Arrowhead Pharmaceuticals Initiates Phase 3 YOSEMITE Study of Investigational Zodasiran for the Treatment of Homozygous Familial Hypercholesterolemia
As an RNAi-based therapeutic targeting ANGPTL3, investigational zodasiran has the potential to treat HoFH in a fundamentally different manner from traditional LDL-C–lowering therapies.
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'Patients living with HoFH are difficult to adequately treat and have a very high risk of developing atherosclerotic cardiovascular disease due to severely elevated LDL-C, often exceeding 500 mg/dL. As an RNAi-based therapeutic targeting ANGPTL3, investigational zodasiran has the potential to treat HoFH in a fundamentally different manner from traditional LDL-C–lowering therapies,' said James Hamilton, M.D., Chief Medical Officer and head of R&D at Arrowhead. 'In Phase 2 clinical studies, patients with HoFH receiving zodasiran achieved reductions from baseline in LDL-C, ApoB, non-HDL-C, and triglycerides, supporting its potential therapeutic role for the treatment of HoFH patients.'
About Homozygous Familial Hypercholesterolemia
Homozygous Familial Hypercholesterolemia (HoFH) is an ultra-rare treatment‐resistant genetic condition characterized by elevated low density lipoprotein cholesterol (LDL-C) and early-onset cardiovascular disease. Most cases of HoFH are due to mutations in the low-density lipoprotein receptor gene (LDLR) coding for the LDL receptor (LDLR). Thus, HoFH represents a unique case where LDL-C lowering therapies not requiring functional LDL receptors may have benefit.
If left untreated, individuals with HoFH can have median LDL-C levels above 500 mg/dL (13 mmol/L), leading to early clinical manifestations of coronary artery disease 1. Patients with HoFH may also have cholesterol deposits under the skin (xanthomas), around the eyes (xanthelasmas), or around the cornea (corneal arcus), but physical signs are not always present, particularly in children. HoFH remains challenging to treat and currently only patients with the more severe HoFH phenotypes get diagnosed and treated early. The estimated prevalence of HoFH globally is between 1:360,000 and 1:250,000 1.
About YOSEMITE Phase 3 Study
YOSEMITE (NCT07037771) is a Phase 3 multicenter, randomized, placebo-controlled study to evaluate the efficacy and safety of zodasiran in adolescent and adult patients with genetically or clinically diagnosed homozygous familial hypercholesterolemia (HoFH) on maximally tolerated lipid lowering therapy. Approximately 60 subjects over the age of 12 will be randomized (2:1) to receive 4 doses (once every 3 months) of 200 mg zodasiran or placebo. The primary endpoint is the percent change from baseline to month 12 in fasting LDL-C. After month 12, eligible participants will be offered an opportunity to continue in an optional open-label extension.
About Zodasiran
Zodasiran, previously called ARO-ANG3, is a first-in-class investigational RNA interference (RNAi) therapeutic designed to reduce production of angiopoietin-like protein (ANGPTL3), which is a hepatocyte expressed regulator of lipid and lipoprotein metabolism with multiple potential modes of action, including inhibition of lipoprotein lipase (LPL) and endothelial lipase (EL) 5,6. ANGPTL3 is an emerging therapeutic target with relevance to hypercholesterolemia, hypertriglyceridemia, and mixed hyperlipidemia. Genetic studies suggest that individuals with ANGPTL3 loss-of-function variants have enhanced lipoprotein lipase and endothelial lipase activity, resulting in lower levels of atherogenic lipoproteins and a reduced risk of ASCVD 2-4.
In prior clinical studies, investigational zodasiran was associated with dose-dependent reductions in triglycerides, triglyceride rich lipoprotein remnants, and total atherogenic lipoproteins, including LDL-C, in patients with homozygous (HoFH) and heterozygous (HeFH) familial hypercholesterolemia and mixed hyperlipidemia. Zodasiran also showed a favorable safety profile. In the Phase 2 GATEWAY study in patients with HoFH, there were no drug discontinuations, drug-related serious adverse events, or deaths. The most frequent adverse events were COVID-19, nasopharyngitis, upper respiratory tract infection, and dizziness.
About Arrowhead Pharmaceuticals, Inc.
Arrowhead Pharmaceuticals, Inc. develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
For more information, please visit www.arrowheadpharma.com, or follow us on X (formerly Twitter) at @ArrowheadPharma, LinkedIn, Facebook, and Instagram. To be added to the Company's email list and receive news directly, please visit http://ir.arrowheadpharma.com/email-alerts.
Safe Harbor Statement under the Private Securities Litigation Reform Act:
This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Any statements contained in this release except for historical information may be deemed to be forward-looking statements. Without limiting the generality of the foregoing, words such as 'may,' 'might,' 'will,' 'expect,' 'believe,' 'anticipate,' 'goal,' 'endeavor,' 'strive,' 'hope,' 'intend,' 'plan,' 'project,' 'could,' 'estimate,' 'potential,' 'target,' 'forecast' or 'continue' or the negative of these words or other variations thereof or comparable terminology are intended to identify such forward-looking statements. In addition, any statements that refer to projections of our future financial performance, trends in our business, expectations for our product pipeline or product candidates, including anticipated regulatory submissions and clinical program results, prospects or benefits of our collaborations with other companies, or other characterizations of future events or circumstances are forward-looking statements. These forward-looking statements include, but are not limited to, statements about the initiation, timing, progress and results of our preclinical studies and clinical trials, and our research and development programs; our expectations regarding regulatory approval for and commercial launch of plozasiran; our expectations regarding the potential benefits of the partnership, licensing and/or collaboration arrangements and other strategic arrangements and transactions we have entered into or may enter into in the future; our beliefs and expectations regarding milestone, royalty or other payments that could be due to or from third parties under existing agreements; and our estimates regarding future revenues, research and development expenses, capital requirements and payments to third parties. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of numerous factors and uncertainties, including the safety and efficacy of our product candidates, decisions of regulatory authorities and the timing thereof, the duration and impact of regulatory delays in our clinical programs, our ability to finance our operations, the likelihood and timing of the receipt of future milestone and licensing fees, the future success of our scientific studies, our ability to successfully develop and commercialize drug candidates, the timing for starting and completing clinical trials, rapid technological change in our markets, the enforcement of our intellectual property rights, and the other risks and uncertainties described in our most recent Annual Report on Form 10-K, subsequent Quarterly Reports on Form 10-Q and other documents filed with the Securities and Exchange Commission from time to time. We assume no obligation to update or revise forward-looking statements to reflect new events or circumstances.
Source: Arrowhead Pharmaceuticals, Inc.
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1. Cuchel, et al. Eur Heart J. 2023;44(25):2277-91
2. Dewey, et al. N Engl J Med. 2017;377 (3):211-21.
3. Minicocci, et al. J Lipid Res. 2013;54(12): 3481-90
4. Musunuru, et al. N Engl J Med. 2010; 363(23):2220-7
5. Adam, et al. J Lipid Res. 2020;61(9): 1271-86.
6. Rosenson. J Lipid Res. 2021:62:100060.
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Share Repurchases During the second quarter of 2025, the Company repurchased and retired 315,696 shares of common stock for a total of $150.0 million. During the two fiscal quarters of 2025, the Company repurchased and retired 430,976 shares of common stock for a total of $200.0 million. As of June 15, 2025, the Company had a total remaining authorized amount for share repurchases of $614.3 million. Comments on Regulation G In addition to the GAAP financial measures set forth in this press release, the Company has included non-GAAP financial measures within the meaning of Regulation G, including free cash flow, income from operations, excluding foreign currency impact and Consolidated Adjusted EBITDA. The Company has also included metrics such as global retail sales, global retail sales growth (excluding foreign currency impact), same store sales growth, net store growth, food basket pricing change, impact of changes in foreign currency exchange rates on international franchise royalty revenues and the leverage ratio, which are commonly used statistical measures in the quick-service restaurant industry that are important to understanding Company performance. The Company uses "global retail sales," a statistical measure, to refer to total worldwide retail sales at Company-owned and franchise stores. The Company believes global retail sales information is useful in analyzing revenues because franchisees pay royalties and advertising fees that are based on a percentage of franchise retail sales. The Company reviews comparable industry global retail sales information to assess business trends and to track the growth of the Domino's Pizza brand and believes they are indicative of the financial health of the Company's franchisee base. In addition, supply chain revenues are directly impacted by changes in franchise retail sales in the U.S. and Canada. As a result, sales by Domino's franchisees have a direct effect on the Company's profitability. Retail sales for franchise stores are reported to the Company by its franchisees and are not included in Company revenues. "Global retail sales growth" is calculated as the change of U.S. Dollar global retail sales against the comparable period of the prior year. "Global retail sales growth, excluding foreign currency impact" is calculated as the change of international local currency global retail sales against the comparable period of the prior year. 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The Company uses "food basket pricing change," a statistical measure, which is calculated as the percentage change of the food basket (including both food and cardboard products) purchased by an average U.S. store (based on average weekly unit sales) from U.S. supply chain centers against the comparable period of the prior year. The Company believes that the food basket pricing change is important to investors and other interested persons to understand the Company's performance. As food basket prices fluctuate, revenues, cost of sales and gross margin percentages in the Company's supply chain segment also fluctuate. Additionally, cost of sales, gross margins and gross margin percentages for the Company's U.S. Company-owned stores also fluctuate. The Company uses "free cash flow," which is calculated as net cash provided by operating activities, less capital expenditures, both as reported under GAAP. The most directly comparable financial measure calculated and presented in accordance with GAAP is net cash provided by operating activities. The Company believes that the free cash flow measure is important to investors and other interested persons, and that such persons benefit from having a measure which communicates how much cash flow is available for working capital needs or to be used for repurchasing debt, making acquisitions, repurchasing common stock or paying dividends. The Company uses "income from operations, excluding foreign currency impact," which is calculated as income from operations as reported under GAAP, less the "impact of changes in foreign currency exchange rates on international franchise royalty revenues," a statistical measure. The most directly comparable financial measure calculated and presented in accordance with GAAP is income from operations. The impact of changes in foreign currency exchange rates on international franchise royalty revenues is calculated as the difference in international franchise royalty revenues resulting from translating current period local currency results to U.S. dollars at current period exchange rates as compared to prior period exchange rates. The Company believes that the impact of changes in foreign currency exchange rates on international franchise royalty revenues is important to investors and other interested persons to understand the Company's international royalty revenues given the significant variability in those revenues and that can be driven by changes in foreign currency exchanges rates. International franchise royalty revenues do not have a cost of sales component, so changes in these revenues have a direct impact on income from operations. The Company uses "Consolidated Adjusted EBITDA," which is calculated as Segment Income as defined by the Company under Accounting Standards Codification 280, Segment Reporting, less corporate administrative costs that have not been allocated to a reportable segment including labor, computer expenses, professional fees, travel and entertainment, rent, insurance and other corporate administrative costs. Consolidated Adjusted EBITDA is defined in the base indenture governing the Company's securitized debt. The Company uses Consolidated Adjusted EBITDA to determine future business objectives and targets and for long-range planning, as well as to evaluate total Company operating performance for the purposes of determining certain variable performance-based compensation. The Company believes Consolidated Adjusted EBITDA is a reliable barometer for the overall success of the Company. It is also used to calculate the leverage ratio (defined below), and other ratios defined in the indenture governing the Company's securitized debt. As such, Consolidated Adjusted EBITDA is important to investors and other interested persons to understand the financial performance of the Company, and to assess the ability of the Company to meet its financial obligations. The Company uses the "leverage ratio1," which is calculated as the Company's securitized debt related to its fixed-rate notes from the recapitalizations completed in 2021, 2019, 2018, 2017 and 2015 and borrowings under its variable funding notes, divided by Consolidated Adjusted EBITDA on a trailing four quarters basis. The Company has historically operated with a leverage ratio between four and six times. The Company reviews its leverage ratio on at least a quarterly basis and believes its leverage ratio is important to investors and other interested persons to understand the capital structure of the Company, and to assess the ability of the Company to meet its financial obligations. The reconciliation of the leverage ratio for the second quarters of 2025 and 2024 is as follows below. June 15,2025 June 16,20242015 Ten-Year Notes$ 742,000 $ 742,0002017 Ten-Year Notes 940,000940,0002018 7.5-Year Notes 402,688402,6882018 9.25-Year Notes 379,000379,0002019 Ten-Year Notes 648,000648,0002021 7.5-Year Notes 826,625826,6252021 Ten-Year Notes 972,500972,500Total fixed-rate notes$ 4,910,813 $ 4,910,813 Segment Income - second quarter of 2025 and 2024$ 273,758 $ 253,565Segment Income - first quarter of 2025 and 2024 268,417260,016Segment Income - fourth quarter of 2024 and 2023 340,968327,098Segment Income - third quarter of 2024 and 2023 252,117237,096Segment Income - trailing four quarters$ 1,135,260 $ 1,077,775 General and administrative - other - second quarter of 2025 and 2024$ (20,925) $ (26,165)General and administrative - other - first quarter of 2025 and 2024 (27,313)(18,173)General and administrative - other - fourth quarter of 2024 and 2023 (27,818)(32,498)General and administrative - other - third quarter of 2024 and 2023 (22,839)(19,809)General and administrative - other - trailing four quarters$ (98,895) $ (96,645) Consolidated Adjusted EBITDA - trailing four quarters$ 1,036,365 $ 981,130Leverage ratio 4.7 x 5.0 x (1)The Company also calculates and reviews its Senior Leverage Ratio and Holdco Leverage Ratio as defined in the indenture governing the Company's securitized debt. Conference Call Information The Company will file its Quarterly Report on Form 10-Q today. As previously announced, Domino's Pizza, Inc. will hold a conference call today at 8:30 a.m. (Eastern) to review its second quarter 2025 financial results. The webcast is available at and will be archived for one year. About Domino's Pizza® Founded in 1960, Domino's Pizza is the largest pizza company in the world, with a significant business in both delivery and carryout. It ranks among the world's top public restaurant brands with a global enterprise of more than 21,500 stores in over 90 markets. Domino's had global retail sales of over $19.4 billion in the trailing four quarters ended June 15, 2025. Its system is comprised of independent franchise owners who accounted for 99% of Domino's stores as of the end of the second quarter of 2025. In the U.S., Domino's generated more than 85% of U.S. retail sales in 2024 via digital channels and has developed many innovative ordering platforms. Order – Info – Assets – Please visit our Investor Relations website at to view news, announcements, earnings releases, investor presentations and conference webcasts. SAFE HARBOR STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995: This press release contains various forward-looking statements about the Company within the meaning of the Private Securities Litigation Reform Act of 1995 (the "Act") that are based on current management expectations that involve substantial risks and uncertainties which could cause actual results to differ materially from the results expressed in, or implied by, these forward-looking statements. The following cautionary statements are being made pursuant to the provisions of the Act and with the intention of obtaining the benefits of the "safe harbor" provisions of the Act. You can identify forward-looking statements by the use of words such as "anticipates," "believes," "could," "should," "estimates," "expects," "intends," "may," "will," "plans," "predicts," "projects," "seeks," "approximately," "potential," "outlook" and similar terms and phrases that concern our strategy, plans or intentions, including references to assumptions. These forward-looking statements address various matters including information concerning future results of operations and business strategy, our anticipated profitability, estimates in same store sales growth, store growth and the growth of our U.S. and international business in general, our ability to service our indebtedness, our future cash flows, our operating performance, trends in our business and other descriptions of future events reflect the Company's expectations based upon currently available information and data. While we believe these expectations and projections are based on reasonable assumptions, such forward-looking statements are inherently subject to risks, uncertainties and assumptions. Important factors that could cause actual results to differ materially from our expectations are more fully described in our filings with the Securities and Exchange Commission, including under the section headed "Risk Factors" in our Annual Report on Form 10-K for the fiscal year ended December 29, 2024. Actual results may differ materially from those expressed or implied in the forward-looking statements as a result of various factors, including but not limited to: our substantial indebtedness as a result of our recapitalization transactions and our ability to incur additional indebtedness or refinance or renegotiate key terms of that indebtedness in the future; the impact a downgrade in our credit rating may have on our business, financial condition and results of operations; our future financial performance and our ability to pay principal and interest on our indebtedness; the strength of our brand, including our ability to compete in the U.S. and internationally in our intensely competitive industry, including the food service and food delivery markets; our ability to successfully implement our growth strategy, including through our participation in the third-party order aggregation marketplace; labor shortages or changes in operating expenses resulting from increases in prices of food (particularly cheese), fuel and other commodity costs, labor, utilities, insurance, employee benefits and other operating costs or negative economic conditions; the effectiveness of our advertising, operations and promotional initiatives; shortages, interruptions or disruptions in the supply or delivery of fresh food products and store equipment; the additional risks our international operations subject us to, which may differ in each country in which we and our franchisees do business; our ability and that of our franchisees to successfully operate in the current and future credit environment; the impact of social media or a boycott on our business, brand and reputation; the impact of new or improved technologies and alternative methods of delivery on consumer behavior; new product, digital ordering and concept developments by us, and other food-industry competitors; our ability to maintain good relationships with and attract new franchisees, and franchisees' ability to successfully manage their operations without negatively impacting our royalty payments and fees or our brand's reputation; our ability to successfully implement cost-saving strategies; changes in the level of consumer spending given general economic conditions, including interest rates, energy prices and consumer confidence or negative economic conditions in general; our ability and that of our franchisees to open new restaurants and keep existing restaurants in operation and maintain demand for new stores; the impact that widespread illness, health epidemics or general health concerns, severe weather conditions and natural disasters may have on our business and the economies of the countries where we operate; changes in foreign currency exchange rates; changes in income tax rates; our ability to retain or replace our executive officers and other key members of management and our ability to adequately staff our stores and supply chain centers with qualified personnel; our ability to find and/or retain suitable real estate for our stores and supply chain centers; changes in government legislation and regulations, including changes in laws and regulations regarding information privacy, payment methods, advertising and consumer protection and social media; adverse legal judgments or settlements; food-borne illness or contamination of products or food tampering or other events that may impact our reputation; data breaches, power loss, technological failures, user error or other cyber risks threatening us or our franchisees; the impact that environmental, social and governance matters may have on our business and reputation; the effect of war, terrorism, catastrophic events, other geopolitical or reputational considerations or climate change; our ability to pay dividends and repurchase shares; changes in consumer tastes, spending and traffic patterns and demographic trends; changes in accounting policies; and adequacy of our insurance coverage. In light of these risks, uncertainties and assumptions, the forward-looking events discussed in this press release might not occur. All forward-looking statements speak only as of the date of this press release and should be evaluated with an understanding of their inherent uncertainty. Except as required under federal securities laws and the rules and regulations of the Securities and Exchange Commission, or other applicable law, we will not undertake, and specifically disclaim, any obligation to publicly update or revise any forward-looking statements to reflect events or circumstances arising after the date of this press release, whether as a result of new information, future events or otherwise. You are cautioned not to place undue reliance on the forward-looking statements included in this press release or that may be made elsewhere from time to time by, or on behalf of, us. All forward-looking statements attributable to us are expressly qualified by these cautionary statements. TABLES TO FOLLOW Domino's Pizza, Inc. and Subsidiaries Condensed Consolidated Statements of Income (Unaudited)Fiscal Quarter EndedJune 15,2025 % ofTotalRevenues June 16,2024 % ofTotalRevenues(In thousands, except share and per share data) Revenues: U.S. Company-owned stores$ 92,456$ 92,264 U.S. franchise royalties and fees 156,261 147,576 Supply chain 687,062 659,244 International franchise royalties and fees 77,164 73,696 U.S. franchise advertising 132,201 124,956 Total revenues 1,145,144100.0 % 1,097,736100.0 % Cost of sales: U.S. Company-owned stores 78,073 76,059 Supply chain 606,101 584,646 Total cost of sales 684,17459.7 % 660,70560.2 % Gross margin 460,97040.3 % 437,03139.8 % General and administrative 107,6089.4 % 115,94710.5 % U.S. franchise advertising 132,20111.5 % 124,95611.4 % Refranchising (gain) loss (3,883)(0.3) % 250.0 % Income from operations 225,04419.7 % 196,10317.9 % Other (expense) income (15,974)(1.4) % 11,3981.0 % Interest expense, net (40,819)(3.6) % (40,502)(3.7) % Income before provision for income taxes 168,25114.7 % 166,99915.2 % Provision for income taxes 37,1603.3 % 25,0212.3 % Net income$ 131,09111.4 %$ 141,97812.9 % Earnings per share: Common stock – diluted$ 3.81$ 4.03 Weighted average diluted shares 34,401,016 35,224,080 Domino's Pizza, Inc. and Subsidiaries Condensed Consolidated Statements of Income (Unaudited)Two Fiscal Quarters EndedJune 15,2025 % ofTotalRevenues June 16,2024 % ofTotalRevenues(In thousands, except share and per share data) Revenues: U.S. Company-owned stores$ 184,054$ 184,913 U.S. franchise royalties and fees 307,261 298,094 Supply chain 1,356,986 1,318,458 International franchise royalties and fees 152,723 145,662 U.S. franchise advertising 256,176 235,256 Total revenues 2,257,200100.0 % 2,182,383100.0 % Cost of sales: U.S. Company-owned stores 154,984 152,517 Supply chain 1,198,099 1,170,965 Total cost of sales 1,353,08359.9 % 1,323,48260.6 % Gross margin 904,11740.1 % 858,90139.4 % General and administrative 216,6859.6 % 216,97110.0 % U.S. franchise advertising 256,17611.4 % 235,25610.8 % Refranchising (gain) loss (3,883)(0.2) % 1580.0 % Income from operations 435,13919.3 % 406,51618.6 % Other income (expense) 8,0530.4 % (7,301)(0.3) % Interest expense, net (82,459)(3.7) % (82,609)(3.8) % Income before provision for income taxes 360,73316.0 % 316,60614.5 % Provision for income taxes 79,9913.6 % 48,8042.2 % Net income$ 280,74212.4 %$ 267,80212.3 % Earnings per share: Common stock – diluted$ 8.14$ 7.61 Weighted average diluted shares 34,477,191 35,199,277 Domino's Pizza, Inc. and Subsidiaries Condensed Consolidated Balance Sheets (Unaudited)June 15,2025 December 29,2024(In thousands) Assets Current assets: Cash and cash equivalents$ 272,859 $ 186,126Restricted cash and cash equivalents 211,734195,370Accounts receivable, net 284,606309,104Inventories 69,70570,919Prepaid expenses and other 45,55640,363Advertising fund assets, restricted 123,098103,396Total current assets 1,007,558905,278Property, plant and equipment, net 290,270301,179Operating lease right-of-use assets 222,676210,302Investment in DPC Dash 46,66782,699Other assets 244,122237,555Total assets$ 1,811,293 $ 1,737,013Liabilities and stockholders' deficit Current liabilities: Current portion of long-term debt$ 1,149,989 $ 1,149,679Accounts payable 131,08885,898Operating lease liabilities 43,00339,920Advertising fund liabilities 120,790101,567Other accrued liabilities 243,311235,398Total current liabilities 1,688,1811,612,462Long-term liabilities: Long-term debt, less current portion 3,825,8473,825,659Operating lease liabilities 192,739181,983Other accrued liabilities 79,15379,200Total long-term liabilities 4,097,7394,086,842Total stockholders' deficit (3,974,627)(3,962,291)Total liabilities and stockholders' deficit$ 1,811,293 $ 1,737,013Domino's Pizza, Inc. and Subsidiaries Condensed Consolidated Statements of Cash Flows (Unaudited)Two Fiscal Quarters EndedJune 15,2025 June 16,2024(In thousands) Cash flows from operating activities: Net income$ 280,742 $ 267,802Adjustments to reconcile net income to net cash provided by operating activities: Depreciation and amortization 40,71340,218Refranchising (gain) loss (3,883)158Loss on sale/disposal of assets 612327Amortization of debt issuance costs 2,4192,475Benefit for deferred income taxes (2,700)(6,246)Non-cash equity-based compensation expense 21,35622,024Excess tax benefits from equity-based compensation (2,343)(20,238)(Benefit) provision for losses on accounts and notes receivable (4)111Unrealized and realized (gain) loss on investments, net (8,053)7,301Changes in operating assets and liabilities 19,663(31,660)Changes in advertising fund assets and liabilities, restricted 18,338(8,122)Net cash provided by operating activities 366,860274,150Cash flows from investing activities: Capital expenditures (35,231)(43,683)Sale of investments 44,085—Proceeds from sale of assets 8,45873Other (2,517)(1,350)Net cash provided by (used in) investing activities 14,795(44,960)Cash flows from financing activities: Repayments of long-term debt and finance lease obligations (1,861)(14,764)Proceeds from exercise of stock options 12,31931,467Purchases of common stock (203,041)(25,000)Tax payments for restricted stock upon vesting (8,472)(9,260)Payments of common stock dividends and equivalents (60,257)(53,100)Net cash used in financing activities (261,312)(70,657)Effect of exchange rate changes on cash 1,848(990)Change in cash and cash equivalents, restricted cash and cash equivalents 122,191157,543 Cash and cash equivalents, beginning of period 186,126114,098Restricted cash and cash equivalents, beginning of period 195,370200,870Cash and cash equivalents included in advertising fund assets, restricted, beginning of period 80,92888,165Cash and cash equivalents, restricted cash and cash equivalents and cash and cash equivalents included in advertising fund assets, restricted, beginning of period 462,424403,133 Cash and cash equivalents, end of period 272,859283,699Restricted cash and cash equivalents, end of period 211,734197,019Cash and cash equivalents included in advertising fund assets, restricted, end of period 100,02279,958Cash and cash equivalents, restricted cash and cash equivalents and cash and cash equivalents included in advertising fund assets, restricted, end of period$ 584,615 $ 560,676 View original content to download multimedia: SOURCE Domino's Pizza, Inc. 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Ether Machine, backed by crypto giants, set to raise over $1.6 billion in Nasdaq debut
(Reuters) -The Ether Reserve, a new crypto venture backed by prominent crypto investors, will list on the Nasdaq through a merger with blank-check firm Dynamix Corporation and is expected to raise over $1.6 billion. The combined entity, to be named The Ether Machine, aims to launch with more than 400,000 Ether on its balance sheet, positioning it as the largest public vehicle for institutional exposure to the world's second-largest cryptocurrency. The deal highlights rising institutional interest in holding crypto on corporate balance sheets, a strategy popularized by Michael Saylor at Strategy. In recent months, several projects have announced plans to publicly list their shares while aiming to wrap crypto assets into equity to attract traditional investors. While most corporate interest has focused on Bitcoin, Ether has surged in recent weeks, hitting a six-month high on Friday. Ether has benefited from increased regulatory clarity around U.S. dollar-pegged stablecoins, most of which are issued and transacted on the Ethereum blockchain. Andrew Keys, a former executive at ConsenSys — a crypto firm founded by Ethereum co-founder Joseph Lubin — will serve as Ether Machine's chairman. Investors in the blank-check deal, including Kraken, and Pantera Capital, are contributing more than $800 million through an upsized common stock offering. The company will trade on the Nasdaq under the symbol "ETHM" upon deal close, which is expected in the fourth quarter of 2025. Erreur lors de la récupération des données Connectez-vous pour accéder à votre portefeuille Erreur lors de la récupération des données Erreur lors de la récupération des données Erreur lors de la récupération des données Erreur lors de la récupération des données
