AstraZeneca boost as EU approves cancer drug
The London-listed drugs maker revealed that its bladder cancer treatment Imfinzi has been approved to treat adult patients in the European Union.
It comes amid reports that AstraZeneca – the FTSE 100's largest company – is considering moving its listing from the UK to the US in what would be a hammer blow to London's stock market.
The speculation was fuelled by the pharmaceutical sector's growing frustration with the UK's rules on approving medicines as well as a row over drug prices between the industry and the NHS.
Dave Fredrickson, head of AstraZeneca's oncology haematology unit, said: 'Imfinzi is poised to transform the standard of care for muscle-invasive bladder cancer in Europe.'
AstraZeneca shares edged up 1.3 per cent yesterday.
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Daily Mail
26 minutes ago
- Daily Mail
Domesday Book village is up in arms as new owner of £585,000 historic cottage applies to bulldoze it in favour of 'modern, bland new-build' homes
Villagers are up in arms after the new owner of a £585,000 historic cottage applied to bulldoze it to make way for new-build homes. Eric Abbott has also hit out at new owners of the property he lived in for more than 60 years after claiming they only sold it on the condition that it would be lived in by a family. Almost a thousand people have now signed a petition to stop the development in Swanmore, Hampshire, and 200 objections were written during the public consultation period for the plans. New owner Simon Smith has submitted an application to Winchester City Council to demolish the house and build two two-storey modern houses with four bedrooms each, parking for three cars and gardens. Neighbours think that the new build won't fit in well with the character of the village, and will cause traffic problems on an already busy street which is around the corner from a primary school. Houses on the street cost an average of £800,000, and some buildings in Swanmore - which is mentioned in the Domesday Book - date back to the 16th or early 17th centuries. Villagers received flyers about the petition against the redevelopment, which has 931 signatures, through their letterboxes. The flyers said that the cottage, known as Hiawatha, is being 'flattened' and replaced with 'two modern, bland new-builds'. Former company director Mr Abbott, 94, raised his family in the property with his wife Peggy. It was sold after being put on the market last year for £585,000. In an objection he wrote against the planning application, Mr Abbott said: 'As the previous owner of Hiawatha I was totally dismayed to see the change of heart of the new owners attempting to destroy Hiawatha and replace with totally unsuitable houses. 'I instructed the estate agent to ensure my wonderful house was only sold to a family who would love it like I did and not destroy it. 'The estate agent assured me that he had made this clear to the new owners and that they had agreed it to be their forever home which is all I ever wanted for another family to love it like I had for the last 64 years. 'It seems they lied and were buying Hiawatha for financial gain. 'I had been offered to sell to many builders and I declined as this house is part of history, it was there before Chapel Road was even made. 'I would never have sold it had I known this was their intention and they knew that. 'There is an ancient well that in the deeds demands that it should be operable for future water shortages in the village and this was a legal requirement. 'I believe Hiawatha was built in the 15th century it is a beautiful flint cottage which should not be replaced with two identical new builds. 'I feel it should remain standing and let the slow worms, birds, bats and many other species carry on living as they have been for many years. 'I strongly object and do hope that this does not go ahead it would be a great shame to the wonderful village of Swanmore.' David Hughes, 63, lives nearby and hopes he's not a 'nimby' for wanting the house to keep its character. The scientist said: 'I put in [an objection] saying I wasn't very keen on it, hopefully not from a nimby point of view. 'If we're not careful, we'll have a lot of new houses here. 'It's an unusual-looking house, it breaks up some of the monotony of the architecture.' The villager admitted that he was surprised 'how many other people were that bothered about it'. Swanmore local John Allen thinks that the council like the idea of the demolition because replacing the house with two houses will bring in more council tax. The 79 year old retiree said: 'The council like it, wouldn't it, more council tax, more money, that sort of thing.' Paraphrasing film producer Samuel Goldwyn in reference to Mr Abbott's agreement with the new owners, he said 'a verbal agreement isn't worth the paper it's written on'. 'He should've got it done legally,' he said. A middle-aged female neighbour who wanted to remain anonymous said she had signed the petition against the redevelopment. She said: 'I don't think it's the prettiest building in the village, but my main concern for it is if they put two properties in it. 'The road is already abused enough with traffic, I know there's three bedrooms [in each house].' 'As we all know, if you've got three teenagers moved in all of a sudden you haven't got enough parking.' An elderly female neighbour who also didn't want to be named said that it's 'bad' that the new owners didn't honour the agreement not to demolish the house. 'That's pretty poor, actually, I think,' she said. 'I mean, they knew what they were going to be doing with it - that doesn't seem very honest.' Ash Bennett, Mr Abbott's former neighbour, a 54 year old air traffic controller said: 'I've lived here 18, 19 years. 'I was aware when they sold the house, I didn't know until more recently about what was going to happen to it. 'I didn't follow it closely, but my understanding was that there was an agreement it wasn't going to be knocked down and developed, it would be renovated which isn't what they wanted to do. 'Personally speaking, I would rather they wouldn't knock it down.' The father of three added that the house needs 'a lot of work'. He said: 'I went in it 18 years ago, nothing much has been done to it since. 'My understanding is it would require a lot of work to it.' On the planning application, Historic England said that there is no evidence to indicate that the building predates the 19th century - it is believed to have been built between 1840 and 1868. It said: 'The building does not illustrate an important aspect of the nation's history, nor does it have the historic associations with nationally important individuals, groups, or events, which might give it historic special interest.' A decision is due to be made about the planning application on July 18.
Auto Blog
34 minutes ago
- Auto Blog
BMW's M Division Is Working On A "Dream Car For Collectors"
By signing up I agree to the Terms of Use and acknowledge that I have read the Privacy Policy . You may unsubscribe from email communication at anytime. Something Should Succeed The Skytop Cast your mind back a decade to 2015, when the F82 M4 GTS was but a Pebble Beach concept. At that point, cars that cost seven figures were scarce, and Bimmers that cost six and didn't have a 7 on the back were non-existent. But nowadays, after selling every example of the – ahem – $750,000 BMW 3.0 CSL, getting several requests about the Concept Touring Coupe, and then finding resounding success with the Skytop and Speedtop, the Bavarians are poised to build on that momentum with something new, reports BMW Blog. What exactly remains to be seen, but it's described as a 'dream car' that will be 'for collectors.' It seems BMW is making hay while the sun shines. Production Crews Know It's Coming, Just Not When Source: BMW Sylvia Neubauer, Vice President of Customer, Brand, and Sales at M, reportedly told BMW Blog that BMW's small-series team had approved a limited-run M: 'We are discussing things, but we need to find the right time to do it. Be assured, we share the same dream and passion. We have been talking with Adrian van Hooydonk [Head of BMW Group Design] and the team who does the small series planning, and there is a slot reserved for BMW M.' As is typically the case with these sorts of projects, you need to build suspense. You don't hear the name of Oppenheimer, nor that it'll be shot on IMAX, before you hear that Christopher Nolan and Cillian Murphy are working on a new project. Getting the media talking about what the producers have in mind builds excitement, and in this case, it gets potential buyers calling to ask for a build slot. What To Expect, And What Not To Hope For BMW has ruled out the idea of reviving the M1 supercar. If it's to be a true supercar like the Audi R8 was (and may again be), it would need a unique chassis, or something close to it, and BMW is still a massive company built on efficiency, where economies of scale need to make sense. If this project is to be a stepping stone to building a department that could make an M1 happen, it needs to be financially viable, and there's still only so much money you can ask for an M. Thus, we can be sure that it will be based on something BMW already makes, which effectively rules out a supercar, but only for the time being, as Neubauer hints: Autoblog Newsletter Autoblog brings you car news; expert reviews and exciting pictures and video. Research and compare vehicles, too. Sign up or sign in with Google Facebook Microsoft Apple By signing up I agree to the Terms of Use and acknowledge that I have read the Privacy Policy . You may unsubscribe from email communication at anytime. 'We always think of where there might be potential markets for the future. Many times, we are doing this together with our [BMW] AG colleagues because we need some base car to then turn it into a high-performance model. There are some ideas we are discussing with our AG colleagues at the moment.' Our best guess? BMW is still deciding what to do for its 8 Series replacement. Some rumors have suggested that the 4 Series and the 8 Series will meet in the middle to become the reborn 6 Series, which is exactly what Mercedes did with the E-Class and C-Class coupes when it came up with the CLE. Once the bean counters decide where to go, and the M division knows what it has to work with, then – and only then – will we start to hear rumblings of what is really going on. Until then, anything is possible in this market – especially when there are third parties that can do the hard work of producing a bespoke chassis. Then again, working with a third party (Lamborghini) is what burned BMW the first time it tried to enter the supercar space. Whatever the special model may be, it can't be poorly timed, and it can't be overpriced. BMW hasn't missed in a while, so fingers crossed. About the Author Sebastian Cenizo View Profile
The Sun
an hour ago
- The Sun
Popular restaurant chain to close city centre location for good – months after closing three other sites
A POPULAR restaurant chain has closed one of its city centre locations for good just months after closing three other sites. The Botanist in Birmingham city centre has permanently closed with bosses saying it was a "difficult decision" to take. 2 2 It comes after the New World Trading Company (NWTC), who are responsible for the chain, closed sites in Coventry, Sheffield and Chester earlier this year. Diners have enjoyed a decade of cocktails, Sunday roasts and trademark hanging kebabs at the restaurant on Temple Street since April 2015. And customers have taken to social media in confusion after its sudden closure. One perplexed user said: "The Botanist in Birmingham (Temple Row) has just closed. "I had a booking and they just cancelled as they are permanently closing." The restaurant has disabled its social media profiles and is now listed as permanently closed on Google. It had earned a respectable 4.3 out of 5 stars on Google reviews from nearly 3,700 customers. One happy customer shared just two weeks ago: "This is my type of restaurant/bar. "I love the sophistication, dedication, decor, vibrancy, atmosphere and everything about this restaurant!" A spokesperson for New World Trading Company said: 'We have made the difficult decision to close our Birmingham, Temple Street site. "This decision has not been taken lightly, but we believe is in the best interests for the overall health of the business. 'We'd like to take this opportunity to thank all our customers for their support and custom over the years and we hope to welcome them to our other Birmingham site located at Gas Street Basin, soon.' The company also added that the closure only affects their Temple Street site. It comes as the NWTC closed sites in Coventry, Sheffield and Chester in January. And that followed the shuttering of three other sites in October 2024. The company has been undergoing a restructure after encountering difficulties and confirmed the bars were not profitable. In October 2024 New World Trading Centre agreed a Company Voluntary Arrangement (CVA), when it said it would refocus on its Botanist brand. Famous fast-food chain dubbed 'Britain's rudest restaurant' to close final UK branch and teases future plans A CVA is a restructuring measure that lets businesses continue to trade whilst also closing stores and pushing through rent cuts. The chain had experienced financial difficulties following the impact of the Covid-19 pandemic, rising inflation and the cost-of-living crisis. As well as closing sites the group has rebranded others and opened a new Botanist site in Bournemouth in May. It currently operates 24 sites under the Botanist brand and also operates other brands including the Oast House, and the Trading House. A swathe of other restaurants are also shutting this month including a huge Asian chain and beloved fine-dining spot. It comes as the restaurant industry struggles amid high energy prices, wholesale costs and tax hikes. What is happening to the hospitality industry? By Laura McGuire, consumer reporter MANY Food and drink chains have been struggling in recently as the cost of living has led to fewer people spending on eating out. Businesses had been struggling to bounce back after the pandemic, only to be hit with soaring energy bills and inflation. Multiple chains have been affected, resulting in big-name brands like Wetherspoons and Frankie & Benny's closing branches. Some chains have not survived, Byron Burger fell into administration last year, with owners saying it would result in the loss of over 200 jobs. Pizza giant, Papa Johns is shutting down 43 of its stores soon. Tasty, the owner of Wildwood, said it will shut sites as part of major restructuring plans
