Guardians vs. Cardinals Prediction, Odds, Picks
Data Skrive
Nolan Jones and the Cleveland Guardians take the field on Saturday at Progressive Field against Miles Mikolas, who is starting for the St. Louis Cardinals. First pitch is set for 4:10 p.m. ET. The Cardinals are -100 moneyline underdogs for this matchup with the favorite Guardians (-120). Cleveland is the run-line favorite (-1.5). An 8.5-run over/under has been set in the matchup.
Check out everything you need to know from a betting perspective on the Guardians-Cardinals game, regarding the run line, moneyline and total, plus expert picks.
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Check out the best moments between the Chicago Cubs and the St. Louis Cardinals. Guardians vs. Cardinals Game Information & Odds When: Saturday, June 28, 2025 at 4:10 p.m. ET
Where: Progressive Field in Cleveland, Ohio
How to watch on TV: CLEG and FDSMW Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Guardians -120 -100 8.5 -108 -112 -1.5 +169 -205 Guardians vs. Cardinals Prediction Score Prediction: Cardinals 4, Guardians 3
Total Prediction: Under 8.5 runs
Win Probabilities: Guardians 50%, Cardinals 50% Guardians vs. Cardinals Betting Insights The Guardians have been favorites in 30 games this season and won 18 (60%) of those contests.
This season Cleveland has won 13 of its 21 games, or 61.9%, when favored by at least -120 on the moneyline.
The implied probability of a win from the Guardians, based on the moneyline, is 54.5%.
The Cardinals have been underdogs in 46 games this season and have come away with the win 24 times (52.2%) in those contests.
St. Louis has a win-loss record of 13-18 when favored by -100 or worse by bookmakers this year.
The moneyline set for this matchup implies the Cardinals have a 50% chance of walking away with the win. Guardians Recent Betting Performance The Guardians have a 3-2 record over the five games they were a moneyline favorite in their last 10 matchups.
In their last 10 matchups, the Guardians and their opponents combined to hit the over on the total two times (all 10 games had set totals).
The Guardians' ATS record is 5-5-0 over their past 10 games. Guardians Recent Stats Stat Avg/Total Record 5-5 Runs Per Game 2.7 HR 7 ERA 3.58 K/9 8.4 Guardians Player Insights Jose Ramirez paces the Guardians with 13 home runs and 38 runs batted in, while putting up a team-high batting average of .317.
Ramirez ranks 39th in home runs and 73rd in RBI among all batters in MLB.
Steven Kwan has 18 doubles, six home runs and 28 walks while batting .306.
Kwan is 169th in homers and 181st in RBI on the season.
Carlos Santana is hitting .234 with six doubles, nine home runs and 35 walks.
Kyle Manzardo is batting .222 with 11 doubles, two triples, 12 home runs and 25 walks.
Manzardo is riding a five-game hitting streak into this one. In his last five games he is hitting .333 with a double, a home run, a walk and an RBI. Cardinals Recent Betting Performance The Cardinals have played as underdogs in five of their past 10 games and won two of those contests.
In their last 10 games with a total, the Cardinals and their opponents have failed to hit the over five times.
The Cardinals have won five of their last 10 games against the spread. Cardinals Recent Stats Stat Avg/Total Record 7-3 Runs Per Game 5.4 HR 15 ERA 3.87 K/9 7.4 Cardinals Player Insights Nolan Arenado is hitting .242 with 11 doubles, a triple, 10 home runs and 24 walks, while getting on base at a rate of .305.
Arenado's home run total places him 84th in the big leagues, and he is 68th in RBI.
Brendan Donovan's .301 batting average paces his team.
Among all major league hitters, Donovan is 203rd in homers and 134th in RBI.
Lars Nootbaar leads the Cardinals with 11 long balls.
Willson Contreras has recorded a team-leading 50 runs batted in.
Check out the best moments between the Toronto Blue Jays and the Cleveland Guardians.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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