Incredible vanishing world recreated in 12,300 hectare outback property
The University of NSW's Professor Katherine Moseby is the lead author of a paper that has tracked dramatic changes over 26 years since rabbits, foxes and cats were excluded from the landscape. When it comes to the elusive spinifex hopping mouse, its population is up to 33 times higher inside than outside the fence.
During the day, you'd have to have sharp eyes to notice signs of any of the tiny mammals that live there. There are small diggings in the soil from reintroduced species like bilbies, but the desert sands and plant life appear near identical.
'If you're driving around in a car, you have to go really slowly so you don't run over all the small mammals because they're just in such high abundance compared to the outside world,' Moseby told Yahoo News.
'If you're driving around outside, you can go at normal speed.'
Related: Concern as rare birds retreat to mountains where giant moa became extinct
The study included nine native species, the spinifex hopping mouse, plains mouse, Bolam's mouse, Forrest's mouse, desert mouse, sandy inland mouse, stripe-faced dunnart, fat-tailed dunnart and Giles' planigale. The tenth species was the introduced house mouse.
During drought, the number of native mammals naturally declines, but after rain, furious breeding helps restore numbers. But the presence of feral predators outside of the fence area appears to interrupt the natural boom and bust breeding cycles, suppressing their recovery and eventually leading to localised extinctions.
The team was 'surprised' to discover that in the absence of introduced predators, mammals were expanding into new habitats where they're not traditionally found. This indicates they have retreated from an array of landscapes since the arrival of Europeans.
The spinifex hopping house had primarily been associated with sand dunes, but behind the fences they have been seen in swales and clay-based lowlands. The plains mouse moved from swales to sand dunes.
Sadly, not all of the animals that once roamed the Red Centre landscape have survived — there are several species missing from the study because they're extinct. But the recovery of 10 highlights how much the nation once looked before European settlement.
'It's incredible how that country would have been so different back then. I think people drive through the desert and think there's nothing out there, but they've just changed so much over the last 150 years,' Moseby said.
Moseby isn't just sad that Australia has changed so dramatically and that few people are aware more species like the carnivorous kowari and greater bilbies are continuing to decline in numbers. She's mostly angry.
In her decades of studying Australia's rare and endangered creatures, she hasn't seen any 'political will' to save those that have survived the initial wave of settlement, and the cocktail of threats that continue to suppress them. The country is famous for wiping out the Tasmanian tiger, very nearly killing off the koala, and it is notable for having the worst mammalian extinction record in the world.
Rare colour footage of extinct Australian animal seen again after 90 years
Major weather event sees town overrun by 'rarely observed' phenomenon
Once common 'extreme' genetic change unlikely to occur again in human history
Director Stephen Spielberg famously recreated a "Lost World" in his movie franchise about bringing dinosaurs back from extinction. The pre-colonial landscape in Australia hasn't yet been lost, but extinction threats are mounting, including climate change, which is heating parts of the desert to uninhabitable levels.
'We know what we need to do. It makes me really frustrated that we could be doing so much more – we can improve land condition, reduce grazing, increase our control of cats and foxes, and improve fire management. We've done the research,' Moseby said.
'We know what we need to do, but it seems like we're banging our heads against a wall, because these things just don't get taken up.'
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WIRED
3 hours ago
- WIRED
Scientists Succeed in Reversing Parkinson's Symptoms in Mice
Jul 10, 2025 6:30 AM The findings of two recent studies give hope that the disease could one day be reversed in humans—but experts warn that this complex disease will likely need multiple complementary treatments. An illustration of the human brain showing a shrunken substantia nigra, a degeneration that occurs with Parkinson's disease. Illustration: KATERYNA KON/SCIENCEAll products featured on WIRED are independently selected by our editors. However, we may receive compensation from retailers and/or from purchases of products through these links. Cases of Parkinson's disease have doubled in the last 25 years, according to figures from the World Health Organization. For decades, the scientists have investigated what triggers this disorder to mitigate its symptoms and anticipate its onset. Now, a series of experimental therapies are laying the groundwork for potentially reversing the condition, which affects nearly 10 million people worldwide and can generate costs of approximately $10,000 per patient per year, when considering direct and indirect medical expenses. Parkinson's disease is a degenerative neurological disorder in which cells that produce dopamine in the brain die, causing symptoms such as tremors, muscle stiffness, slowness of movement, and alterations in balance. So far there is no cure, and treatments are limited. Kay Double, a professor at the University of Sydney's School of Medical Sciences, has been researching the biological mechanisms underlying this disease for more than a decade, with the aim of finding ways to slow or even halt its progression. In 2017, he led a study that identified for the first time an abnormal form of a protein called SOD1 in Parkinson's patients. Under normal conditions, this protein acts as an antioxidant enzyme, protecting brain cells from damage caused by free radicals, highly reactive molecules that contain oxygen and can deteriorate cells if not properly neutralized. Free radicals are produced by natural bodily processes as well as by external factors, like diet, smoking, and exposure to pollution. In people with Parkinson's disease, SOD1 suffers alterations that prevent it from fulfilling its protective function, with it instead accumulating in the brain and causing neuronal damage, according to the findings of Double's team. Based on these results, the team then conducted further research, with results suggesting that copper supplementation in the brain could be an effective way to slow and even reverse the symptoms of Parkinson's (copper is crucial to SOD1's function). To test this hypothesis, they evaluated the efficacy of a drug called CuATSM, designed to cross the blood-brain barrier and deliver copper directly to brain tissue. This experiment, written up and published in Acta Neuropathologica Communications, was divided into two phases. The first was to determine the optimal dose of the drug to induce a response in the brain. To find this, CuATSM was administered daily for three weeks to 27 eight-week-old wild-type mice, with concentrations of copper and other metals then measured in the mice's tissues. This revealed that 15 milligrams per kilogram was the ideal dose to effectively increase the levels of copper in the brain. In the second stage, this dose was applied to 10 mice genetically modified to develop Parkinson's-like symptoms. The animals were divided into two groups: one received CuATSM daily for three months, while the other received a placebo without the active ingredient. The results showed that the mice treated with the placebo experienced a deterioration in their motor skills. In contrast, those that received the copper supplement showed no alterations in their movement. It appears the treatment corrected the dysfunctions of SOD1 and restored its protective properties. In the mice receiving the copper treatment, dopamine neurons were preserved in an area of the brain called the substantia nigra, an area essential for the control of movement, coordination, learning, and certain cognitive functions. 'All of the mice we treated showed dramatic improvement in their motor skills. The results exceeded our expectations and suggest that, after further study, this therapeutic approach could slow the progression of Parkinson's in humans,' says Double. But experts caution that Parkinson's is a complex condition that will likely require multiple combined interventions. A single treatment may have limited effect, but its efficacy may be enhanced by integrating it with other therapeutic approaches. In that context, Double's team's findings could be complemented by recent research from Stanford University focused on restoring communication between neurons in a subtype of Parkinson's linked to mutations in the gene responsible for producing an enzyme called LRRK2. In these cases, the mutation causes hyperactivity of the enzyme, altering the structure of brain cells and disrupting signaling between dopaminergic neurons and those in the striatum, a deep brain region related to movement, motivation, and decision-making. It is estimated that about 25 percent of Parkinson's cases are genetic in origin, and the LRRK2 mutation is one of the most frequent. The team led by Stanford neuroscientist Suzanne Pfeffer proposed that inhibiting the excessive activity of this enzyme could stabilize symptoms, especially if detected in early stages. The goal was to regenerate primary cilia, antenna-like structures that enable communication between cells. The hypothesis was tested in mice genetically modified to exhibit LRRK2 hyperactivity and early symptoms of the disorder. For two weeks, these animals were administered with a compound called MLi-2, which binds to the enzyme and reduces its activity. In this first test, no relevant changes were observed, which the researchers attributed to the fact that the examined neurons and glia—another type of cell in the nervous system, which support neurons—were already mature and were not in the cell division phase. However, a review of the scientific literature revealed that, even if mature, certain neurons can regenerate their primary cilia depending on their sleep-wake cycles. 'The findings that other nonproliferative cells can develop cilia made us think that the inhibitor still had therapeutic potential,' Pfeffer explains. The team then decided to extend the treatment to three months. After this period, they found that the percentage of neurons and glial cells in the striatum with primary cilia was comparable to that of healthy mice without the genetic mutation. This restoration of cellular structures made it possible to reactivate communication between dopaminergic neurons and the striatum. As a result, neurotransmitters affected by the LRRK2 protein induced the production of neuroprotective factors at levels similar to those of a healthy brain, something that had been diminished as a result of LRRK2 hyperactivity. In addition, density markers of dopaminergic nerve endings were doubled, suggesting a possible recovery of previously damaged neurons. 'These findings suggest that it is not only possible to stabilize the disease, but also to improve the condition of patients. This therapeutic approach has great potential to restore neuronal activity in Parkinson's-affected circuits. There are currently several ongoing clinical trials with LRRK2 inhibitors, and we hope that these results in mice can be translated to humans,' says Pfeffer. The authors stress that, to maximize the effectiveness of this treatment, it is essential to identify early symptoms, which can occur up to 15 years before the characteristic tremors. The hope is that people with the LRRK2 mutation will be able to start treatment early. The next step would be to assess whether other Parkinson's variants, not associated with this genetic mutation, could also benefit from this strategy. It is estimated that the number of Parkinson's cases worldwide could exceed 25 million by 2050, which would represent a 112 percent increase over 2021 figures, according to projections published in the British Medical Journal. Although these estimates are not definitive, the scientific community warns that they reflect a growing challenge for public health systems. For this reason, developing therapies capable of mitigating, stabilizing, and even reversing the progression of the disease is a global priority. This story originally appeared on WIRED en Español and has been translated from Spanish.
Yahoo
5 hours ago
- Yahoo
Remarkable 26-year change revealed on Aussie desert property
In the heart of Australia's outback, a vanishing world has been created that only springs to life at night. Behind towering fences at South Australia's 12,300-hectare Arid Recovery Reserve, 10 mammal species are being protected from invasive predators behind high fences, reestablishing a complex ecosystem that few people alive today have seen. The University of NSW's Professor Katherine Moseby is the lead author of a paper that has tracked dramatic changes over 26 years since rabbits, foxes and cats were excluded from the landscape. When it comes to the elusive spinifex hopping mouse, its population is up to 33 times higher inside than outside the fence. During the day, you'd have to have sharp eyes to notice signs of any of the tiny mammals that live there. There are small diggings in the soil from reintroduced species like bilbies, but the desert sands and plant life appear near identical. 'If you're driving around in a car, you have to go really slowly so you don't run over all the small mammals because they're just in such high abundance compared to the outside world,' Moseby told Yahoo News. 'If you're driving around outside, you can go at normal speed.' Related: Concern as rare birds retreat to mountains where giant moa became extinct The study included nine native species, the spinifex hopping mouse, plains mouse, Bolam's mouse, Forrest's mouse, desert mouse, sandy inland mouse, stripe-faced dunnart, fat-tailed dunnart and Giles' planigale. The tenth species was the introduced house mouse. During drought, the number of native mammals naturally declines, but after rain, furious breeding helps restore numbers. But the presence of feral predators outside of the fence area appears to interrupt the natural boom and bust breeding cycles, suppressing their recovery and eventually leading to localised extinctions. The team was 'surprised' to discover that in the absence of introduced predators, mammals were expanding into new habitats where they're not traditionally found. This indicates they have retreated from an array of landscapes since the arrival of Europeans. The spinifex hopping house had primarily been associated with sand dunes, but behind the fences they have been seen in swales and clay-based lowlands. The plains mouse moved from swales to sand dunes. Sadly, not all of the animals that once roamed the Red Centre landscape have survived — there are several species missing from the study because they're extinct. But the recovery of 10 highlights how much the nation once looked before European settlement. 'It's incredible how that country would have been so different back then. I think people drive through the desert and think there's nothing out there, but they've just changed so much over the last 150 years,' Moseby said. Moseby isn't just sad that Australia has changed so dramatically and that few people are aware more species like the carnivorous kowari and greater bilbies are continuing to decline in numbers. She's mostly angry. In her decades of studying Australia's rare and endangered creatures, she hasn't seen any 'political will' to save those that have survived the initial wave of settlement, and the cocktail of threats that continue to suppress them. The country is famous for wiping out the Tasmanian tiger, very nearly killing off the koala, and it is notable for having the worst mammalian extinction record in the world. Rare colour footage of extinct Australian animal seen again after 90 years Major weather event sees town overrun by 'rarely observed' phenomenon Once common 'extreme' genetic change unlikely to occur again in human history Director Stephen Spielberg famously recreated a "Lost World" in his movie franchise about bringing dinosaurs back from extinction. The pre-colonial landscape in Australia hasn't yet been lost, but extinction threats are mounting, including climate change, which is heating parts of the desert to uninhabitable levels. 'We know what we need to do. It makes me really frustrated that we could be doing so much more – we can improve land condition, reduce grazing, increase our control of cats and foxes, and improve fire management. We've done the research,' Moseby said. 'We know what we need to do, but it seems like we're banging our heads against a wall, because these things just don't get taken up.' Love Australia's weird and wonderful environment? 🐊🦘😳 Get our new newsletter showcasing the week's best stories.
Yahoo
6 hours ago
- Yahoo
Melting ice will strengthen the monsoon in northern Australia – but cause drier conditions north of the Equator
Almost two-thirds of the world's population is affected by the monsoon – the annual arrival of intense rains in areas north and south of the Equator. These drenching rains tend to arrive during each hemisphere's summer. The East Asian monsoon north of the equator is the best known and best studied, because it affects the largest land area and the most people. But the southern Indo-Australian monsoon is vitally important to northern Australia, Indonesia and Papua New Guinea. To date, it has been studied much less. To help fill this gap in knowledge, we analysed deep sediment from an unusual lagoon near Darwin in northern Australia. We looked at ancient pollen and chemical isotopes (different versions of the same chemical element) to look about 150,000 years back in time and glimpse changes to the monsoon. When types of pollen change, it tells us the monsoon has changed. Drier conditions favour the emergence of grasslands, while wetter climates favour forests. Our new research suggests as the world gets hotter, the Indo-Australian monsoon will intensify and northern Australia will get wetter. This finding is consistent with research suggesting the East Asian monsoon could weaken, threatening agriculture and nature in heavily populated countries. To examine how monsoons change over time, researchers drill sediment cores to track changes in pollen and chemical isotopes. For example, changes in hydrogen isotopes indicate changes in the intensity of the monsoon rain. The problem is, these cores have to come from long-undisturbed lake sediments, because such places provide a continuous record of change. To reconstruct past changes in monsoon patterns, undisturbed sediments have to be sampled carefully by extracting a thin 'core' from the bottom sediments. Once researchers have this precious core, they can examine the changing proportions of pollen, chemical isotopes and other properties. The deeper you drill the core, the farther back in time you can look. These exacting requirements are one reason the Indo-Australian monsoon is not as well understood as its northern cousin. Fortunately, we have found one place which has kept a detailed environmental record over a long period: Girraween Lagoon on the outskirts of Darwin in the Northern Territory. This lagoon was created after a sinkhole formed more than 200,000 years ago. It has contained permanent water ever since, and is slowly filling with sediment and pollen blown in from the surrounding landscape. The 18-metre core from Girraween's sediments gave us a 150,000-year record of environmental change in Australia's northern savannahs. If you walk around Girraween Lagoon today, you'll see a tall and dense tree canopy with a thick grass understory in the wet season. But it hasn't always been that way. During the last ice age 20,000–30,000 years ago, the sea level was much lower and the polar ice caps much larger. As a result, the lagoon was more than 300 kilometres from the coast. At that time, the lagoon was surrounded by an open, grassy savannah with fewer, shorter trees. About 115,000 years ago (and again 90,000 years ago), Australia was dotted with gigantic inland 'megalakes'. At those times, the lagoon expanded into a large, shallow lake surrounded by lush monsoon forest, with almost no grass. At times, tree cover changed radically. In fact, over one 3,000-year period, the percentage of tree pollen soared from 15% to 95%. That suggests a sweeping change from grassland to dense forest – meaning a switch from drier to wetter climate at a rate too fast to be explained by changes in Earth's orbit. Some of these changes are linked to the shifting distance between coastline and lagoon as well as predictable variation in how much solar energy reaches Earth. Huge ice sheets covered large areas of the Northern Hemisphere during previous ice ages. Remarkably, the evidence of their melting at the end of previous ice age was there in the sediment core from Girraween Lagoon. When glacial ice melts rapidly, huge volumes of fresh water flood into the North Atlantic. These rapid pulses are known as Heinrich events. These pulses can shut down the warm Gulf Stream current up the east coast of North America. As a result, the Northern Hemisphere cools and the Southern Hemisphere warms. Over the last 150,000 years, there have been 14 of these events. We could see evidence of them in the sediment cores. Every gush of fresh water in the Atlantic triggered higher rainfall over northern Australia because of the buildup of heat in the Southern Hemisphere as the Gulf Stream slowed. All this suggests the Indo-Australian monsoon will get more intense as the world gets hotter and more ice melts. That would mean a wetter northern Australia. It could also bring more rainfall to other Australian regions, and neighbouring countries. At this stage, it's too uncertain to predict what an intensifying monsoon would do to the southern parts of Australia. We might already be seeing this shift. Weather records since the 1960s show northern Australia getting steadily wetter, and less rain in Australia's southeast and southwest. What would this mean for people? Australia's tropical north is not densely populated, which would reduce the human impact of an intensifying monsoon. But while our research suggests the Indo-Australian monsoon strengthens during Heinrich events, earlier research has shown the East Asian and other Northern Hemisphere monsoons will weaken. Without reliable monsoonal rains, food and water supplies for billions of people could be at risk. This article is republished from The Conversation. It was written by: Corey J. A. Bradshaw, Flinders University; Cassandra Rowe, James Cook University, and Michael Bird, James Cook University Read more: Earth's 'oldest' impact crater is much younger than previously thought – new study Where do giant volcanic eruptions come from? New study finds missing link to 'blobs' deep within Earth Thirsty future: Australia's green hydrogen targets could require vastly more water than the government hopes Corey J. A. Bradshaw receives funding from the Australian Research Council. Cassandra Rowe receives funding from the Australian Research Council. Michael Bird receives funding from the Australian Research Council.