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Yahoo
5 minutes ago
- Yahoo
Merging deep tech and biomedical science expertise, ChronicleBio aims to accelerate breakthroughs for millions living with complex chronic conditions
New venture harnesses multi-omic data and AI to develop the largest platform on complex chronic illnesses to drive breakthroughs in POTS, ME/CFS, Long COVID, and other neuroimmune disorders SAN FRANCISCO, Aug. 5, 2025 /PRNewswire/ -- ChronicleBio, a techbio startup focused on radically accelerating insights on neuroimmune disorders, officially launched Tuesday with a bold mission: to build the world's richest, AI-ready data platform for historically overlooked conditions like POTS, ME/CFS, Long COVID, and other complex chronic conditions. ChronicleBio is uniquely led by a founding team that unites elite tech, healthcare, and life sciences: Fidji Simo (Co-founder), current CEO of Instacart and the incoming CEO of OpenAI's applications division, brings deep expertise in consumer-scale technology, product innovation, and health systems transformation. Rohit Gupta (Co-founder & CEO), a biobanking and precision medicine leader who previously oversaw centers at Stanford and UCSF, is the leading scientific and strategic force behind ChronicleBio. Rishi Reddy (Co-founder & Executive Chairman), of Tarsadia Investments, brings an entrepreneurial and venture-backed perspective and a track record in health and life sciences investing. Together, they are tackling a critical gap in biomedical research. ChronicleBio is creating a scalable, ethically driven data ecosystem, integrating clinical, molecular, biospecimen, and patient-reported insights to drive biomarker discovery, patient stratification, and precision therapeutic development. "Entire communities of patients have been ignored for too long, not because their conditions aren't debilitating and prevalent, but because the systems weren't built to understand them," said Fidji Simo, co-founder of ChronicleBio. "ChronicleBio is developing a future where patients can enlist in research, and where the data we collect from them goes directly towards better diagnostics and therapeutics. By building these critical missing datasets and leveraging the massive advances in AI, we aim to accelerate the path to cures." These complex chronic conditions impact nearly 300 million people worldwide, but remain woefully understudied, leaving patients hopeless and without meaningful treatments. It's a disease space desperate for data, and ChronicleBio is offering the scalable solutions to provide it. "Neuroimmune disorders remain some of the most poorly understood in medicine and not for lack of interest, but because the underlying data simply doesn't exist at the scale or structure required for serious breakthroughs," said Rohit Gupta, co-founder and CEO of ChronicleBio. "We're empowering patients and clinicians to get involved in this effort to grow our research-grade biobank and AI-ready data platform so we can close that gap and provide the tools to finally interrogate these diseases with scientific rigor and precision, bringing an end to complex chronic conditions." ChronicleBio partners directly with patients, clinics, and research collaborators to generate longitudinal, multi-modal datasets, including genomics, immune profiling, and real-world outcomes designed for exploration and clinical trial readiness. Its platform is already being used in multiple high-integrity clinics in the U.S. and India, as well as through research collaborations with thousands of patients contributing data and biosamples. "We're creating an ecosystem with global reach, designed not just to generate data, but to fundamentally shift how we discover, develop, and deliver treatments at scale. The opportunity for impact—scientifically, medically, and societally—is enormous," said Rishi Reddy, co-founder and Executive Chairman of ChronicleBio. "We're building the foundational infrastructure for a massive medical need that has been hiding in plain sight." ChronicleBio's founding vision isn't just ambitious. It's personal. Both Simo and Reddy have been diagnosed with at least one of the very conditions the company is focused on researching. Gupta's family also suffers from neuroimmune disorders. The group's world-class expertise is outshined only by its heartfelt determination to rewrite the scientific narrative for the millions of patients overlooked by traditional research and transform lived experience into actionable discovery. ChronicleBio's approach includes: A global biobank platform collecting and connecting data on neuroimmune illnesses A proprietary, AI-ready data engine designed to integrate multi-omic, clinical, and real-world evidence Strategic partnerships with clinics, research consortia, and biotech sponsors looking to unlock hard-to-crack therapeutic areas A decentralized clinical trial network accelerating drug development through real-world access to patients and clinicians For more information, visit or follow ChronicleBio on LinkedIn, X, Instagram, and Facebook. Media Contact:media@ View original content to download multimedia: SOURCE ChronicleBio Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
5 minutes ago
- Yahoo
US Plans Record $100 Billion Bill Sale as Borrowing Needs Mount
(Bloomberg) -- The US government plans to borrow $100 billion in a single Treasury debt sale this week, an unprecedented figure that showcases both the magnitude of its borrowing needs and its ability to attract investors. PATH Train Service Resumes After Fire at Jersey City Station Mayor Asked to Explain $1.4 Billion of Wasted Johannesburg Funds Chicago Curbs Hiring, Travel to Tackle $1 Billion Budget Hole All Hail the Humble Speed Hump The Treasury said on Tuesday that it will auction $100 billion of four-week bills on Thursday, a record for the maturity and an increase of $5 billion from the previous week. The department has been boosting bill sales to rebuild its cash balance after the debt ceiling was lifted at the beginning of July. But the mammoth size is also likely a harbinger of growing bill auctions ahead to help plug the federal budget deficit. Last week, the Treasury signaled it will rely more on the shortest-dated securities to fund the spending gap at least until 2026, after Treasury Secretary Scott Bessent said in June that yields on longer maturities were too high to consider increasing sales of such debt. The department said it anticipates additional increases in October. 'The increase is just the start given Treasury's desire to focus on additional bill issuance in the coming quarters and years,' said Gennadiy Goldberg, head of US interest-rate strategy at TD Securities. 'So while markets will likely focus on the size, bill auction sizes are only likely to grow further in the coming years.' To put the size of the four-week offering in context, the government will also sell a combined $125 billion of coupon-bearing securities this week: $58 billion of three-year notes on Tuesday, $42 billion of 10-year notes Wednesday and $25 billion of 30-year debt Thursday. The four-week bill offer is also equivalent to more than a quarter of the total amount of bonds the UK sold in its 2024-2025 fiscal year. The latest T-bill increase follows the $5 billion boost in the six-week tenor that was announced last week, to be sold Tuesday. Treasury will also sell $65 billion of 17-week bills Wednesday and $85 billion of 8-week bills on Thursday. Both amounts are unchanged. With cash flowing into US money-market funds, which now hold about $7.4 trillion, there appears to be ample demand for the upsized bill sales, at least for now. Fed Watch One potential complication for money-fund managers is that the Federal Reserve is expected to lower interest rates again as soon as September. When rate cuts are seen as being on the horizon, as has been the case for months, the funds tend to extend the weighted average maturity of their holdings, favoring bills that will carry higher rates for longer. As a result, the weighted average maturity of government money funds — which invest primarily in securities such as T-bills, repurchase agreements and agency debt — has been around 40 days since May, near a record high, according to Bank of America. To BofA strategists Katie Craig and Mark Cabana, that means the funds may not have much capacity to extend and absorb bill supply at tenors longer than 1.5 months. Still, at this point there's little reason to worry about a broad decline in appetite for T-bills on the part of money funds, given that even those that aren't Treasury-only funds use the securities to help fulfill daily liquidity requirements, according to Peter Crane, president of Crane Data LLC. To be sure, Treasury has already borrowed larger amounts via a single security, but those were created via a series of auctions spread out over months. For example, the single largest Treasury on record is a $335 billion issue that matured in April. It began as a $46 billion 1-year bill sold in April 2024 and was expanded via a succession of bill auctions over the following year. The Trump administration has said that its economic policies will lift US growth and increase the Treasury's revenue — reducing deficits. However, most analysts expect outsize borrowing needs for years to come, suggesting the government eventually will need to boost sales of debt across maturities. One reason is that doing so would prevent bills from comprising too great a share of US debt outstanding. The ratio at the end of June level was about 20%. That's the level that the Treasury Borrowing Advisory Committee, an outside panel, recommended last year that bills should average over time. --With assistance from Elizabeth Stanton and David Goodman. (Adds comparison to UK issuance in 7th paragraph.) Russia's Secret War and the Plot to Kill a German CEO AI Flight Pricing Can Push Travelers to the Limit of Their Ability to Pay Government Steps Up Campaign Against Business School Diversity What Happens to AI Startups When Their Founders Jump Ship for Big Tech How Podcast-Obsessed Tech Investors Made a New Media Industry ©2025 Bloomberg L.P. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
The Verge
6 minutes ago
- The Verge
Grok's ‘spicy' video setting instantly made me Taylor Swift nude deepfakes
The 'spicy' mode for Grok's new generative AI video tool feels like a lawsuit waiting to happen. While other video generators like Google's Veo and OpenAI's Sora have safeguards in place to prevent users from creating NSFW content and celebrity deepfakes, Grok Imagine is happy to do both simultaneously. In fact, it didn't hesitate to spit out fully uncensored topless videos of Taylor Swift the very first time I used it — without me even specifically asking the bot to take her clothes off. Grok's Imagine feature on iOS lets you generate pictures with a text prompt, then turn them quickly into video clips with four presets: 'Custom,' 'Normal,' 'Fun,' and 'Spicy.' While image generators often shy away from producing recognizable celebrities, I asked it to generate 'Taylor Swift celebrating Coachella with the boys' and was met with a sprawling feed of more than 30 images to pick from, several of which already depicted Swift in revealing clothes. From there, all I had to do was open a picture of Swift in a silver skirt and halter top, tap the 'make video' option in the bottom right corner, select 'spicy' from the drop-down menu, and confirm my birth year (something I wasn't asked to do upon downloading the app, despite living in the UK where the internet is now being age-gated.) The video promptly had Swift tear off her clothes and begin dancing in a thong for a largely indifferent AI-generated crowd. Swift's likeness wasn't perfect, given that most of the images Grok generated had an uncanny valley offness to them, but it was still recognizable as her. The text-to-image generator itself wouldn't produce full or partial nudity on request; asking for nude pictures of Swift or people in general produced blank squares. The 'spicy' preset also isn't guaranteed to result in nudity — some of the other AI Swift Coachella images I tried had her sexily swaying or suggestively motioning to her clothes, for example. But several defaulted to ripping off most of her clothing. The image generator will also make photorealistic pictures of children upon request, but thankfully refuses to animate them inappropriately, despite the 'spicy' option still being available. You can still select it, but in all my tests, it just added generic movement. You would think a company that already has a complicated history with Taylor Swift deepfakes, in a regulatory landscape with rules like the Take It Down Act, would be a little more careful. The xAI acceptable use policy does ban 'depicting likenesses of persons in a pornographic manner,' Grok Imagine simply seems to do nothing to stop people creating likenesses of celebrities like Swift, while offering a service designed specifically to make suggestive videos including partial nudity. The age check only appeared once and was laughably easy to bypass, requesting no proof that I was the age I claimed to be. If I could do it, that means anyone with an iPhone and a $30 SuperGrok subscription can too. More than 34 million images have already been generated using Grok Imagine since Monday, according to xAI CEO Elon Musk, who said usage was 'growing like wildfire.' Posts from this author will be added to your daily email digest and your homepage feed. See All by Jess Weatherbed Posts from this topic will be added to your daily email digest and your homepage feed. See All AI Posts from this topic will be added to your daily email digest and your homepage feed. See All Report Posts from this topic will be added to your daily email digest and your homepage feed. See All Tech Posts from this topic will be added to your daily email digest and your homepage feed. See All Twitter - X Posts from this topic will be added to your daily email digest and your homepage feed. See All xAI
