Dutch Princess Amalia undergoes surgery after breaking arm in horse riding fall
The 21-year-old, formally known as the Princess of Orange, sustained the injury on Tuesday and underwent surgery the same evening at the University Medical Center Utrecht hospital, according to a Royal House statement.
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Brain Scans Reveal Why Waking Up Is Sometimes Such a Difficult Experience
Want to wake up feeling great? The secret might not be so simple as a multi-step nighttime routine, early bedtime, or a no-device rule. A new study suggests that how we fall asleep and how we wake up the next day may not be so similar as we once thought. Neuroscientists tracked 20 people's brain activity as they woke up from sleep—sometimes naturally, sometimes by setting off an alarm—recording more than 1,000 awakenings in total. They found a pattern of neural activity signaled waking, but that the pattern was slightly different in people who were deep in dream-laden REM sleep as opposed to those in non-REM sleep. And people woken from REM sleep were more likely to say they felt tired on waking. 'The surprise is how consistent [this pattern] was across every awakening and also how it related to the subjective measures,' Francesca Siclari, the study's senior author and neuroscientist at the Netherlands Institute for Neuroscience, told Nature. The results were published this week in Current Biology. Each participant had 256 sensors attached to their scalps, which allowed the researchers to track their brain activity at a second-to-second timescale. From there, the researchers were able to reconstruct a visual map of each participant's brain activity and compared it to how sleepy each participant said they were on waking. They found that when people were roused during REM sleep, a neural 'wave of activation' moved from the front to the back of the brain: the prefrontal cortex, which manages executive function and decision-making, fired up first, followed by a slow 'wave' of alertness that ended at the region associated with vision. During non-REM sleep, the wave started in a central 'hotspot' and then progressed along the same front-to-back pattern. The findings could help researchers tease out why some people who struggle with sleep find it hard to wake up feeling refreshed, although more work is needed to understand whether other issues during sleep, like movement, may be at play. Less subjective measures of wakefulness could also help refine the results. 'Knowing exactly how brain activity is characterized during a normal awakening [means] we can better compare it to these abnormal awakenings,' Siclari told Nature.
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Carlsmed seeks up to $103M IPO haul to fuel spine surgery growth
This story was originally published on MedTech Dive. To receive daily news and insights, subscribe to our free daily MedTech Dive newsletter. Dive Brief: Carlsmed has set the target range for its initial public offering, outlining plans to raise up to $103.3 million to support development and commercialization of its spine surgery platform. Carlsmed plans to offer 6.7 million shares of common stock at an expected range of $14 to $16 per share, as well as an underwriters' option to purchase more than 1 million shares. The company, which set the price range Tuesday, sells artificial intelligence-enabled software, custom implants and single-use instruments for spine surgeries. Cross-trial comparisons suggest the custom devices may improve alignment and reduce revisions compared to stock implants. Carlsmed's products compete with stock spine implants sold by companies including Medtronic, Johnson & Johnson and Globus Medical. The company is much smaller than its rivals but growing quickly, with sales increasing by almost 100% in 2024 and on track to rise again this year. Dive Insight: Carlsmed is developing its platform to address the limitations of traditional spine fusion procedures. The company has identified the lack of sufficient pre-operative planning, the fit of stock interbody implants and complicated surgical workflows as problems. Targeting a $13.4 billion addressable market, Carlsmed is working to address these issues to improve patient outcomes and cut healthcare costs. The resulting platform uses diagnostic imaging and AI-enabled algorithms to develop personalized digital surgical plans and design custom interbody implants for each patient. Carlsmed collects real-world, post-operative data to improve the planning process. Researchers have generated evidence of the effectiveness of the platform, including through a registry that is tracking real-world clinical outcomes. An interim analysis of 67 adult spinal deformity patients in the registry found the rate of revision surgery attributable to mechanical complications was 1.5% after a mean follow-up of 14.7 months, according to a federal securities filing. The one-year revision rate in another study of stock implants was 8.7%. Carlsmed reported revenue of $27.2 million last year, up almost 100% compared to 2023, and is on track to grow again in 2025. The company generated sales of around $22.2 million over the first half of 2025. Carlsmed plans to keep growing by adding users and increasing use by existing customers. The number of surgeons who have used the platform increased from 103 as of March 2024 to 199 as of June 2025. Carlsmed's IPO paperwork reveals some of the challenges the company is facing as it scales operations. The company's net loss increased last year, rising to $24.2 million, and its reliance on a limited number of contract manufacturing organizations has hurt margins. Delays in the approval of surgical plans or late changes in surgery dates can cause CMOs to charge expedite fees. The fees drove margins down in the second quarter. Carlsmed expects expedite fees to decrease over time as it tries to improve operational processes and procedural workflows used by surgeons. Carlsmed's filing to list on Nasdaq adds to the uptick in medtech IPO activity seen this year. IPO filings are still well down from the pandemic-era peak but, after years of limited activity, some analysts believe a backlog of companies is waiting for favorable conditions to list. The success or failure of companies such as Carlsmed could inform whether the IPO window opens or closes. Recommended Reading The medtech IPO window is finally open. Or is it? Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
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Boy, six, diagnosed with brain tumour after parents told he was just 'anxious'
A boy of six was diagnosed with a brain tumour after his parents were told for months that he was anxious over the arrival of his baby brother. Parents Amy Bott and Adam Brown said the "incredible" staff at Birmingham Children's Hospital saved their son Ethan's life after the mass was removed in a 12-hour emergency operation. It was identified as a low-grade, non-cancerous growth and he is now recovering at home, relearning how to walk, eat and write. READ MORE: First picture of Birmingham worker who died at industrial estate as police charge two men READ MORE: Birmingham bin strike latest after waste wagons delayed again at depots Ethan will need regular MRI scans and specialist care for five years and his parents, from Telford, aim to raise £5,000 for the hospital to show their gratitude. "He had three months of worsening symptoms and werre told constantly by doctors the symptoms were due to anxiety due to the arrival of his baby brother in February," the couple said. "Symptoms included ongoing headaches, panic attacks, behavioural changes, poor sleep and weakened muscles and coordination. "The symptoms were caused by the tumour but also a build-up of fluid on his brain due to the tumour blocking the flow of fluid to the brain stem (hydrocephalus). "On the day of diagnosis, we were sent via blue light ambulance from our local hospital in Telford to Birmingham Children's Hospital. "The next morning he was in for a 12-hour surgery to remove the tumour and ten days later we were given the news the tumour was low grade and non cancerous (polycytic astrocytoma). Thankfully they were able to remove the tumour due to its location. "We spent two-and-a-half weeks in hospital and have been home for four weeks where our son continues his rehabilitation. "He has had to learn everything from scratch again such as walking, eating and writing. He will also have regular MRI scans over the next five years and other ongoing care from Birmingham. "We're extremely grateful for the incredible staff and support of the hospital who saved Ethan's life. "It's been a hard six weeks but we feel incredibly lucky that the tumour was caught in time. We're now focussing on Ethan's healing and recovery which can take around six months. "We've set a goal to fundraise £5k for Birmingham Children's Hospital in the next 12 months. Amy also plans to donate profits from her business on an ongoing basis when she returns from maternity leave. "During our time in hospital, we met other families who are still in the trenches of treatment and recovery. We really hope these donations go on to help them and any other children who need the support of the hospital in future. "If you can help by donating or sharing this page it really would mean the world." To donate to the fund, click here.
