Best Brain Supplements for Longevity: Boost Memory, Focus & Clarity in 2025
In 2025, brain supplements have taken center stage in the wellness world. From those seeking deep focus to others invested in memory retention, the cognitive enhancement market is booming, with nootropics now a $10+ billion industry and growing. But in a world of overhyped formulas, which ingredients actually support long-term cognitive health?
Here's what the data is starting to support.
Lion's mane mushroom (Hericium erinaceus) is gaining serious attention for its potential to support neurogenesis. Studies suggest it may stimulate nerve growth factor (NGF), a protein essential for the growth and repair of neurons. In one double-blind study, older adults taking lion's mane daily showed statistically significant improvements in cognitive function after just 16 weeks.
It's featured in products by Four Sigmatic and Host Defense, known to reduce anxiety and improve attention, especially when paired with caffeine.
Claims: Promotes neuron regeneration and mental clarity, especially useful in mild memory impairment.
Unlike traditional magnesium, magnesium L-threonate crosses the blood-brain barrier and boosts synaptic density, key for memory and learning. Preclinical trials showed enhanced memory performance and synaptic function in aging animals, with potential implications for human cognitive aging.
Supplements like Neuro-Mag by Life Extension and Thorne's Magnesium L-Threonate offer this in clinically relevant doses. Many users also report better sleep, which directly benefits memory consolidation.
Claims: Supports synaptic function and learning while promoting restorative sleep.
NAD+ (nicotinamide adenine dinucleotide) plays a crucial role in energy production and DNA repair, but levels decline dramatically with age. Research shows that replenishing NAD+ (using precursors like NMN or NR) may improve mitochondrial function, reduce fatigue, and support brain resilience.
Supplements like Tru Niagen and Elysium Basis have been studied for their effects on NAD+ levels, and a growing body of research suggests potential cognitive benefits, including improved cerebral blood flow and cellular repair.
Claims: May protect against age-related brain fatigue by supporting cellular energy.
Omega-3 fatty acids (especially DHA) are essential for brain structure and function. An analysis of 38 studies found that omega-3 supplementation supports cognitive performance in older adults and may delay age-related decline. Top sources include fish like sardines and salmon or vegan options such as Calgee (algae-based DHA) and Nordic Naturals.
Claims: Strengthens brain cell membranes and supports memory and mood regulation.
Beyond lion's mane, mushrooms like reishi, chaga, and turkey tail are being explored for their role in immunity, gut health, and stress response, each a contributor to better cognitive function. These fungi are packed with beta-glucans, antioxidants, and compounds that influence the gut-brain axis, which plays a major role in mood and mental clarity.
Popular blends like MUD\WTR and Laird Superfood's Performance Mushrooms combine multiple varieties with brain-friendly ingredients like coffee fruit extract and L-theanine. If you've also found yourself pausing on those Instagram coffee ads promising a laundry list of brain-boosting benefits and feel compelled to buy, you're not alone.
Claims: Supports cognition, immunity, and stress resilience.
Form matters. Choose liposomal or chelated ingredients for superior absorption. Quality counts. Look for third-party tested, clinically backed brands. Dosing is key. Ensure ingredients are used in research-supported quantities, skip the fairy dust.
Pro Tip: Introduce supplements gradually and consult a healthcare professional, especially if taking medication or managing chronic health conditions.
Brain supplements aren't magic pills — but paired with movement, sleep, hydration, and stress management, they can offer measurable support for cognitive clarity and longevity.
Click here to learn more about Laird Superfood
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Los Angeles Times
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"NAD plus supplements can help by boosting the body's repair systems, which may reduce wrinkles and other signs of aging over time," he says. "They won't completely stop aging but they could help your cells stay healthier and function better, which might slow things down a little." Patel tells CNET that these supplements are still actively being studied. While some research shows that they can help improve the appearance of skin or give people more energy, he believes more clinical trials are "necessary" to fully establish efficacy in "aging prevention." He also stresses that these supplements should never be used as a replacement for healthy habits, as those are some of the best ways to keep your body youthful as you continue to age. "Exercise, good nutrition, adequate sleep and stress management are crucial for overall well-being," he says, adding that if you're going to try the supplements, take care in choosing them. 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Do not make any changes to your diet without consulting your doctor first. Patel seconded that exercise and a generally healthy lifestyle are highly recommended throughout your life but especially as you age. "Regular exercise has been shown to boost NAD plus levels by stimulating the production of NAD plus precursors," he says. "Additionally, lifestyle choices like adequate sleep hygiene and stress management can positively affect NAD plus levels." What you eat can also affect your NAD plus levels, especially if you reach for foods rich in vitamin B3 and niacin, which are precursors for NAD Plus (meaning the body turns them into NAD plus). Foods rich in vitamin B3 and niacin include: Beef Broccoli Cabbage Dairy Fish Fruit Nuts Peanuts Seeds Turkey Whole grains The bottom line As we age, the body's naturally occurring coenzyme NAD plus decreases, leading to tiredness and skin aging. However, this can be counteracted with a healthy lifestyle of regular exercise and a diet rich in vitamin B3 and niacin. Lifting weights is also a great way to stay healthy as you age. Adding an NAD plus supplement into your daily routine under the supervision of a medical professional can also help boost NAD plus levels. Research on NAD plus supplements is limited, so medical professionals urge people to approach them with caution and under the care of their own doctor. However, these supplements could help tackle signs of aging from decreased NAD plus levels.
