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Pill-testing scrapped as deadly opioid emerges

Pill-testing scrapped as deadly opioid emerges

Yahoo21-03-2025
A state government has been slammed for abandoning permanent pill-testing clinics after extremely potent synthetic opioids were found in Australian wastewater for the first time.
Queensland has decided not to renew contracts for fixed pill testing sites at Brisbane's Bowen Hills and Burleigh Heads on the Gold Coast, with doors set to close on April 4.
Australian Medical Association Queensland president Dr Nick Yim said he was disappointed the state government had discontinued the service, and feared it would lead to higher rates of harm.
"It is disappointing the Crisafulli government, who was elected on a promise that they would listen to the experts, has once again dismissed the evidence supported by doctors," he said in a statement to AAP.
Dr Yim was concerned the sites were closing after a deadly synthetic opioid 40 times more powerful than fentanyl was detected for the first time in wastewater testing across Australia over the New Year period.
Two highly potent and addictive variants of nitazene - a psychoactive synthetic substance - were detected at five separate sites in Australia and the United States.
Protonitazene is one of the variants and is three times stronger than fentanyl, a drug that has driven an overdose crisis in the US.
The other is etonitazepyne which is 40 times more powerful than fentanyl.
Nitazene has led to fatal overdoses globally often due to being mixed with other illegal drugs like MDMA or ketamine. Considering the Australian wastewater findings, Dr Yim said now was the best time for Queensland to have permanent pill-testing clinics.
"Without regulated testing, already vulnerable community members remain exposed to these hidden dangers," he said.
He said health authorities could lose visibility of what dangerous substances, like synthetic opioids, are circulating.
The Queensland Mental Health Commission has been tasked with developing an overdose monitoring system but without an early warning system like pill-testing, Dr Yim said it would do little to protect people.
Health Minister Tim Nicholls stood by the decision to rip up the clinic contracts, citing the Liberal National Party's stance against drugs.
"We have made it abundantly clear that there is no good way to acquire drugs in the shadows, under the counter and we don't believe that pill testing is going to resolve those issues," he told reporters on Friday.
Meanwhile, the state government made a pharmacist prescription program permanent after a six-month trial.
Mr Nicholls said he received reports of 92 per cent satisfaction with the program that allows pharmacists to prescribe a range of common medications for contraception, nausea, acne and allergies.
Pharmacy prescription models have been rolled out in NSW and Victoria.
The decision was welcomed by the Pharmacy Guild of Australia which said it turned pharmacies into urgent care clinics to provide access across the state.
But Dr Yim said the trial had not been evaluated and he was concerned the government would ignore advice if the review came back negative.
"This is what they have done by refusing to follow the evidence about our world-leading drug diversion, pill testing and alcohol harm reduction programs," he said.
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Doctor Raises Concerns Over Medical Cannabis Use With Cancer Treatment
Doctor Raises Concerns Over Medical Cannabis Use With Cancer Treatment

Newsweek

time3 days ago

  • Newsweek

Doctor Raises Concerns Over Medical Cannabis Use With Cancer Treatment

Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. Despite its growing popularity among cancer patients for managing symptoms like nausea, pain and reduced appetite, a new study has warned that the use of medicinal cannabis could make immunotherapy less effective. This is the warning of Australian medical cannabis advocate Dr. Ben Jansen, whose newly-published review paper poses the question: "Are cannabinoids with cancer immunotherapy contributing to early death?" "As both a physician involved in the medicinal cannabis industry and an advocate for patient care, I find the discussion and patient informed consent around this interaction critical," Jansen wrote in his study. "Three key studies on this topic offer preliminary data suggesting a potential reduction in immunotherapy efficacy from cannabis use," he continued. "Though the results remain limited and controversial, warranting caution and additional research." Medical marijuana over official looking subscription document. Medical marijuana over official looking subscription document. thegoodphoto/Getty Images The first study looked into patients receiving the immunotherapy drug nivolumab for advanced cancers, including lung cancer, renal cell carcinoma and melanoma. It compared those on nivolumab alone (89 patients) and those on both nivolumab and cannabis (51 patients). The findings, Jansen noted, showed a significantly lower treatment response rate in patients using cannabis than in those on just nivolumab (15.9 vs. 37.5 percent.) The analysis excluded patients with advanced disease with survival of less than two months. "This suggests that patients using cannabis were approximately three times more likely to have a poor response to immunotherapy. Notably, cannabis use did not significantly impact progression-free survival or overall survival," Jansen wrote. Building on this, the second study compared 34 patients prescribed both immunotherapy and cannabis with 68 patients receiving the cancer treatment alone. That study found that tumors tended to take less than three-and-a-half months to grow or spread in the patients taking cannabis, as compared to more than a year for patients on immunotherapy alone. It also found the median overall survival time for cannabis users was 6.4 months compared to 28.5 months for non-users. A colourful illustration representing immune cells and white blood cells. A colourful illustration representing immune cells and white blood cells. quantic69/Getty Images It should be noted that both studies had inherent limitations—including small sample sizes and a focus on inhaled cannabis, rather than the orally-administered versions Jansen notes is favored in his experience with patients. Jansen added: "Factors such as smoking and other lifestyle elements, which heavily influence cancer risk and treatment outcomes, should be carefully considered when assessing cannabis' role in immunotherapy efficacy and cancer progression, and when interpreting the studies." The third study looked at 105 patients with tumors developing in solid organs—e.g. the breast, lung or prostate—receiving immune checkpoint inhibitors, and cannabis use primarily in the form of prescribed dronabinol. (Immune checkpoint inhibitors are a form of immunotherapy treatment that works by blocking proteins that prevent the immune system from attacking cancer cells.) 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Dropper with medical cannabis CBD hemp oil for oral use. 24K-Production/Getty Images "One of the challenges in interpreting these studies is the inherent complexity of cannabis as a therapeutic agent," wrote Jansen. Past research, Jansen notes, has found that cannabis can suppress the immune system through its active compounds: CBD, THC and other minor cannabinoids. At the same time, however, studies undertaken both in vitro and in living organisms have suggested that cannabinoids can both kill cancer cells and stop from spreading. "These findings hold particular relevance for patients considering, or currently using, medical cannabis during immunotherapy," the doctor said. "As medical practitioners, we must weigh the benefits of cannabis in managing cancer-related symptoms (such as pain, nausea and anorexia) against its potential to compromise treatment efficacy." "While cancer has a promising role in supportive cancer care, these early findings support careful consideration when patients are concurrently undergoing immunotherapy." Jansen emphasized how important it is that clinicians ensure patients are well informed of potential interactions, particularly until we have a clearer understanding of the situation, and has called for more thorough research and trials. "Future studies should aim to control for variables such as cancer type, cannabis dosage, socio-economic status and patient lifestyle factors, particularly tobacco use, which may confound results," he concluded. Do you have a tip on a health story that Newsweek should be covering? Do you have a question about cancer? Let us know via health@ References Bar-Sela, G., Cohen, I., Campisi-Pinto, S., Lewitus, G. M., Oz-Ari, L., Jehassi, A., Peer, A., Turgeman, I., Vernicova, O., Berman, P., Wollner, M., Moskovitz, M., & Meiri, D. (2020). Cannabis Consumption Used by Cancer Patients during Immunotherapy Correlates with Poor Clinical Outcome. Cancers, 12(9), Article 9. Hadid, T., Biedny, A., Mamdani, H., Azmi, A., Kim, S., Jang, H., Uprety, D., Al Hallak, M. N., & Sukari, A. (2024). Association between cannabis use and clinical outcomes in patients with solid malignancies receiving immune checkpoint inhibitors. Therapeutic Advances in Vaccines and Immunotherapy, 12, 25151355241309095. Jansen, B. (2025). Are cannabinoids with cancer immunotherapy contributing to early death? A call for caution and further study. New Zealand Medical Journal, 138(1619). Taha, T., Meiri, D., Talhamy, S., Wollner, M., Peer, A., & Bar‐Sela, G. (2019). Cannabis Impacts Tumor Response Rate to Nivolumab in Patients with Advanced Malignancies. The Oncologist, 24(4), 549–554.

Drug User Advocacy Groups Challenge ‘Recriminalization' in Court
Drug User Advocacy Groups Challenge ‘Recriminalization' in Court

Hamilton Spectator

time3 days ago

  • Hamilton Spectator

Drug User Advocacy Groups Challenge ‘Recriminalization' in Court

The federal government was in court this week listening to arguments that it made a mistake when it allowed British Columbia to roll back its decriminalization pilot project. Counsel for a coalition of 13 drug user advocacy groups argued in an application for a judicial review that Health Canada didn't properly consider all the evidence before it when it broadly recriminalized public drug use in 2024. Canadian drug laws are set out in the federal Controlled Drugs and Substances Act. To provincially change drug laws for decriminalization, B.C. had to ask Health Canada for an exemption under the act. It later asked Health Canada to amend that exemption to recriminalize public drug use. The process will see a federal judge examine the evidence that was available to the federal government at the time, and rule on whether or not the government's decision to allow the decriminalization rollback was fair. Justice Meaghan M. Conroy heard the coalition's arguments Monday and Health Canada's defence Tuesday. She is expected to make a decision in the coming months. She could agree the decision was unfair and ask Health Canada to go over the evidence again, say the decision was fair and no further action is needed, or something in between. While B.C.'s government has made a lot of changes since decriminalization was introduced in January 2023, the judicial review is looking at only the most recent change, which essentially made it illegal again to have or use drugs in all public spaces across B.C. Decriminalization was a three-year pilot project introduced by the BC NDP to help people access harm reduction services and reduce the number of fatal overdoses. It let anyone 18 and older carry and use up to 2.5 grams of opioids, methamphetamines, powdered cocaine or MDMA in most places across B.C. without risking arrest. There were some exemptions — drugs were not allowed on school grounds or licensed child-care facilities, for example. In September 2023 the province added to that list, making playgrounds, splash pads, wading pools and skate parks drug-free zones. One month later it attempted to amend decriminalization further with Bill 34, which would have given police additional powers to control people who use drugs, or people who were suspected of using drugs, and introduced a confusing patchwork of places where people weren't allowed to use drugs. But Bill 34 was blocked by a temporary injunction before it could come into force, after a judge said the bill could cause 'irreparable harms' to people who use drugs. After Bill 34 was blocked, the province asked Health Canada to make possession and public drug use illegal again in April 2024. Drugs were still allowed in homes or shelters. This has been dubbed 'recriminalization' by drug user advocacy groups. The request was approved by Health Canada. This decision is the subject of the judicial review. B.C.'s Ministry of Health told The Tyee that decriminalization is just one part of a multi-pronged approach it is taking to address toxic drug deaths. Drug deaths have been climbing since early 2014 when the synthetic opioid fentanyl started being added to illicit, unregulated drugs in the province. Unregulated drugs have killed more than 17,800 British Columbians since then. Representing the coalition were lawyers Lindsay Frame and Jack Ruttle, who argued recriminalization contravened the general goal of Canada's drug policies, which is to keep people healthy and safe. Prohibiting public drug use, Frame argued, will push people to use drugs while isolated or alone, which increases their risk of fatal overdose because someone might not be around to call 911, administer naloxone or provide first aid. The current unregulated drug supply is often referred to as 'toxic' because of the unpredictability and potency of the supply, which can mean a regular dose can include unexpected drugs, such as benzodiazepines, and be hundreds or thousands times more potent than expected. Representing the federal government was lawyer Adrienne Copithorne, who delivered a technical argument, focusing on how most of the coalition's complaints went against the broad drug prohibitions laid out in the Controlled Drugs and Substances Act, rather than Health Canada's decision to roll back decriminalization. Decriminalization didn't set a permanent standard that potential future harms can be compared against, she added. It was meant to be only a temporary measure that the health minister could adjust as needed. The federal government was asking to throw the case out due to these technicalities. How prohibition harms the most marginalized The court heard from the coalition that one reason B.C. asked Health Canada to recriminalize drugs was that police weren't able to maintain public order, and the 'vibrancy' of public spaces was being impacted by people who use drugs. But even with decriminalization, police still had laws against public intoxication, littering and trespassing, Frame said. Copithorne disagreed, pointing out how police tried to use the tools they had and later asked for more power when those tools weren't working. Frame said the public and political pushback against decriminalization often conflated poverty and the rise of homelessness with decriminalization. There is no evidence that decriminalization increased drug use, she said. But there was an increase in homelessness that made more people visible while they used drugs, she said. Copithorne said the core problem was still that people were using drugs in public and causing a disturbance. Frame also told the court that recriminalization disproportionately impacts marginalized communities, effectively treating them as second-class citizens. For example, remote Indigenous communities are less likely to have access to harm reduction sites where they can use while supervised by someone who can step in if there's an emergency, such as an overdose prevention site or supervised consumption site, she said. Indigenous people are disproportionately harmed by unregulated drugs, and recriminalizing drugs will reintroduce a lot of those harms, Frame said. At the time of Health Canada's decision to recriminalize drugs, the crisis was killing seven people in B.C. per day. Indigenous people were dying at six times the rate non-Indigenous people were, and First Nations women were dying at 12 times the rate of non-Indigenous women in the province, she said. 'Racism, colonialism and intergenerational trauma all contribute to these drug deaths,' Frame said. Copithorne said the change doesn't specifically target any particular groups and is applied to all people in B.C. equally. Frame argued that there is a 'profound unmet need for places to safely use' across the province, which means unhoused people have nowhere else to use but in public spaces. But using in public spaces increases a person's risk of interacting with a police officer, which can lead to arrest or drugs being confiscated. Both things increase a person's risk of a fatal overdose, Frame said. When someone's drugs are confiscated, Frame said, they might have to turn to an unfamiliar supply, risk going into life-threatening withdrawal or lose drug tolerance, which puts them at a higher risk of overdose the next time they use. An arrest can impact a person's housing, job or access to their children. 'Criminalization feeds into cycles of harm,' Frame said. Kali Rufus-Sedgemore said they feel 'hopeful' that Conroy 'will see the government did something wrong.' Rufus-Sedgemore is the executive director of the Coalition of Peers Dismantling the Drug War. They spoke to The Tyee on behalf of the coalition of 13 organizations that applied for the judicial review. Rufus-Sedgemore said politicians have been feeding into a 'mass hysteria' about people who use drugs, which ignores people's humanity and overlooks the reasons why they might take drugs. Rufus-Sedgemore, who has ADHD, takes methamphetamine, for example. They say drug use calms their brain down and lets them work effectively in their community. They sometimes use a prescription to treat their ADHD but say the medications are expensive, can make them sick and are not strong enough to properly medicate them. But police and health-care workers don't see that and treat Rufus-Sedgemore, who is from the 'Namgis First Nation/Kwakwaka'wakw, like they might become violent at any moment. This is something Indigenous people and stimulant users often have to deal with, Rufus-Sedgemore told The Tyee. 'I've never been violent,' they say softly. 'But if I go to St. Paul's [Hospital] I have to take a sobriety and drug test, with a security guard posted outside of my room. I don't drink and I have to wait for hours before someone even asks me what's wrong.' To actually end the ongoing toxic drug crisis, Rufus-Sedgemore said, the government needs to bring back decriminalization, introduce a regulated safer supply that is more accessible and actually separates people from the unregulated supply, and create comprehensive drug education for kids. They've worked with youth before and remember being asked if you can un-burn microwave popcorn by microwaving it again, or, if drugs are making you feel weird, taking more drugs will make you feel better. Kids are still figuring this world out and won't know something if we don't teach them, they said. Error! Sorry, there was an error processing your request. There was a problem with the recaptcha. Please try again. You may unsubscribe at any time. By signing up, you agree to our terms of use and privacy policy . This site is protected by reCAPTCHA and the Google privacy policy and terms of service apply. Want more of the latest from us? Sign up for more at our newsletter page .

Mauna Kea Technologies Enters Australian Market with Endotherapeutics Partnership
Mauna Kea Technologies Enters Australian Market with Endotherapeutics Partnership

Business Wire

time3 days ago

  • Business Wire

Mauna Kea Technologies Enters Australian Market with Endotherapeutics Partnership

PARIS & BOSTON--(BUSINESS WIRE)--Regulatory News: Mauna Kea Technologies (Euronext Growth: ALMKT), inventor of Cellvizio®, the multidisciplinary probe and needle-based confocal laser endomicroscopy (p/nCLE) platform, today announces its entry into the Australian market by signing a new exclusive distribution agreement with Endotherapeutics Pty Ltd, a leading Australia-based distributor of cutting-edge medical devices, to bring the Cellvizio platform to Australian physicians. This strategic expansion comes as Mauna Kea experiences growing momentum for its CellTolerance application, prompting the company to open new geographic markets with strong growth potential. The three-year agreement grants Endotherapeutics the exclusive rights to distribute and promote the Cellvizio platform in Australia. As part of the market entry, a submission for Therapeutic Goods Administration (TGA) approval for the latest generation of Cellvizio products is underway. Mauna Kea Technologies has already been granted TGA clearance in the past and does not anticipate any hurdles in obtaining it again. The partnership will leverage the upcoming launch of the CellTolerance program with Professor Gerald Holtmann, MD, PhD, MBA, a leading Australian physician at Princess Alexandra Hospital in Brisbane, who is planning to acquire one Cellvizio for food intolerance applications. 'This technology brings hope of change for millions of patients suffering from food-related IBS symptoms,' commented Professor Holtmann. 'Cellvizio is truly unique in its ability to help identify the root causes of patient symptoms, enabling the creation of tailored diets. My entire team is excited to explore its full potential and improve the lives of our patients.' 'We're very pleased to partner with Mauna Kea Technologies to introduce Cellvizio to the vibrant Australian GI market,' stated Rob Curtin, Business Manager for GI at Endotherapeutics. 'The potential for Cellvizio and its key indications, particularly pancreatic cyst characterization and food intolerance detection is very significant.' Sacha Loiseau, Chairman and CEO of Mauna Kea Technologies, added: "We are thrilled to partner with Endotherapeutics, a premier distributor of cutting-edge medical devices and a trusted partner with deep roots in the Australian healthcare system. This partnership marks a key milestone in our international expansion strategy. As we see good momentum in the adoption of our platform, particularly for CellTolerance, we are taking key initiatives to expand our market reach in territories with strong growth potential.' *** About Endotherapeutics Pty Ltd Endotherapeutics is a leading Healthcare Technologies distributor serving customers across Australia and New Zealand, headquartered in Sydney, Australia. Endotherapeutics' mission is to improve healthcare and achieves this by supplying innovative healthcare solutions with the highest levels of service and support. To find out more, visit About Mauna Kea Technologies Mauna Kea Technologies is a global medical device company that manufactures and sells Cellvizio®, the real-time in vivo cellular imaging platform. This technology uniquely delivers in vivo cellular visualization which enables physicians to monitor the progression of disease over time, assess point-in-time reactions as they happen in real time, classify indeterminate areas of concern, and guide surgical interventions. The Cellvizio® platform is used globally across a wide range of medical specialties and is making a transformative change in the way physicians diagnose and treat patients. For more information, visit Disclaimer This press release contains forward-looking statements about Mauna Kea Technologies and its business. All statements other than statements of historical fact included in this press release, including, but not limited to, statements regarding Mauna Kea Technologies' financial condition, business, strategies, plans and objectives for future operations are forward-looking statements. Mauna Kea Technologies believes that these forward-looking statements are based on reasonable assumptions. However, no assurance can be given that the expectations expressed in these forward-looking statements will be achieved. These forward-looking statements are subject to numerous risks and uncertainties, including those described in Chapter 2 of Mauna Kea Technologies' 2024 Annual Report filed with the Autorité des marchés financiers (AMF) on April 30, 2025, which is available on the Company's website ( as well as the risks associated with changes in economic conditions, financial markets and the markets in which Mauna Kea Technologies operates. The forward-looking statements contained in this press release are also subject to risks that are unknown to Mauna Kea Technologies or that Mauna Kea Technologies does not currently consider material. The occurrence of some or all of these risks could cause the actual results, financial condition, performance or achievements of Mauna Kea Technologies to differ materially from those expressed in the forward-looking statements. This press release and the information contained herein do not constitute an offer to sell or subscribe for, or the solicitation of an order to buy or subscribe for, shares of Mauna Kea Technologies in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. The distribution of this press release may be restricted in certain jurisdictions by local law. Persons into whose possession this document comes are required to comply with all local regulations applicable to this document.

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