World-first clinical trial launched in Southampton for a fridge-free vaccine
The Stablepharma tetanus-diphtheria vaccine (SPVX02) is completely stable at room temperature and the firm behind it says up to 60 other vaccines may benefit from the advanced technology.
The first-in-human trial of the vaccine is taking place at the National Institute for Health and Care Research (NIHR) Southampton clinical research facility at University Hospital Southampton.
One of the biggest barriers to people getting vaccines in some parts of the world is the 'cold chain' required to keep vaccines cold from manufacture to the point they are injected.
The World Health Organisation (WHO) estimates that up to half of vaccines are wasted globally every year – largely because of a lack of temperature control and the logistics needed to support an unbroken cold-chain.
UK-based biotech company Stablepharma has shown it can convert existing approved vaccines to fridge-free versions that can be stored for long periods of time at room temperature.
Health and Social Care Secretary, Wes Streeting, said: 'For years, vaccines have been held back by the need to be stored in a fridge – causing endless amounts of wastage and making it difficult to deliver them to remote communities.
'But thanks to this Government's vision and our investment through the National Institute for Health and Care Research, all that could be about to change.
'We are leading the charge by pushing through the world's first trial for fridge-free vaccines.
'This could be a real game changer and lifesaver globally – as it unlocks new ways for poorer nations to deliver vaccines to their patients, where they're often needed the most.
'Groundbreaking science is amongst the things that Britain does best, and this innovation reaffirms our position as a world leader in vaccine development and research, boosting growth and economic security – the cornerstone of our Plan for Change.'
The clinical trial is being led by Professor Saul Faust from the University of Southampton and Stablepharma chief development officer, Dr Karen O'Hanlon.
Prof Faust said: 'It is fantastic to see cutting-edge UK science reach the milestone of a first clinical trial and to be able to give the opportunity for people living on the south coast to take part.
'This research will be an important step toward exploring whether this innovation could eradicate vaccine wastage and move away from the need for the cold-chain.'
The trial is expected to complete this summer, with results published by the end of the year.
Stablepharma hopes the new vaccine will be in use globally by 2027.
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