-inflammatory disorders, GPCRs, and select oncology targets.
Artem Evdokimov, PhD, Orogen's head of research, noted, 'We anticipate this collaboration will add a set of much-needed next-generation DELs to the arsenal of early drug discovery tools. Harmonization of DEL designs with REAL space chemistry enables rapid follow-up on screening: off-DNA compounds and thousands of their SAR-expanding chemical space neighbors can be made both expeditiously and economically – accelerating the early discovery process for much-needed novel, safe, and effective medicines.'
Olga Tarkhanova, PhD, CEO of Chemspace: 'DEL technology is a powerful approach for efficiently exploring vast chemical space, enabling rapid hit identification, structure-activity relationship (SAR) development, and the discovery of novel binding sites. We are excited to join forces with Orogen, a leader in DEL-based drug discovery, to bring the Chemspace/Enamine chemical space into next-generation DEL design. With this collaboration, we bring the benefits of scalable, make-on-demand combinatorial chemistry to the DEL field, addressing a key bottleneck in moving from encoded hits to optimized compounds. By applying the REAL Space concept to DELs and integrating our proven Make-On-DEmand chemistry, this collaboration aims to simplify off-DNA hit synthesis and optimization, accelerate DMTA (design–make–test–analyze) cycles, and help advance new therapies.'
About Orogen Therapeutics
Orogen Therapeutics' mission is to deliver groundbreaking clinical solutions to patients with serious unmet medical needs. The company is revolutionizing small-molecule drug discovery through its proprietary platform integrating DNA-encoded libraries (DEL) with massive chemical diversity of billions of compounds, virtual screening and AI-driven computation. The company's proprietary, one-of-a-kind target-specific FocusDEL ™ (patent pending) seeks to innovate the DEL landscape by enabling enriched hit yields from immense chemical spaces. This unique foundation is designed to enable the efficient derivation of novel drug candidates against a broad range of target classes.
Orogen's team includes scientists with decades of drug development experience and deep expertise in all aspects of small-molecule R&D, including DNA-encoded libraries, target selection and evaluation, cutting-edge AI and data science. For more information, please visit: www.orogentx.com.
About Chemspace
Chemspace is a global provider of drug discovery services. We can streamline hit finding by integrating our Computational Chemistry tools, Bioinformatics, and Machine Learning-based services for smarter drug discovery. By exploring ultra-large chemical spaces, we deliver high-quality hit molecules for discovery projects. Our integrated projects combine hit identification services with biological validation, providing a seamless path from hit identification to pre-clinical studies. For more information, please visit: https://chem-space.com.
About Enamine
Enamine is the leading provider of chemical compounds and a scientifically driven integrated discovery Contract Research Organisation for integrated discovery with unique partnering opportunities in exploring new chemical space. The company combines access to the in-house produced screening compounds (>> (350K in stock) with a comprehensive platform of integrated discovery services in bioinformatics, biology, and chemistry to advance and accelerate the efforts in drug discovery. For more information, please visit: enamine.net
Forward-Looking Statements
'Forward-looking statements' that may be contained in this communication are made within the meaning of federal securities laws, including Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In this context, forward-looking statements often address expected future performance, and often contain words such as 'expect,' 'anticipate,' 'should,' 'hope,' 'project,' 'estimate,' 'predict,' 'goals,' 'intend,' 'plan,' 'believe,' 'seek,' 'will,' 'would,' 'target, 'outlook,' and similar expressions and variations or negatives of these words. All statements, other than those of historical fact, are forward-looking statements, including statements regarding outlook, expectations and guidance. Forward-looking statements address matters that are uncertain and subject to risks, uncertainties, and assumptions that could cause actual results to differ materially from those expressed in any forward-looking statements.
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Our innovative treatments aim to guarantee compliance with medical prescriptions, to improve the effectiveness and accessibility of medicines, and to reduce their environmental footprint. They combine active pharmaceutical ingredients with our proprietary BEPO® technology which controls the delivery of a drug at a therapeutic level for several days, weeks or months from the subcutaneous or local injection of a simple deposit of a few millimeters, entirely bioresorbable. The first treatment based on BEPO® technology, intended for the treatment of schizophrenia, was approved by the FDA in April 2023, and is now distributed in the United States by Teva under the name UZEDY® (BEPO® technology is licensed to Teva under the name SteadyTeq™). We collaborate with leading pharmaceutical companies and foundations to improve global health through new treatment options. Based in Montpellier, Medincell currently employs more than 140 people representing more than 25 different nationalities. UZEDY® and SteadyTeq™ are registered trademarks of Teva Pharmaceuticals. This press release may contain forward-looking statements, particularly concerning the progress of the Company's clinical trials. Although the Company considers that its forecasts are based on reasonable assumptions, any statements other than statements of historical fact that may be contained in this press release relating to future events are subject to change without notice, to factors beyond the Company's control and to the Company's financial capabilities. These statements may include, but are not limited to, any statements beginning with, followed by or including words or expressions such as "objective", "believe", "expect", "aim", "intend", "may", "anticipate", "estimate", "plan", "project", "will", "may", "probably", "should", "could" and other words or expressions of similar meaning or used in the negative. 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Except as required by law, the Company undertakes no obligation to publicly update these forward-looking statements, nor to update the reasons why actual results may differ materially from those anticipated in the forward-looking statements, even if new information becomes available. The Company's updating of one or more forward-looking statements does not imply that it will or will not update these or any other forward-looking statements. This press release is published for information purposes only. The information contained herein does not constitute an offer to sell or a solicitation of an offer to buy or subscribe for securities of the Company in any jurisdiction whatsoever, particularly in France. Similarly, this press release does not constitute investment advice and should not be treated as such. It is not intended to address the investment objectives, financial situation or specific needs of any particular recipient. It should not be relied upon as a substitute for the exercise of your own judgement. All opinions expressed in this document are subject to change without notice. The distribution of this press release may be restricted by law in certain jurisdictions. Persons into whose possession this press release comes are required to inform themselves about and to observe any such restrictions. Appendices – Rothschild Martin Maurel from 01/01/2025 to 30/06/2025 DATE NB_BUY NB_SALE QTE_BUY QTE_SALE CAPITAL_BUY CAPITAL_SALE 02/01/2025 89 132 1,607 5,257 26,949.39 89,631.85 03/01/2025 65 61 2,170 2,570 38,343.90 45,900.20 06/01/2025 111 85 3,509 2,609 63,758.53 47,562.07 07/01/2025 135 116 7,131 4,281 126,432.63 75,688.08 08/01/2025 63 66 3,356 3,356 57,924.56 58,025.24 09/01/2025 86 52 3,965 1,715 67,167.10 29,103.55 10/01/2025 70 43 2,336 1,336 39,011.20 22,391.36 13/01/2025 110 76 2,580 2,830 41,899.20 45,987.50 14/01/2025 50 51 1,848 1,848 30,196.32 30,362.64 15/01/2025 57 55 1,708 1,708 27,891.64 28,011.20 16/01/2025 31 51 2,238 3,238 36,277.98 52,585.12 17/01/2025 42 51 1,063 1,813 17,199.34 29,424.99 20/01/2025 47 32 1,971 1,971 32,028.75 32,068.17 21/01/2025 243 133 7,060 7,560 113,736.60 128,822.40 22/01/2025 48 75 1,456 2,706 23,179.52 43,323.06 23/01/2025 59 53 2,014 2,264 31,962.18 36,020.24 24/01/2025 44 98 1,850 2,810 29,507.50 45,044.30 27/01/2025 47 54 1,495 2,535 23,979.80 40,990.95 28/01/2025 61 135 555 1,555 9,301.80 25,828.55 29/01/2025 254 161 16,266 10,766 269,852.94 177,208.36 30/01/2025 226 230 16,770 16,520 259,767.30 256,060.00 31/01/2025 51 96 1,340 3,188 21,064.80 50,211.00 01/2025 1,989 1,906 84,288 84,436 1,387,432.98 1,390,250.83 03/02/2025 45 95 2,511 2,413 39,046.05 37,811.71 04/02/2025 48 47 2,065 2,065 32,895.45 32,978.05 05/02/2025 45 59 1,100 5,100 17,644.00 82,263.00 06/02/2025 41 39 1,826 1,826 29,928.14 29,946.40 07/02/2025 82 31 3,387 887 54,632.31 14,227.48 10/02/2025 161 69 4,812 2,062 74,537.88 32,167.20 11/02/2025 49 62 3,412 2,512 51,760.04 38,132.16 12/02/2025 52 38 1,643 1,793 24,743.58 27,038.44 13/02/2025 92 80 3,027 1,527 45,072.03 22,843.92 14/02/2025 156 160 4,414 3,414 63,164.34 48,547.08 17/02/2025 91 128 2,886 4,886 41,183.22 69,967.52 18/02/2025 144 95 3,940 3,403 55,238.80 47,744.09 19/02/2025 243 265 12,992 11,529 177,210.88 157,370.85 20/02/2025 245 126 3,818 4,318 52,039.34 59,070.24 21/02/2025 96 92 2,295 2,372 31,212.00 32,354.08 24/02/2025 78 54 1,618 1,541 22,020.98 21,065.47 25/02/2025 125 79 3,641 2,141 48,388.89 28,432.48 26/02/2025 240 295 6,989 11,489 95,819.19 160,156.66 27/02/2025 172 119 4,575 4,075 65,422.50 58,476.25 28/02/2025 110 109 2,625 2,625 37,170.00 37,511.25 02/2025 2,315 2,042 73,576 71,978 1,059,129.62 1,038,104.33 03/03/2025 80 110 832 2,532 11,964.16 36,435.48 04/03/2025 174 129 6,650 4,450 94,762.50 63,991.00 05/03/2025 117 266 8,281 11,081 119,163.59 159,677.21 06/03/2025 92 62 3,934 2,134 56,020.16 30,537.54 07/03/2025 122 153 8,000 7,000 112,320.00 98,280.00 10/03/2025 105 100 10,000 8,000 137,800.00 110,640.00 11/03/2025 84 77 3,416 2,156 46,491.76 29,450.96 12/03/2025 34 96 1,951 8,560 27,040.86 118,641.60 13/03/2025 106 94 7,706 5,757 107,421.64 80,425.29 14/03/2025 81 60 7,716 5,016 107,406.72 70,324.32 17/03/2025 71 114 7,879 10,921 109,518.10 152,020.32 18/03/2025 64 78 11,612 14,940 165,819.36 213,940.80 19/03/2025 91 112 11,437 11,808 166,865.83 172,396.80 20/03/2025 42 46 5,941 6,000 86,916.83 87,900.00 21/03/2025 71 87 9,902 9,152 147,935.88 137,005.44 24/03/2025 88 30 9,351 5,001 140,171.49 75,015.00 25/03/2025 67 56 4,661 3,961 69,029.41 58,662.41 26/03/2025 25 73 4,004 7,003 59,979.92 104,904.94 27/03/2025 67 45 6,457 4,558 96,467.58 68,005.36 28/03/2025 52 65 2,768 6,668 41,298.56 99,753.28 31/03/2025 91 30 7,061 1,361 102,808.16 20,006.70 03/2025 1,724 1,883 139,559 138,059 2,007,202.51 1,988,014.45 01/04/2025 106 93 8,067 6,567 115,922.79 94,433.46 02/04/2025 84 103 6,275 7,275 88,979.50 103,668.75 03/04/2025 55 27 4,332 3,422 61,124.52 48,318.64 04/04/2025 44 37 2,700 2,810 36,801.00 38,216.00 07/04/2025 2 3 150 570 1,923.00 7,341.60 08/04/2025 38 56 2,213 4,043 29,875.50 54,701.79 09/04/2025 63 50 4,913 3,463 64,311.17 45,053.63 10/04/2025 82 52 4,514 4,014 60,893.86 54,108.72 11/04/2025 74 50 4,515 3,690 58,559.55 47,970.00 14/04/2025 27 72 1,575 4,900 20,868.75 65,219.00 15/04/2025 31 57 1,525 4,025 21,106.00 55,625.50 16/04/2025 71 106 10,148 10,148 142,883.84 142,883.84 17/04/2025 54 66 4,844 4,844 68,300.40 68,494.16 22/04/2025 62 86 5,796 6,796 82,766.88 97,182.80 23/04/2025 121 110 10,326 10,326 150,966.12 151,172.64 24/04/2025 105 110 8,794 10,794 130,590.90 160,506.78 25/04/2025 115 58 9,039 4,039 136,217.73 60,544.61 28/04/2025 77 88 8,327 9,327 124,571.92 139,625.19 29/04/2025 96 107 10,750 10,750 160,927.50 161,250.00 30/04/2025 100 92 10,209 10,209 155,380.98 155,687.25 04/2025 1,407 1,423 119,012 122,012 1,712,971.91 1,752,004.36 02/05/2025 46 84 4,802 8,802 73,614.66 135,286.74 05/05/2025 102 103 10,750 9,500 164,045.00 145,350.00 06/05/2025 130 98 9,918 10,418 151,348.68 159,395.40 07/05/2025 110 92 7,131 7,881 109,104.30 120,894.54 08/05/2025 69 85 7,463 7,463 115,377.98 115,601.87 09/05/2025 48 36 4,721 4,721 73,553.18 73,600.39 12/05/2025 142 132 11,275 10,775 169,914.25 162,379.25 13/05/2025 113 92 11,500 10,000 174,455.00 151,700.00 14/05/2025 45 53 1,041 3,041 15,781.56 46,314.43 15/05/2025 69 13 5,050 1,050 77,063.00 15,960.00 16/05/2025 26 60 1,981 4,981 30,071.58 75,611.58 19/05/2025 52 44 3,166 4,166 49,421.26 65,072.92 20/05/2025 135 114 10,628 9,628 164,946.56 149,522.84 21/05/2025 50 80 3,791 4,791 59,025.87 74,979.15 22/05/2025 113 69 7,466 6,966 118,186.78 110,411.10 23/05/2025 145 141 5,722 5,722 91,609.22 92,410.30 26/05/2025 152 144 10,400 7,650 176,904.00 130,126.50 27/05/2025 85 125 8,270 10,020 140,259.20 170,039.40 28/05/2025 204 176 12,204 11,704 201,610.08 194,052.32 29/05/2025 145 123 12,000 9,357 199,680.00 155,887.62 30/05/2025 141 137 7,853 12,496 130,988.04 208,183.36 05/2025 2,122 2,001 157,132 161,132 2,486,960.20 2,552,779.71 02/06/2025 201 128 13,078 8,078 216,179.34 133,690.90 03/06/2025 193 156 10,185 10,657 164,589.60 173,282.82 04/06/2025 102 88 9,000 7,278 144,450.00 116,811.90 05/06/2025 89 139 5,250 11,500 84,892.50 186,415.00 06/06/2025 106 59 8,810 4,864 143,603.00 79,477.76 09/06/2025 83 76 6,319 6,223 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