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FibroBiologics Files Patent for Methods of Generating Multipotent Cells from Donor Tissue for Clinical Applications
HOUSTON, July 28, 2025 (GLOBE NEWSWIRE) -- FibroBiologics, Inc. (Nasdaq: FBLG) ('FibroBiologics'), a clinical-stage biotechnology company with 275+ patents issued and pending with a focus on the development of therapeutics and potential cures for chronic diseases using fibroblasts and fibroblast-derived materials, announced the filing of a patent application with the United States Patent and Trademark Office covering methods of generating multipotent cells from fibroblasts found in donor tissue for clinical applications. Multipotency refers to a flexible cellular state in which a cell has the potential to differentiate into multiple specialized cell types, depending on the environmental conditions or stimuli it encounters. While stem cells have garnered the most attention on being multipotent, fibroblasts are also considered multipotent and can be directly differentiated into many cell types including chondrocytes, osteocytes, hepatocytes and cardiomyocytes. This patent application broadly relates to methods for generating multipotent cells directly from fibroblasts found in human donor tissues. 'This method provides us with the ability to obtain larger quantities of stable and easily scalable multipotent cells from donor-derived fibroblasts for use in clinical applications,' said Hamid Khoja, Ph.D., Chief Scientific Officer of FibroBiologics. 'Multipotent fibroblasts also show enhanced ability to form 3D spheroid structures, further expanding their potential across a range of therapeutic and drug development areas.' Pete O'Heeron, Founder and Chief Executive Officer of FibroBiologics, said, 'By enabling the generation of stable, multipotent cells directly from donor tissue, this innovation addresses long-standing challenges in the field and opens new possibilities for scalable, regenerative treatments.' For more information, please visit FibroBiologics' website or email FibroBiologics at info@ Cautionary Statement Regarding Forward-Looking Statements This communication contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995. Forward-looking statements include information concerning the potential of multipotent fibroblasts across a range of therapeutic and drug development areas and new possibilities for scalable, regenerative treatments. These forward-looking statements are based on FibroBiologics' management's current expectations, estimates, projections and beliefs, as well as a number of assumptions concerning future events. These forward-looking statements are not guarantees of future performance, conditions or results, and involve a number of known and unknown risks, uncertainties, assumptions and other important factors, many of which are outside FibroBiologics' management's control, that could cause actual results to differ materially from the results discussed in the forward-looking statements, including those set forth under the caption "Risk Factors" and elsewhere in FibroBiologics' annual, quarterly and current reports (i.e., Form 10-K, Form 10-Q and Form 8-K) as filed or furnished with the SEC and any subsequent public filings. Copies are available on the SEC's website, These risks, uncertainties, assumptions and other important factors include, but are not limited to: (a) risks related to FibroBiologics' liquidity and its ability to maintain capital resources sufficient to conduct its business; (b) expectations regarding the initiation, progress and expected results of our R&D efforts and preclinical studies; (c) the unpredictable relationship between R&D and preclinical results and clinical study results; and (d) the ability of FibroBiologics to successfully prosecute its patent applications. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and FibroBiologics assumes no obligation and, except as required by law, does not intend to update, or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. FibroBiologics gives no assurance that it will achieve its expectations. About FibroBiologics Based in Houston, FibroBiologics is a clinical-stage biotechnology company developing a pipeline of treatments and seeking potential cures for chronic diseases using fibroblast cells and fibroblast-derived materials. FibroBiologics holds 275+ US and internationally issued patents/patents pending across various clinical pathways, including wound healing, multiple sclerosis, disc degeneration, psoriasis, orthopedics, human longevity, and cancer. FibroBiologics represents the next generation of medical advancement in cell therapy and tissue regeneration. For more information, visit General Inquiries:info@ Investor Relations:Nic JohnsonRusso Partners(212) 845-4242fibrobiologicsIR@ Media Contact:Liz PhillipsRusso Partners(347) in to access your portfolio
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"'Oh, This Is Whole Foods?'": People Share Their Experiences With Very, Very Wealthy Friends, And I'm Genuinely Shocked At How Out Of Touch They Are
Unfortunately, wealth disparity exists in this world. Cough — the Bezos-Sánchez $50 million wedding comes to mind. In r/ask, when someone asked, "Something your rich friends have said that made your jaw drop?", people weighed in on how this exists all around us. And wow, what a peek into a gilded reality. Here's what people had to say: 1."A group of us went to McDonald's, and after he got his cheeseburger, he went back to the counter to ask them to center his cheese." —bunk3rk1ng 2."'I don't get it. What would he need two jobs for?'" —superkow 3."I accidentally found out that what I made in a year, working full time, he made in a month. Yeah, I knew he was wealthy, but that put it into perspective." —Interesting_Day2277 4."I had the 17-year-old daughter of a rich acquaintance visit our city with a few of her friends for spring break. I was helping her check into their hotel (the most expensive one in the city) when she decided she didn't like the suite and wondered if an upgrade was available. Indeed, there was —the penthouse, but it would cost an additional $8k or more. Without batting an eye, she whips out HER CREDIT CARD and says, 'Use this one.' A 17-year-old with a five-digit credit card limit, who didn't need her parents' permission to use it, just blew my mind." —Middle-Luck-997 5."I was a council house kid. I went to school with lots of better-off kids and some rich ones. Some were OK, but some didn't seem to understand, or care, for that matter. What gets me is the calm acceptance. You want a new bicycle? Here, have one. Clothes? Sure, have what you like. A Bang & Olufsen stereo for your room? Here it is, son. Motorbikes, cars, even houses. No problem. Must be nice to have 'stuff,' although some of the parents weren't that interested in their kids from what I could see. A couple of the blokes I've known later in life who came from monied families, reckoned they were basically treated as an inconvenience, and packed off to boarding school as soon as possible." WB / Via —Amplidyne 6."Not friends, but some estranged family I've recently connected with dropped this line: 'We're middle class.' Yet, they own three houses, multiple business ventures, and she does triathlons all over the world. They just extended their vacation in, I think, Guam, because she wanted to adopt two dogs off the street, but couldn't bring them home during their current vacation time due to the pups' health concerns. Completely out of touch. Also, they asked me, 'Why do you guys rent in San Diego when you could just buy a house instead and build up the equity?' Like that's a possibility." —nobeer4you 7."'We'll keep it small, just a few friends over.' It turned out to be a 50-person party with wedding-worthy flowers, an eight-person catering staff, and two live entertainment acts. 12 people I didn't know brought presents for my son." —NightSisterSally 8."'I traveled economy once. Ugh, it was so narrow.'" —shiroandae 9."'How did your parents invest the money they saved for you?' Bro. My parents didn't save money for me. They fed me, clothed me, supported me, and paid for some extracurriculars. I'm grateful. Not all parents have the ability to save as well." —Foreign-Yak-3223 10."One didn't notice an entire family gym membership leaking out of their bank account for a year. They thought they'd canceled it. It was £300 a month." —South-Bank-stroll 11."'We need poor people for society to function.'" —Poulop 12."Their parent's salary equates to my lifetime income." —Intelligent_Way_9450 13."His parents bought him a house near the university because they didn't see the point in paying for a year of rent." —Financial_Change_183 14."A friend from uni gave me a ride in a $50k Mercedes. I said it was a cool car, and he said, 'You should have seen the other one,' but he crashed it. It was a $100k car. Mind you, we were 18 and 19 at the time." —SignalElderberry600 15."A best friend growing up got a full ride to go to college, even though he was filthy rich. Our friend group was talking about student loans, and he chimed in, saying he took out $20k in loans and spent it on shoes and liquor because that's what college is about. We stopped talking." —Cocoononthemoon 16."A woman I worked for recommended a $35 mouthwash to me. It was 1.5 ounces." —chudock74 17."I heard a rich guy say that people don't use the word groceries anymore." —Hister333 "What does he mean?" —PassengerNo2022 18."I went to Whole Foods with my friend, and he said, 'Oh, this is Whole Foods? So, this is where [House Manager Name] goes to get our food!'" —Dull_Wrongdoer_3017 19."On what to do for my 18th birthday, she suggested flying my friends out to another country and renting a private yacht. That would've cost $2,500 for just the tickets and the yacht, plus more, for other expenses like cabs, food, and whatnot." —SoggyDoughnut69 20."'I think my trust fund is around $9 million.' Later that day, he found out it was $23 million. This is a person in their late 30s." —sixjasefive 21."They want to go golfing in the middle of the day, on a weekday." —3rody 22."'I'm not materialistic.'" HBO / Via HBO / Via —Tak-Tik-2 finally, "'I keep spending money and more just shows up in the account.' I almost cried." —ohyesiam1234 I'm crying in pennies. Any wealthy friend stories to share? Let us know in the comments! Note: Responses have been edited for length/clarity. Solve the daily Crossword
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Darren Walker's new book is still hopeful despite growing inequality as he leaves Ford Foundation
NEW YORK (AP) — Darren Walker needed to be convinced of his new book's relevance. The outgoing Ford Foundation president feared that 'The Idea of America," set to publish in September just before he leaves the nonprofit, risked feeling disjointed. In more than eight dozen selected texts dating back to 2013, he reflects on everything from his path as a Black, gay child from rural Texas into the halls of premiere American philanthropies to his solutions for reversing the deepening inequality of our 'new Gilded Age." 'To be clear, not everything I said and wrote over the last 12 years is worthy of publication," Walker said. A point of great regret, he said, is that he finds American democracy weaker now than when he started. Younger generations lack access to the same 'mobility escalator' that he rode from poverty. And he described President Donald Trump's administration's first six months as 'disorienting' for a sector he successfully pushed to adopt more ambitious and just funding practices. Despite that bleak picture, Walker embraces the characterization of his upcoming collection as patriotic. 'My own journey in America leaves me no option but to be hopeful because I have lived in a country that believed in me,' he said. Walker recently discussed his tenure and the book's call for shared values with the Associated Press inside his Ford Foundation office — where an enlarged picture of a Black child taken by Malian portrait photographer Seydou Keïta still hangs, one of many underrepresented artists' works that populated the headquarters under his leadership. This interview has been edited and condensed for clarity. Q: Upon becoming Ford Foundation's president, you suggested that 'our most important job is to work ourselves out of a job' — a 2013 statement you include in the book. How would you grade your efforts? A: The past 12 years have been both exhilarating and exhausting. Exhilarating because there's never been a more exciting time to be in philanthropy. And exhausting because the political, socioeconomic dynamics of the last 12 years are very worrisome for our future. Philanthropy can play a role in helping to strengthen our democracy. But philanthropy can't save America. I would probably give myself a B or a B-. I don't think where we are as a nation after 12 years is where any country would want to be that had its eye on the future and the strength of our democracy. Q: Is there anything you would do differently? A: In 2013 and those early speeches, I identified growing inequality as a challenge to the strength of our democracy. And a part of that manifestation of growing inequality was a growing sense of disaffection — from our politics, our institutions, our economy. For the first time, a decade or so ago, we had clear evidence that working class white households were increasingly downwardly mobile economically. And the implications for that are deep and profound for our politics and our democracy. We started a program on increasing our investments in rural America, acknowledging some of the challenges, for example, of the trends around the impacts of the opioid epidemic on those communities. I underestimated the depth and the collective sense of being left behind. Even though I think I was correct in diagnosing the problem, I think the strategy to respond was not focused enough on this population. Q: Many people credit you for using Ford Foundation's endowment to increase grantmaking during the pandemic. Is that sort of creativity needed now with the new strains faced by the philanthropic sector? A: One of the disappointments I have with philanthropy is that we don't take enough risk. We don't innovate given the potential to use our capital to provide solutions. I do think that, in the coming years, foundations are going to be challenged to step up and lean in in ways that we haven't since the pandemic. The 5% payout is treated as a ceiling by a lot of foundations and, in fact, it's a floor. During these times when there's so much accumulated wealth sitting in our endowments, the public rightly is asking questions about just how much of that we are using and towards what end. Q: Where do you derive this sense of 'radical hope' at the end of your book? A: As a poor kid in rural Texas, I was given the license to dream. In fact, I was encouraged to dream and to believe that it will be possible for me to overcome the circumstances into which I was born. I've lived on both sides of the line of inequality. And I feel incredibly fortunate. But I'm also sobered by the gap between the privileged and the poor and the working-class people in America. It has widened during my lifetime and that is something I worry a lot about. But I'm hopeful because I think about my ancestors who were Black, enslaved, poor. African Americans, Black people, Black Americans have been hopeful for 400 years and have been patriots in believing in the possibility that this country would realize its aspirations for equality and justice. That has been our North Star. Q: Heather Gerken, the dean of Yale's law school, was recently named as your successor. Why is it important to have a leader with a legal background and an expertise in democracy? A: She is the perfect leader for Ford because she understands that at the center of our work must be a belief in democracy and democratic institutions and processes. She is also a bridge builder. She is a coalition builder. She's bold and courageous. I'm just thrilled about her taking the helm of the Ford Foundation. It is a signal from the Ford Foundation Board of Trustees that we are going to double down on our investment and our commitment to strengthening, protecting and promoting democracy. Q: Youtold AP last year that, when you exited this building for the last time, you'd only be looking forward. What does 'forward' mean to you now? A: I have resolved that I don't want to be a president or a CEO. I don't need to be a president of CEO. I think leaders can become nostalgic and hold onto their own history. Now there's no doubt, I know, that my obituary is going to say, 'Darren Walker, the president of the Ford Foundation." That's the most important job I'll ever have. But hopefully I'll be able to add some more important work to that. ___ Associated Press coverage of philanthropy and nonprofits receives support through the AP's collaboration with The Conversation US, with funding from Lilly Endowment Inc. The AP is solely responsible for this content. For all of AP's philanthropy coverage, visit James Pollard, The Associated Press
