India expands use of AstraZeneca's drug for advanced breast cancer cases
AstraZeneca Pharma India has received approval from India's drug regulator to expand the use of a breast cancer treatment that could bring new hope to many women with advanced disease.The medicine, Trastuzumab deruxtecan, was already available for some breast and stomach cancers.Now, it has been approved to treat more patients, specifically adults with HER2-low or HER2-ultralow metastatic breast cancer who have already tried hormone-based treatment.advertisement
This approval by the Central Drugs Standard Control Organisation (CDSCO) means more patients in India with hard-to-treat breast cancers can access the drug.WHAT IS HER2-LOW BREAST CANCER?HER2 is a protein found on the surface of some cancer cells. When levels of HER2 are high, certain targeted treatments can work. However, many patients have low or very low levels of this protein, these are known as HER2-low or HER2-ultralow cancers.Until recently, there were limited treatment options for these patients. But this drug offers a targeted approach even in those with lower HER2 levels.THE SCIENCE BEHIND THE APPROVALThe decision is based on results from a large international study called DESTINY-Breast06, which compared Trastuzumab deruxtecan with standard chemotherapy.The trial involved patients who had already received at least one hormone therapy but no chemotherapy for their metastatic cancer.advertisementThe results were promising:Patients who took Trastuzumab deruxtecan lived longer without the disease getting worse.For those with HER2-low breast cancer, the average time without disease progression was 13.2 months, compared to 8.1 months for those on chemotherapy.The risk of disease progression or death was reduced by nearly 40%.Dr. Sandeep Arora, Director of Medical Affairs at AstraZeneca India, said, "This approval marks a shift in how we treat advanced breast cancer in India. It highlights the importance of testing tumors for even minimal HER2 expression to identify patients who may benefit."WHY THIS MATTERS IN INDIABreast cancer is the most commonly diagnosed cancer worldwide, with over 2 million cases in 2020, according to the World Health Organisation. In India, the number of breast cancer cases has risen by 40% in the past 25 years.Dr. Sanjeev Panchal, Managing Director of AstraZeneca India, called it part of a broader effort to "follow the science" and deliver better, more personalised cancer care.The drug was first introduced in India in 2024 and is now approved for three types of breast and gastric cancers. Experts hope that with wider use, this medication could significantly improve survival rates for women with advanced breast cancer.advertisementDoctors say it will now be important to test tumors for HER2 expression, even at very low levels, to identify who could benefit from this treatment.While not a cure, Trastuzumab deruxtecan represents another important step in making breast cancer treatment more precise and more effective for Indian patients.
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Hindustan Times
31 minutes ago
- Hindustan Times
How monsoons may increase risk of migraines
Migraine is a chronic neurological condition that affects millions globally, and India is no exception. With the onset of monsoons, many individuals report an uptick in migraine episodes, often linked to environmental triggers. While the cool, rainy season brings relief from the scorching summer, it also introduces significant changes in air pressure, humidity, and stress levels—factors that can exacerbate migraine symptoms. Migraine(Image by Pixabay) Understanding how monsoons impact migraine sufferers can help individuals take proactive measures to minimise discomfort and improve their quality of life. Monsoons introduce a unique set of environmental challenges that can lead to frequent and severe migraine episodes. Some key triggers during this season include: Changes in barometric pressure--One of the most commonly cited triggers is sudden shifts in air pressure. The drop in atmospheric pressure can cause chemical and vascular changes in the brain, increasing the likelihood of migraine attacks. Studies indicate that a decrease in barometric pressure can lead to vasodilation in the brain's blood vessels, which is a significant factor in migraine onset. Increased humidity levels--Humidity levels spike during the monsoon season, leading to dehydration, excessive sweating, and electrolyte imbalances. Since hydration plays a crucial role in preventing migraines, inadequate fluid levels can easily trigger an episode. A report by the Indian Meteorological Department (IMD) indicates that monsoon humidity levels in cities like Mumbai and Chennai often exceed 80%, which can contribute to increased migraine complaints. Rise in allergens and airborne pollutants--Monsoon dampness encourages the growth of mold and mildew, while stagnant water leads to an increase in air pollution. These environmental irritants can inflame the sinuses and exacerbate migraine symptoms. Data from the National Environmental Engineering Research Institute (NEERI) suggests that air pollution levels spike in Indian metropolitan areas during the monsoons due to increased moisture and microbial activity. Disruptions in sleep patterns--Rainy weather, power outages, and gloomy skies contribute to irregular sleep cycles. Poor sleep quality is a known trigger for migraines, as it can lead to hormonal imbalances and heightened stress levels. A study published in the Indian Journal of Neurology highlights that sleep irregularities are one of the top three non-food-related triggers for migraines among Indian patients. Dietary shifts and emotional stress--Monsoons bring food cravings—particularly for fried and processed snacks high in preservatives. These foods can trigger migraines in sensitive individuals. 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A leading neurologist recommends five expert-backed strategies for effective migraine management during the rainy season: Maintain a consistent routine--Irregular sleeping and eating habits disrupt the body's natural rhythm, increasing the likelihood of migraines. Sticking to a structured schedule helps regulate energy levels and prevent unnecessary triggers. Stay hydrated and avoid processed foods--Water is essential for maintaining electrolyte balance and reducing inflammation. Avoiding dehydrating drinks like caffeine and alcohol, along with processed foods high in preservatives, can keep migraine episodes at bay. Manage stress through mindfulness--Yoga, meditation, and deep breathing techniques can help alleviate stress, which is one of the primary migraine triggers. Incorporating relaxation practices into daily life can significantly lower the chances of monsoon-induced headaches. 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Prioritising preventive health care, identifying triggers, and seeking medical advice can help migraine sufferers enjoy the rainy season without the debilitating effects of chronic headaches. If migraine symptoms persist despite precautions, professional consultation remains the best course of action for effective long-term management. This article is authored by Dr Ramesh Babu Mutiki, senior consultant neuro physician, Apollo Hospitals, Visakhapatnam.
NDTV
2 hours ago
- NDTV
How Haldi Kalonji Water Helps Ease Menstrual Discomfort, Naturally
For many women, periods are more than just a monthly inconvenience. They come with a host of physical symptoms, including cramps, bloating, back pain, fatigue, and mood swings. In fact, menstrual pain, known as dysmenorrhea, is so common that around 70-80 percent of adolescent girls in India experience it, according to the Indian Journal of Community Medicine. Most women rely on quick fixes like painkillers, hot water bags, or even rest days. But there is a growing interest in natural remedies that are gentle on the body and easy to prepare at home. One such traditional remedy gaining attention is Haldi Kalonji Water - a simple herbal drink made using turmeric (haldi) and black seeds (kalonji). Let's explore its benefits in detail. Also Read: Tired Of Period Cramps? 5 Drinks That May Help You Reduce Menstruation Pain What Is Haldi Kalonji Water? Haldi Kalonji water is exactly what it sounds like. It is water infused with haldi and kalonji, sometimes with a touch of black pepper. It is typically consumed warm, once or twice a day, especially during menstruation. Why Turmeric? Turmeric has been a staple in Indian kitchens and Ayurvedic medicine for centuries. Its bright yellow compound, curcumin, is well known for its anti-inflammatory, antioxidant, and pain-relieving properties. Why Kalonji? Nigella seeds, or kalonji, are used in Unani and Ayurvedic systems to manage a variety of ailments. They are known for supporting digestive health, balancing hormones, and boosting the immune system. Also Read: Nutritionist Rujuta Diwekar Shares 5 Simple Tips For Natural Period Pain Relief Photo Credit: iStock Benefits Of Haldi Kalonji Water During Periods: 1. Helps reduce inflammation and pain: Cramps during periods are caused by prostaglandins - hormone-like compounds that trigger uterine contractions. Curcumin, the active ingredient in turmeric, acts as a natural anti-inflammatory and helps reduce prostaglandin production. A study in the journal Complementary Therapies in Clinical Practice found that curcumin significantly reduced the severity and duration of menstrual pain when taken regularly. Additionally, turmeric supports liver health, which may aid in hormone regulation. 2. Supports hormonal balance and eases discomfort: Kalonji possesses analgesic (pain-relieving) and antispasmodic (muscle-relaxing) properties. According to the Avicenna Journal of Phytomedicine, Nigella sativa oil reduced pain intensity in women with primary dysmenorrhea. Kalonji is also believed to regulate menstrual cycles and reduce bloating. Additional Benefits Of Haldi-Kalonji Water Durind Periods: 1. Improves digestion: Periods can disrupt gut function, leading to constipation or diarrhoea. Both turmeric and kalonji can promote digestive health and relieve gas. 2. Boosts mood and energy: Curcumin influences neurotransmitters like serotonin and dopamine, which may help manage PMS-related mood swings and fatigue. 3. Strengthens immunity: Rich in antioxidants, haldi and kalonji may help the body fight infections, especially when energy levels dip. 4. Reduces bloating and water retention: Kalonji acts as a mild diuretic, aiding in the elimination of excess water. Also Read: 5 Powerful Ingredients to Regulate Your Periods - Plus, A Simple Tea Recipe To Try Photo Credit: iStock How To Make Haldi Kalonji Water At Home Boil one glass of water. Turn off the flame and add half tsp turmeric and one-fourth tsp kalonji. Optional: Add a pinch of black pepper to enhance curcumin absorption. Stir well and let it steep for 5-10 minutes. Strain into a glass and drink it warm, preferably in the morning or at bedtime. Who Should Avoid It? While generally safe, those with low blood pressure or kidney issues should be cautious, as kalonji and turmeric may aggravate these conditions. People taking blood thinners or diabetes medications should consult a healthcare professional before including this drink in their routine, as interactions may occur. The Bottom Line: Not A Miracle Cure, But A Time-Tested Remedy The blend of turmeric's anti-inflammatory strength with kalonji's hormonal support makes this a gentle yet effective ally during menstruation. However, every body is different. What works wonders for one person may have limited effects for another. So, before adding any remedy to your daily routine, it is best to consult a medical professional. Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your doctor for more information. NDTV does not claim responsibility for this information. Advertisement About Somdatta Saha Explorer- this is what Somdatta likes to call herself. Be it in terms of food, people or places, all she craves for is to know the unknown. A simple aglio olio pasta or daal-chawal and a good movie can make her day. For the latest food news, health tips and recipes, like us on Facebook or follow us on Twitter and YouTube. Tags: Haldi Kalonji Water Natural Remedy Period Pain Show full article Comments
Time of India
3 hours ago
- Time of India
Ayurveda gets the spotlight in new documentary, The Double Helix of Life
A powerful new documentary on Ayurveda—Ayurveda: The Double Helix of Life—just had its grand premiere in New Delhi. Clocking in at 90 minutes and shot in English, the film dives deep into how this ancient Indian system of medicine might just be the answer to some of modern healthcare's biggest challenges. The premiere took place at the Film Division Theatre. Union Minister of State for AYUSH and Health & Family Welfare, Prataprao Jadhav, and AYUSH Secretary Rajesh Kotecha were there to do the honors, alongside a lineup of dignitaries from the health and wellness space. The film, produced by Dr. A.V. Anoop under AVA Productions in collaboration with the Ayurvedic Medicine Manufacturers Organisation of India (AMMOI), is directed by Vinod Mankara. Attendees included major voices in the Ayurvedic and medical world—Dr. P Ramkumar (AMMOI President), E.T. Neelakandan Moos (AMMOI Treasurer), Prof. Rabinarayan Acharya (Director General of CCRAS), Padma Shri Vaidya Balendu Prakash, Sanjay Shrivastava of Maharishi Ayurveda , and Promod Sharma from Baidyanath. So, what's the big message? That Ayurveda isn't just about herbal powders and yoga poses—it's a holistic, preventive approach backed by actual research. The film busts common myths that Ayurveda is all belief and no science, and instead shows how it's supported by over a thousand peer-reviewed studies, modern lab testing, and real-world case stories. With chronic illnesses like diabetes, arthritis, and autoimmune diseases draining healthcare systems across the U.S., Germany, and Switzerland, The Double Helix of Life argues that Ayurveda offers something mainstream medicine often lacks—prevention. And when it's supported by evidence, it's not just effective—it's cost-efficient and low on side effects too. 'Ayurveda gives us tools to not just treat, but prevent disease,' says Dr. A.V. Anoop. 'It's time to shift from managing symptoms to addressing root causes.' Director Vinod Mankara adds, 'This film isn't just about looking back at tradition—it's about looking ahead. Ayurveda is already included in wellness insurance in countries like Germany and Switzerland. In India, it's part of the Ayushman Bharat mission. It can really ease the pressure on our public health system.'
