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Opinion: Trump budget bill would end health insurance for 650K North Carolinians

Opinion: Trump budget bill would end health insurance for 650K North Carolinians

Yahoo15 hours ago
With the health care landscape facing significant shifts, there has never been a more important time to expand consumer-directed health care services. As policymakers consider changes that could reshape Medicaid, potentially reducing federal support by $793 billion over the next decade, states like North Carolina have a unique opportunity to lead with innovation and compassion. By expanding consumer-directed services, we can empower individuals to make choices that best suit their needs, even in the face of fiscal challenges.
One in four North Carolina residents are enrolled in Medicaid. This program for lower-income individuals not only provides health care, but also funds nursing homes and long-term services and supports that are required by people with disabilities or who are aging in place. Through Medicaid expansion, North Carolina was able to offer support to more people with disabilities and people who are 65 or older. These individuals account for 23% of Medicaid enrollees. They, like thousands of others, are fearful of how their health and wellbeing may be impacted in light of proposed Medicaid changes.
The bill currently being discussed in the U.S. Senate has provisions that may jeopardize enhanced federal matching funds for Medicaid expansion, which could immediately end health insurance coverage for the more than 650,000 North Carolinians who benefit from Medicaid expansion. Overall, North Carolina could face federal Medicaid funding cuts of $32 billion over the next decade, but the state has the chance to protect and uplift those who rely on Medicaid by investing in flexible, person-centered solutions that put people in charge of their support. North Carolina's consumer-directed care programs include person-centered planning and budget management, which promote greater independence, higher satisfaction, and better health care outcomes for participants.
If Medicaid is not protected, the proposed cuts may put valuable consumer-direction programs and the people they serve at increased risk. Programs like Community Alternative Program for Children and Disabled Adults and Coordinated Caregiving enable participants to hire family members or other trusted caregivers, reduce administrative overhead, and avoid unnecessary or institutional services. People can safely stay in their homes and communities rather than in high-cost settings like hospitals or nursing facilities
With the aid of financial management service providers, individuals in consumer-direction programs have support in navigating the details that come with becoming an employer. An FMS helps manage payroll, taxes and budgets, and can provide guidance when it comes to hiring, supervising, and even firing personal care assistants. It also provides an extra layer of accountability, helping ensure compliance with a program's rules. With this behind-the-scenes support, individuals can focus on what matters most: their health, autonomy, and quality of life.
The person-centered approach of consumer-directed programs leads to more efficient use of Medicaid funds and long-term savings. While institutional care costs generally exceed $90,000 per year, similar home and community-based services — such as homemaker services and home health aide services that are often consumer directed in programs like CAP/C, CAP/DA, and Coordinated Caregiving — cost approximately $68,000 annually, as tracked by Genworth's Cost of Care survey.
Proposed cuts that impact Medicaid funding formulas raise concerns that North Carolina could resort to reduced services to make the math work. Some options to accommodate reduced funding could include changing eligibility requirements, making it more difficult for people to participate in a program; reducing provider payments; and revisiting benefits and services to reduce or eliminate some items currently covered. For individuals, they may see authorized budgets fall, which would likely have knock-on effects, from reducing a caregiver's employment hours or pay rate to limiting access to the vital supports to maintain independence and quality of life.
Proposed changes to Medicaid are not yet certain, and North Carolinians still have time to make their voices heard. The state should continue to look to its proven solution of consumer-direction to serve more people who need long-term services and supports. Even more individuals could be supported at a lower cost, less restrictive, more comfortable settings, and for those looking ahead to future care needs, the North Carolina Department of Health and Human Services is the place to start for consumer-direction information.
Home and community-based services funded by Medicaid are not a luxury. They are a core strategy for delivering high-quality, cost-effective, medically necessary, and critical care for North Carolina's most vulnerable populations in a way that allows for choice and control.
More: Opinion: NC's HOP program has led to healthier residents, lower medical costs. It needs funding
More: Opinion: Fallout from Big Beautiful Bill voted for by Chuck Edwards would be far-reaching
Terrasel Jones is a Director of Operations for GT Independence, a financial management service provider that supports people choosing consumer-direction in North Carolina.
This article originally appeared on Asheville Citizen Times: Opinion: Trump budget cuts funds for Medicaid and most vulnerable
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When disasters fall out of the public eye, survivors continue to suffer – a rehabilitation professional explains how sustained mental health support is critical to recovery
When disasters fall out of the public eye, survivors continue to suffer – a rehabilitation professional explains how sustained mental health support is critical to recovery

Yahoo

time39 minutes ago

  • Yahoo

When disasters fall out of the public eye, survivors continue to suffer – a rehabilitation professional explains how sustained mental health support is critical to recovery

The devastating losses from the historic flooding in Texas Hill Country on July 4, 2025, are still coming into grim focus, with 121 deaths confirmed and more than 100 still missing as of July 10. As emergency responders focus on clearing debris and searching for victims, a less visible and slower disaster has been unfolding: the need for ongoing mental health support long after headlines fade. This phase is no less critical than restoring power or rebuilding bridges. Disasters destabilize emotional well-being, leaving distress, prolonged recovery and long-term impacts in their wake long after the event is over. Without sustained emotional support, people and communities face heightened risks of prolonged trauma and stalled recovery. As an educator and practitioner focused on disability and rehabilitation, I explore the intersection of disaster recovery and the impact of disasters on mental health. 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Amylyx Pharmaceuticals Presents New Exploratory Analyses from Phase 2 and Phase 2b Clinical Trials of Avexitide in Post-Bariatric Hypoglycemia at ENDO 2025
Amylyx Pharmaceuticals Presents New Exploratory Analyses from Phase 2 and Phase 2b Clinical Trials of Avexitide in Post-Bariatric Hypoglycemia at ENDO 2025

Associated Press

timean hour ago

  • Associated Press

Amylyx Pharmaceuticals Presents New Exploratory Analyses from Phase 2 and Phase 2b Clinical Trials of Avexitide in Post-Bariatric Hypoglycemia at ENDO 2025

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jul 13, 2025-- Amylyx Pharmaceuticals, Inc. (NASDAQ: AMLX) ('Amylyx' or the 'Company') today announced the presentation of new exploratory analyses from the Phase 2 PREVENT and Phase 2b clinical trials of avexitide, an investigational, first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist for the treatment of post-bariatric hypoglycemia (PBH) at the Endocrine Society's annual meeting (ENDO 2025). In the Phase 2b trial, avexitide 90 mg once daily, the dose being evaluated in the pivotal Phase 3 LUCIDITY trial, led to a 64% least-squares (LS) mean reduction (p=0.0031) vs. baseline in the composite rate of Level 2 and Level 3 hypoglycemic events in PBH, with more than half of the participants experiencing no events during the treatment period. LUCIDITY is a multicenter, randomized, double-blind, placebo-controlled Phase 3 clinical trial evaluating the efficacy and safety of avexitide in approximately 75 participants with PBH following Roux-en-Y gastric bypass surgery. The FDA-agreed-upon primary endpoint of LUCIDITY is reduction in the composite of Level 2 and Level 3 hypoglycemic events. Consistent reductions in composite rate of Level 2 and Level 3 hypoglycemic events also were seen with avexitide 45 mg twice daily studied in the Phase 2b trial and avexitide 30 mg twice daily and 60 mg once daily studied in the Phase 2 PREVENT trial. New pharmacokinetic (PK) and pharmacodynamic (PD) data were also presented demonstrating continuous pharmacologic activity of the 90 mg once daily dose regimen for a 24-hour period. 'Post-bariatric hypoglycemia can profoundly disrupt daily life, requiring individuals to carefully manage meals, social interactions, and routines, often while living in fear of their next hypoglycemic event. The new analysis presented at ENDO 2025 continues to support that avexitide may significantly reduce the frequency of these events,' said Marilyn Tan, MD, FACE, Principal Investigator of the LUCIDITY trial and Clinical Associate Professor at Stanford University. Camille L. Bedrosian, MD, Chief Medical Officer of Amylyx, added, 'Post-bariatric hypoglycemia is a serious and underrecognized condition with no FDA-approved treatments. The data presented show that, in an exploratory analysis from the Phase 2 PREVENT and Phase 2b clinical trials, avexitide significantly reduced the composite rate of Level 2 and 3 hypoglycemic events, including at the 90 mg once daily dose that is being studied in our pivotal Phase 3 LUCIDITY trial. We are particularly encouraged that over half of participants did not experience Level 2 or Level 3 hypoglycemic events during the treatment period. In addition, the pharmacokinetic and pharmacodynamic data demonstrated continuous pharmacologic activity of avexitide 90 mg once daily dose over 24 hours. We continue to be encouraged by avexitide's potential to deliver consistent, meaningful benefit to people living with PBH.' The population PK and PD analyses presented at ENDO 2025 demonstrated that avexitide 90 mg once daily maintained consistent GLP-1 receptor inhibition from morning to midnight and between doses. In vitro potency studies showed an IC₅₀ of approximately 20-30 nM (70-100 ng/mL), indicating robust target inhibition even in the presence of significant levels of GLP-1. PK modeling demonstrated that avexitide plasma levels exceeded IC₅₀ for a full 24-hour period. LUCIDITY was informed by data from five PBH clinical trials of avexitide showing consistent, dose-dependent effects, including statistically significant and clinically meaningful reductions in hypoglycemic events. Avexitide was generally well-tolerated, with a favorable safety profile replicated across clinical trials. Completion of recruitment for LUCIDITY is expected in 2025, with a data readout anticipated in the first half of 2026 and, if approved, commercial launch anticipated in 2027. The presentation and posters are available on the ' Presentations ' tab of the Amylyx website. Webcast Information Amylyx will host an investor event today, July 13, 2025, at 6:00 p.m. PT / 9:00 p.m. ET in San Francisco to discuss post-bariatric hypoglycemia and avexitide. A live webcast of the presentation and Q&A portion of the event can be accessed under 'Events and Presentations' in the Investor section of the Company's website, The webcast will be archived and available for replay for 90 days following the event. About Avexitide Avexitide is an investigational, first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist that has been evaluated in five Phase 1 and Phase 2 clinical trials for post-bariatric hypoglycemia (PBH) and has also been studied in congenital hyperinsulinism (HI). The U.S. Food and Drug Administration (FDA) has granted avexitide Breakthrough Therapy Designation for both indications, Rare Pediatric Disease Designation in congenital HI, and Orphan Drug Designation for the treatment of hyperinsulinemic hypoglycemia (which includes PBH and congenital HI). Avexitide is designed to bind to the GLP-1 receptor on pancreatic islet beta cells and inhibit the effect of GLP-1 to mitigate hypoglycemia by decreasing insulin secretion and stabilizing blood glucose levels. In PBH, excessive GLP-1 can lead to the hypersecretion of insulin and subsequent debilitating hypoglycemic events. In two Phase 2 PBH clinical trials, avexitide demonstrated highly statistically significant reductions in hypoglycemic events. These events can lead to autonomic and neuroglycopenic symptoms that can have a devastating impact on daily living. About Post-Bariatric Hypoglycemia (PBH) Post-bariatric hypoglycemia (PBH) is a condition that is estimated to affect approximately 8% of people in the U.S. who have undergone the two most common types of bariatric surgery, sleeve gastrectomy and Roux-en-Y gastric bypass (approximately 160,000 people in the U.S.). PBH is thought to be caused by an excessive glucagon-like peptide-1 (GLP-1) response leading to hypoglycemia and impaired quality of life. PBH can cause debilitating hypoglycemic events associated with inadequate supply of glucose to the brain, known as neuroglycopenia. Clinical manifestations can include impaired cognition, loss of consciousness, and seizures. PBH is also associated with a high degree of disability that can result in major disruptions to independent living. There are no approved therapies for PBH. About the LUCIDITY Trial LUCIDITY ( NCT06747468 ) is an approximately 75-participant, multicenter, randomized, double-blind, placebo-controlled Phase 3 clinical trial evaluating the efficacy and safety of avexitide in participants with PBH following Roux-en-Y gastric bypass (RYGB) surgery. The Phase 3 trial will be conducted at approximately 20 sites in the U.S. Participants will be randomized 3:2 to receive either 90 mg of avexitide subcutaneously once daily or placebo. The trial includes an up to six-week screening period, including a three-week run-in period, and a 16-week double-blind treatment period. Participants who complete the double-blind period will be eligible to enter an open-label extension (OLE) period with a duration of 32 weeks. The primary efficacy objective of LUCIDITY will evaluate the FDA-agreed upon primary outcome of reduction in the composite of Level 2 and Level 3 hypoglycemic events through Week 16. Safety and tolerability will also be evaluated. About Amylyx Pharmaceuticals At Amylyx, our mission is to usher in a new era of treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are currently focused on three investigational therapies across several neurodegenerative and endocrine diseases in which we believe they can make the greatest impact. For more information, visit and follow us on LinkedIn and X. For investors, please visit Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are 'forward-looking statements' within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, Amylyx' expectations regarding: the potential of avexitide as a treatment for PBH; expectations regarding the timing for recruitment completion and topline data readout of the Phase 3 LUCIDITY trial of avexitide in PBH; and expectations regarding timing for potential commercialization of avexitide. Any forward-looking statements in this press release and related comments in the Company's earnings conference call are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. Risks that contribute to the uncertain nature of the forward-looking statements include: the success, cost, and timing of Amylyx' program development activities; Amylyx' ability to execute on its regulatory development plans and expectations regarding the timing of results from its planned data announcements and initiation of clinical studies; the risk that early-stage results may not reflect later-stage results; Amylyx' ability to fund operations, and the impact that global macroeconomic uncertainty, geopolitical instability, and public health events will have on Amylyx' operations, as well as the risks and uncertainties set forth in Amylyx' United States Securities and Exchange Commission (SEC) filings, including Amylyx' Annual Report on Form 10-K for the year ended December 31, 2024, and subsequent filings with the SEC. All forward-looking statements contained in this press release and related comments in our earnings conference call speak only as of the date on which they were made. Amylyx undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law. View source version on CONTACT: Media Amylyx Media Team (857) 320-6191 [email protected] Lindsey Allen (857) 320-6244 [email protected] KEYWORD: UNITED STATES NORTH AMERICA MASSACHUSETTS INDUSTRY KEYWORD: HEALTH CLINICAL TRIALS RESEARCH PHARMACEUTICAL SCIENCE BIOTECHNOLOGY SOURCE: Amylyx Pharmaceuticals, Inc. Copyright Business Wire 2025. PUB: 07/13/2025 05:00 PM/DISC: 07/13/2025 05:00 PM

Here's the nasty reason why you should never trust the plastic hygiene liners on bathing suits
Here's the nasty reason why you should never trust the plastic hygiene liners on bathing suits

Yahoo

time2 hours ago

  • Yahoo

Here's the nasty reason why you should never trust the plastic hygiene liners on bathing suits

When it comes to swimwear shopping, one of the worst things you can do is try on a suit fully nude. Although bathing suit bottoms usually have a plastic hygiene liner in them — according to a microbiologist, that's the last thing you want near your privates. Nicholas Aicher is a scientist from Chicago. He took it upon himself to swab the plastic seal of two different bathing suit bottoms that hung in a retail store and place them into a petri dish to see what kind of bacteria live on them. 'I thought it would be fun for people to know all the little nastiness that we don't think about every day,' he told What's The Jam. Once home, he transferred the samples to an incubator and let them sit for a bit before revealing some shocking, gross news. The sample from one of the bathing suits had a high amount of Staphylococcus bacteria, which causes staph infections. Common symptoms of staph infections include boils and oozing blisters, and they can turn fatal if the 'bacteria invade deeper into your body, entering your bloodstream, joints, bones, lungs or heart,' according to Mayo Clinic. The results from the other sampled swimsuit were less severe, although it did have 'smaller pin-prick colonies' of the bacteria, according to Jam Press. The moral of the story is to always try on bathing suits with some sort of barrier — whether it be full coverage underwear or tight-fitting pants, like leggings — between your skin and the fabric. And bathing suits are not the only things to be wary of. A TikToker (@‌onenevertwhoo_one), who only wanted to be referred to by his social media handle, contracted a skin infection most likely due to never washing the clothes he bought from a thrift store, according to Jam Press. He explained in a video — that has since gone viral — that he contracted molluscum contagiosum, a viral skin infection that consists of small, raised, painless bumps on the skin. Apparently the contagious condition that spreads through either skin-to-skin contact or contact with infected objects is harmless and does not require treatment, according to NeedToKnow. Dr. Charles Puza, a board-certified NYC dermatologist, also reiterated in a TikTok video the importance of washing your clothes before putting them on, '…especially if you like fast fashion like Shein and Temu.'

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