‘Trojan horse' treatment given green light for NHS use
The targeted therapy can stop myeloma from progressing by nearly three times as long as existing treatments, studies suggest.
It is estimated that around 1,500 patients a year with multiple myeloma – an incurable cancer of the bone marrow – will benefit from the treatment.
It comes after the National Institute for Health and Care Excellence (Nice) approved belantamab mafodotin, also known as Blenrep and made by GlaxoSmithKline, for NHS use.
NHS England said that it is the first health system in the world to roll out the treatment.
Officials said that the drug can now be offered to patients whose cancer has progressed or not responded to another first-line treatment.
The treatment, which is given as an infusion every three weeks along with other cancer drugs, is a type of antibody drug which targets and attaches to cancer cells.
It has been dubbed a 'Trojan horse' treatment because it works by being taken into a cancer cell, before releasing a high concentration of a lethal molecule to destroy the cell from inside.
'Myeloma is an aggressive type of blood cancer, but we have seen a steady improvement in the outlook for patients over recent years as we have introduced new targeted therapies,' Professor Peter Johnson, NHS England's national clinical director for cancer, said.
'I am delighted that patients in England will be the first to benefit from this new treatment, which has the potential to keep cancer at bay for years longer, giving people the chance of more precious time with friends and family.
'This treatment could be life-changing for many patients and their families, and that's why it is so important that the NHS continues to secure quick access to the latest, innovative treatments like this, at affordable prices to the taxpayer.'
🚨 Do you know the key symptoms of #myeloma? 🚨
Help us spread the word by sharing this post! Early diagnosis makes all the difference. If something feels off, don't wait – talk to your GP! #BloodCancerAwarenessMonth @MyelomaUK pic.twitter.com/8owed3w4Kn
— DKMS UK | We Delete Blood Cancer (@DKMS_uk) September 6, 2024
Helen Knight, director of medicines evaluation at Nice, said: 'We're delighted that people in the UK will become among the first in the world to access belantamab mafodotin for this indication.
'This recommendation demonstrates our commitment to getting the best care to patients fast, while ensuring value for the taxpayer.'
Trials have suggested that the treatment, in combination with bortezomib and dexamethasone, delayed progression of the disease by an average of three years, compared to just over a year for patients taking commonly-used drug daratumumab along with the other treatments.
Patient Paul Silvester, 60, from Sheffield, was diagnosed with myeloma in July 2023 and received treatment at the Royal Hallamshire Hospital.
The first treatment he was given failed to stop his cancer from progressing so he was given belantamab mafodotin through an early access programme.
'I feel like this treatment has brought the party balloons back in the house. It has been amazing – within the first two or three weeks, after the first dose, I was in remission,' he said.
'It gives me quite a lot of confidence in the drugs and it makes me more optimistic about the future.
'I've been feeling well and I'm still quite active – that's what's important in terms of your quality of life.
'One of my daughters is graduating from university in October and it's a goal for me to be there.'
Shelagh McKinlay, director of research and advocacy at blood cancer charity Myeloma UK, said: 'It's fantastic to see the UK at the forefront of myeloma treatment.
'We have been working very hard for the last year to get this treatment approved and we know it will transform the lives of thousands of people with myeloma.'
Health Minister Karin Smyth said: 'This groundbreaking therapy puts the NHS at the forefront of cancer innovation.
'By harnessing cutting-edge 'trojan horse' technology, we're offering new hope to blood cancer patients across the country.'
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
South Wales Guardian
27 minutes ago
- South Wales Guardian
‘Groundbreaking' drug could slow down progression of type 1 diabetes
Teplizumab, which is already approved in the US, trains the immune system to stop attacking pancreatic cells, delaying the need for insulin by an average of three years. With type 1 diabetes, the immune system attacks insulin-producing cells in the pancreas, meaning blood sugar levels are no longer regulated by the body. If blood sugar is too high or low, it can cause serious health problems and even death. People with type 1 therefore need daily insulin. Dentist and mother-of-two, Hannah Robinson, from Devon, is the first adult in the UK to try the drug in the hope it can delay the condition. She is having treatment at the Royal Devon University Healthcare NHS Foundation Trust after discovering during pregnancy she was in the early stages of developing type 1. A handful of people are being given the medicine on a case-by-case basis while it is reviewed for wider use on the NHS. The 36-year-old said: 'For me, this new drug offers more freedom and the chance to focus on my health before I have to start thinking differently and managing life as somebody needing daily insulin. 'This isn't just about what I eat or monitoring my glucose, it is also about having more control and not feeling defined by my condition. 'This treatment could potentially pave the way for a future cure for type 1 diabetes, which is incredible. I feel very lucky to be part of this.' The new drug teplizumab must be given at the earliest stage of the disease to be effective. Dr Nick Thomas, diabetes consultant and academic clinical lecturer at the University of Exeter, said: 'This new treatment represents a really exciting shift in how we manage type 1 diabetes. 'For the first time ever, we will be able to provide targeted treatment early enough in the process to alter the underlying immune process, aiming to slow down how quickly people need insulin. 'Approximately half of all type 1 diabetes cases develop in adulthood, and Hannah will be the first adult in the UK to receive this treatment. 'My hope is that in the future, we may be able to stop people with early type 1 diabetes from needing insulin at all.' Experts at the Royal Devon and the University of Exeter are using genetics and other testing to spot people at high risk of developing type 1 diabetes. The hope is more people could be offered the drug to delay type 1. Dr Lucy Chambers, head of research impact and communications at Diabetes UK, said: 'For people in the early stages of type 1 diabetes, teplizumab offers a groundbreaking opportunity to buy them precious extra years insulin-free. 'Right now, it's only available in research settings – and while the excitement is real, urgent work is still needed to ensure it reaches everyone who could benefit. 'That means securing a UK licence for teplizumab, establishing national screening programmes to identify people with early-stage type 1 diabetes before symptoms appear, and preparing the NHS to deliver this treatment at scale. 'Diabetes UK is proud to be at the forefront of these efforts – funding pioneering research and working closely with the NHS towards a future where immunotherapies become the first-line treatment for tackling the autoimmune attack at the root of type 1 diabetes.' Professor Richard Oram, consultant physician at the Royal Devon and professor at the University of Exeter, said: 'Excitingly, teplizumab is the first drug with the potential to delay type 1 diabetes, but needs to be given before clinical diagnosis due to high blood glucose. 'It is really important to find new and improved approaches for identifying individuals at elevated risk.'
South Wales Guardian
27 minutes ago
- South Wales Guardian
Medicine shortages put patients at risk, MPs and peers warn
A new report from the All-Party Parliamentary Group (APPG) on pharmacy called for urgent action to ensure shortages do not become the 'new normal'. It also highlights the impact that shortages are having on patients with the likes of ADHD (attention deficit hyperactivity disorder), menopause and diabetes. Writing in the report, Steve Race, chairman of the APPG on pharmacy, said many MPs 'have received a growing volume of correspondence from constituents who are understandably anxious about the availability of their medicines'. 'Whether it is a parent unable to access antibiotics for a sick child, an elderly patient facing delays in obtaining life-sustaining medication, or a pharmacist overwhelmed by the need to source alternatives, the human impact is both visible and deeply troubling,' he wrote. The report said that while medicine shortages are 'not a new phenomenon', they have 'become increasingly severe, persistent, and disruptive' in recent years – leading to consequences for patients, staff and the wider health service. Mr Race said: 'Medicines shortages have moved from isolated incidents to a chronic structural challenge for both the NHS and pharmacy sector. 'As Government continues to recognise and invest in the expanded clinical role of community pharmacy, we must ensure the medicines supply chain underpinning that care is equally robust, resilient and patient-focused. 'Pharmacy is central to NHS recovery and transformation, but frontline teams cannot safely expand clinical services while daily supply disruptions continue to impact the health of patients.' The findings also highlight how shortages severely impact patients with conditions like ADHD, menopause and diabetes. More than nine in 10 pharmacists, GPs and prescribers told an APPG survey ADHD medicines had been affected by shortages. Around three quarters (76%) said HRT and diabetes drugs had been affected, while 44% said antibiotics. One patient with ADHD told the inquiry they had been self-medicating with cannabis due to an ongoing shortage of methylphenidate. The report said: 'These shortages are having a significant impact on patients' ability to access treatments and in some cases are having serious impact on patients' health and well-being.' Mr Race added: 'Medicines security must be treated as a core component of NHS planning, alongside funding, workforce and digital infrastructure. 'Failure to act risks further undermining patient care and destabilising a community pharmacy sector that millions depend upon.' The APPG has laid out a number of recommendations, which includes a number of measures to better support patients. People impacted by shortages, particularly those with chronic conditions, struggle to find information on out of stock drugs, leading to 'frustration, dangerous delays in care, and unnecessary anxiety and harm', it said. It also welcomed work being carried out by the Department of Health and Social Care to potentially change pharmacist prescribing protocols to allow pharmacists to make dose and formulation changes during shortages. Elsewhere, the inquiry found more than eight in 10 pharmacists face daily shortages, with many spending hours every day finding alternative treatment and communicating with distressed patients. One told the APPG they are 'constantly firefighting'. Reacting to the report, Henry Gregg, chief executive of the National Pharmacy Association (NPA), said: 'Pharmacy teams are under enormous pressure but are forced to spend hours hunting down stock for distressed and frustrated patients. 'It is particularly frustrating for pharmacists to be unable to meet a clear need when they have a perfectly safe and effective solution in their pharmacy already. 'MPs are right that it is madness to send someone back to their GP to get a prescription changed, and it risks a patient either delaying taking vital medication or forgoing it altogether, which poses a clear risk to patient safety. 'As the APPG says, the Government must allow pharmacists – who are highly trained health care practitioners – to use their professional judgment to supply an appropriate alternative medication when the prescribed version is unavailable.' A Department of Health and Social Care spokesperson said: 'This government inherited ongoing global supply problems, but we have robust measures in place to mitigate disruption for patients. 'We are working to build the resilience of medicine supply chains and prevent future disruption as we get the NHS back on its feet. 'We have recently agreed an extra £617 million of funding over two years with Community Pharmacy England to support the sector and provide patients with more services closer to home as part of our 10 Year Health Plan.'
North Wales Chronicle
34 minutes ago
- North Wales Chronicle
Medicine shortages put patients at risk, MPs and peers warn
A new report from the All-Party Parliamentary Group (APPG) on pharmacy called for urgent action to ensure shortages do not become the 'new normal'. It also highlights the impact that shortages are having on patients with the likes of ADHD (attention deficit hyperactivity disorder), menopause and diabetes. Writing in the report, Steve Race, chairman of the APPG on pharmacy, said many MPs 'have received a growing volume of correspondence from constituents who are understandably anxious about the availability of their medicines'. 'Whether it is a parent unable to access antibiotics for a sick child, an elderly patient facing delays in obtaining life-sustaining medication, or a pharmacist overwhelmed by the need to source alternatives, the human impact is both visible and deeply troubling,' he wrote. The report said that while medicine shortages are 'not a new phenomenon', they have 'become increasingly severe, persistent, and disruptive' in recent years – leading to consequences for patients, staff and the wider health service. Mr Race said: 'Medicines shortages have moved from isolated incidents to a chronic structural challenge for both the NHS and pharmacy sector. 'As Government continues to recognise and invest in the expanded clinical role of community pharmacy, we must ensure the medicines supply chain underpinning that care is equally robust, resilient and patient-focused. 'Pharmacy is central to NHS recovery and transformation, but frontline teams cannot safely expand clinical services while daily supply disruptions continue to impact the health of patients.' The findings also highlight how shortages severely impact patients with conditions like ADHD, menopause and diabetes. More than nine in 10 pharmacists, GPs and prescribers told an APPG survey ADHD medicines had been affected by shortages. Around three quarters (76%) said HRT and diabetes drugs had been affected, while 44% said antibiotics. One patient with ADHD told the inquiry they had been self-medicating with cannabis due to an ongoing shortage of methylphenidate. The report said: 'These shortages are having a significant impact on patients' ability to access treatments and in some cases are having serious impact on patients' health and well-being.' Mr Race added: 'Medicines security must be treated as a core component of NHS planning, alongside funding, workforce and digital infrastructure. 'Failure to act risks further undermining patient care and destabilising a community pharmacy sector that millions depend upon.' The APPG has laid out a number of recommendations, which includes a number of measures to better support patients. People impacted by shortages, particularly those with chronic conditions, struggle to find information on out of stock drugs, leading to 'frustration, dangerous delays in care, and unnecessary anxiety and harm', it said. It also welcomed work being carried out by the Department of Health and Social Care to potentially change pharmacist prescribing protocols to allow pharmacists to make dose and formulation changes during shortages. Elsewhere, the inquiry found more than eight in 10 pharmacists face daily shortages, with many spending hours every day finding alternative treatment and communicating with distressed patients. One told the APPG they are 'constantly firefighting'. Reacting to the report, Henry Gregg, chief executive of the National Pharmacy Association (NPA), said: 'Pharmacy teams are under enormous pressure but are forced to spend hours hunting down stock for distressed and frustrated patients. 'It is particularly frustrating for pharmacists to be unable to meet a clear need when they have a perfectly safe and effective solution in their pharmacy already. 'MPs are right that it is madness to send someone back to their GP to get a prescription changed, and it risks a patient either delaying taking vital medication or forgoing it altogether, which poses a clear risk to patient safety. 'As the APPG says, the Government must allow pharmacists – who are highly trained health care practitioners – to use their professional judgment to supply an appropriate alternative medication when the prescribed version is unavailable.' A Department of Health and Social Care spokesperson said: 'This government inherited ongoing global supply problems, but we have robust measures in place to mitigate disruption for patients. 'We are working to build the resilience of medicine supply chains and prevent future disruption as we get the NHS back on its feet. 'We have recently agreed an extra £617 million of funding over two years with Community Pharmacy England to support the sector and provide patients with more services closer to home as part of our 10 Year Health Plan.'
