
KA-EX, the world's first fast-acting cortisol stress reducer, is finally available in the U.S.
You'll never believe the story behind this citrus-flavored, highly effective drink: KA-EX, the dedicated sports nutrition brand, was originally launched in Switzerland as … wait for it … a hangover cure. This not-too-sweet natural beverage was widely embraced by the Swiss following long nights out, but almost as quickly, KA-EX was also embraced by professional and amateur athletes, due to its recovery benefits after a hard workout, sports game, competition or marathon.
KA-EX reduces the 'stress hormone' cortisol within just 48 hours, while other benefits include reduction in muscle soreness, an increase in energy, longer REM sleep duration, reduction in mood disturbances, and protection against sport-induced premature skin aging. Something that can improve both sleep and skin – where do we sign up?
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The brain behind KA-EX is CEO and founder Pedro Schmidt, a self-proclaimed 'nerd' who graduated from the pharmaceutical sciences program at the ETH Zurich – the same prestigious university that Albert Einstein attended. That's where, Schmidt tells the New York Post, 'I got interested in researching ways to improve hangover recovery – basically accelerate and also minimize the toxic effects of alcohol.' After all, most college students party too hard, and feeling good the next day is top of mind.
CEO and Founder Pedro Schmidt
Photo courtesy of KA-EX
After Schmidt graduated, he started working at a high-paying pharmaceutical company in oncology and hepatology, but continued on his hangover-cure research before becoming a full-time entrepreneur. 'I was fascinated by the whole topic, and I got my first prototype, which I myself found very efficacious,' he explains. 'I gave it to my friends to test, and they basically pushed me to quit my job and bring it to market.'
After a successful launch in pharmacies, KA-EX ('kater' is the German word for 'hangover,' and ex as in 'gone') quickly gained in popularity in Switzerland. Then something unexpected happened: 'More and more people started writing to us that KA-EX is an absolute game-changer for their post-workout recovery,' he recalls. 'They sleep better, feel more energized the next day, and see some significant progress in their [workout] performance.'
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Eventually, professional athletes started approaching KA-EX, asking if it was safe to use. After three successful clinical trials, along with many athletes' stamp of approval, KA-EX repositioned itself as a dedicated sports nutrition brand.
Schmidt unlocked the science on how to successfully reduce cortisol, which linked workout recovery and hangover recovery. 'In sports, cortisol management is an absolute game-changer, but it also plays a role in hangover recovery,' he says. 'So that is why I targeted cortisol management in the first place.'
According to an independent study, the scientific staff of the Swiss national football team tested their players' cortisol levels and how KA-EX affected their recovery. After a game, an athlete's cortisol spikes, and it would take them 72 hours to get back to normal. After drinking KA-EX, however, their cortisol levels changed within 48 hours with a decrease of 36%. That percentage can make a huge difference in recovery!
Here are some signs you have high cortisol levels:
It's hard to make progress in your training, and you feel like you've plateaued
You're not able to achieve maximal performance potential
You have a hard time falling asleep
You wake up in the middle of the night
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'While phosphatidylserine is the key ingredient directly involved in lowering cortisol, its fast-acting efficacy comes from a synergistic formula that supports multiple biological processes,' Schmidt explains. 'By promoting muscle repair and sleep through targeted amino acids, normalizing tissue pH levels, and reducing inflammation, the overall stress response is calmed more rapidly and effectively.'
Photo courtesy of KA-EX
Some of the biggest early supporters of KA-EX are members of professional sports teams, including world champions and Olympic winners across a variety of sports. Fabian Cancellara, a two-time Olympic gold medalist and CEO of Tudor Pro Cycling Team, states, 'As a holistic recovery product, KA-EX is the perfect complement to offer our rider the best possible conditions for top performance.' Zhou Guanyu, F1 driver for Alfa Romeo, says, 'Our team relies on KA-EX to be at our best in every circumstance.'
Schmidt adds, 'Although KA-EX became popular through high-performing athletes, in Switzerland now it is one of the best-selling supplements on the market, sold in pharmacies, supermarkets, convenience stores and gyms. It is used by a very broad audience who are looking to improve their general well-being and day-to-day energy.'
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This product comes in a patented bottle that keeps the powder separate from the pre-mixed liquid to preserve the stability of sensitive ingredients. The separation ensures that acidic and alkaline substances remain apart until activation. Once mixed, it should be consumed within an hour.
After a successful launch last year at California locations of Equinox, KA-EX is currently available at Equinox Earthbar locations in New York and Los Angeles, Happier Grocery in New York City, GoPuff, BevMo, several F45 studios, Amazon, and The Feed. You can also find it online at KA-EX.com.

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National Geographic
2 hours ago
- National Geographic
What is methylene blue and can it really boost your brain power?
The trendy supplement was originally developed as a fabric dye—and later used as a malaria treatment. We asked experts if it really has the cognitive benefits touted on social media. A solution of methylene blue in an erlenmeyer flask. The trending dye was invented by German chemist Heinrich Caro in 1876. Photograph by asikkk, Getty Images If you've spotted someone recently with a blue tongue, that inky stain could actually be the side effect of a new health trend. Biohacking enthusiasts have been using a substance called methylene blue as a daily supplement, sharing videos of their stained tongues on TikTok. Users claim the highly pigmented compound, which was originally developed as a fabric dye before being used for medical purposes, can improve cognitive function, energy levels and mood, and could even prevent Alzheimer's disease. But what do experts have to say? Here's what doctors and researchers say you need to know about potential effects of using methylene blue as a supplement. The history of methylene blue dates back to the late 19th century, when it was synthesized as a textile dye. The trending blue dye was invented in 1876 by German chemist Heinrich Caro. As he was searching for novel dyes for cotton derived from byproducts of the coal industry, one of his experiments accidentally created a vivid blue compound. Methylene blue's chemical structure gives it its signature blue color. 'It absorbs photons of certain wavelengths and the blue photons are the only ones left to be reflected rather than absorbed by the molecule,' explains Dr Roger Rothenberg, assistant professor of clinical medicine at Temple University Hospital's Lewis Katz School of Medicine. In other words, it absorbs all the colors that make up the rainbow spectrum apart from blue, which is reflected back to our eyes, making it appear blue. A decade after Caro's accidental invention, another German scientist, Paul Ehrlich, discovered during an experiment that the organic compound turned parasite cells blue under a microscope. One of the dye's most famous uses is identifying malaria cells and it was later administered in Germany, France and the UK as a treatment for the illness. (To fight malaria, scientists want to poison mosquitoes—with human blood.) 'There was some efficacy for its use in malaria,' Rothenberg says, 'but not as much as the standard treatment for malaria at the time [quinine], so it fell out of favor for that purpose.' What is methylene blue used for? Nowadays, the treatment of methemoglobinemia is methylene blue's only FDA-approved use. Methemoglobinemia is a disorder in which red blood cells can't adequately deliver oxygen to the mitochondria, where it's needed for energy production, leading to symptoms including fatigue, dizziness and shortness of breath. In serious cases, it can be life-threatening. Methylene blue is also still used as a stain in surgical or diagnostic procedures. Physicians have used the compound to help visualize the urinary tract or lymph nodes in colorectal cancer. Methylene blue may be given intravenously for the treatment of methemoglobinemia, a disorder that reduces the blood's ability to carry oxygen. Photograph by James Mutter, Gett Images Initially, methylene blue was initially used for dying textiles. As it turns out, methylene blue is also excellent for dying cell nuclei and cytoplasm, as well as nerve fibers such as the motor neuron above. Micrograph by Ed Reschke, Getty Images Raphael E. Cuomo, scientist and professor at University of California, San Diego School of Medicine, says that as a supplement taken in low doses, methylene blue 'has the potential to enhance mood and energy, and possibly cognitive function, because it inhibits monamine oxidase and also has benefits on mitochondrial activity.' Monamine oxidase (MAO) is an enzyme which breaks down neurotransmitters like serotonin and dopamine. Allowing these feel-good chemicals to flow freely in theory creates a mood boost, while aiding the delivery of oxygen to mitochondria—the 'powerhouses' of cells, can result in more energy. (How to get high on your own hormones—naturally.) However, evidence for these effects in humans is limited, Rothenberg says. 'This is based entirely in theory, from studies on isolated tissue cultures and rats. There are maybe four to six randomized studies in human beings on this general cognition indication. That seems to be the reason people are taking it as a supplement.' For example, a 2021 study of 248 elderly adults found methylene blue administered intravenously significantly reduced postoperative cognitive disorders. Claims that methylene blue can alleviate the symptoms of Alzheimer's disease may be more reasonable, Rothenberg believes. 'The few human studies were done on Alzheimer's patients. There was a statistically significant, though very small, effect of methylene blue in mild to moderate Alzheimer's disease, showing five points [of improvement] on a 70-point scale,' says Bronwyn Holmes. Holmes specializes in regenerative and longevity medicine and says the results should be interpreted with caution. 'A man and a woman who have Alzheimer's, or any neurological disease, they metabolize methylene blue differently, so [the effect may be] very different depending on the patient,' says Holmes. What experts say about oral methylene blue Physicians are seeing the trend of methylene blue used as a supplement skyrocket, thanks in part to viral videos across social media. TikTok specifically is flooded with videos in which users rave about the latest nootropic, meaning a supplement with cognitive benefits. Holmes, who is on the Medical Advisory Board at healthcare provider Eden Health, says she first had patients asking her about the 'neurological benefits' of methylene blue around three years ago. Some experts are skeptical about off-label use of methylene blue as a brain booster. 'Never has a patient come to me with perimenopausal or post-menopausal brain fog, taken methylene blue, and all of a sudden the brain fog has declined,' says Holmes. Rothenberg suggests, 'it's very hard to really prove or disprove these claims when you have individuals taking it rather than a well-controlled, well-designed scientific study.' Due to its vibrant color, methylene blue can also turn human waste products blue or green – a harmless but potentially alarming side effect – and cause teeth staining. 'I had to work with the dentist once because a patient had taken so much meth blue,' Holmes adds. Methylene blue's impact on your health Beyond cosmetic concerns, doctors warn there are a number of health risks associated with consuming methylene blue as a supplement. The most serious is serotonin syndrome, a rare but potentially life-threatening condition which can occur if it is taken in conjunction with selective serotonin reuptake inhibitors (SSRIs), which are widely used to treat depression and anxiety disorders. (What's the right way to wean off antidepressants?) 'If you're on an SSRI, it interacts with methylene blue and compounds the drug's effects,' Holmes explains, causing symptoms of anxiety, fast heart rate, sweating, and tremors. In severe cases, the surge of serotonin can lead to seizures, irregular heartbeat, fever, hallucinations, or loss of consciousness. A 2013 study shows that those with a G6PD deficiency—people missing a key enzyme that protects red blood cells from damage—should avoid methylene blue as it can trigger hemolytic anemia, which is a condition where red blood cells break down rapidly. Less serious side effects can include headache, dizziness, and nausea, while 'at extremely high doses, paradoxically, we see that methylene blue can be causative of methemoglobinemia, which is the very indication it has been approved to treat,' Cuomo says. 'The concern is that people are taking methylene blue as liquid drops, so it is very easy to overdose.' (Why supplements may hurt your health more than help.) If you're concerned about your cognitive health, experts recommend addressing other nutrition and lifestyle factors rather than doing any DIY dosing. 'Unless you really want to turn your toilet bowl blue, there is no compelling reason to take it outside of an indicated medical setting,' says Rothenberg. 'Nootropics that we know absolutely are effective are caffeine, exercise, and appropriate sleep. The latter two specifically are what I would recommend to anyone who wants to boost their cognition.'


New York Post
3 hours ago
- New York Post
How to get TRT in 2025: A step-by-step guide to optimizing your testosterone levels
New York Post may receive revenue from affiliate and advertising partnerships for sharing this content and/or when you make a purchase. If you've been feeling a little low in more than one aspect of life, you're not alone, and chances are you're not going crazy, either. You may be experiencing the symptoms of low testosterone. Testosterone is the sex hormone that is responsible for a range of important functions, from hair growth and bone density to sperm count and libido levels. Low testosterone affects millions of men, and the symptoms can feel like a slow drag on daily life. Nearly 39% of men aged 45 years and older have low testosterone, also known as hypogonadism, according to the University of Washington's School of Public Health. Advertisement The symptoms are not the same for everyone, which can make it more challenging for men to identify the root cause. Some notice their muscles looking a little less defined than they used to. Or, possibly, they've struggled to maintain energy throughout the day. Others feel that they're sex drive is nearly non-existent. Fortunately, there are treatment options for men with low testosterone: FDA-approved injections, creams, gels, tablets, and even natural supplements that are designed to support testosterone production. Find Out About Our Top TRT Pick Ulo Ulo Feeling low on energy? Ulo offers a personalized approach to testosterone replacement therapy (TRT), starting with an at-home lab test and virtual consultation with a licensed provider. If TRT is recommended, treatment options — including injections, gels, and oral medications — are delivered straight to your door. Plans start at $159/month. You'll only be charged if a provider determines treatment is appropriate and writes a prescription. Treatment is currently available in select states and includes ongoing support throughout your plan. Learn more about how it works and if it's available in your state at Ulo's website. LEARN MORE Advertisement 'TRT stands for Testosterone Replacement Therapy,' explained Deep Patel, the co-founder of Ulo, a telehealth company that offers tailored TRT protocols. 'It's a way of bringing your testosterone levels back into a healthy range when your body isn't producing enough. You're not taking extra. You're restoring what your system is missing.' If you're new to the TRT space, chances are you're not too familiar with the process for getting a TRT prescription or what types of treatments are available. The good news is that Testosterone Replacement Therapy (TRT) has become much more accessible through legitimate telehealth clinics like Ulo. The Post has consulted several men's health experts and leaders in the hormone space to create a step-by-step guide to getting TRT in 2025. 1. Consider your symptoms Advertisement Low testosterone can manifest through various symptoms. These include low sex drive, trouble focusing, mood swings or irritability, loss of muscle or strength despite working out, constant fatigue (even when you're sleeping enough), increased belly fat, and even depression or anxiety. According to Patel, many guys suffering from 'Low T' feel like they're hitting a wall when it comes to their physical health and overall well-being. 'The most common things guys say are 'I can't focus like I used to,' 'I feel flat mentally, physically, sexually,' 'I've lost my drive,' 'I work out and eat clean but don't see results,' 'I just don't feel like me anymore,'' he shared. Often they've tried everything else — better sleep, different diets, supplements, lifestyle changes. 'TRT is rarely the first thing they try,' said Patel. 'But for many with genuinely low levels, it's the solution that finally works.' 2. Consult a men's health expert or find a legitimate online TRT clinic After identifying symptoms, the next step is to consider different providers. There are a few different options for men interested in learning more about TRT. Advertisement For anyone seeking medical advice, it's important to consult your primary care physician, especially before starting a new healthcare or wellness routine. Primary care physicians are also able to access your medical history, which is important to consider when starting TRT. Nowadays, there are more online clinics offering TRT services. The challenge is finding one that is legitimate, affordable, and provides services that are tailored to your specific needs. Sites like Hone, Ulo, Hims, and PeterMD offer well-regarded testosterone services, with different treatment plans available. 'There are plenty of clinics that advertise TRT online,' suggested Dr. Michael Aziz, an anti-aging internist and regenerative medicine specialist at Lenox Hill Hospital in New York City. 'But, patients should only consider clinics that have physicians who are board-certified and are specialized in endocrinology, urology, and internal medicine with anti-aging training.' Aziz added that patients should also read the online reviews about the doctors' experience, and look for positive feedback about ease of communication, as well as rapid response to issues and treatments. It's also important to verify that the clinic is using legitimate U.S.-based pharmacies and is fully compliant with telehealth laws and DEA regulations for controlled substances. 3. Get your bloodwork done To get a testosterone prescription, you'll need to take a TRT blood test. TRT blood tests examine the amount of the male hormone present in the blood. Some tests offer more detailed analyses than others, including additional health markers, such as free and total testosterone, sex hormone-binding globulin (SHBG), the prostate-specific antigen (PSA), and other hormones that could be affected by TRT. These tests are most accurate when administered in the morning, when testosterone levels peak. Advertisement The normal testosterone range is considered to be anywhere between 300 and 1,000 nanograms per deciliter. The FDA only approves TRT for specific conditions, such as hypogonadism or diminished functional activity of the gonads. Most clinics also only consider testosterone prescription for men who are experiencing symptoms and have levels under 300 ng/dl. Today, TRT clinics can mail blood tests to your door. At-home tests require a simple finger prick that you can do yourself and send back to a laboratory for analysis. 4. Wait for a diagnosis and prescription After a licensed health provider evaluates your blood work, it's important to meet with them to discuss your symptoms and medical history. 'The clinic should require comprehensive labs, a detailed intake process, and a real conversation with a knowledgeable provider,' said Tomo Marjanovic, the owner of Aspire Rejuvenation Clinic, a wellness center specializing in personalized hormone therapy. Advertisement Marjanovic warned that if the only interaction is an automated signup form or a rushed consult, that is a red flag. Diagnosis should never rely on numbers alone — some men at his clinic experience serious symptoms, even when their testosterone levels are slightly over 300ng/dl. In addition to clinical symptoms and hormone levels, Marjanovic considers a patient's family history (specifically heart disease, prostate issues, and hormone disorders) and lifestyle factors (such as stress, diet, sleep, and substance use). 'If clinical symptoms align with hormone deficiencies confirmed by lab results, the provider may prescribe TRT. This isn't something you should get from a simple online form because it's a medical therapy that needs real evaluation, not checkbox medicine,' he explained. 5. Consider the cost and check with your insurance for coverage options Be sure to check with your insurance provider to see if TRT is covered. Most providers require patients to meet certain thresholds and provide medical documentation that indicates their testosterone has fallen below the normal levels, in addition to recorded symptoms. Advertisement The cost of TRT will depend on the type of treatment you are interested in. Most testosterone injections cost between $50 and $150, oral tablets around $300, and patches can reach $400. There are certain telehealth companies that offer broader health services, which may include TRT. Subscription plans can range from $100 to $300 per month. 6. Consider the potential benefits and risks TRT comes with a number of benefits; everything from increased energy at the gym to better sleep at night, enhanced mood, and improved intimate performance. Advertisement 'When done right, TRT can give you your life back,' Patel pointed out. 'The benefits people report most often are way more energy, better workouts and faster recovery, higher libido, clearer thinking and focus, emotional stability, and a sense of drive and confidence that returns.' A 2019 study on prescription testosterone found that 52% of men claimed testosterone improved their energy, 42% saw improvements in their libido, and 29% reported muscle growth. While there are several benefits, Patel and many other experts are very transparent about the potential risks associated with TRT. 'The most common side effects include acne, water retention, or elevated red blood cell counts, which can thicken your blood. Some men experience testicular shrinkage or reduced fertility. There are also concerns about cardiovascular risks in certain populations, particularly men with existing heart conditions,' he explained. It's important to consider that TRT significantly suppresses natural testosterone production, which can also reduce sperm production. If fertility is important to you, Patel mentions there are medications like HCG or clomiphene that can be taken alongside TRT to preserve it. In a 2021 study, over 90% of men maintained normal sperm counts when using these fertility-preserving medications with TRT. 7. Discuss treatment plans There are a few different forms of TRT available, and most reputable online TRT clinics offer different types of TRT to cover individuals' needs and preferences. 'The clinic's approach to TRT should be comprehensive rather than just giving a script for testosterone treatment,' Aziz stressed. 'The delivery method of TRT is best chosen by both the doctor and the patient based on the patient's lifestyle and symptoms.' Aziz says that different gels, creams, tablets, and injections are well-researched and vetted. However, some differences must be observed: 'Gels are used daily but can be transferred to sexual partners and children. Injections can be self-injected once to twice a week, or administered by the doctor every 10 weeks.' Most experts agree that injections consistently offer the most predictable results. An article in The Journal For Nurse Practitioners outlines the most viable treatment options, citing that Depo-Testosterone is the most cost-efficient TRT option and Androderm is the most efficacious TRT medication, with up to 92% of patients reaching normal testosterone levels with consistent use. 8. Start treatment and wait for the results Many online TRT clinics can ship treatment to your front door as soon as the prescription is in place. But that's just the beginning of the process; it takes some time to feel and see the benefits, and the timeline can also depend on the form of treatment you're using. 'As for results, most guys feel a difference within four to six weeks. More energy, better mood, stronger libido,' Patel explained. He said that body composition changes — like more muscle and less fat — usually take a bit longer to notice. Some physical changes can be expected around two to three months. 'I remember one person telling us he knew it was working when he woke up one morning and actually wanted to go to the gym for the first time in years,' Patel exclaimed. It's not just changes in performance or appearance, but how men view themselves. 'More energy, stronger sex drive, better workouts, and a sense of confidence they hadn't felt in years,' he added. 9. Monitor progress and adjust protocols if necessary Once you begin your treatment, it's very important to monitor your results, watch for any potential side effects, and communicate openly with your providers. 'TRT isn't a one-and-done therapy because hormones are dynamic, and treatment should evolve based on regular lab monitoring and patient feedback,' Marjanovic explained. Without proper diagnosis and ongoing tracking, you risk underdosing, overdosing (a lot of people don't think this can happen, but it can), or ignoring other hormonal imbalances like estrogen dominance or thyroid dysfunction that can derail progress.' Marjanovic recommends that TRT providers repeat labs every 8 to 12 weeks early in therapy, check symptoms regularly, and make any adjustments necessary. It's important to address any markers that could signify side effects, including elevated hematocrit, estrogen imbalances, or libido issues. 'Personalized plan means tailoring dosage, delivery method, ancillary meds (like enclomiphene and hCG if needed), and lifestyle support based on individual needs. This is all crucial…' he explained. 'TRT without follow-up isn't therapy — it's gambling.' This article was written by Miska Salemann, New York Post Commerce Writer/Reporter. As a health-forward member of Gen Z, Miska seeks out experts to weigh in on the benefits, safety and designs of both trending and tried-and-true fitness equipment, workout clothing, dietary supplements and more. Taking matters into her own hands, Miska intrepidly tests wellness products, ranging from Bryan Johnson's Blueprint Longevity Mix to home gym elliptical machines to Jennifer Aniston's favorite workout platform – often with her adorable one-year old daughter by her side. Before joining The Post, Miska covered lifestyle and consumer topics for the U.S. Sun and The Cannon Beach Gazette.


New York Post
18 hours ago
- New York Post
Skip the spa with 33% off the customer-loved TOLOCO Massage Gun on Amazon
New York Post may be compensated and/or receive an affiliate commission if you click or buy through our links. Featured pricing is subject to change. Readers, we could really use a massage. It was a nice weekend and all, but all that [hiking/swimming/partying/walking/pickleball/tennis/squash/fill in the blank with the summer activity of your choosing] left us sore, and we're ready for a massage. Lucky for us (and you, by extension), earlier this year, we spoke to Camila Perez, a licensed massage therapist, esthetician, and certified manual lymphatic drainage therapist, to tap into her 20-plus years of expertise in determining the best massage guns on the market. One such option? The TOLOCO Massage Gun is available for a cool 33% off this week on Amazon. Yes, readers, Prime Day may have technically come and gone, but there are still tons of Prime-Day-worthy Amazon deals popping up every day, and this customer-loved Massage Gun is no exception. This week on Amazon, join over 30,000 other shoppers who've purchased the TOLOCO in just the last month alone, and experience everything a spa has to offer from the comfort of your own home. And you don't just have to take our word for it. Check out one satisfied customer's review below: 'I've been using the TOLOCO Massage Gun for a few weeks now, and I'm really impressed. The different attachments are perfect for targeting various muscle areas, and it's powerful yet quiet. I love that the carry case makes it easy to take on the go, and the build feels solid and durable. Even at the lower settings, it provides a deep massage, which is great for sore muscles after a workout or just relieving everyday tension.' We're sold! Amazon The TOLOCO Massage Gun is a powerful, handheld device designed to relieve muscle soreness and tension. With multiple speed settings and interchangeable heads, it targets various muscle groups effectively. Lightweight and portable, it's perfect for athletes and everyday users alike. Its quiet motor and ergonomic design ensure a comfortable, user-friendly experience, making it ideal for at-home recovery. Best of all? It's available for 33% off today on Amazon. This article was written by P.J. McCormick, New York Post Commerce Deals Writer/Reporter. P.J. is an expert deal-finder, sifting through endless brands and retailers to deliver only the best savings opportunities on truly worthwhile products. P.J. finds Prime Day-worthy deals all year long on some of our favorite products we've tested and our readers' beloved best-sellers, from Wayfair furniture sales to the lowest prices on Apple AirPods. P.J. has been scouring sales for Post Wanted shoppers since 2022 and previously held positions at Rolling Stone, Pitchfork and Hyperallergic. Please note that deals can expire, and all prices are subject to change. Hunting for a headline-worthy haul? Keep shopping with Post Wanted.