
ESET participates in operation to disrupt the infrastructure of Danabot infostealer
While primarily developed as an infostealer, Danabot also has been used to distribute additional malware, including ransomware.
Danabot's authors promote their toolset through underground forums and offer various rental options to potential affiliates.
This ESET Research analysis covers the features used in the latest versions of the malware, the authors' business model, and an overview of the toolset offered to affiliates.
Poland, Italy, Spain and Turkey are historically one of the most targeted countries by Danabot.
PRAGUE and BRATISLAVA, Czech Republic, May 22, 2025 (GLOBE NEWSWIRE) — ESET has participated in a major infrastructure disruption of the notorious infostealer, Danabot, by the US Department of Justice, the FBI, and US Department of Defense's Defense Criminal Investigative Service. U.S. agencies were working closely with Germany's Bundeskriminalamt, the Netherlands' National Police, and the Australian Federal Police. ESET took part in the effort alongside Amazon, CrowdStrike, Flashpoint, Google, Intel471, PayPal, Proofpoint, Team Cymru and Zscaler. ESET Research, which has been tracking Danabot since 2018, contributed assistance that included providing technical analysis of the malware and its backend infrastructure, as well as identifying Danabot's C&C servers. During that period, ESET analyzed various Danabot campaigns all over the world, with Poland, Italy, Spain and Turkey historically being one of the most targeted countries. The joint takedown effort also led to the identification of individuals responsible for Danabot development, sales, administration, and more.
'Since Danabot has been largely disrupted, we are using this opportunity to share our insights into the workings of this malware-as-a-service operation, covering the features used in the latest versions of the malware, the authors' business model, and an overview of the toolset offered to affiliates. Apart from exfiltrating sensitive data, we have observed that Danabot is also used to deliver further malware, which can include ransomware, to an already compromised system,' says ESET researcher Tomáš Procházka, who investigated Danabot.
The authors of Danabot operate as a single group, offering their tool for rental to potential affiliates, who subsequently employ it for their malicious purposes by establishing and managing their own botnets. Danabot's authors have developed a vast variety of features to assist customers with their malevolent motives. The most prominent features offered by Danabot include: the ability to steal various data from browsers, mail clients, FTP clients, and other popular software; keylogging and screen recording; real-time remote control of the victims' systems; file grabbing; support for Zeus-like webinjects and form grabbing; and arbitrary payload upload and execution. Besides utilizing its stealing capabilities, ESET Research has observed a variety of payloads being distributed via Danabot over the years. Furthermore, ESET has encountered instances of Danabot being used to download ransomware onto already compromised systems.
In addition to typical cybercrime, Danabot has also been used in less conventional activities such as utilizing compromised machines for launching DDoS attacks… for example, a DDoS attack against Ukraine's Ministry of Defense soon after the Russian invasion of Ukraine.
Throughout its existence, according to ESET monitoring, Danabot has been a tool of choice for many cybercriminals and each of them has used different means of distribution. Danabot's developers even partnered with the authors of several malware cryptors and loaders, and offered special pricing for a distribution bundle to their customers, helping them with the process. Recently, out of all distribution mechanisms ESET observed, the misuse of Google Ads to display seemingly relevant, but actually malicious, websites among the sponsored links in Google search results stands out as one of the most prominent methods to lure victims into downloading Danabot. The most popular ploy is packing the malware with legitimate software and offering such a package through bogus software sites or websites falsely promising users to help them find unclaimed funds. The latest addition to these social engineering techniques are deceptive websites offering solutions for fabricated computer issues, whose only purpose is to lure victims into execution of a malicious command secretly inserted into the user's clipboard.
The typical toolset provided by Danabot's authors to their affiliates includes an administration panel application, a backconnect tool for real-time control of bots, and a proxy server application that relays the communications between the bots and the actual C&C server. Affiliates can choose from various options to generate new Danabot builds, and it's their responsibility to distribute these builds through their own campaigns.
'It remains to be seen whether Danabot can recover from the takedown. The blow will, however, surely be felt, since law enforcement managed to unmask several individuals involved in the malware's operations,' concludes Procházka.
For technical overview of Danabot and insight into its operation, check out ESET Research blogpost: 'Danabot: Analyzing a fallen empire' on WeLiveSecurity.com. Make sure to follow ESET Research on Twitter (today known as X), BlueSky, and Mastodon for the latest news from ESET Research.
Worldwide Danabot detections as seen in ESET telemetry since 2018
About ESET
ESET® provides cutting-edge digital security to prevent attacks before they happen. By combining the power of AI and human expertise, ESET stays ahead of emerging global cyberthreats, both known and unknown— securing businesses, critical infrastructure, and individuals. Whether it's endpoint, cloud, or mobile protection, our AI-native, cloud-first solutions and services remain highly effective and easy to use. ESET technology includes robust detection and response, ultra-secure encryption, and multifactor authentication. With 24/7 real-time defense and strong local support, we keep users safe and businesses running without interruption. The ever-evolving digital landscape demands a progressive approach to security: ESET is committed to world-class research and powerful threat intelligence, backed by R&D centers and a strong global partner network. For more information, visit www.eset.com or follow our social media, podcasts and blogs.
A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/2306cbf1-1ef7-4040-8c12-ca8be3cc6689
Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same.

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


Miami Herald
18 hours ago
- Miami Herald
MIRA Reports Potent Inflammatory Pain Relief from Non-Psychoactive Marijuana Analog Mira-55 in Animal Model, Matching Morphine Without Opioid Risks
With Mira-55 and Ketamir-2, MIRA is advancing complementary non-opioid therapies for two of the largest pain markets MIAMI, FLORIDA / ACCESS Newswire / July 3, 2025 / MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA) ("MIRA" or the "Company"), a clinical-stage pharmaceutical company developing novel therapeutics for neurologic, neuropsychiatric, and metabolic disorders, today announced positive preclinical data demonstrating that Mira-55, the Company's proprietary non-psychotropic marijuana analog, delivered morphine-comparable pain relief in a validated model of inflammatory pain-without causing local inflammation. Mira-55 is a next-generation analog of marijuana, engineered to selectively activate CB2 cannabinoid receptors, which are associated with anti-inflammatory and analgesic effects. Unlike THC, Mira-55 minimizes activation of CB1 receptors, reducing the risk of euphoria, sedation, and pro-inflammatory side effects. "These results reinforce the value of Mira-55 as a differentiated cannabinoid-based therapy with real clinical potential," said Erez Aminov, Chairman and CEO of MIRA. "We believe the drug's ability to match morphine's pain relief-without the baggage of addiction, sedation, or THC-like effects-makes Mira-55 an ideal candidate for large, underserved inflammatory pain markets. It's another step in building a non-opioid pain franchise that addresses both inflammatory and neuropathic pain." Study Overview and Key Findings Mira-55 was tested using the formalin model, a gold-standard preclinical method for studying inflammatory pain. In this model, formalin is injected into the rat's paw, producing a pain response that mimics human inflammatory pain. Pain sensitivity was assessed using Von Frey Filament testing, which measures tactile pain thresholds, and inflammation was measured by paw edema volume. Key findings: Mira-55 reduced pain sensitivity by approximately threefold, restoring thresholds to near-baseline analgesic effect was equivalent to morphine, the standard opioid comparator in the sedation or inflammatory swelling was observed with Mira-55 treatment. Importantly, following a scientific review, the U.S. Drug Enforcement Administration (DEA) determined that Mira-55 is not classified as a controlled substance. This designation supports the compound's long-term clinical and commercial viability and removes key barriers typically associated with cannabinoid-based drug development. These results build on prior data from a separate inflammatory pain model conducted by a leading U.S. academic research center, where Mira-55 blocked both thermal and mechanical hyperalgesia without increasing inflammation. In contrast, low-dose THC in that model exacerbated inflammation-further validating Mira-55's selective pharmacological profile. "Mira-55 offers the pain-relieving potential of cannabinoids without the liabilities traditionally seen in THC-based drugs," said Dr. Itzchak Angel, Chief Scientific Advisor at MIRA. "Its novel structure and unique profile with CB2 selectivity and non-scheduled DEA status make it a compelling candidate for treating inflammation-driven pain conditions that are poorly managed by today's standards." Strategic Fit Within MIRA's Pain Portfolio Mira-55 complements Ketamir-2, MIRA's clinical-stage NMDA receptor antagonist, which is advancing through Phase 1 development for neuropathic pain. While Ketamir-2 addresses nerve-related pain through central mechanisms, Mira-55 targets inflammatory pain through the endocannabinoid system. Together, they represent two mechanistically distinct, non-opioid approaches to treating chronic pain. "With Mira-55 and Ketamir-2, we now have two highly differentiated drug candidates with the potential to transform how inflammatory and neuropathic conditions are treated," added Aminov. "We're advancing each asset methodically, and we're energized by the momentum we've built across the pipeline." Corporate Update on SKNY Merger MIRA also announced continued progress on its previously disclosed acquisition of SKNY Pharmaceuticals, the developer of SKNY-1, a novel investigational therapy targeting both obesity and nicotine addiction. In recent studies, SKNY-1 demonstrated a 30% reduction in body weight without muscle loss, along with a reversal of nicotine cravings-highlighting its potential as a differentiated treatment in two major markets. The U.S. Securities and Exchange Commission (SEC) has completed its review of the merger proxy with no comments, allowing MIRA to proceed with shareholder approval and the final steps toward completing the transaction. "We are pleased to report that the SEC had no comments on our merger filing, which reflects the quality of our regulatory and business preparation," said Aminov. "This milestone allows us to advance toward shareholder approval with clarity and confidence as we prepare for the next phase of growth." Next Steps MIRA Pharmaceuticals is advancing Mira-55 toward an Investigational New Drug (IND) submission, with ongoing activities supporting future clinical development in inflammatory pain. The Company remains focused on progressing both lead programs-Mira-55 and Ketamir-2-toward their next regulatory and clinical milestones. About MIRA Pharmaceuticals, Pharmaceuticals, Inc. (NASDAQ:MIRA) is a clinical-stage pharmaceutical company focused on the development and commercialization of novel therapeutics for neurologic, neuropsychiatric, and metabolic disorders. The Company's pipeline includes oral drug candidates designed to address significant unmet medical needs in areas such as neuropathic pain, inflammatory pain, obesity, addiction, anxiety, and cognitive decline. Cautionary Note Regarding Forward-Looking StatementsThis press release and the statements of MIRA's management related thereto contain "forward-looking statements," which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements may be identified by words such as "aims," "anticipates," "believes," "could," "estimates," "expects," "forecasts," "goal," "intends," "may," "plans," "possible," "potential," "seeks," "will," and variations of these words or similar expressions that are intended to identify forward-looking statements. Any statements in this press release that are not historical facts may be deemed forward-looking. Any forward-looking statements in this press release are based on MIRA's current expectations, estimates, and projections only as of the date of this release and are subject to a number of risks and uncertainties (many of which are beyond MIRA's control) that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements, including related to MIRA's potential merger with SKNY Pharmaceuticals, Inc. These and other risks concerning MIRA's programs and operations are described in additional detail in the Annual Report on Form 10-K for the year ended December 31, 2024, and the Form 14A filed by MIRA on June 18, 2025, and other SEC filings, which are on file with the SEC at and on MIRA's website at MIRA explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law. Contact:Helga Moyainfo@ 432-9792 SOURCE: MIRA Pharmaceuticals


USA Today
18 hours ago
- USA Today
MIRA Reports Potent Inflammatory Pain Relief from Non-Psychoactive Marijuana Analog Mira-55 in Animal Model, Matching Morphine Without Opioid Risks
With Mira-55 and Ketamir-2, MIRA is advancing complementary non-opioid therapies for two of the largest pain markets MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA) ('MIRA' or the 'Company'), a clinical-stage pharmaceutical company developing novel therapeutics for neurologic, neuropsychiatric, and metabolic disorders, today announced positive preclinical data demonstrating that Mira-55, the Company's proprietary non-psychotropic marijuana analog, delivered morphine-comparable pain relief in a validated model of inflammatory pain-without causing local inflammation. Mira-55 is a next-generation analog of marijuana, engineered to selectively activate CB2 cannabinoid receptors, which are associated with anti-inflammatory and analgesic effects. Unlike THC, Mira-55 minimizes activation of CB1 receptors, reducing the risk of euphoria, sedation, and pro-inflammatory side effects. 'These results reinforce the value of Mira-55 as a differentiated cannabinoid-based therapy with real clinical potential,' said Erez Aminov, Chairman and CEO of MIRA. 'We believe the drug's ability to match morphine's pain relief-without the baggage of addiction, sedation, or THC-like effects-makes Mira-55 an ideal candidate for large, underserved inflammatory pain markets. It's another step in building a non-opioid pain franchise that addresses both inflammatory and neuropathic pain.' Study Overview and Key Findings Mira-55 was tested using the formalin model, a gold-standard preclinical method for studying inflammatory pain. In this model, formalin is injected into the rat's paw, producing a pain response that mimics human inflammatory pain. Pain sensitivity was assessed using Von Frey Filament testing, which measures tactile pain thresholds, and inflammation was measured by paw edema volume. Key findings: Mira-55 reduced pain sensitivity by approximately threefold, restoring thresholds to near-baseline levels. Its analgesic effect was equivalent to morphine, the standard opioid comparator in the study. No sedation or inflammatory swelling was observed with Mira-55 treatment. Importantly, following a scientific review, the U.S. Drug Enforcement Administration (DEA) determined that Mira-55 is not classified as a controlled substance. This designation supports the compound's long-term clinical and commercial viability and removes key barriers typically associated with cannabinoid-based drug development. These results build on prior data from a separate inflammatory pain model conducted by a leading U.S. academic research center, where Mira-55 blocked both thermal and mechanical hyperalgesia without increasing inflammation. In contrast, low-dose THC in that model exacerbated inflammation-further validating Mira-55's selective pharmacological profile. 'Mira-55 offers the pain-relieving potential of cannabinoids without the liabilities traditionally seen in THC-based drugs,' said Dr. Itzchak Angel, Chief Scientific Advisor at MIRA. 'Its novel structure and unique profile with CB2 selectivity and non-scheduled DEA status make it a compelling candidate for treating inflammation-driven pain conditions that are poorly managed by today's standards.' Strategic Fit Within MIRA's Pain Portfolio Mira-55 complements Ketamir-2, MIRA's clinical-stage NMDA receptor antagonist, which is advancing through Phase 1 development for neuropathic pain. While Ketamir-2 addresses nerve-related pain through central mechanisms, Mira-55 targets inflammatory pain through the endocannabinoid system. Together, they represent two mechanistically distinct, non-opioid approaches to treating chronic pain. 'With Mira-55 and Ketamir-2, we now have two highly differentiated drug candidates with the potential to transform how inflammatory and neuropathic conditions are treated,' added Aminov. 'We're advancing each asset methodically, and we're energized by the momentum we've built across the pipeline.' Corporate Update on SKNY Merger MIRA also announced continued progress on its previously disclosed acquisition of SKNY Pharmaceuticals, the developer of SKNY-1, a novel investigational therapy targeting both obesity and nicotine addiction. In recent studies, SKNY-1 demonstrated a 30% reduction in body weight without muscle loss, along with a reversal of nicotine cravings-highlighting its potential as a differentiated treatment in two major markets. The U.S. Securities and Exchange Commission (SEC) has completed its review of the merger proxy with no comments, allowing MIRA to proceed with shareholder approval and the final steps toward completing the transaction. 'We are pleased to report that the SEC had no comments on our merger filing, which reflects the quality of our regulatory and business preparation,' said Aminov. 'This milestone allows us to advance toward shareholder approval with clarity and confidence as we prepare for the next phase of growth.' Next Steps MIRA Pharmaceuticals is advancing Mira-55 toward an Investigational New Drug (IND) submission, with ongoing activities supporting future clinical development in inflammatory pain. The Company remains focused on progressing both lead programs-Mira-55 and Ketamir-2-toward their next regulatory and clinical milestones. About MIRA Pharmaceuticals, Inc. MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA) is a clinical-stage pharmaceutical company focused on the development and commercialization of novel therapeutics for neurologic, neuropsychiatric, and metabolic disorders. The Company's pipeline includes oral drug candidates designed to address significant unmet medical needs in areas such as neuropathic pain, inflammatory pain, obesity, addiction, anxiety, and cognitive decline. Cautionary Note Regarding Forward-Looking Statements This press release and the statements of MIRA's management related thereto contain 'forward-looking statements,' which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements may be identified by words such as 'aims,' 'anticipates,' 'believes,' 'could,' 'estimates,' 'expects,' 'forecasts,' 'goal,' 'intends,' 'may,' 'plans,' 'possible,' 'potential,' 'seeks,' 'will,' and variations of these words or similar expressions that are intended to identify forward-looking statements. Any statements in this press release that are not historical facts may be deemed forward-looking. Any forward-looking statements in this press release are based on MIRA's current expectations, estimates, and projections only as of the date of this release and are subject to a number of risks and uncertainties (many of which are beyond MIRA's control) that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements, including related to MIRA's potential merger with SKNY Pharmaceuticals, Inc. These and other risks concerning MIRA's programs and operations are described in additional detail in the Annual Report on Form 10-K for the year ended December 31, 2024, and the Form 14A filed by MIRA on June 18, 2025, and other SEC filings, which are on file with the SEC at and on MIRA's website at MIRA explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law. Contact: Helga Moya info@ (786) 432-9792 SOURCE: MIRA Pharmaceuticals View the original press release on ACCESS Newswire


Business Wire
19 hours ago
- Business Wire
Precisio Biotix Therapeutics, Inc. (Precisio) Announces Dosing of a First Patient with ClyO (Staph Lysin) to Treat a Multi Drug-Resistant Prosthetic Joint Infection
DOVER, Del.--(BUSINESS WIRE)-- Precisio announced a first-in-man dosing of its staph lysin called ClyO (LYSG101) to a patient with a prosthetic joint infection that had not responded to other treatments. The FDA approved this treatment under a compassionate care IND filed by The patient appears to have tolerated the treatment without any adverse events. It is too early to assess full efficacy, but this is certainly a significant step toward providing additional options to patients, particularly when traditional treatments have failed. Dr. Raymond Schuch, VP, Director of US Operations, notes, 'Our sole company focus is the systematic engineering of native lysins and generation of drug-like, optimized and engineered lysins vs. antimicrobial-resistant human pathogens that are associated with high unmet medical needs. Our team possesses unique experience of developing these lysins and transitioning lysins into clinical studies and into patients. To date, our efforts have focused on respiratory, skin, and vaginal infections. We are excited to add prosthetic joint infections to the portfolio of infections we think that we can effectively treat.' Mark Engel, Founder and CEO of Precisio said, 'We are a platforms plus products company. The key to developing best-in-world lysins is that we use multiple self-developed high-tech proprietary tools. These include tools in bioinformatics, machine-learning, and AI (Zeus™-LysiThru™). We are now at a point where we think we can develop lysin products against many infections including those resistant to standard antibiotics. This patient at Mayo Clinic is the first of what we hope are many examples that we announce in the coming months. Doctors around the globe are anxious to start using our treatments on a compassionate basis since large numbers of patients are not responding to existing treatments.' Dr. Assaf Raz, VP of Research and Development noted: 'Drug-resistant infections are a pressing global health issue, causing at least 700,000 deaths each year. Without decisive action, this number could rise to 10 million annually by 2050, according to the UN Ad hoc Interagency Coordinating Group on Antimicrobial Resistance. Our research team is dedicated to developing new lysin therapeutics for large areas of need that bypass antibiotic resistance. We are highly encouraged that our technologies allow us to rapidly create effective solutions for multidrug-resistant pathogens, combating resistant infections and improving patient outcomes.' Mr. Engel summarizes that, 'The engineered lysins we are developing will have a tremendous impact as additional tool for treating and preventing infections. We think that our lysins will be effective against both gram-positive and gram-negative bacteria. Because we are so efficient in developing them, we will be able to produce our lysins in highly stable formulations with low cost-of-goods, thereby making them available to both developed markets and in the LMIC markets. This presents an opportunity to dramatically change health outcomes around the globe. We are now seeking both strategic and financial support to move forward more rapidly. Our team is highly motivated since we know that every day wasted means lives lost.' About Lysins: Lysins are members of a promising new class of antimicrobials - direct lytic agents. Unlike traditional antibiotics, lysins actively hydrolyze the bacterial cell wall, causing extremely rapid lysis and cell death. Due to this unique mechanism of action, lysins are targeted to specific pathogens, can effectively degrade biofilms, and are effective against bacteria resistant to traditional antibiotics. Critically, unlike traditional antibiotics, they do not cause bacterial resistance. About Precisio Biotix Therapeutics Inc. ( Precisio is a US clinical stage biotech company creating lower-cost novel precision engineered biological antibacterials, with an initial focus on respiratory, skin, lung, and prosthetic joint infections. Precisio is a platform-plus-product company (Rx and consumer). The Company has additional R&D operations in India, China, and the UK. Management has had multiple previous successful exits and currently seeks strategic partners for all aspects of the business. Recent news includes (1) a grant award from the Gates Foundation for the development of lysins to treat Bacterial Vaginosis and (2) regulatory approval of a topical Lysin in the EU.