
UK Cancer Deaths Drop 22% in 50 Years Despite Rising Cases
The Cancer in the UK Report 2025 provides the first 50 years of UK-wide data on cancer mortality and cases. Death rates fell from around 328 per 100,000 people in 1973 to around 252 per 100,000 in 2023.
CRUK described the findings as 'profound'. The charity said improvements in diagnosis, treatment, and smoking reduction had helped drive the decline.
People today are twice as likely to survive their disease for at least 10 years compared to 50 years ago. Survival rates improved from one in four people in the early 1970s to one in two today.
Rising Incidence Despite Progress
Cancer incidence rates increased sharply by 47% during the same period. Cases rose from around 413 to 607 per 100,000 people.
However, the charity noted that because of the UK's growing and ageing population, actual numbers continue to rise. Nearly 1100 new cases are diagnosed daily, with more than 460 deaths each day.
This occurs despite significant progress in prevention, detection, diagnosis, and treatment.
CRUK called on the government to ensure that its upcoming National Cancer Plan for England is 'ambitious and fully funded'.
Early Diagnosis Rates Stagnant
Research into improving screening programmes, tests, and drugs helped reduce death rates. Policy action on smoking reduced rates for cancers with poor survival outcomes.
Lung cancer mortality rates decreased from 80.9 per 100,000 people in 1971-1973 to 49.8 in 2021-2023. Bowel cancer rates fell from 48.0 to 26.3, whilst breast cancer dropped from 30.7 to 16.9.
However, pancreatic cancer rates remained stable at around 15 per 100,000 people. Some cancers showed increases, including prostate cancer from 13.3 to 18.3 and oesophageal cancer from 9.2 to 12.0.
Just over half of cancers (54%) were diagnosed at an early stage in England, the report found. This proportion has not changed for almost a decade.
Around half of all new cancer diagnoses occur in people aged 70 and over. However, incidence rates are rising fastest in younger people, with a 23% increase in people aged 20 to 49 since the early 1990s.
Screening Programmes Save Lives
Three cancer screening programmes save around 5000 lives every year across the UK, according to CRUK.
Smoking remains the biggest cause of cancer in the UK. It accounts for around a fifth of all cancer deaths each year. Around one in 20 UK cancer deaths are now linked to being overweight or obese.
Michelle Mitchell, CRUK's chief executive, welcomed the reduced death rates and doubled survival rates. However, she stressed that too many cases are diagnosed at a late stage.
"If we want to change that, we need bold action from the UK government," Mitchell said.
Professor Peter Johnson, NHS national clinical director for cancer, highlighted recent innovations. These include lung cancer screening in car parks and AI technology to spot skin cancer.
Mitchell urged that the upcoming National Cancer Plan for England must improve survival and transform services. She said the plan "could save countless lives across England and ensure people affected by cancer live longer, better lives".
CRUK has also published devolved nation summaries of its findings for Scotland, Wales, and Northern Ireland.
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'This could be important for preventing chronic gut inflammation and related disorders like inflammatory bowel disease or metabolic syndrome.' Although research is still in the early stages, some studies suggest that spermidine may help keep the lining of the gut strong and intact, preventing harmful substances, like toxins, bacteria and partially digested food particles, from leaking into the body and triggering inflammation. There is also evidence that it helps gut-residing immune cells function better, which could be especially beneficial as we age. Adding spermidine to your diet One of the easiest and safest ways to get more spermidine is through your diet. Aged cheese, mushrooms, soy products, whole grains and legumes are all good sources. Wheat germ is especially high in spermidine, which you can sprinkle on your yogurt or cereal at breakfast. A tablespoon of wheat germ provides around 1.2 milligrams of spermidine, and 100g of mushrooms or cheddar can offer up to 10mg. Studies suggest that a daily intake of 5mg to 10mg may support health benefits, which can be achieved through a balanced mix of these foods consumed regularly throughout the week.A large US study found that people with the highest spermidine intake from foods like cereals, vegetables, legumes and cheese had significantly lower risks of cardiovascular disease and all-cause mortality. Kiechl advises a measured approach for now. 'Evidence is strong but there are no 'gold standard' large-scale intervention trials which are necessary for standard medical recommendations,' he says. As spermidine is naturally found in a wide range of everyday foods, it should be easy to boost intake if you don't want to use supplements. That said, for those who prefer a more targeted approach, there are now a number of spermidine supplements on the market that are specifically tested for purity, safety and consistency. 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