Private Markets Can Withstand Shocks, Blue Owl's Clarke Says
The alternative assets industry is democratizing to allow individuals to take part in a full suite of investments, the firm's global head of institutional capital said in an interview on Bloomberg TV on Tuesday.
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$515M Bet on Musk, AI, and Space: Glade Brook Goes All-In While Others Retreat
Glade Brook Capital Partners just pulled in $515 million for its fourth fund and it's placing its bets on the edge of what's next: AI, space, defense, and fintech. The firm, which already holds stakes in SpaceX, Stripe, and Elon Musk's Neuralink, plans to double down on late-stage tech startups navigating some of the most volatile capital markets in recent memory. Founder Paul Hudson didn't sugarcoat the conditions, calling it the most challenging fundraising environment he's seen in his career even as the fund ended up oversubscribed. Despite the headwinds, Glade Brook is leaning into momentum. It's already backing Musk's xAI and Artisan AI, signaling a clear tilt toward artificial intelligence. That comes on top of a portfolio that includes ramping fintech player Ramp and previously backed giants like Uber (NYSE:UBER) and Airbnb (NASDAQ:ABNB). And in a move that tracks closely with broader market appetite, the firm is betting that innovation in complex, capital-intensive sectors like AI and defense could offer asymmetric upside if timed right. Tesla (NASDAQ:TSLA) remains part of the broader Musk-aligned orbit Glade Brook is exposed to, adding even more edge to its late-stage tech focus. Their 2021 fund a $430 million vehicle reportedly ranks in the top 5% of its vintage, according to private Cambridge Associates data. While past performance doesn't guarantee future returns, it does suggest Glade Brook knows how to play late-stage cycles. In a market where many VCs are stuck in wait-and-see mode, Glade Brook appears to be playing offense betting that when the next wave breaks, it'll be the firms already in position that ride it the farthest. This article first appeared on GuruFocus. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
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Next-Generation Sequencing Enhancing Accuracy, Precision Medicine Advancements Propel Growth
The global companion diagnostics market is set to surge from USD 7.03 Billion in 2024 to USD 22.83 Billion by 2034, driven by rising cancer prevalence and precision medicine advancements. Key trends include enhanced diagnostic technologies like NGS and PCR, regulatory approvals, and growing targeted therapies demand. Companion Diagnostics Market Dublin, July 23, 2025 (GLOBE NEWSWIRE) -- The "Companion Diagnostics Market Report and Forecast 2025-2034" report has been added to global companion diagnostics market was valued at USD 7.03 Billion in 2024, driven by the rising prevalence of cancer across the globe. The market is anticipated to grow at a CAGR of 12.50% during the forecast period of 2025-2034 to achieve a value of USD 22.83 Billion by 2034. Companion diagnostic tests help in the diagnosis of diseases and determines the most effective drug for a specific patient. These tests are crucial in cancer treatment, identifying biomarkers that indicate a patient's suitability for individualised treatment. Pharmaceutical companies integrate companion diagnostics into drug development to enhance efficacy, ensuring that only patients most likely to benefit receive targeted global companion diagnostics market is witnessing robust growth due to advancements in precision medicine and increasing demand for targeted therapies. Rising cancer prevalence, the need for biomarker-based diagnostics, and regulatory support for new test approvals drive market expansion. Moreover, the growing adoption of next-generation sequencing (NGS) and polymerase chain reaction (PCR) technologies further enhances diagnostic accuracy, enabling personalised treatment Drivers and Adoption TrendsThe companion diagnostic market is expanding due to rising demand for precision cancer treatments. Companies like Foundation Medicine lead innovations with products like FOUNDATIONONE CDx, which analyses cancer-related genes in solid tumors. Increasing regulatory approvals and advancements in companion diagnostic tests further support market growth. The rising prevalence of cancer has prompted greater adoption of companion diagnostics, ensuring effective treatment Approvals and COVID-19 ImpactThe U.S. FDA is approving novel companion diagnostic (CDx) tests, such as the Oncomine Dx Target Test by Thermo Fisher Scientific Inc., designed to detect HER2 (ERBB2) activating mutations in non-small cell lung cancer. However, the COVID-19 pandemic initially reduced demand for companion diagnostics products, delaying novel diagnostic tests. Despite this, the global companion diagnostics market is expected to recover and expand significantly during the forecast Companion Diagnostics Market TrendsExpanding IndicationsThe market is broadening beyond oncology to include neurological, cardiovascular, and infectious diseases. Regulatory approvals for new indications enable the development of biomarker-driven therapies, improving patient outcomes. This trend enhances diagnostic applications, supporting pharmaceutical innovations and expanding the market's potential across diverse therapeutic on Precision MedicineThe shift towards precision medicine is driving the demand for companion diagnostics, ensuring targeted drug selection. Advances in genomic profiling allow for personalised treatment plans, reducing adverse reactions and enhancing efficacy. Pharmaceutical companies increasingly integrate biomarker-based diagnostics to develop tailored therapies, improving patient care and optimising treatment Healthcare ExpendituresIncreasing healthcare investments globally support the growth of companion diagnostics, with governments and private entities funding research and development. The demand for early disease detection and advanced diagnostics drives higher spending, ensuring improved diagnostic capabilities and expanding access to innovative treatments, particularly in emerging in TechnologiesCutting-edge technologies like next-generation sequencing (NGS), artificial intelligence (AI), and digital pathology enhance the efficiency of companion diagnostics. Automated platforms enable faster, more accurate biomarker detection, supporting precision medicine. Continuous innovation in diagnostic tools strengthens the market, improving patient outcomes through highly specialised, data-driven Diagnostics Market Growth Factors Rising Cancer Incidence to Drive the Demand for Companion DiagnosticsThe increasing global burden of cancer is a key factor propelling the growth of the companion diagnostics market. According to the American Cancer Society, cancer cases are projected to reach 35 million by 2050, primarily due to population growth and ageing demographics. This surge in cases necessitates advanced diagnostic solutions for early detection, effective treatment, and improved patient outcomes. Companion diagnostics play a crucial role in guiding targeted therapies, ensuring personalised treatment strategies, and enhancing the efficacy of cancer technological advancements such as next-generation sequencing (NGS) and liquid biopsy techniques have further bolstered market expansion. These innovations facilitate rapid genetic profiling, helping oncologists identify specific biomarkers associated with different cancer types. The rising adoption of precision medicine by healthcare providers and pharmaceutical companies is also a significant growth driver. As demand for customised cancer treatments increases, the market for companion diagnostics is expected to expand Approvals for Novel Diagnostic Tests to Fuel Market ExpansionThe approval of new companion diagnostic tests for various indications is another critical factor driving market growth. Regulatory bodies such as the U.S. FDA, European Medicines Agency (EMA), and other global health authorities continue to approve innovative diagnostic solutions for targeted therapies. These approvals validate the clinical efficacy of companion diagnostics, increasing their adoption across healthcare facilities. The expanding pipeline of biomarker-driven therapies further encourages diagnostic companies to develop novel tests, contributing to overall market regulatory support ensures that new diagnostics meet stringent safety and accuracy standards, enhancing physician confidence in their effectiveness. Recent approvals of companion diagnostic assays for lung, breast, and colorectal cancers have provided patients with access to personalised treatment options. As pharmaceutical firms continue to collaborate with diagnostic developers, the market is poised for sustained growth, driven by innovation and regulatory Factors Challenges in Reimbursement Policies and Strict Regulatory Requirements Hindering Market GrowthThe companion diagnostics market faces significant challenges due to complex reimbursement policies. Many healthcare systems lack well-defined reimbursement frameworks for companion diagnostic tests, making it difficult for patients and healthcare providers to afford these tests. The high cost of developing and validating these diagnostics further complicates accessibility, limiting their widespread adoption. Additionally, variations in reimbursement policies across different countries create inconsistencies in market regulatory requirements act as another major barrier, as companion diagnostics must undergo rigorous approval processes to ensure accuracy and efficacy. Regulatory bodies such as the U.S. FDA, EMA, and other global agencies enforce strict guidelines, leading to prolonged approval timelines. Compliance with these complex regulations requires substantial investment and expertise, delaying market entry for new high cost of companion diagnostics is another critical factor restricting market expansion. Next-generation sequencing (NGS) and polymerase chain reaction (PCR) technologies involve expensive equipment and specialised expertise, making these diagnostics unaffordable for many healthcare institutions. The financial burden on smaller laboratories and emerging markets further limits accessibility, restricting the overall growth of the limited awareness and adoption rates in developing regions pose additional challenges. A lack of trained professionals, inadequate infrastructure, and limited integration of precision medicine hinder the widespread implementation of companion diagnostics. Addressing these barriers requires increased investment in education, regulatory simplifications, and improved reimbursement models to unlock the market's full potential. Key Industry Developments In October 2024, Roche secured FDA approval for its VENTANA Claudin 18 (43-14A) RxDx Assay, making it the first immunohistochemistry (IHC) companion diagnostic for CLDN18 protein expression in gastric and gastroesophageal junction adenocarcinoma patients. This breakthrough enabled eligible patients to receive Astellas' targeted therapy VYLOY (zolbetuximab), enhancing treatment precision in gastrointestinal cancers. In August 2024, Illumina, Inc. announced FDA approval of its TruSightT Oncology (TSO) Comprehensive test, a single in vitro diagnostic (IVD) that can profile over 500 genes in solid tumors. This test is designed to identify both adult and pediatric patients with solid tumors that have neurotrophic tyrosine receptor kinase (NTRK) gene fusions. If the test detects this, the patient may benefit from Bayer's VITRAKVI (larotrectinib). The test is also approved for identifying adult patients with advanced or metastatic non-small-cell lung cancer (NSCLC) that has rearranged during transfection (RET) gene fusions. These patients may benefit from treatment with Lilly's RETEVMO (selpercatinib). In August 2024, QIAGEN expanded its collaboration with AstraZeneca to develop companion diagnostics (CDx) for chronic diseases. Using QIAGEN's QIAstat-Dx platform, the partnership aimed at create a genotyping assay that facilitates real-time patient screening, helping healthcare providers determine patient eligibility for AstraZeneca's genomically targeted medicines, ultimately improving treatment accessibility and clinical decision-making. In July 2024, BD and Quest Diagnostics entered a global collaboration to develop flow cytometry-based companion diagnostics (CDx) for cancer and other diseases. This partnership aimed at providing an end-to-end CDx solution pharmaceutical companies. It ranged from exploratory panel development to FDA-approved diagnostic kit distribution, so as to advance precision medicine for better treatment selection. Key Attributes: Report Attribute Details No. of Pages 400 Forecast Period 2025 - 2034 Estimated Market Value (USD) in 2025 $7.03 Billion Forecasted Market Value (USD) by 2034 $22.83 Billion Compound Annual Growth Rate 12.5% Regions Covered Global Supplier Landscape Abbott F. Hoffmann-La Roche Ltd. Agilent Technologies, Inc. Illumina, Inc. Guardant Health Thermo Fisher Scientific Inc. BIOMERIEUX QIAGEN Myriad Genetics, Inc. Global Companion Diagnostics Market SegmentationMarket Breakup by Offerings Products Assays, Kits and Reagents Instruments & Systems Software Services Market Breakup by Technology Polymerase Chain Reaction Immunohistochemistry In Situ Hybridization Next-Generation Sequencing Others Market Breakup by Indication Cancer Neurological Diseases Infectious Diseases Others Market Breakup by End User Pharmaceutical & Biopharmaceutical Companies Reference Laboratories Contract Research Organizations Others Market Breakup by Region North America Europe Asia Pacific Latin America Middle East and Africa For more information about this report visit About is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Attachment Companion Diagnostics Market CONTACT: CONTACT: Laura Wood,Senior Press Manager press@ For E.S.T Office Hours Call 1-917-300-0470 For U.S./ CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900Sign in to access your portfolio
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ASX jumps as Trump talks trade deals
Australia's sharemarket jumped in line with the Asian markets, after US President Donald Trump announced a 'massive deal' with Japan. The benchmark ASX 200 gained 60 points or 0.69 per cent to finish trading on Wednesday at 8,737.20, while the broader All Ordinaries climbed 59.90 points or 0.67 per cent to close at 9,001.49. Australia's dollar rose 0.13 per cent and at the time of writing was buying 65.62 US cents. In an agreement between the US and Japan, the US will impose a 15 per cent levy on Japanese imports, down from 25 per cent. Japan in return will invest $US550bn into the United States. Stocks on Japan's Nikkei index rallied and the yen leapt on the news the country was able to sort a trade deal with Mr Trump, including on the critical car manufacturing sector. Last year, cars shipped to the US were around 28 per cent of Japan's 21.3 trillion yen of total exports to the world's largest economy. Global X senior investment strategist Billy Leung said Japanese equities hit a record high on Wednesday on the back of the announcement. 'This isn't just about a one-day rally. Japan is the world's largest robot manufacturing country and its role in global tech supply chains especially in high-precision manufacturing and automation makes it a key beneficiary of both tariff clarity and the broader reconfiguration of US-aligned production,' he said Australia's sharemarket followed with 10 of the 11 sectors gaining, led by the miners, banks and energy sector. The big three iron ore miners all finished in the green, with BHP up 0.9 per cent to $41.85, Rio Tinto gaining 1 per cent to $119.47 and Fortescue gaining 2.3 per cent to $18.21. Woodside Energy shares were up 1.45 per cent to $25.21, Yancoal Australia jumped 2.81 per cent to $6.58 and Whitehaven Coal soared 6.53 per cent to $7.18. On an overall strong day for the financial sector, three of the four major banks gained during Wednesday's trading. Commonwealth Bank shares finished 0.51 per cent higher trading at $173.30, Westpac shares gained 1.41 per cent to $33.11 and ANZ soared 2.52 per cent to $30.57. NAB slipped 0.05 per cent to $37.20. In company news, shares in Telix Pharmaceuticals plunged 15.13 per cent to $21.32 after it told the market it had received a subpoena from the US Securities and Exchange Commission for various documents primarily related to the company's disclosure regarding its prostate cancer therapy. Shares in Australia's top fuel retailer Ampol Limited rallied 3.27 per cent to $27.77 despite telling the market it forecasts weaker half yearly earnings on the back of sea-freight conditions impacting its supply chains. Iluka Resources jumped 4.05 per cent to $5.39 after the global critical minerals business after telling the market it achieved its full-year production guidance for Zircon by June 30. Sign in to access your portfolio
