GSK, Spero to stop urinary tract infection drug trial due to early success
Spero shares nearly tripled to $2 in premarket trading.
The decision comes after a recommendation from an independent committee that completed a pre-specified interim analysis of data from 1,690 patients enrolled in the trial.
The companies were studying the oral drug, tebipenem HBr, as a treatment for complicated urinary tract infections, including pyelonephritis, in which kidneys become infected.
In the trial, the drug showed it was at least as good as an existing intravenous treatment in hospitalized adult patients.
GSK plans to work with U.S. regulatory authorities to include the data as part of a filing in the second half of the year.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
The Independent
15 minutes ago
- The Independent
Sprains, strains and ACL tears: What to know about some of NFL players' most common injuries
Some of the most important players on NFL teams are those that might not necessarily start the season on the field. Depth is crucial during a rigorous 17-game regular-season schedule that's preceded by a month of training camp practices in hot conditions as players try to make team's 53-man active rosters. Injuries can play as big a role in an NFL team's successes or failures as the best game plans. So being able to navigate injuries and ailments to key players could make all the difference between a team seeing its season sink or making the playoffs. Here's a look at some of the most common injuries suffered by NFL players throughout the season: Achilles tendon tears The Achilles is the longest and strongest tendon in the body and stretches from the heel to the calf. It's a springy band located behind the ankle and just above the heel that helps players push off their feet, jump and accelerate. Due to overuse or excessive force placed on the tendon, it can tear or rupture. Surgery is typically necessary to reconnect the ends, sidelining a player for several months because of the extensive rehabilitation needed. ACL /PCL/MCL/LCL tears The anterior cruciate, posterior cruciate, medial collateral and lateral collateral ligaments are all located in the knee and serve different purposes. The ACL connects the thigh bone to the shin bone in the front of the knee. While a sprain could sideline a player for a few weeks, a tear can end a season. The PCL is located behind the ACL, crisscrossing it to form an "X" in the center of the knee. The MCL connects the thigh bone to the shin bone on the inner side of the knee, while the LCL connects the thigh bone to the top of the lower leg, or fibula, and is located on the outer side of the knee. Concussions A concussion is a brain injury caused by a hit to the head or a sudden movement that causes the head and brain to shake violently. Symptoms may include headaches, neck pain, nausea, dizziness and feeling sluggish. The NFL has been regularly testing and upgrading helmets for players to help reduce the risk of concussions. Eight position-specific helmets for quarterbacks and linemen were approved by the NFL and the NFL Players Association last year. Several players also have worn Guardian Caps, soft, protective helmet covers that the NFL authorized players to use during games last season in an effort to reduce head injuries. Chronic traumatic encephalopathy, or CTE, is a degenerative brain disease that has been linked to concussions and can only be diagnosed posthumously. It can cause memory loss, depression and violent mood swings. Hamstring injuries The hamstring is a group of four muscles that run along the back of the thigh, stretching from the hip to the knee, and they help a person bend their leg at the knee. These injuries vary in severity, and in turn, their timetable in sidelining a player. A mild pull of one of the muscles, commonly referred to as a Grade I injury, can sideline a player for a few days to a couple of weeks and can be a lingering condition if not sufficiently rested and healed. A Grade II hamstring injury involves a partial tear, while a Grade III injury is a complete tear of the hamstring that could require surgery and is likely season-ending. High ankle sprains When a player suffers a high ankle sprain, the ligaments above the ankle — which connect the tibia to the fibula — are affected rather than the ligaments outside the ankle in a low ankle sprain. High ankle sprains take much longer to recover from — six to eight weeks, and sometimes longer — than a classic ankle sprain, which might sideline a player for several days to a couple of weeks. Hip pointers The injury could sideline a player for a week or a couple of months, depending on the severity. A hip pointer is bruising in the pelvis and abdomen area, usually caused by blunt force, such as a hard tackle. The bleeding can affect several other muscles in the area, making it difficult to run or even walk. Lisfranc injuries A serious foot injury that can be career-threatening because of its complexity. A Lisfranc sprain or fracture is an injury in the middle of the foot in which at least one (or sometimes, all) of the small bones (or metatarsals) is broken or the ligaments that support the foot in that area are torn. Even a minor sprain not requiring surgical repair could take six to eight weeks to heal. Meniscus tears The meniscus is a crescent-shaped rubbery disk of cartilage that serves as a shock absorber on the inside and outer edges of the knee. Both help a person balance weight across the knee. When a meniscus is torn, the knee can lock up and swell. A minor tear can be treated with rest, but a severe tear could require surgery that may sideline a player for several weeks or months. Oblique strains An oblique strain involves the muscles on the side of the body between the ribs and pelvis. This type of injury can occur when a player takes a hard hit to the waist area or from overuse or sudden use of the muscles — for instance, a quarterback throwing a pass or a defensive back turning to defend a receiver. Oblique strains are usually treated with rest and could take a few weeks to heal, or could become a lingering issue otherwise. Patellar tendon injuries The patellar tendon allows a person to straighten a leg by acting with the quadriceps. Technically, it's a ligament because it connects the kneecap to the shin bone. Complete tears or ruptures often need to be surgically sewn back together and recovery is typically at least four to six months. Plantar fasciitis An injury that affects the bottom of the foot and can lead to intense heel pain. Plantar fasciitis occurs when the ligament supporting the arch of the foot — the plantar fascia — is strained and worsens when small tears develop in the ligament. The injury can sap players of speed while they deal with it. Rest, icing of the arch and finding new footwear are among typical treatments. It can linger for months. Turf toe An extremely painful injury that can sideline players for months. It occurs when the ligaments under the joint of the big toe are sprained or ruptured as a result of the toe being hyperextended. The injury makes it extremely difficult to push off and cut while running. ___
Reuters
15 minutes ago
- Reuters
Trump axes loan for Grain Belt power transmission project
WASHINGTON, July 23 (Reuters) - The administration of President Donald Trump on Wednesday axed a loan guarantee for the Grain Belt Express transmission project to send power from wind and solar energy projects in Kansas to cities in the Midwest and East. American farmers had opposed the conditional $4.9 billion loan guarantee that was initiated by the administration of former President Joe Biden, mainly due to the Grain Belt filing dozens of eminent domain, or compulsory acquisition, petitions against state landowners. The 800-mile (1,290 km) project, backed by private company Invenergy, was described by the company as the second-longest transmission line in U.S. history and a national "energy security backbone" that would connect four grid regions, including the PJM Interconnection, the largest U.S. grid spanning states from Illinois to New Jersey. The Department of Energy's Loan Programs Office, or LPO, issued the conditional loan guarantee in November. The department said in a release on Wednesday it found the conditions necessary to issue the guarantee were unlikely to be met and "it is not critical for the federal government to have a role in supporting this project." Invenergy did not immediately respond to a request for comment. The project would also have supported Trump's "energy dominance" policy of maximizing energy output. The White House on May 9 had praised a $1.7 billion Invenergy investment in the project in a "list of wins" that bolster the U.S. economy and enhance national security. But Grain Belt also jarred with the administration's opposition to renewable energy sources, which it views as unreliable and expensive compared to fossil fuels. Trump only tapped the LPO for nuclear power in his first term. The Energy Department has said it is reviewing loans, including the $85 billion in closed loans and conditional commitments LPO made between the day Trump won the election in November to the day he came back into office in January.
Reuters
15 minutes ago
- Reuters
Senators seek to upgrade US airport security, reduce checkpoint lines
WASHINGTON, July 23 (Reuters) - A bipartisan group of senators on Wednesday proposed spending hundreds of millions of dollars to invest in new modern baggage screening systems and shrink airport security lines as traffic hits new records. Senator Jerry Moran, a Republican who chairs a subcommittee on aviation, along with Democratic Senators Chris Van Hollen and Michael Bennet and Republican John Boozman, said since 2014 more than $13 billion in security ticket fees have been diverted to non-security uses. The bill would tap those funds for enhanced security efforts as air travel set a record last year and is expected to set a new one this year.
