
Mollisonia symmetrica: Fossil suggests spiders originated in the sea
What did scientists discover?
An international team of experts led by the University of Arizona in the US, decided to take a closer look at a half-a-billion-year-old marine fossil of an extinct animal called Mollisonia symmetrica.They undertook a detailed analysis of its well-preserved features including its brain and central nervous system. Until now, the creature was thought to be an ancient member of a specific group of arthropods known as chelicerates, which lived during the Cambrian period (around 500 million years ago) and are ancestors to modern-day horseshoe crabs. However, to the team's surprise, they found that the brain structure of the Mollisonia symmetrica was not similar to that of horseshoe crabs, as would be expected.Instead, it had more in common with modern spiders and their relatives.This led scientists to suggest that the first spiders were marine, originating in the ocean.
Professor Nicholas Strausfield, the lead author of the study, said that many questions still remain over how arachnids evolved and moved from the sea to the land."It is still vigorously debated where and when arachnids first appeared and whether these were marine or semi-aquatic like horseshoe crabs."He also suggested what these ancient spiders could have fed on when they first moved on to the land. "We might imagine that a Mollisonia-like arachnid also became adapted to terrestrial life making early insects and millipedes their daily diet," Professor Strausfield added.The team now think that Mollisonia symmetrica could be the ancient ancestor of a wide range of arachnids including spiders and scorpions.
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BBC News
6 minutes ago
- BBC News
German pharma firm signs deal worth up to $1bn with QUB spin out
A medical technology company founded by Queen's University academics has signed a licensing agreement with a major pharmaceutical firm which could ultimately be worth up to $1bn (£744.1m).Re-Vana Therapeutics, which was set up in 2016, develops products to improve the delivery of drugs for chronic eye diseases, increasing the quality of care for major benefit of its technology is that it reduces the number of eye injections patients require making them more likely to follow their Ingelheim, a German pharmaceutical firm, is licensing the drug delivery system to combine it with its eye medications. The German firm will take responsibility for regulatory approvals and global commercialization of products developed using the Re-Vana Ingelheim said the deal involves "upfront, development, regulatory and commercial milestone payments to Re-Vana, with total potential deal value exceeding $1bn for the initial three targets, in addition to royalty payments on net sales".Re-Vana was founded by Professor Raj Thakur and Professor David Jones with investors including Qubis, the commercialisation arm of Queen's company is now based in the US but still has its research base in O'Rourke, Re-Vana's Chief Executive Officer, said the collaboration with Boehringer Ingelheim is a "transformational moment".The deal has also been welcomed by NI Secretary of State Hillary Benn who said it "represents a huge vote of confidence in Northern Ireland's innovation and skills".


The Guardian
2 hours ago
- The Guardian
The life of microplastic: how fragments move through plants, insects, animals
The story starts with a single thread of polyester, dislodged from the weave of a cheap, pink acrylic jumper as it spins around a washing machine. This load of washing will shed hundreds of thousands of tiny plastic fragments and threads – up to 700,000 in this one washing machine cycle. Along with billions of other microscopic, synthetic fibres, our thread travels through household wastewater pipes. Often, it ends up as sewage sludge, being spread on a farmer's field to help crops grow. Sludge is used as organic fertiliser across the US and Europe, inadvertently turning the soil into a huge global reservoir of microplastics. One wastewater treatment plant in Wales found 1% of the weight of sewage sludge was plastic. From here, it works its way up the food chain through insects, birds, mammals and even humans. Perhaps our jumper's life as a garment will end soon, lasting only a few outings before it emerges from the wash shrunken and bobbling, to be discarded. But our thread's life will be long. It might have only been part of a jumper for a few weeks, but it could voyage around the natural world for centuries. Spread on the fields as water or sludge, our tiny fibre weaves its way into the fabric of soil ecosystems. A worm living under a wheat field burrows its way through the soil, mistaking the thread for a bit of old leaf or root. The worm consumes it – but cannot process it like ordinary organic matter. The worm joins nearly one in three earthworms that contain plastic, according to a study published in April, as well as a quarter of slugs and snails that ingest plastic as they graze across soil. Caterpillars of peacock, powder blue and red admiral butterflies all contain plastic too, perhaps from feeding on leaves contaminated with it, research shows. With the plastic in its gut, the burrowing earthworm will find it more difficult to digest nutrients, and is likely to start shedding weight. The damage might not be visible but for insects, eating plastic has been linked to stunted growth, reduced fertility and problems with the liver, kidney and stomach. Even some of the tiniest lifeforms in our soil, such as mites and nematodes – which help maintain the fertility of land – are negatively affected by plastic. Plastic pollution in the marine environment has been widely documented, but a UN report found soil contains more microplastic pollution than the oceans. This matters not only for the health of soils, but because creepy crawlies such as beetles, slugs and snails form the building blocks of food chains. Our worm is now enabling this plastic fibre to become an international traveller. In a suburban garden, a hedgehog snuffles through a dozen invertebrates in a night, consuming plastic fibres within them as it goes. One of them is our worm. A study that looked at the faeces of seven hedgehogs, found four of them contained plastics, one of which contained 12 fibres of polyester, some of which were pink. If hedgehogs don't live in your country, substitute another small, scurrying mammal or bird: the same study found mice, voles and rats were also eating plastic, either directly or via contaminated prey. Birds that eat insects such as swifts, thrushes and blackbirds are also ingesting plastic via their prey. A study earlier this year found for the first time that birds have microplastics in their lungs because they are inhaling them too. 'Microplastics are now ubiquitous at every level of the food web,' says Prof Fiona Mathews, environmental biologist at the University of Sussex. The meat, milk and blood of farm animals also contain microplastics. At the top of the food chain, humans consume at least 50,000 microplastic particles a year. They are in our food, water, and the air we breathe. Fragments of plastic have been found in blood, semen, lungs, breast milk, bone marrow, placenta, testicles and the brain. Even as it makes its way up the animal food chain, our polyester fibre has not been broken down. At some point, the thread returns to the dirt when the creature that consumed its host dies, and a new adventure starts. The body will decay, but the polyester fibre will endure. Once in the soil, it is ploughed in by the farmer before crops are sown. But it may not stay there for long – strong winds blow the dry, degraded soil into the air, taking with it a pink fragment of plastic. In heavy rain, the fibre could be swept into a river flowing to the sea: a major source of marine contamination is run-off from land. This process of moving through natural systems over years has been called 'plastic spiralling'. Scientists have found that microplastics equivalent to 300m plastic water bottles have rained down on the Grand Canyon, Joshua Tree and other US national parks. Even the most remote places are contaminated. One scientist found 12,000 microplastic particles a litre in samples of Arctic sea ice, swept there by ocean currents and blown in by the wind. With the passage of time, our plastic thread has still not rotted, but has broken into fragments, leaving tiny pieces of itself in the air, water and soil. Over the course of years, it could become so small that it infiltrates the root cell wall of a plant as it sucks up nutrients from the soil. Nanoplastics have been found in the leaves and fruits of plants and, once inside, they can affect the plant's ability to photosynthesise, research suggests. Here, inside the microscopic systems of the plant, the bits of our pink fibre cause all kinds of havoc – blocking nutrient and water channels, harming cells and releasing toxic chemicals. Staples such as wheat, rice and lettuce have been shown to contain plastic, which is one way they enter the human food chain. From its humble beginnings, our fibre may have journeyed around the world, shedding bits of itself along the way, and working its way into almost every layer of different ecosystems and the far reaches of the natural world. Extracting it once it begins that journey is extremely difficult. The best way to prevent its spread is to stop it at the outset – before the worm, before the soil, before the washing machine, even before the jumper is made. Since the 1950s, humans have produced in excess of 8.3bn tonnes of plastic – equivalent to the weight of one billion elephants. It finds its way into packaging, textiles, agricultural materials and consumer goods. Opting to live without it is almost impossible. Fast fashion companies, drinks giants, supermarket chains and big agricultural companies have failed to take responsibility for the damage this has caused, says Emily Thrift, who researches plastic in the environment at the University of Sussex. She says individual consumers can reduce their consumption but should not feel that this is entirely their responsibility. 'If you do make this level of waste, there needs to be some form of penalisation for doing it,' she says. 'I truly believe until there is policy and ways to hold big corporations accountable, I don't see it changing much.'


The Sun
2 hours ago
- The Sun
Intense grief after the loss of a loved one doubles the risk of dying within 10 years, warn experts
PEOPLE intensely grieving a loved one are nearly twice as likely to die within a decade of their loss, say scientists. While grief for the loss of a relative is a natural response, in a minority of the bereaved, grief is so overwhelming it can lead to physical and mental illness - even if it doesn't qualify for a diagnosis. 1 Previous studies have shown people who recently lost a loved one use healthcare services more often and have an increased mortality rate, over the short term. But now, researchers in Denmark demonstrated bereaved people with persistent high levels of intense grief used more healthcare services and were more likely to die within 10 years. Study corresponding author Dr Mette Kjærgaard Nielsen, a postdoctoral researcher at the Research Unit for General Practice in Aarhus, said: "This is the first study to investigate the long-term use of healthcare and patterns of mortality over a decade after bereavement in a large-scale cohort." Starting in 2012, Dr Nielsen and her colleagues followed a group of 1,735 bereaved women and men living in Denmark with an average age of 62 on enrolment. Of the participants, 66 per cent had recently lost their partner, 27 per cent a parent, and 7 per cent another kind of loved relation. Through the national register of drug prescriptions, the researchers knew which patients had recently been prescribed treatment for a terminal condition. They were able to contact those dying patients to invite them and their loved ones to participate in the study. Previously, Dr Nielsen and her colleagues. had identified five common "trajectories" among the group, based on changes in the intensity of grief symptoms over the first three years after losing a loved one. Those on the "low" trajectory (38 per cent) displayed persistently low levels of grief symptoms, while 6 per cent followed a "high" trajectory with persistently elevated levels. Three other categories lay between those extremes: 18 per cent and 29 percent followed a "high but decreasing" and a "moderate but decreasing" trajectory, respectively, with 9 per cent on a "late onset" trajectory with a peak of symptoms around six month after bereavement. There are many treatments available on the NHS to help with low mood and depression The research team extended their follow-up of the participants for a total of 10 years until 2022, except for those who died or emigrated earlier. They used data from the Danish National Health Service Register to assess how often each participant received " talk therapy" from a GP or specialist, or were prescribed any psychotropic medication. The results revealed for participants on the "high" trajectory, the hazard rate of dying within 10 years was 88 per cent higher than for participants on a "low" trajectory. The findings, published in the journal Frontiers in Public Health, also showed participants on the "high" trajectory were most likely to receive additional health care services beyond three years after bereavement. For example, they had 186 per cent higher odds of receiving talk therapy or other mental health services, 463 per cent higher odds of being prescribed antidepressants, and 160 per cent higher odds of being prescribed sedatives or anxiety drugs. Differences in the frequency of use of healthcare services between the five trajectories were no longer significant after the first eight years, but the excess mortality of participants on the "high" trajectory remained pronounced over the full 10 years of follow-up. Dr Nielsen said: "We have previously found a connection between high grief symptom levels and higher rates of cardiovascular disease, mental health problems, and even suicide. "But the association with mortality should be further investigated." She says people at risk for a "high" grief trajectory may be recognisable for intervention early, since the data showed that those patients were prescribed psychotropic medication more often even before their loss. Dr Nielsen added: "The 'high grief' group had lower education on average, and their more frequent use of medication before bereavement suggested that they had signs of mental vulnerability, which may cause greater distress on bereavement. "A GP could look for previous signs of depression and other severe mental health conditions. "They can then offer these patients tailored follow-up in general practice, or refer them to a private-practice psychologist or secondary care. "The GP may also suggest a bereavement follow-up appointment focusing on mental health." Where to seek grief support Need professional help with grief? Child Bereavement UK Cruse Bereavement Relate The Good Grief Trust You can also always speak to your GP if you're struggling. You're Not Alone Check out these books, podcasts and apps that all expertly navigate grief… Griefcast: Cariad Lloyd interviews comedians on this award-winning podcast. The Madness Of Grief by Rev Richard Coles (£9.99, W&N): The Strictly fave writes movingly on losing his husband David to alcoholism. Terrible, Thanks For Asking: Podcast host Nora McInerny encourages non-celebs to share how they're really feeling. Good Mourning by Sally Douglas and Imogen Carn (£14.99, Murdoch Books): A guide for people who've suffered sudden loss, like the authors who both lost their mums. Grief Works: Download this for daily meditations and expert tips. How To Grieve Like A Champ by Lianna Champ (£3.99, Red Door Press): A book for improving your relationship with death.