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Rapamycin may extend lifespan as effectively as dietary restrictions

Rapamycin may extend lifespan as effectively as dietary restrictions

Research is ongoing about potential strategies to prolong life. A meta-analysis found that the drug rapamycin prolongs life in several vertebrate species.Rapamycin appeared to prolong life at a level similar to dietary restrictions. How to prolong life is a key area of scientific research. Experts are interested in medications that have the potential to boost longevity.A recent meta-analysis published in Aging Cell explored how rapamycin and metformin influenced longevity among several animals.The results confirmed that dietary restriction appears to prolong life and that rapamycin offers similar benefits. Researchers also found that metformin did not seem to prolong life. More research is required to see how rapamycin might help boost longevity in people. Rapamycin: Does it increase lifespan?In this paper, researchers note that decreasing food intake without malnourishment appears to prolong life but that this strategy is difficult for people to stick to. Thus, looking into possible medications that produce similar effects is an area of research. The two medications that were the focus of this analysis were rapamycin and metformin. According to the National Cancer Institute, rapamycin has a few functions, such as being an immunosuppressant and antibiotic, and it can help people who get transplants.Metformin helps with type 2 diabetes management. This analysis involved a systematic literature search to find relevant data. The final analysis included data from 167 papers looking at eight total vertebrate species, seeking to see how both medications affected longevity and how they compared to dietary restrictions.Researchers extracted information on average and median lifespan from the papers. For this analysis, the two types of dietary restriction were caloric reduction and fasting, and researchers also sought to see if the results differed based on the sex of the animals involved. The data came from animals like mice, rats, turquoise killifish, and rhesus macaques. Overall, there were more males studied than females. There was also the most data on dietary restriction, and the most common type of dietary restriction was decreasing the number of calories. Regarding dietary restriction, the findings suggested great variation regarding the effects. Overall, researchers found that dietary restriction and rapamycin had a similar impact and appeared to contribute to prolonged life. Metformin appeared to only have a minimal impact on life extension.Aside from one metformin model, there appeared to be no consistent differences between male and female animals regarding longevity. Study author Zahida Sultanova, PhD, a Leverhulme Early Career Research Fellow with the University of East Anglia, in the United Kingdom summarized the key findings of the study to Medical News Today: 'We checked whether the two best-known 'diet-mimic' drugs increase lifespan similar to eating less in animals. By pooling data from 167 studies, we found that rapamycin is almost as reliable as eating less for increasing lifespan, whereas metformin is not. In other words, a compound that was extracted from soil bacteria 50 years ago seems able to copy many of the biological effects of a permanent diet, at least in lab animals.'Do the same benefits apply to people?This research analyzed animal data but did not include data about people. Additionally, most of these studies involved these animals in a laboratory setting and only looked at a small number of species.This meta-analysis was also the work of only three researchers, sometimes with only one researcher doing a component of the work, which could have impacted the results.Researchers had the least amount of data on metformin, so more research about this medication might be helpful. They also operated under the assumption that if a paper did not specify male or female subjects, it was a mixed group, which could have been incorrect. The authors further note that the 'results were sensitive to how lifespan was reported.' Researchers also acknowledge strong publication bias and a lot of heterogeneity. Additionally, the type of measure used in study reporting affected results. In one measurement, the impact on life extension disappeared for rapamycin.For the most part, the authors did not find a consistent difference in results based on the sex of the animals. They explain this could be because of 'differences in taxonomic groups studied […] and the calculated effect size.' Sultanova noted the following cautions regarding the findings: 'This study includes a high number of scientific studies conducted on different organisms such as mice, fish and monkeys. However, survival results in humans are not included because these drugs were not tested in humans for lifespan extension. Even if they are, the studies will take a long time considering the length of human lifespan. So, we do not recommend people to take rapamycin before the results of human trials consistently show that there are no side effects.'Why is it hard to study rapamycin in humans?Researchers suggest the need for research involving other species in natural and laboratory settings. They also note the need to understand the difference in impact for 'different strains of the same species exposed to the same treatment.'Future research can further focus on the differences between rapamycin and metformin and why they impact lifespan differently. More research into the differences in rapamycin's results in males and females could be helpful as well. More research can be done to see if rapamycin can promote prolonged life in people, but there may be some challenges in this area.Mir Ali, MD, a board-certified general surgeon, bariatric surgeon, and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, who was not involved in the study, told MNT that it 'shows the contribution of the immune system to lifespan, as rapamycin is an immunosuppressive medication.'According to him: 'The most logical next step is to explore the findings in humans; however, this would be a difficult study to design as rapamycin is a medication used in specific cancers and organ transplant and has significant side effects.'Despite this, the results show a potential benefit of rapamycin that warrants more research.Sultanova explained that: 'Clinically, that puts rapamycin (and the mTOR pathway it targets) at the front of the queue for future anti-ageing therapies in humans. The compound had already been used for organ-transplant patients, so medical professionals understand its potential side effects.''The next step is waiting for the results of ongoing human trials that test lower and intermittent doses of rapamycin and refining the compound to 'rapalog' versions that keep the benefits while omitting side-effects such as immune suppression,' she told us.'Another important next step would be developing drugs that are similar in structure and function to rapamycin but without the side-effects. Scientists have already started refining rapamycin and producing the so-called rapalogs,' Sultanova noted.
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The seven-minute home workout that doesn't require any fancy kit
The seven-minute home workout that doesn't require any fancy kit

Telegraph

time19 minutes ago

  • Telegraph

The seven-minute home workout that doesn't require any fancy kit

Can you get fit in seven minutes a day? As a mother of two with a busy job and an ingrained aversion to working out, I would love to believe it. I coasted through my twenties and thirties avoiding exercise. Now 44, I'm increasingly aware of the impact of my sedentary lifestyle on bone density and muscle mass – and how important those things are going to become as I get older. Could this seven-minute workout, with no specialist equipment required, only a chair and a wall (or in my case, chair and a tree), be my saviour? I came across the impressive-sounding 'exercise physiologist' Chris Jordan on my trawl for a workout that wouldn't completely floor me. Unlike other workouts which promise results, but never seem that convincing (and look terrifying), I was drawn to this one, as it seemed to have some decent science behind. Studies have shown noticeable cardiovascular and strength benefits which can be achieved with just seven minutes, assuming you're pushing yourself hard in that time. Plus the only bit of kit you need was a pair of trainers. Jordan devised the seven-minute workout over 10 years ago, at the Human Performance Institute in Orlando with the results published in the American College of Sports Medicine's Health & Fitness Journal. It soon become a phenomenon across the world introducing millions, who lacked time, but sought a fitness boost, to the benefits of brief bursts of exercise – and routines have been modelled on it ever since. The enticing subhead alone drew me in: 'Maximum Results With Minimal Investment'. Comprising 12 exercises, the idea is to do 30 seconds of each, with five seconds to move between exercises, totalling seven minutes. I turn to a local expert to put me through my paces. 'The exercises are familiar but the problem is they're often done incorrectly,' says Laura Wilson, specialist musculoskeletal physiotherapist and director of The Swiss Touch clinic. 'The key is to slow down, and pay close attention to your alignment. If you do this religiously you'll notice improvement in muscle strength, bone density, posture and balance.' Personal trainer Louisa Drake agrees, but adds that the order of the exercises is also important, as it allows each muscle group to rest while another is worked. 'It's a great example of using your own bodyweight to do a full-body workout, promising effective fitness 'in your pyjamas'' she says. But, of course, when it comes to the reality of actually focussing on these exercises as intensely as the experts suggest, it's not that simple. I quickly discover when I try the routine out (in my pyjamas); exercises like jumping jacks and running on the spot don't work for me without a proper sports bra. Not only that, but reading the small print of the study suggests that optimum results are achieved by doing three rounds of the workout, totalling 21 minutes – admittedly still not a huge time commitment, but quite different to the seven-minute headline. The trouble is, she explains, people often give up when a seemingly-easy routine doesn't work for them. 'Someone with dodgy knees shouldn't feel defeated because they can't do jumping jacks,' she says. 'And someone managing hormonal fluctuations needs modifications, not a rigid prescription.' Drake argues that the pros (accessibility, convenience, very little time needed) outweigh any cons. 'If it all starts with seven minutes in your living room, then brilliant.' Plus all the exercises can be adapted to suit different needs and dodgy knees. For me, getting out for a run, or to a class, often feels impossible to fit in, whereas seven minutes in my living room – or garden – is always doable. First thing in the morning is an excellent start to the day; certainly better than seven minutes spent doom-scrolling with my cup of tea. Here are the 12 exercises, with expert support on how to get the most out of them – plus variations to make them easier. 1. Jumping Jacks 'An excellent cardiovascular exercise, engaging multiple muscle groups while rapidly elevating heart rate,' says Drake. 'The high-impact nature of it can stress joints, and is particularly problematic for women with pelvic floor issues. In these cases, a step-touch version (step one foot out, bring it back, repeat on other side) provides similar cardiovascular benefits with significantly less impact and bouncing.' 2. Wall Sit Wilson says this deceptively simple exercise is good for building strength in your thighs and glutes, while challenging your postural control. 'Have your knees at roughly 90 degrees, keeping your back straight and your weight in your heels,' she says. 'Once you've got the hang of it, you can add a small ball between your knees to activate your inner quadricep muscles; a great exercise for knee pain.' 3. Push-ups 'It's a brilliant compound exercise simultaneously targeting chest, shoulders, triceps and core, but it can be problematic for anyone with wrist issues, lymphoedema concerns or limited upper body strength,' says Drake. 'A good starting point is wall push-ups (hands against wall, lean in and push back), moving onto incline push-ups using a chair or bench. If wrist-loading is tolerable, try modified knee push-ups.' 4. Abdominal Crunches 'I see this performed incorrectly all the time,' says Drake. 'It's also problematic for many women, particularly post-pregnancy, as they can worsen diastasis recti (abdominal separation).' If you don't have these issues, then Wilson says the key is to move from the rib cage, rather than pulling on your neck. 'Keep your chin slightly tucked, and imagine peeling each vertebra off the floor one at a time.' If you're struggling, come up only very slightly, or support your head. Drake prefers dead bugs, where you lie on your back with arms and legs raised, then slowly lower opposite arm and leg. 5. Step-ups 'These mimic real-life movements like climbing stairs, so are excellent for building functional strength and stability,' says Wilson. 'Step up with control, pressing through the front heel and keeping your hips level. Avoid using momentum or pushing off the back leg. You can make them easier by lowering the step height, or harder by holding dumbbells and slowing down the movement.' 6. Squats A classic for a reason, squats are a fabulous functional exercise. 'They strengthen the hips, thighs and core,' says Wilson. 'Start by thinking of sitting back into a chair; keep your chest lifted, knees tracking over the toes, and spine neutral. Avoid collapsing your chest or letting your knees drop inward.' If you're a beginner, use a chair behind you, and just touch it lightly with your bum before standing up again. More advanced? Make it harder by holding a weight, or adding a band around your knees. 7. Triceps Dips 'These are great for targeting the backs of the arms,' says Wilson, which is music to my bingo wings. 'But they can be tough on the shoulders if not done carefully. Keep your chest open, shoulder blades back and down, and elbows pointing straight behind you, not out to the sides. Move within a comfortable range and avoid sinking too low.' You can make them easier by bending your knees and keeping your feet close; or make them harder by straightening your legs or slowing the tempo. 8. Plank Another one that looks easy, but needs attention to detail to be effective. 'Planks strengthen the shoulders, glutes, postural muscles and core,' says Wilson. 'The goal is to hold a long line from head to heels without dropping your hips or arching your lower back. Keep your belly gently drawn in, glutes engaged, and shoulders strong.' 9. High Knees This one is easily adaptable; you can run on the spot, or march, to reduce the impact on your joints. 'Whether you're running or marching, this combines cardio with core activation in one powerful movement,' says Wilson. 'Stay tall and avoid leaning back or collapsing through your middle. Drive the knees up with energy and use your arms to help create rhythm. To increase intensity, focus on speed and lift while keeping movement crisp and light.' 10. Lunges 'This unilateral exercise builds leg strength while challenging balance and coordination,' says Drake. 'At first, you could hold onto a wall or chair for balance support, and start with stationary lunges before progressing to walking lunges.' 11. Push-up & Rotation 'It builds upper body strength while also training the core and improving spinal mobility,' says Wilson. 'The key is to rotate from the upper back, not the lower spine, and keep the hips steady. You can modify it by performing the push-up from your knees, or reducing the rotation if balance is tricky.' 12. Side Plank 'This one targets the often-neglected lateral core muscles, which are crucial for spine stability,' says Drake. 'If you need a modification, try lying on your side with knees bent – it's much easier. And side-lying leg lifts target similar muscles, if the plank position just isn't happening for you.' My verdict As a way of getting back into exercise, if you haven't done it regularly for ages, this is a brilliant way to start. Even by doing just seven minutes I noticed they were easier to do by the end of the week. Some of my favourite moves include the jumping jacks (especially the step-touch version, a saviour for the pelvic floor) which are fun and easy to do on a sunny day, as are the wall sits, with my garden tree standing in perfectly for the wall. I was dreading the push-ups, having always struggled with upper body strength. I also had a mastectomy with axillary lymph node clearance in 2021 and, since then, have been warned against putting my weight on my wrists, because of lymphoedema (swelling). But luckily, there are lots of modifications like the knee version, which I found a lot easier. I thought a push-up with rotation was the most difficult exercise on this list, but then I realised this one is just a pimped-up push-up. While intimidating at first, it's a highly effective movement. I might swap out the ab crunches for the 'dead bug' movement, as recommended by my trainer. All in all, I can fit these exercises into a quick routine that slots easily into my life – and with no loud, blaring gyms or heavy weights required. I am a convert, sign me up.

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