Central Garden & Pet to Announce Q3 Fiscal 2025 Financial Results
A live webcast, replay and related materials will be available at http://ir.central.com. To join by phone, please dial +1 (201) 689-8345 for both domestic and international participants.
About Central Garden & Pet
Central Garden & Pet Company (NASDAQ: CENT) (NASDAQ: CENTA) understands home is central to life and has proudly nurtured happy and healthy homes for over 45 years. With fiscal 2024 net sales of $3.2 billion, Central is on a mission to lead the future of the pet and garden industries. The Company's innovative and trusted products are dedicated to helping lawns grow greener, gardens bloom bigger, pets live healthier, and communities grow stronger. Central is home to a leading portfolio of more than 65 high-quality brands including Amdro ®, Aqueon ®, Cadet ®, C&S ®, Farnam ®, Ferry-Morse ®, Four Paws ®, Kaytee ®, Nylabone ® and Pennington ®, strong manufacturing and distribution capabilities, and a passionate, entrepreneurial growth culture. Central is based in Walnut Creek, California, with over 6,000 employees primarily across North America. Visit www.central.com to learn more.
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Pipeline Updates Myeloproliferative Neoplasms (MPNs) and Graft-Versus-Host Disease (GVHD) – key highlights In June 2025, data from the Phase 1 study evaluating INCA033989 in mutCALR positive patients with essential thrombocythemia (ET) were presented during a late-breaking session at the 2025 European Hematology Association (EHA) Congress in Milan, Italy. The data showed rapid and durable normalization of platelet counts across all dose levels and importantly, a reduction in peripheral blood mutCALR variant allele frequency (VAF) correlating with hematologic response. INCA033989 was well tolerated with a favorable safety profile with no dose limiting toxicities reported. Together, the data demonstrates the potential of INCA033989 for disease modification by directly inhibiting and eliminating oncogenic mutCALR cells, while sparing healthy cells and restoring normal blood cell production. 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Inflammation and Autoimmunity (IAI) – key highlights Ruxolitinib Cream In April 2025, Incyte announced positive topline results from the Phase 3 (TRuE-AD4) study evaluating ruxolitinib cream in adult patients with moderate atopic dermatitis. The study met the co-primary endpoints at Week 8, with a statistically significant proportion of patients achieving both Investigator's Global Assessment Treatment Success (IGA-TS) and EASI75, which is defined as a 75% or greater improvement in the Eczema Area Severity Index score from baseline. In addition, the study met all key secondary endpoints. Ruxolitinib cream was well tolerated with no new safety signals. The full dataset will be presented at an upcoming medical conference. In June 2025, two Phase 3 studies (TRuE-HS2 and TRuE-HS2) evaluating ruxolitinib cream in mild to moderate hidradenitis suppurativa (HS) were initiated and are ongoing. In June 2025, the FDA extended the review period for the supplemental New Drug Application (sNDA) for ruxolitinib cream (Opzelura) for the treatment of children 2-11 years old with mild to moderate atopic dermatitis (AD). The Prescription Drug User Fee Act (PDUFA) action date was extended by three months to September 19, 2025. Povorcitinib (INCB54707) Two Phase 3 studies (STOP-V1 and STOP-V2) evaluating povorcitinib versus placebo in patients with vitiligo are ongoing. The Phase 3 data are anticipated in 2026. Two Phase 3 studies (STOP-PN1 and STOP-PN2) evaluating povorcitinib versus placebo in patients with PN are ongoing. The Phase 3 data are anticipated in 2026. A Phase 2 trial evaluating povorcitinib in asthma is ongoing. Data are anticipated in the second half of 2025. IAI and Dermatology Programs Indication and status Ruxolitinib cream (Opzelura)1 (JAK1/JAK2) Atopic dermatitis: Phase 3 pediatric study (TRuE-AD3); sNDA under review in the U.S. Hidradenitis suppurativa: Phase 3 (TRuE-HS1, TRuE-HS2) Prurigo nodularis: Phase 3 (TRuE-PN1, TRuE-PN2) Povorcitinib (JAK1) Hidradenitis suppurativa: Phase 3 (STOP-HS1, STOP-HS2) Vitiligo: Phase 3 (STOP-V1, STOP-V2) Prurigo nodularis: Phase 3 (STOP-PN1, STOP-PN2) Chronic spontaneous urticaria: Phase 2 Asthma: Phase 2 INCA034460 (anti-CD122) Vitiligo: Phase 1 1 Novartis' rights to ruxolitinib outside of the United States under our Collaboration and License Agreement with Novartis do not include topical administration. Other Other Program Indication and Phase Zilurgisertib (ALK2) Fibrodysplasia ossificans progressiva: Pivotal Phase 2 2025 Second Quarter Financial Results The financial measures presented in this press release for the three and six months ended June 30, 2025 and 2024 have been prepared by the Company in accordance with U.S. Generally Accepted Accounting Principles ("GAAP"), unless otherwise identified as a Non-GAAP financial measure. Management believes that Non-GAAP information is useful for investors, when considered in conjunction with Incyte's GAAP disclosures. Management uses such information internally and externally for establishing budgets, operating goals and financial planning purposes. These metrics are also used to manage the Company's business and monitor performance. The Company adjusts, where appropriate, for expenses in order to reflect the Company's core operations. The Company believes these adjustments are useful to investors by providing an enhanced understanding of the financial performance of the Company's core operations. The metrics have been adopted to align the Company with disclosures provided by industry peers. Non-GAAP information is not prepared under a comprehensive set of accounting rules and should only be used in conjunction with and to supplement Incyte's operating results as reported under GAAP. Non-GAAP measures may be defined and calculated differently by other companies in our industry. As changes in exchange rates are an important factor in understanding period-to-period comparisons, Management believes the presentation of certain revenue results on a constant currency basis in addition to reported results helps improve investors' ability to understand its operating results and evaluate its performance in comparison to prior periods. Constant currency information compares results between periods as if exchange rates had remained constant period over period. The Company calculates constant currency by calculating current year results using prior year foreign currency exchange rates and generally refers to such amounts calculated on a constant currency basis as excluding the impact of foreign exchange or being on a constant currency basis. These results should be considered in addition to, not as a substitute for, results reported in accordance with GAAP. Results on a constant currency basis, as the Company presents them, may not be comparable to similarly titled measures used by other companies and are not measures of performance presented in accordance with GAAP. Financial Highlights Financial Highlights (unaudited, in thousands, except per share amounts) Three Months Ended June 30, Six Months Ended June 30, 2025 2024 2025 2024 Total GAAP revenues $ 1,215,529 $ 1,043,759 $ 2,268,427 $ 1,924,648 Total GAAP operating income (loss) 530,314 (478,130 ) 735,482 (386,232 ) Total Non-GAAP operating income (loss) 382,579 (378,801 ) 666,220 (217,618 ) GAAP net income (loss) 404,999 (444,601 ) 563,202 (275,053 ) Non-GAAP net income (loss) 311,927 (396,132 ) 541,386 (263,413 ) GAAP basic EPS $ 2.09 $ (2.04 ) $ 2.91 $ (1.24 ) Non-GAAP basic EPS $ 1.61 $ (1.82 ) $ 2.79 $ (1.19 ) GAAP diluted EPS1 $ 2.04 $ (2.04 ) $ 2.84 $ (1.24 ) Non-GAAP diluted EPS1 $ 1.57 $ (1.82 ) $ 2.73 $ (1.19 ) 1 All stock options and stock awards were excluded from the diluted share calculation for the three and six months ended June 30, 2024 because their effect would have been anti-dilutive, as we were in a net loss position. Revenue Details Revenue Details (unaudited, in thousands) Three Months Ended June 30, %Change(asreported) %Change(constantcurrency)1 Six Months Ended June 30, %Change(as reported) %Change(constantcurrency)1 2025 2024 2025 2024 Net product revenues: Jakafi $ 763,788 $ 705,973 8 % NA $ 1,473,200 $ 1,277,812 15 % NA Opzelura 164,499 121,695 35 % 34 % 283,204 207,419 37 % 36 % Iclusig 32,729 26,862 22 % 16 % 62,273 57,205 9 % 8 % Pemazyre 22,192 20,269 9 % 8 % 40,632 37,945 7 % 7 % Minjuvi/ Monjuvi 31,131 31,116 0 % (1 %) 60,682 54,990 10 % 10 % Niktimvo 36,154 — NM NA 49,767 — NM NA Zynyz 8,921 651 1,270 % NA 11,930 1,118 967 % NA Total net product revenues 1,059,414 906,566 17 % 16 % 1,981,688 1,636,489 21 % 21 % Royalty revenues: Jakavi 109,714 99,317 10 % 7 % 201,859 188,912 7 % 8 % Olumiant 33,482 31,702 6 % 4 % 64,282 62,291 3 % 5 % Tabrecta 6,632 5,298 25 % NA 13,045 10,532 24 % NA Other 1,287 876 47 % NM 2,553 1,424 79 % NM Total royalty revenues 151,115 137,193 10 % 281,739 263,159 7 % Total net product and royalty revenues 1,210,529 1,043,759 16 % 2,263,427 1,899,648 19 % Milestone and contract revenues 5,000 — NM NM 5,000 25,000 (80 %) (80 %) Total GAAP revenues $ 1,215,529 $ 1,043,759 16 % $ 2,268,427 $ 1,924,648 18 % NM = not meaningful NA = not applicable 1 Percentage change in constant currency is calculated using 2024 foreign exchange rates to recalculate 2025 results. Product and Royalty Revenues Total net product revenues for the quarter ended June 30, 2025 increased 17% over the prior year comparative period. Total net product and royalty revenues for the quarter ended June 30, 2025 increased 16% over the prior year comparative period, primarily driven by the following: Jakafi net product revenue increased 8% versus the prior year comparable period, driven by an increase in paid demand of 8% reflecting continued demand growth in all indications. Jakafi inventory levels were within normal range at the end of the second quarter of 2025. Opzelura net product revenue increased 35% due to increased patient demand and refills in the U.S. in both AD and vitiligo, and increased contribution from ex-U.S. driven by continued uptake in France, and growth from the recent launches in Italy and Spain. Opzelura inventory levels were within normal range at the end of the second quarter of 2025. Niktimvo net product revenue reflects continued strong uptake of the product following its commercial launch during the first quarter of 2025. Zynyz net product revenue increase driven by the approval of the product in squamous cell anal carcinoma in the second quarter of 2025. Total royalty revenues for the quarter increased 10% versus the prior year comparable period, primarily driven by growth in Jakavi royalty revenue. Operating Expenses Operating Expense Summary (unaudited, in thousands) Three Months Ended June 30, %Change Six Months Ended June 30, %Change 2025 2024 2025 2024 GAAP cost of product revenues $ 78,766 $ 76,634 3 % $ 151,954 $ 137,590 10 % Non-GAAP cost of product revenues1 72,544 70,899 2 % 139,489 125,858 11 % Contract dispute settlement (242,251 ) — NM (242,251 ) — NM Non-GAAP contract dispute settlement2 — — NM — — NM GAAP research and development 494,917 1,138,380 (57 %) 932,196 1,567,640 (41 %) Non-GAAP research and development3 455,635 1,089,089 (58 %) 855,655 1,477,526 (42 %) GAAP selling, general and administrative 331,022 305,982 8 % 656,713 606,238 8 % Non-GAAP selling, general and administrative4 304,771 262,572 16 % 607,063 539,907 12 % GAAP loss (gain) on change in fair value of acquisition-related contingent consideration 22,761 893 NM 34,333 437 NM Non-GAAP loss (gain) on change in fair value of acquisition-related contingent consideration — — NM — — NM GAAP (profit) and loss sharing under collaboration agreements — — NM — (1,025 ) NM 1 Non-GAAP cost of product revenues excludes the amortization of licensed intellectual property for Iclusig relating to the acquisition of the European business of ARIAD Pharmaceuticals, Inc. and the cost of stock-based compensation. 2 Non-GAAP contract dispute settlement excludes the contract dispute settlement reached with Novartis. 3 Non-GAAP research and development expenses exclude the cost of stock-based compensation, MorphoSys transition costs, and Escient acquisition related compensation expense related to cash settled unvested Escient equity awards and severance payments. 4 Non-GAAP selling, general and administrative expenses exclude the cost of stock-based compensation, MorphoSys transition costs, and Escient acquisition related compensation expense related to cash settled unvested Escient equity awards and severance payments. Cost of product revenues GAAP and Non-GAAP cost of product revenues for the quarter ended June 30, 2025 increased 3% and 2% respectively, compared to the same period in 2024, primarily driven by growth in net product revenues, the Niktimvo profit share and increased manufacturing related costs, partially offset by the impact of the contract dispute settlement with Novartis. Contract dispute settlement In May 2025, Incyte and Novartis entered into a settlement agreement with respect to litigation relating to the duration of royalty payments owed under the Collaboration and License Agreement between Incyte and Novartis. Under the settlement agreement, the royalty rate payable by Incyte on future net sales of Jakafi in the United Stated is reduced by 50% beginning January 1, 2025 and Incyte paid Novartis $280.0 million as the settlement of disputed royalties on net sales of Jakafi in the United States through December 31, 2024. The reduced royalty paid for the quarter ending March 31, 2025, was approximately $14.9 million. The difference of $242.2 million between the accrued royalties and the total amount paid by us to Novartis as disclosed above was recorded in contract dispute settlement on the condensed consolidated statement of operations for the three and six months ended June 30, 2025. Research and development expenses GAAP and Non-GAAP research and development expenses for the quarter ended June 30, 2025 decreased 57% and 58%, respectively, compared to the same period in 2024, primarily due to $691.9 million of expense relating to the Escient acquisition that occurred during the quarter ended June 30, 2024. Excluding the upfront consideration paid related to the Escient transaction and other upfront and milestone payments, research and development expenses for the quarter ended June 30, 2025 increased 8% compared to the same period in 2024 primarily driven by continued investment in our late stage development assets. Selling, general and administrative expenses GAAP and Non-GAAP selling, general and administrative expenses for the quarter ended June 30, 2025 increased 8% and 16%, respectively, compared to the same period in 2024, primarily due to increased legal costs relating to the Novartis contract dispute settlement and other matters and timing of consumer marketing activities. The 2024 Non-GAAP selling, general and administrative expenses exclude $21.5 million of expense relating to the Escient acquisition that occurred during the second quarter of 2024. Other Financial Information Change in fair value of acquisition-related contingent consideration The change in fair value of contingent consideration during the quarter ended June 30, 2025, compared to the same period in 2024, was primarily due to fluctuations in foreign currency exchange rates impacting future revenue projections of Iclusig. Operating income GAAP and Non-GAAP operating income for the three months ended June 30, 2025 increased 211% and 201%, respectively, compared to the same period in 2024, driven primarily by the aforementioned costs relating to the Escient acquisition in 2024, the Novartis contract dispute settlement in 2025 and growth in net product revenues. Cash, cash equivalents and marketable securities position As of June 30, 2025 and December 31, 2024, cash, cash equivalents and marketable securities totaled $2.4 billion and $2.2 billion, respectively. The balance reflects the Novartis contract dispute settlement payment made during the second quarter of 2025, which offsets cash flows from operating activities. 2025 Financial Guidance Incyte's guidance for the fiscal year 2025 is summarized below. Incyte is raising its revenue guidance for Jakafi to account for higher demand in the first half of 2025. Incyte is also raising its revenue guidance for other oncology products, to reflect the strength of the Niktimvo launch, higher demand for Zynyz in the first half of the year and the positive impact of foreign currency exchange rates. Incyte is updating its cost of product revenues guidance to reflect the reduction in the Jakafi royalty rate payable to Novartis, as a result of the contract dispute settlement. Furthermore, Incyte is updating its expense guidance for research and development to reflect the increase due to upfront and ongoing expenses related to new collaborations with Genesis and Biotheryx. Current Previous Jakafi net product revenues $3,000 - $3,050 million $2,950 - $3,000 million Opzelura net product revenues Unchanged $630 - $670 million Other oncology net product revenues(1) $500 - $520 million $415 - $455 million GAAP Cost of product revenues 8.0% - 9.0% of net product revenues 8.5% - 9.0% of net product revenues Non-GAAP Cost of product revenues(2) 7.0% - 8.0% of net product revenues 7.5% - 8.0% of net product revenues GAAP Research and development expenses $1,965 - $1,995 million $1,930 - $1,960 million Non-GAAP Research and development expenses(3) $1,815 - $1,840 million $1,780 - $1,805 million GAAP Selling, general and administrative expenses Unchanged $1,280 - $1,310 million Non-GAAP Selling, general and administrative expenses(3) Unchanged $1,160 - $1,185 million 1Pemazyre in the U.S., EU and Japan; Niktimvo, Monjuvi and Zynyz in the U.S.; and Iclusig and Minjuvi in the EU. 2Adjusted to exclude the amortization of licensed intellectual property for Iclusig relating to the acquisition of the European business of ARIAD Pharmaceuticals, Inc. and the estimated cost of stock-based compensation. 3Adjusted to exclude the estimated cost of stock-based compensation. Conference Call and Webcast Information Incyte will hold a conference call and webcast this morning at 8:00 a.m. ET. To access the conference call, please dial 877-407-3042 for domestic callers or 201-389-0864 for international callers. When prompted, provide the conference identification number, 13754581. If you are unable to participate, a replay of the conference call will be available for 90 days. The replay dial-in number for the United States is 877-660-6853 and the dial-in number for international callers is 201-612-7415. To access the replay you will need the conference identification number, 13754581. The conference call will also be webcast live and can be accessed at About Incyte A global biopharmaceutical company on a mission to Solve On., Incyte follows the science to find solutions for patients with unmet medical needs. Through the discovery, development and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Oncology and Inflammation & Autoimmunity. Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe and Asia. For additional information on Incyte, please visit or follow us on social media: LinkedIn, X, Instagram, Facebook, YouTube. About Jakafi® (ruxolitinib) Jakafi® (ruxolitinib) is a JAK1/JAK2 inhibitor approved by the U.S. FDA for treatment of polycythemia vera (PV) in adults who have had an inadequate response to or are intolerant of hydroxyurea; intermediate or high-risk myelofibrosis (MF), including primary MF, post-polycythemia vera MF and post-essential thrombocythemia MF in adults; steroid-refractory acute GVHD in adult and pediatric patients 12 years and older; and chronic GVHD after failure of one or two lines of systemic therapy in adult and pediatric patients 12 years and older. Jakafi is a registered trademark of Incyte. About Opzelura® (ruxolitinib) Cream Opzelura® (ruxolitinib) cream, a novel cream formulation of Incyte's selective JAK1/JAK2 inhibitor ruxolitinib, approved by the U.S. Food & Drug Administration for the topical treatment of nonsegmental vitiligo in patients 12 years of age and older, is the first and only treatment for repigmentation approved for use in the United States. Opzelura is also approved in the U.S. for the topical short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis (AD) in non-immunocompromised patients 12 years of age and older whose disease is not adequately controlled with topical prescription therapies, or when those therapies are not advisable. Use of Opzelura in combination with therapeutic biologics, other JAK inhibitors, or potent immunosuppressants, such as azathioprine or cyclosporine, is not recommended. In Europe, Opzelura (ruxolitinib) cream 15mg/g is approved for the treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age. Incyte has worldwide rights for the development and commercialization of ruxolitinib cream, marketed in the United States as Opzelura. Opzelura and the Opzelura logo are registered trademarks of Incyte. About Monjuvi® (tafasitamab-cxix) Monjuvi® (tafasitamab-cxix) is a humanized Fc-modified cytolytic CD19-targeting monoclonal antibody. Tafasitamab incorporates an XmAb® engineered Fc domain, which mediates B-cell lysis through apoptosis and immune effector mechanism including Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Antibody-Dependent Cellular Phagocytosis (ADCP). Incyte licenses exclusive worldwide rights to develop and commercialize tafasitamab from Xencor, Inc. In the U.S., Monjuvi is approved by the U.S. Food and Drug Administration in combination with lenalidomide and rituximab for the treatment of adult patients with relapsed or refractory follicular lymphoma (FL). Monjuvi is not indicated and is not recommended for the treatment of patients with relapsed or refractory marginal zone lymphoma outside of controlled clinical trials. Additionally, Monjuvi received accelerated approval in the United States in combination with lenalidomide for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, including DLBCL arising from low grade lymphoma, and who are not eligible for autologous stem cell transplant (ASCT). In Europe, Minjuvi® (tafasitamab) received conditional Marketing Authorization from the European Medicines Agency in combination with lenalidomide, followed by Minjuvi monotherapy, for the treatment of adult patients with relapsed or refractory DLBCL who are not eligible for ASCT. XmAb® is a registered trademark of Xencor, Inc. Monjuvi, Minjuvi, the Minjuvi and Monjuvi logos and the "triangle" design are registered trademarks of Incyte. About Pemazyre® (pemigatinib) Pemazyre® (pemigatinib) is a kinase inhibitor indicated in the United States for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test. This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). Pemazyre is also the first targeted treatment approved for use in the United States for treatment of adults with relapsed or refractory myeloid/lymphoid neoplasms (MLNs) with FGFR1 rearrangement. In Japan, Pemazyre is approved for the treatment of patients with unresectable biliary tract cancer (BTC) with a fibroblast growth factor receptor 2 (FGFR2) fusion gene, worsening after cancer chemotherapy. In Europe, Pemazyre is approved for the treatment of adults with locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement that have progressed after at least one prior line of systemic therapy. Pemazyre is a potent, selective, oral inhibitor of FGFR isoforms 1, 2 and 3 which, in preclinical studies, has demonstrated selective pharmacologic activity against cancer cells with FGFR alterations. Pemazyre is marketed by Incyte in the United States, Europe and Japan. Pemazyre is a trademark of Incyte. About Iclusig® (ponatinib) tablets Iclusig® (ponatinib) targets not only native BCR-ABL but also its isoforms that carry mutations that confer resistance to treatment, including the T315I mutation, which has been associated with resistance to other approved TKIs. In the EU, Iclusig is approved for the treatment of adult patients with chronic phase, accelerated phase or blast phase chronic myeloid leukemia (CML) who are resistant to dasatinib or nilotinib; who are intolerant to dasatinib or nilotinib and for whom subsequent treatment with imatinib is not clinically appropriate; or who have the T315I mutation, or the treatment of adult patients with Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) who are resistant to dasatinib; who are intolerant to dasatinib and for whom subsequent treatment with imatinib is not clinically appropriate; or who have the T315I mutation. Click here to view the Iclusig EU Summary of Medicinal Product Characteristics. Incyte has an exclusive license from Takeda Pharmaceuticals International AG to commercialize ponatinib in the European Union and 29 other countries, including Switzerland, UK, Norway, Turkey, Israel and Russia. Iclusig is marketed in the U.S. by Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited. About Zynyz® (retifanlimab-dlwr) Zynyz® (retifanlimab-dlwr) is a humanized monoclonal antibody targeting programmed death receptor-1 (PD-1), indicated in combination with carboplatin and paclitaxel (platinum-based chemotherapy) for the first-line treatment of adult patients with inoperable locally recurrent or metastatic squamous cell carcinoma of the anal canal (SCAC) and as a single agent for the treatment of adult patients with locally recurrent or metastatic SCAC with disease progression or intolerance to platinum-based chemotherapy in the U.S. Zynyz is also indicated for the treatment of adult patients with metastatic or recurrent locally advanced Merkel cell carcinoma (MCC) in the U.S. This indication is approved under accelerated approval based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. Zynyz is marketed by Incyte in the United States. In 2017, Incyte entered into an exclusive collaboration and license agreement with MacroGenics, Inc. for global rights to retifanlimab. Zynyz is a registered trademark of Incyte. About Niktimvo™ (axatilimab-csfr) Niktimvo™ (axatilimab-csfr) is a first-in-class colony stimulating factor-1 receptor (CSF-1R)-blocking antibody approved for use in the U.S. for the treatment of chronic graft-versus-host disease (GVHD) after failure of at least two prior lines of systemic therapy in adult and pediatric patients weighing at least 40 kg (88.2 lbs). In 2016, Syndax licensed exclusive worldwide rights to develop and commercialize axatilimab from UCB. In September 2021, Syndax and Incyte entered into an exclusive worldwide co-development and co-commercialization license agreement for axatilimab in chronic GVHD and any future indications. Axatilimab is being studied in frontline combination trials in chronic GVHD – a Phase 2 combination trial with ruxolitinib (NCT06388564) and a Phase 3 combination trial with steroids (NCT06585774) are underway. Axatilimab is also being studied in an ongoing Phase 2 trial in patients with idiopathic pulmonary fibrosis (NCT06132256). Niktimvo is a trademark of Incyte. All other trademarks are the property of their respective owners. Forward-Looking Statements Except for the historical information set forth herein, the matters set forth in this release contain predictions, estimates and other forward-looking statements, including any discussion of the following: Incyte's potential for continued performance and growth; Incyte's ability to achieve both its full-year and long-term objectives; Incyte's financial guidance for 2025, including its expectations regarding sales of and demand for Jakafi and Opzelura; expected revenue contribution from Niktimvo and other hematology and oncology products; Incyte's potential to have more than 10 high impact launches by 2030; the disease modifying/curative potential of INCA033989 and plans to develop same; the potential blockbuster opportunity presented by povorcitinib and plans to develop same, including the submission of an NDA in early 2026; the possibility for H2 of 2025 to be transformational for Incyte in terms of regulatory approvals, data readouts and initiation of pivotal studies; the potential and progress of programs in our pipeline; ongoing clinical trials and clinical trials to be initiated; expectations regarding discussions with regulators, regulatory submissions and regulatory approvals; and 2025 newsflow items. These forward-looking statements are based on Incyte's current expectations and subject to risks and uncertainties that may cause actual results to differ materially, including unanticipated developments in and risks related to: further research and development and the results of clinical trials possibly being unsuccessful or insufficient to meet applicable regulatory standards or warrant continued development; the ability to enroll sufficient numbers of subjects in clinical trials and the ability to enroll subjects in accordance with planned schedules; determinations made by the FDA, EMA and other regulatory agencies; Incyte's dependence on its relationships with and changes in the plans of its collaboration partners; the efficacy or safety of Incyte's products and the products of Incyte's collaboration partners; the acceptance of Incyte's products and the products of Incyte's collaboration partners in the marketplace; market competition; unexpected variations in the demand for Incyte's products and the products of Incyte's collaboration partners; the effects of announced or unexpected price regulation or limitations on reimbursement or coverage for Incyte's products and the products of Incyte's collaboration partners; sales, marketing, manufacturing and distribution requirements, including Incyte's and its collaboration partners' ability to successfully commercialize and build commercial infrastructure for newly approved products and any additional products that become approved; greater than expected expenses, including expenses relating to litigation or strategic activities; variations in foreign currency exchange rates; and other risks detailed in Incyte's reports filed with the Securities and Exchange Commission, including its annual report on form 10-K for the year ended December 31, 2024. Incyte disclaims any intent or obligation to update these forward-looking statements. INCYTE CORPORATION CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (unaudited, in thousands, except per share amounts) Three Months Ended June 30, Six Months Ended June 30, 2025 2024 2025 2024 GAAP GAAP Revenues: Product revenues, net $ 1,059,414 $ 906,566 $ 1,981,688 $ 1,636,489 Product royalty revenues 151,115 137,193 281,739 263,159 Milestone and contract revenues 5,000 — 5,000 25,000 Total revenues 1,215,529 1,043,759 2,268,427 1,924,648 Costs, expenses and other: Cost of product revenues (including definite-lived intangible amortization) 78,766 76,634 151,954 137,590 Contract dispute settlement (242,251 ) — (242,251 ) — Research and development 494,917 1,138,380 932,196 1,567,640 Selling, general and administrative 331,022 305,982 656,713 606,238 Loss on change in fair value of acquisition-related contingent consideration 22,761 893 34,333 437 (Profit) and loss sharing under collaboration agreements — — — (1,025 ) Total costs, expenses and other 685,215 1,521,889 1,532,945 2,310,880 Income (loss) from operations 530,314 (478,130 ) 735,482 (386,232 ) Interest income 25,136 41,476 48,065 88,246 Interest expense (594 ) (657 ) (1,254 ) (1,087 ) (Loss) gain on equity investments (4,151 ) 39,241 (5,494 ) 139,188 Other, net 7,307 8,293 15,403 6,267 Income (loss) before provision for income taxes 558,012 (389,777 ) 792,202 (153,618 ) Provision for income taxes 153,013 54,824 229,000 121,435 Net income (loss) $ 404,999 $ (444,601 ) $ 563,202 $ (275,053 ) Net income (loss) per share: Basic $ 2.09 $ (2.04 ) $ 2.91 $ (1.24 ) Diluted $ 2.04 $ (2.04 ) $ 2.84 $ (1.24 ) Shares used in computing net income (loss) per share: Basic 193,995 218,175 193,853 221,329 Diluted 198,744 218,175 198,526 221,329 INCYTE CORPORATION CONDENSED CONSOLIDATED BALANCE SHEETS (unaudited, in thousands) June 30, 2025 December 31, 2024 ASSETS Cash, cash equivalents and marketable securities $ 2,421,738 $ 2,158,092 Accounts receivable 842,892 853,154 Property and equipment, net 798,543 763,411 Finance lease right-of-use assets, net 29,001 30,803 Inventory 451,531 407,199 Prepaid expenses and other assets 330,044 181,382 Equity investments 13,313 18,814 Other intangible assets, net 126,419 113,803 Goodwill 155,593 155,593 Deferred income tax asset 652,280 762,071 Total assets $ 5,821,354 $ 5,444,322 LIABILITIES AND STOCKHOLDERS' EQUITY Accounts payable, accrued expenses and other liabilities $ 1,407,216 $ 1,765,733 Finance lease liabilities 36,235 37,961 Acquisition-related contingent consideration 207,000 193,000 Stockholders' equity 4,170,903 3,447,628 Total liabilities and stockholders' equity $ 5,821,354 $ 5,444,322 INCYTE CORPORATION RECONCILIATION OF GAAP NET (LOSS) INCOME TO SELECTED NON-GAAP ADJUSTED INFORMATION (unaudited, in thousands, except per share amounts) Three Months Ended June 30, Six Months Ended June 30, 2025 2024 2025 2024 GAAP Net Income (Loss) $ 404,999 $ (444,601 ) $ 563,202 $ (275,053 ) Adjustments1: Non-cash stock compensation from equity awards (R&D)2 37,700 34,541 74,424 71,333 Non-cash stock compensation from equity awards (SG&A)2 26,071 21,748 49,470 44,121 Non-cash stock compensation from equity awards (COGS)2 838 351 1,697 964 Non-cash interest3 81 144 163 252 Loss (gain) on equity investments4 4,151 (39,241 ) 5,494 (139,188 ) Amortization of acquired product rights5 5,384 5,384 10,768 10,768 Loss on change in fair value of contingent consideration6 22,761 893 34,333 437 Contract dispute settlement7 (242,251 ) — (242,251 ) — MorphoSys transition costs8 — 2,373 — 6,952 Escient acquisition related compensation expense9 1,762 34,039 2,297 34,039 Tax effect of Non-GAAP pre-tax adjustments10 50,431 (11,763 ) 41,789 (18,038 ) Non-GAAP Net Income (Loss) $ 311,927 $ (396,132 ) $ 541,386 $ (263,413 ) Non-GAAP net income (loss) per share: Basic $ 1.61 $ (1.82 ) $ 2.79 $ (1.19 ) Diluted11 $ 1.57 $ (1.82 ) $ 2.73 $ (1.19 ) Shares used in computing Non-GAAP net income (loss) per share: Basic 193,995 218,175 193,853 221,329 Diluted11 198,744 218,175 198,526 221,329 1 Included within the Milestone and contract revenues line item in the Condensed Consolidated Statements of Operations (in thousands) for the three and six months ended June 30, 2025 are milestones of $5,000 and $5,000 earned from our collaborative partners, as compared to $0 and $25,000 of milestones earned for the three and six months ended June 30, 2024. Included within the Research and development expenses line item in the Condensed Consolidated Statements of Operations (in thousands) for the three and six months ended June 30, 2025 are upfront consideration and milestones of $12,550 and $28,050, respectively, related to our collaborative partners as compared to upfront consideration and milestones of $414 and $1,414, respectively, for the three and six months ended June 30, 2024. 2 As included within the Cost of product revenues (including definite-lived intangible amortization) line item; the Research and development expenses line item; and the Selling, general and administrative expenses line item in the Condensed Consolidated Statements of Operations. 3 As included within the Interest expense line item in the Condensed Consolidated Statements of Operations. 4 As included within the (Loss) gain on equity investments line item in the Condensed Consolidated Statements of Operations. 5 As included within the Cost of product revenues (including definite-lived intangible amortization) line item in the Condensed Consolidated Statements of Operations. Acquired product rights of licensed intellectual property for Iclusig is amortized utilizing a straight-line method over the estimated useful life of 12.5 years. 6 As included within the Loss on change in fair value of acquisition-related contingent consideration line item in the Condensed Consolidated Statements of Operations. 7 As included within the Contract dispute settlement line item in the Condensed Consolidated Statements of Operations. 8 Included within the Research and development line item in the Condensed Consolidated Statements of Operations (in thousands) is $2,232 and $6,263 for the three and six months ended June 30, 2024, and $141 and $689 is included within the Selling, general and administrative expenses line item in the Condensed Consolidated Statements of Operations (in thousands) for the three and six months ended June 30, 2024. MorphoSys transition costs primarily represent employee related costs to transition research and development and selling, general and administrative activities to us under the former collaboration agreement with MorphoSys. 9 Included within the Research and development line item in the Condensed Consolidated Statements of Operations (in thousands) is $1,582 and $2,117 for the three and six months ended June 30, 2025, and included within the Selling, general and administrative expenses line item in the Condensed Consolidated Statements of Operations is $180 for the three and six months ended June 30, 2025. Included within the Research and development line item in the Condensed Consolidated Statements of Operations is $12,518 for the three and six months ended June 30, 2024, and included within the Selling, general and administrative expenses line item in the Condensed Consolidated Statements of Operations is $21,521 for the three and six months ended June 30, 2024. Escient acquisition related compensation expense represents non-recurring charges associated with (i) cash settled unvested Escient equity awards in connection with the acquisition, and (ii) severance payments to former Escient employees. 10 Income tax effects of Non-GAAP pre-tax adjustments are calculated using an estimated annual effective tax rate, taking into consideration any permanent items and valuation allowances against related deferred tax assets. 11 All stock options and stock awards were excluded from the diluted share calculation for the three and six months ended June 30, 2024 because their effect would have been anti-dilutive, as we were in a net loss position. View source version on Contacts Media media@ Investors ir@ Sign in to access your portfolio
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NETGEAR Expands WiFi 7 Orbi Portfolio with the Launch of Orbi 370 Series - the Company's Most Affordable WiFi 7 Mesh System
Delivering trusted home connectivity, the new Orbi 370 broadens the NETGEAR WiFi 7 Orbi mesh family for every household SAN JOSE, Calif., July 29, 2025--(BUSINESS WIRE)--NETGEAR® Inc. (NASDAQ: NTGR), a global leader in intelligent networking solutions designed to power extraordinary experiences, today launched the Orbi 370 Series. Engineered for today's connected households, this high-performance WiFi 7 Mesh System delivers ultra-fast internet and whole-home WiFi coverage with advanced security and privacy features at NETGEAR's most accessible price point yet. As WiFi 7 adoption accelerates, NETGEAR is expanding its Orbi portfolio to deliver reliable, future-ready connectivity. The Orbi 370 Series delivers next-generation WiFi performance, empowering households to unlock the full potential of their devices without paying a premium. Designed for customers with moderately demanding WiFi needs, the Orbi 370 series ensures ultra-fast WiFi speeds up to 5Gbps. Perfect for future proofing a home network, Orbi is designed to extend as needs evolve. Households with growing or changing needs can quickly and easily add a satellite for expanded coverage in just a few clicks. Improved Mesh Networking, Unmatched Value Today's connected homes have more than 20 devices online at once, placing unprecedented demands on WiFi networks. In these challenging environments, the Orbi 370 Series helps each family member enjoy smooth video calls, buffer-free streaming, responsive and immersive gaming, and reliable smart home automation. Orbi's advanced and powerful features do the heavy lifting behind the scenes, helping families work, live and play without limits. Powered by the latest WiFi 7 technology, Multi-Link Operation (MLO) combines 2.4GHz and 5GHz bands to boost speed, reduce latency, and increase performance of connected devices. A 2.5Gbps internet port ensures the system is ready to support multi-gig (over 1Gigabit) internet service plans, now widely available from leading internet providers. The integrated 2.5Gbps Ethernet ports on both the router and satellite offer flexible wired or wireless connection options for demanding devices such as smart TVs, gaming consoles, or PCs. Meanwhile Orbi's sleek, minimalist design blends elegantly into any home décor. "With the Orbi 370 Series, we're making next-generation WiFi more accessible than ever for today's connected families," said Jonathan Oakes, Senior Vice President and General Manager of NETGEAR's Home Networking Division. "We designed this system in response to the growing demand for reliable and trusted WiFi connectivity. Orbi is an unbeatable combination of speed, coverage, and value, without compromising quality or security, all backed by NETGEAR's trusted expertise in mesh networking." Designed to Protect What Matters The home router is the digital front door to the home, and NETGEAR routers serve as a strong front door lock as the first line of defense against evolving cyber threats. Orbi systems are equipped with state-of-the-art firewall protection and advanced security technologies that help proactively defend against vulnerabilities with the ability to provide live security patches to enhance protection against new and rising threats. Additionally, Orbi comes standard with built-in security features such as automatic firmware updates, VPN support, cutting-edge WPA3 security, access control, and guest WiFi network options. These features are included out of the box, with no monthly fees required for fundamental protection. For added peace of mind, a 30-day trial for NETGEAR Armor™ Powered by Bitdefender provides advanced threat protection across connected devices in the home and added privacy with VPN when connecting at home or on the road. Unlike traditional antivirus products for computers, Armor is a security solution that runs on the router for added protection of devices on the home network - computers, security cameras, baby monitors and other IoT devices – reducing the need for multiple security subscriptions or software. NETGEAR Smart Parental Controls™ are also included to help manage screentime, provide online safety, and promote good online habits for the family. Basic features are available free of charge. A subscription fee applies for a premium plan after a 30-day trial. NETGEAR is committed to protecting the privacy of customers. We never monitor information about the websites they visit or monetize any of their network data. With NETGEAR, individuals and families can feel confident that their online activity is safeguarded with strong privacy and security measures--supported by a company they can trust to respect their data. Orbi 370 Technical Specifications WiFi 7 Technology – Next-gen wireless standard delivers higher speed, lower latency, and backward compatibility with WiFi 4/5/6/6E. Multi-link Operation – Combines two WiFi bands at once, for both backhaul (shared 2.4GHz & 5GHz) and fronthaul (2.4GHz & 5GHz) to improve network reliability, reduce latency, and ensure data is delivered at reliable speeds. Multi-Gig Speeds with 2.5 Gig Internet Port – Use the 2.5 Gig internet port for multi-gig cable and fiber plans. Compatible with any internet service provider. Multi-gig Wired ports on Router and Satellites – Plug in wired devices to improve performance or set up a multi-gig wired connection between the router and satellites via the 2.5Gbps Ethernet ports. Do It All with the Orbi® App – Easily manage your network from anywhere, including pausing the internet, running internet speed tests, tracking your Internet data usage, setting up separate guest networks, and more. Availability The NETGEAR Orbi 370 Series® is available now at Amazon and Best Buy. RBE373: Router and 2 Satellites – 3 pack, $349.99 MSRP RBE372: Router and 1 Satellite – 2 pack, $249.99 MSRP RBE370: Add-on Satellite, $149.99 MSRP About NETGEAR, Inc. Founded in 1996 and headquartered in the USA, NETGEAR® (NASDAQ: NTGR) is a global leader in innovative networking technologies for businesses, homes, and service providers. NETGEAR delivers a wide range of award-winning, intelligent solutions designed to unleash the full potential of connectivity and power extraordinary experiences. For businesses, NETGEAR offers reliable, easy-to-use, high-performance networking solutions, including switches, routers, access points, software, and AV over IP technologies, tailored to meet the diverse needs of small and medium enterprises. NETGEAR's consumer products deliver advanced connectivity, powerful performance, and enhanced security features right out of the box, designed to help keep families safe online, whether at home or on the go. More information is available from the NETGEAR Press Room or by calling (408) 907-8000. Connect with NETGEAR: Facebook, Instagram and the NETGEAR blog at ©2025 NETGEAR, Inc. NETGEAR, Orbi and the NETGEAR logo are trademarks and/or registered trademarks of NETGEAR, Inc. and/or its affiliates in the United States and/or other countries. Other brand and product names are for identification purposes only and may be trademarks or registered trademarks of their respective holder(s). The information contained herein is subject to change without notice. NETGEAR shall not be liable for technical or editorial errors or omissions contained herein. All rights reserved. Source: NETGEAR-G View source version on Contacts U.S. Media Contact: Valerie NETGEAR@ U.S. Sales Inquiries: (408) 907-8000, sales@
