An end to migraines, cravings and brain fog: New pill hope for the cruel condition as scientists hail breakthrough that cuts symptoms
But there is also a lesser-known period, the premonitory, or prodromal phase, with its own set of debilitating symptoms – including brain fog and fatigue, mood changes (irritability and anxiety), neck pain, dizziness, passing more urine and yawning.
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Reuters
20 minutes ago
- Reuters
Summit, AstraZeneca in talks over $15 billion cancer drug licensing deal, Bloomberg News reports
July 3 (Reuters) - AstraZeneca (AZN.L), opens new tab is in talks with Summit Therapeutics (SMMT.O), opens new tab to license an experimental lung-cancer drug under a deal worth as much as $15 billion, Bloomberg News reported on Thursday, citing people familiar with the matter. Shares of Summit Therapeutics surged 9.7% to $25.81 in morning trade. The Menlo Park, California-based drug developer did not immediately respond to Reuters' request seeking comment, while an AstraZeneca spokesperson declined to comment. A deal could include an upfront payment of several billion dollars to Summit, besides milestone payments later on, Bloomberg News said. The talks could still fall apart or Summit could opt for a different partner for licensing, according to the report. The negotiations involve ivonescimab, a drug Summit secured rights for through a separate deal worth up to $5 billion with China-based Akeso ( opens new tab in December 2022. Summit is testing ivonescimab to treat patients with a type of lung cancer who have received prior treatment. The drug has already been approved in China in May last year, and Summit plans to file for marketing approval in the United States. In a late-stage study, ivonescimab, in combination with chemotherapy, showed a positive trend in overall survival, but "without achieving a statistically significant benefit," the company said in May. An earlier data last year had shown some lung cancer patients having better survival rates on the drug than those on Merck's (MRK.N), opens new tab blockbuster Keytruda. Summit and Akeso were testing ivonescimab-chemotherapy regime in a study conducted in China, against BeiGene's ( opens new tab approved drug Tevimbra in combination with chemotherapy.
The Independent
25 minutes ago
- The Independent
Your holiday cookout could be killing you
Could your Fourth of July cookout lead to an early death? Estimates from the National Hot Dog and Sausage Council show Americans consume some 150 million hot dogs during the holiday weekend. Now, researchers say that eating any processed meat and other foods leaves Americans at a heightened risk for chronic conditions, including type 2 diabetes, ischemic heart disease, and colorectal cancer. The conditions result in the deaths of hundreds of thousands of people each year. 'Habitual consumption of even small amounts of processed meat, sugary drinks, and trans fatty acids is linked to increased risk of developing type 2 diabetes, ischemic heart disease and colorectal cancer,' Dr. Demewoz Haile, a research scientist at the Institute for Health Metrics and Evaluation in Seattle, told CNN this week. Analyzing data from more than 60 previous related studies, the researchers found that eating processed meat – as little as just one hot dog a day – was associated with at least an 11 percent average increase in type 2 diabetes risk and a 7 percent increase in colorectal cancer risk. Those who drank a sugar-sweetened beverage had an 8 percent average increase in type 2 diabetes risk and a 2 percent increase in ischemic heart disease risk. The study builds on years of research tying processed foods to higher risks of obesity, heart disease, diabetes, and even cancer. The Dietary Guidelines recommend limiting these foods and drinks, including sodas, hot dogs, and sausages. Although, researchers say it remains unclear exactly what aspects of processed foods pose potential health risks. It could be due to inflammation, Dr. Minyang Song, an associate professor of clinical epidemiology and nutrition at the Harvard T.H. Chan Schoo of Public Health, told CNN. He was not involved in the latest study. Processed meats also often contain chemicals known as nitrates nitrites that serve as a preservative and give the meat its rosy color. 'Nitrates convert to nitrites, and in the stomach's acidic environment, nitrites interact with certain components concentrated in meat to form N-nitroso compounds, which are potential carcinogens,' according to Harvard Medical School. Dr. Walter Willett, a professor of nutrition and epidemiology at the Harvard T.H. Chan School of Public Health, points out that processed meats contain other additives and are high in sodium, which is a risk factor for high blood pressure and heart disease. Dr. Ashkan Afshin, an assistant professor at the institute who was not a co-author of the new study, previously found that poor diet is responsible for more deaths globally than tobacco, high blood pressure, or any other health risk. "Poor diet is an equal opportunity killer," he said in 2019. "We are what we eat and risks affect people across a range of demographics, including age, gender, and economic status."
The Guardian
28 minutes ago
- The Guardian
Twelve key takeaways from Labour's 10-year NHS plan
The 10-year NHS plan aims to make healthcare more digital, focus on preventing ill health and provide more services locally, rather than in hospitals. It will greatly expand the NHS app and increase the use of AI and other technology. Structural changes aim to bring routine healthcare closer to patients, with the aim that most outpatient care will happen outside hospitals, while new neighbourhood health centres will provide most services so that acute hospitals can focus on looking after the most unwell. The main measures include: The NHS app will be expanded to become a 'doctor' in patients' pockets. A new part of it, My NHS GP, will use AI to help people navigate the service better, taking patients' symptoms, asking questions and providing guidance. Patients will also be able to use the NHS app to book remote or face-to-face appointments, manage prescriptions, enrol in a clinical trial and check their vaccines are up to date. They will be able to book urgent appointments rather than wait for hours in A&E, with services able to triage patients in advance. The plan claims that ending the '8am scramble for a GP appointment' and allowing patients to book an appointment digitally, rather than via 'today's convoluted process', would save £200m over three years. Patients will be able to choose where they have their care, in a section of the app called My Choices. To help them choose, from this summer, the NHS will publish easy-to-understand 'league tables'. The NHS app will also provide data on waiting times, patient ratings and quality of care, including data on particular clinical teams and clinicians. Complaints processes will be speeded up. The NHS will once again grapple with integrating IT across a disparate health and care system. Ministers announced a new law would be passed to ensure all providers of health and care services have to log any patient information they hold on a'single patient record'. From 2028, patients, as well as health and care professionals, will be able to access this record on the NHS app, which will hold their medical records, personal health risk and other data. Pharmacies will be given more responsibility to manage long-term conditions, which will also be linked to the single patient record. The plan ends the need for GPs to refer patients for some outpatient services. Anyone will be able to use the NHS app to self-refer for musculoskeletal issues, podiatry, audiology and mental health talking therapies in a move that ministers hope will 'dramatically slash' waiting lists and free up GPs and the new neighbourhood health services. The red book – which provides a physical record of babies' and children's development – will be digitised, with parents able to access their child's medical records via the NHS app. The app will also provide advice and guidance on weaning, healthy habits and will eventually record feeding times, sleep patterns and offer advice when children are unwell. Hospitals will be 'freed up' to make greater use of AI and other new technology. AI scribes will be used for administrative tasks such as filling in patient notes and writing letters, making AI 'every nurse's and doctor's trusted assistant' to save them time and help them in decision-making. Greater use will be made of genomic sequencing, with a view to make it universal for all newborns. Wearables are to become standard in preventive, chronic and post-acute NHS treatment by 2035, with all NHS patients given access to them. Devices will be given for free in areas with the highest health and deprivation. The use of surgical robots will be expanded from 2026. About 180,000 people currently have a personal budget, allowing them to decide how to spend money for their care on things such as physiotherapy, mobility aids, a particular wheelchair or activities. But too few people get personal health budgets. Ministers want to double the number of people offered these personal budgets by April 2029, with 1 million patients offered them by 2030. By 2035, ministers want the budgets to be available to everyone entitled to them. Across England, 250-300 neighbourhood health centres will be established, ministers announced, with 50 up and running by 2029, providing a single place for more 'integrated' care, available at least 12 hours a day, six days a week. They will be staffed by GPs, nurses, physios, care workers, mental health workers and employment advisers. The cost of each centre will vary 'from the low millions to around £20m', the health secretary, Wes Streeting, said, 'depending on whether it's an upgrade, a refurb, an expansion, or indeed a new-build'. The aim is to 'end hospital outpatients as we know it' by 2035. Urgent treatment centres and other same-day emergency care services that prevent patients needing to be admitted to acute hospitals will also be expanded. The plan promises to end what it describes as 'the disgraceful spectacle of corridor care' and to bring back the NHS target for 92% of patients to begin treatment within 18 weeks of referral. The plan announced £120m to be spent on about 85 mental health emergency departments, so people do not end up in A&E. Mental health support teams in school and young futures hubs will be expanded to increase support for children's mental health. The NHS will negotiate new contracts to enable more people to access weight loss jabs. People will be encouraged to become healthier through a new 'health reward scheme'. Junk food advertising targeted at children will be restricted, the sale of high-caffeine energy drinks to under-16s will be banned and mandatory health food sales reporting will be introduced for large food companies. Alcoholic drinks will have to display consistent nutritional information and health warnings, while the no-alcohol and low-alcohol market will be encouraged. The plan will create 2,000 more nursing apprenticeships, 1,000 speciality training posts, and expand medical school places, prioritising UK students. Thousands more GPs will be trained and the number of nurse consultants will be expanded. Recruitment from overseas is to be limited to 10% by 2035. Dentists trained in the UK will have to work for the NHS for three years.
