Prince Frederik of Luxembourg Dies at 22 From Rare Genetic Disorder
Frederik's family announced the news of his passing via the POLG Foundation website—which he founded in 2022—on March 1, revealing that he died in Paris on February 28 from the condition.
"Last Friday, February 28th, on 'Rare Disease Day,' our beloved son called us in to his room to speak to him for one last time. Frederik found the strength and the courage to say goodbye to each of us in turn—his brother, Alexander; his sister, Charlotte; me; his three cousins, Charly, Louis, and Donall; his brother-in-law, Mansour; and finally, his Aunt Charlotte and Uncle Mark," the family wrote in the statement. "He had already spoken all that was in his heart to his extraordinary mother, who had not left his side in 15 years. After gifting each of us with our farewells—some kind, some wise, some instructive—in true Frederik fashion, he left us collectively with a final long-standing family joke. Even in his last moments, his humor, and his boundless compassion, compelled him to leave us with one last laugh….to cheer us all up."
The statement further revealed the details of Frederik's experience with POLG, noting that he was first diagnosed when he was 14 with his symptoms "Showing more clearly and when the progression of his disease had become more acute." The family explained that POLG affects multiple organ systems and has no treatment options or cure, adding that it is a "genetic mitochondrial disorder that robs the body's cells of energy, in turn causing progressive multiple organ (brain, nerves, liver, intestines, muscles, swallowing and ocular function, etc.) dysfunction and failure. One might compare it to having a faulty battery that never fully recharges, is in a constant state of depletion and eventually loses power."
The family thanked the POLG community for their support, and expressed a desire to continue the research that Frederik's foundation has started in order to one day find a cure to the disease.
"With our superhero's help we hope to turn our deep grief into positive results and therewith follow his unwavering example," the statement concluded. "His ultimate message is one of hope, compassion, and resilience! We are all so very proud of you, Frederik...We love you!"
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