Metastatic Breast Cancer Highlights From ASCO 2025
Beginning with HER2-positive disease, Dr Partridge reports on the DESTINY-Breast09 trial investigating whether trastuzumab deruxtecan (T-DXd) + pertuzumab (P) could improve upon results from the standard of care regimen, taxane + trastuzumab + P (THP), in the first-line setting. T-DXd + P increased progression-free survival (PFS), offering a future option for patients with very aggressive disease — although, Dr Partridge notes, several clinical questions remain.
She highlights three studies in HER2-negative disease, starting with the SERENA-6 trial in which some patients treated with endocrine therapy who had ESR1 mutation, detected by circulating tumor DNA analysis, were switched to camizestrant. The camizestrant arm demonstrated meaningful PFS improvement.
She also notes the first phase 3 trial of a proteolysis-targeting chimera, vepdegestrant, which demonstrated improved PFS in patients with ESR1 mutation.
Continuing in the HER2-negative setting, she reports the updated overall survival results for inavolisib that continue to demonstrate positive PFS results.
Switching gears to triple-negative disease, she discusses promising results from the ASCENT-04 trial, which tested the antibody-drug conjugate sacituzumab govitecan against chemotherapy.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
2 minutes ago
- Yahoo
Mom, 25, Cries for Her Kids After Learning Breast Cancer Spread to Spine, Ribs, Lungs: ‘Hope I Get to See Them Grow Up'
NEED TO KNOW Savannah Caldwell says she was 'so tired all the time' — the first symptom that something was going on with the 25-year-old newlywed — before being diagnosed with stage 4 breast cancer The mom of four explains that it has spread throughout her body, and she is sharing her journey online as she undergoes brutal, aggressive treatment 'I want to fight and I want to live,' Caldwell saysA 25-year-old woman is facing the unthinkable after being diagnosed with breast cancer that's metastasized throughout her body. 'Fatigue was the main symptom' for newlywed Savannah Caldwell, who told WSAZ-TV, 'I'm 25, I shouldn't be feeling so tired all the time. And extreme pain in my bones [that was] unexplainable. There was no reason [for it].' Caldwell, who is raising four children with her husband Nick, found a lump on her chest and doctors ordered a biopsy this past spring. That's when she was diagnosed with cancer — stage 4 invasive ductal carcinoma. While it's the most common type of breast cancer, it generally affects women 55 and older, according to the Cleveland Clinic. 'I was in complete shock,' Caldwell said. 'I remember staring at the floor, not knowing what to think, not knowing what was next, that was a big worry. Worrying about my family, worrying about my life. I've grown up faster in a week than I have in 25 years.' She started chemotherapy immediately — and began documenting her treatment journey on a Facebook page, Savannah's Breast Cancer Battle, and TikTok, Savishay14, to raise awareness as more women under 40 are diagnosed with the disease. As she shared, 'the breast cancer has metastasized in my spine, ribs, lungs,' and doctors are testing to see if it's spread to her brain. Her first chemo treatment took nearly 12 hours, she shared, and according to a GoFundMe established by a close friend to help her pay for treatment, Caldwell — who had tested positive for the BRCA gene, which means you're more likely to develop breast or ovarian cancer — is expected to undergo radiation and immunotherapy as well. After her seventh chemotherapy treatment, Caldwell shared that she was recovering from a virus that caused her to become 'very ill and I dropped to 86 pounds … fatigue has set in a lot.' The virus was debilitating, a friend shared in a Facebook update after Caldwell's eighth round of chemotherapy. 'Now the neuropathy has set in — her fingers and toes are tingling and numb. On top of that, she's dealing with extreme hot flashes that come in waves and leave her soaked, exhausted, and unable to sleep.' The post continued: 'And as if that wasn't enough, she's still coughing up remnants of the infection she just battled. It's like her body just can't catch a break. But even with all of that… she's still here. Still fighting. Still holding on with everything she's got. And I couldn't be prouder of her.' 'For the most part, I'm optimistic. I want to fight and I want to live,' Caldwell told WSAZ. 'Being so positive isn't about living in denial — it's about being resilient, and I want to show that so much.' 'At night, especially when I'm with my kids,' she said. 'When we're cuddled up at night and I look over at my kids, I just hope I get to see them grow up.' 'I want my story to be a beautiful one no matter how long or short it is.' Never miss a story — sign up for to stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories. Read the original article on People
Fox News
3 minutes ago
- Fox News
Eating foods in this order could help with weight loss and blood sugar, experts say
The order in which you eat foods during meals may affect your health, according to some nutrition experts. The concept — known as "meal sequencing" — involves first eating fiber-rich, non-starchy vegetables, followed by protein and then fats, before eating the carbohydrates on your plate. This orderly way of eating may help prevent blood sugar spikes, increase feelings of fullness and help with weight loss, according to nutrition experts who spoke to Fox News Digital. "Starting with vegetables, protein and healthy fats — before eating starches or sugary foods — may help blunt post-meal glucose spikes," Caroline Susie, a registered dietitian based in Dallas, Texas, told Fox News Digital. "This effect is particularly beneficial for people with insulin resistance, prediabetes or type 2 diabetes," said Susie, who is also a spokesperson for the Academy of Nutrition and Dietetics. The expert noted, however, that people with diabetes should receive personalized guidance from a medical expert. Elevated blood sugar levels (known as hyperglycemia) after meals can increase an individual's risk for type 2 diabetes, according to a UCLA report. Controlling blood sugar levels can help benefit the treatment of diabetes and obesity. Previous research published in the journal Nutrients found that patients who followed the meal sequencing method — eating vegetables before refined carbohydrates — showed a significant improvement in glycemic control and blood sugar after a five-year period, while the group that did not follow the approach did not show improvement. "What causes the sugar spikes is eating too many carbs." "What causes the sugar spikes is eating too many carbs," Sandra J. Arevalo, a New York-based registered dietitian and spokesperson for the Academy of Nutrition and Dietetics, told Fox News Digital. "Eating them alone makes it even worse," she cautioned. "When eating them together with protein and fiber, we are cushioning their effect by slowing their absorption." In addition to lowering blood sugar levels, meal sequencing may also assist with weight loss. Studies have shown that eating protein before refined carbs promotes the secretion of the hormone glucagon-like peptide-1 (GLP-1) from the gut, which delays gastric emptying and suppresses appetite. "When you eat other foods first — mainly fiber-rich foods — and then you drink water, the fiber from the foods helps you feel satisfied, thus decreasing your appetite," Arevalo told Fox News Digital. "And let's not forget that fiber also helps to reduce the absorption of sugar in the blood, helping to cushion your sugar levels." Complex carbohydrates — such as most vegetables, beans and legumes — are rich in fiber and slow to digest, which causes a gradual rise in blood sugar levels, according to the UCLA report. Refined carbohydrates — such as sugar, white rice and white flour — have higher glycemic levels, which are easier to break down and contribute to faster blood sugar spikes. As nutrition experts pointed out, eating fiber before refined carbohydrates can help slow the carbs' absorption, which helps blood sugar levels stay lower during digestion. To assist with healthier food choices and to monitor blood sugar levels after a meal, experts recommend using a food rating system called the glycemic index. This rating scale determines how quickly certain foods can cause blood sugars to rise and fall, according to the UCLA report. For those interested in trying meal sequencing, Susie laid out the following steps. For more Health articles, visit Everyone reacts differently to different meal plans, Arevelo noted. Both dietitians emphasized the importance of working with a licensed registered dietitian nutritionist who can help with planning balanced meals and monitoring blood sugar levels.
CBS News
5 minutes ago
- CBS News
Crisis nursery has been helping Twin Cities families care for their kids for over 40 years
There are 3.6 million cases of child abuse reported every year in the U.S. For every incident of child abuse or neglect that's reported, an estimated two incidents go unreported. But what can you do to stop abuse before it happens? For four decades, a group in south Minneapolis has been figuring it out. The Greater Minneapolis Crisis Nursery was established by Junior League women who realized there was nowhere to turn when parents were in crisis and needed help caring for their kids. It's where one mother of three found her strength. "I feel so recharged, rejuvenated, refreshed," Victoria Andrews said. Andrews' beloved kids are 9, 4 and 2. Her mother is her emotional rock, but with her health, she isn't able to physically help. "I don't really have people to keep my kids for me. I don't have anybody, actually," Andrews said. On a particularly exhausting day eight years ago, her mom suggested she try out the Crisis Nursery. "It was very hard at that time. I remember, it was a snowstorm, and I didn't have a vehicle, so they, I believe, they gave me a cab ride home. And I think I cried the whole cab ride home," Andrews said. "I breastfed full-time, exclusively, so it just felt like I betrayed him, like I failed him, in a sense." She felt shame; they saw bravery. "Every parent who calls us wants something better for their family, they want to improve them in some way, shape or form," Laura Wagner with the Greater Minneapolis Crisis Nursery said. "And so there's absolutely nothing shameful about that. And so we, from the moment that they call us, the moment that they come in, we want to follow their lead as a parent. We want to reinforce that you're an amazing parent." The nursery is free. Women get up to 30 days a year of free overnight care, no questions asked. They want to create safer homes with less abuse and less isolation. "We are that place. We are a place where families, when they feel like they don't have anyone else that can care for their children if they feel like they need a break. And that they can prevent something bad from happening in their family by having that partner, and that's where we come in," Wagner said. Support is what Andrews got. "It's very personalized. What's their shoe size, diaper size? Do they need ocean sounds at night? What's their favorite character to sleep in?" Andrews said. She has been using the nursery now for eight years, much to the glee of her kids. "They love the staff. Teacher Dee is Princeton's favorite, and then Princeton has a special teacher. And yeah, they're just warm," Andrews said. "It's inviting. It's comforting. Even the front desk, when you first walk in, Amanda, she's always just warm and loving so we love it there." Her kids have gotten around-the-clock care, and she's gotten her feet underneath her. She now has a full-time job counseling peers, and her children are thriving. "Yeah, I'm not breaking. I think it's broken. I've broken the curse that was on my family, the generational patterns, the forms of discipline, the trauma. It stopped with me and my mom, and it had to be done," Andrews said. "All of that I had to work through, the pain, the trauma, basically, and I had to face it head-on so my kids didn't have to." They now provide over 5,000 nights of care per year. "I feel like you are stronger for reaching out, because you have to literally put your pride to the side, swallow that, you know, swallow the pride, and then ask for help," Andrews said. The help is there 24/7, a place of unconditional love and peace. The nursery says they welcome anyone who needs a break, and they don't define what a crisis is. For help, you can call the crisis helpline at 763-591-0100.
