Marlins vs. Padres Prediction, Odds, Picks
The San Diego Padres will look to Manny Machado for continued success at the plate when they hit the field against Otto Lopez and the Miami Marlins on Monday, in the first game of a three-game series at loanDepot park. The Marlins are favored in this one, at -131, while the underdog Padres have +111 odds to win. Miami is a 1.5-run favorite (at +159 odds). The total for the contest has been set at 8 runs.
Take a look at everything you need to know from a betting perspective on the Marlins-Padres game, regarding the run line, moneyline and total, plus expert picks.
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Check out the best moments from this MLB matchup between the San Diego Padres and the Washington Nationals. Marlins vs. Padres Game Information & Odds When: Monday, July 21, 2025 at 6:40 p.m. ET
Where: loanDepot park in Miami, Florida
How to watch on TV: FDSFL and SDPA Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Marlins -131 +111 8 -118 -102 -1.5 +159 -192 Marlins vs. Padres Prediction Score Prediction: Marlins 5, Padres 4
Total Prediction: Over 8 runs
Win Probabilities: Marlins 52%, Padres 48% Marlins vs. Padres Betting Insights The Marlins have won five, or 45.5%, of the 11 games they've played as favorites this season.
This season Miami has won one of its six games when favored by at least -131 on the moneyline.
The implied probability of a win from the Marlins, based on the moneyline, is 56.7%.
The Padres have been victorious in 23, or 48.9%, of the 47 contests they have been chosen as underdogs in this season.
This season, San Diego has come away with a win 16 times in 35 chances when named as an underdog of at least +111 or longer on the moneyline.
The moneyline set for this matchup implies the Padres have a 47.4% chance of walking away with the win. The Marlins have not been the moneyline favorite over the last 10 games.
Over their last 10 matchups, the Marlins and their opponents combined to go over the total four times (all 10 games had set totals).
The Marlins are 6-4-0 against the spread over their past 10 games. Stat Avg/Total Record 6-4 Runs Per Game 5.3 HR 11 ERA 3.27 K/9 7.6 Not only does Kyle Stowers lead the Marlins in hitting with his .295 average, he also paces the squad with 21 home runs and 59 RBI.
Among all hitters in MLB, Stowers' home run total ranks him 14th, and his RBI tally puts him 22nd.
Lopez has 11 doubles, 11 home runs and 31 walks while hitting .250.
Lopez ranks 108th in homers in baseball, and 52nd in RBI.
Lopez enters this game looking for his fifth game in a row with a hit. In his last five games he is hitting .250 with two doubles, a home run, three walks and six RBIs.
Xavier Edwards has 15 doubles, two triples, a home run and 33 walks while hitting .286.
Edwards has at least one base hit in five straight games. In his last five games he is batting .318 with four doubles, a triple, a home run, a walk and four RBIs.
Agustin Ramirez has 21 doubles, a triple, 14 home runs and 19 walks while batting .244. The Padres have played as underdogs in four of their past 10 games and won three of those contests.
In their last 10 games with a total, the Padres and their opponents are 5-5-0 when it comes to hitting the over.
Over their last 10 games, the Padres are 6-4-0 against the spread. Stat Avg/Total Record 6-4 Runs Per Game 3.7 HR 11 ERA 3.13 K/9 8.6 Machado leads the Padres in home runs (18), runs batted in (60) and has put up a team-high batting average of .288.
In all of the majors, Machado ranks 28th in homers and 20th in RBI.
Fernando Tatis Jr. is batting .264 with 13 doubles, two triples, 16 home runs and 54 walks.
Tatis is 46th in homers and 88th in RBI among all hitters in MLB.
Luis Arraez is batting .284 with 17 doubles, four triples, five home runs and 19 walks.
Xander Bogaerts is batting .267 with 20 doubles, six home runs and 42 walks.
Check out the best moments from this MLB matchup between the San Diego Padres and the Washington Nationals.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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