
Healthy Returns: What to know about a CDC vaccine panel's votes against a mercury preservative in flu shots
The group, called the Advisory Committee on Immunization Practices, or ACIP, voted Thursday to recommend annual single-dose flu vaccines to Americans and against influenza shots containing thimerosal – even though there is no evidence of harm from that preservative. It was the first ACIP meeting since Health and Human Services Secretary Robert F. Kennedy Jr. gutted the panel and stacked it with new members, including several well-known vaccine skeptics.
The Centers for Disease Control and Prevention still needs to sign off on that recommendation. If the agency does, it would affect roughly 4% to 5% of the U.S. flu vaccine supply.
The rest of the nation's flu shots were thimerosal-free during the last season of the virus, according to CDC data. But when it comes to vaccinating an entire country, "small percentages matter," Dr. Sean O'Leary, an infectious disease expert with the American Academy of Pediatrics, told reporters last week.
If the few thimerosal-containing flu shots were removed from the market,
"that would inevitably lead to fewer people being vaccinated, at least in the short term, perhaps longer term, and subsequently more hospitalizations and deaths," O'Leary said.
The recommendation also reinforces longstanding, unfounded fears that the substance can lead to developmental disabilities, such as autism. Kennedy's vaccine skepticism comes full circle with the panel's vote: A decade before stepping into his current role, he published a book that called for the removal of thimerosal from shots and linked it to developmental disorders.
"A very common anti-vaccine talking point is around thimerosal, so that's a very clear strategy to sow distrust in vaccines," O'Leary said.
Here's why thimerosal is important. It has been widely used for decades as a preservative to prevent the growth of harmful bacteria in several medicines and vaccines with multiple doses. More than 40 studies over many decades have found no link between thimerosal and developmental delays.
But its use in approved vaccines has dropped sharply as manufacturers have shifted to single-dose packaging for their shots, which doesn't require preservatives. The Food and Drug Administration around 25 years ago asked manufacturers to remove the substance from childhood vaccines out of an abundance of caution, not because of evidence of harm, according to the CDC.
"The thought was, well, mercury is a scary sounding word, and let's just get it out, let's just make this a non-issue," O'Learly said. He added that "many studies have shown that it is entirely safe, is not associated with any neurodevelopmental disorders or any other adverse effects."
Some multi-dose forms of flu vaccines for adults still contain thimerosal, including Sanofi's Fluzone and two shots from biotech company CSL Seqirus.
One member of the panel, Dr. Cody Meissner, a professor of pediatrics at the Dartmouth Geisel School of Medicine, said he was worried that discouraging the use of multidose vials could increase the cost of vaccination and limit access for some groups. He also expressed concerns about the message the recommendation would send to other countries where the use of multi-dose flu vaccines is more common.
"That might limit the availability of the influenza vaccine for some people," he said during the meeting after he voted against restricting thimerosal flu vaccines.
Before the votes at the meeting, Lyn Redwood, a nurse practitioner who has been involved with anti-vaccine organizations, presented on thimerosal in flu vaccines. Redwood is among the "mercury moms" who pushed for Kennedy to get involved with mercury and children's health. She has also served for years as president of Children's Health Defense, the anti-vaccine organization founded by Kennedy.
Feel free to send any tips, suggestions, story ideas and data to Annika at annikakim.constantino@nbcuni.com.
Health-care data platform Arcadia has been acquired by the private equity firm Nordic Capital, the companies announced on Tuesday.
Arcadia turns health-care data into predictive insights that payers and providers can use to help improve care for patients, reduce costs and increase revenue. The company characterized the deal with Nordic Capital as a "strategic partnership" where the firm will become the "majority owner" of Arcadia, according to a release.
Michael Meucci, Arcadia's CEO, said working with Nordic Capital will allow Arcadia to continue to improve its customer experience, expand on its artificial intelligence capabilities, explore new M&A opportunities and drive growth in its core segments, including value-based care.
"It's hugely validating," Meucci told CNBC in an interview. "It's validating that there are large-cap institutional investors who are as committed to transforming us (U.S.?) health care and global health care as we have been."
Arcadia and Nordic Capital did not disclose the terms of the acquisition. The deal is expected to close in the second half of the year, though it's still subject to regulatory approvals.
Meucci said he's known the Nordic Capital team for a couple years, and that the firm had been watching Arcadia's progress as a business. Arcadia is profitable and carried out a successful acquisition last year. Meucci said these milestones helped Nordic Capital feel confident that the company was ready for its next stage of growth.
Arcadia last raised outside funding in 2023, when it announced $125 million in financing from Vista Credit Partners. Nordic Capital's acquisition serves as an exit for earlier investors, Arcadia said.
"This partnership aligns seamlessly with Nordic Capital's investment strategy and Nordic Capital is excited to support Arcadia in its next phase of growth," Daniel Berglund, partner and co-head of health care at Nordic Capital, said in a statement.
TripleTree served as Nordic Capital's financial advisor for the transaction, and Lazard advised Arcadia.
"This is just a further reinforcement of our mission, that we have to change the cost of health care," Meucci said.
Read the full release here.
Feel free to send any tips, suggestions, story ideas and data to Ashley at ashley.capoot@nbcuni.com.
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Miami Herald
an hour ago
- Miami Herald
FDA chocolate recall warns of ‘serious or life-threatening' risk
Americans eat an estimated 2.8 billion pounds of chocolate each year, which isn't surprising, given how many delicious forms the sweet treat comes in. That rounds out to around 11 pounds per person of chocolate each year. We don't hold the title for the most chocolate consumed, though. That belongs to the Swiss, although the United States does produce more chocolate than any other country in the world. Don't miss the move: Subscribe to TheStreet's free daily newsletter The FDA has strict production standards for the chocolate that U.S. companies produce and sell, including regulating the minimum amount of cocoa solids that have to be present in chocolate for the products to carry the chocolate label. Beyond production issues, there are also many other rules in place to make sure people are not sickened by the chocolate they consume. Unfortunately, one company has failed to live up to these obligations recently, and its lapse is putting chocolate eaters at risk. The FDA recently issued an urgent safety recall. The chocolate company originally alerted customers on June 25, 2025, and the FDA published it on June 30, 2025, in order to sound the alarm to the public as a whole and make sure word got out. The FDA warned that the recall was a very serious one, with potentially life-threatening consequences. The recalled items were made by the Mellace Family Brands California, Inc. of Warren, Ohio, and include Wegmans Semi-Sweet Chocolate Nonpareils. The affected items were distributed through Wegmans grocery stores in eight different states: DelawareMarylandMassachusettsNorth CarolinaNew JerseyNew YorkPennsylvaniaVirginiaWashington D.C. The problem with the candies that prompted the recall is an undeclared allergen. It was discovered that the Nonpareils contained a milk allergen and were distributed in packaging that did not alert consumers to the presence of this ingredient. Related: CDC sounds the alarm on growing global travel concern A temporary breakdown in the supplier's manufacturing process caused the problem to occur, and as the FDA alert makes clear, "people who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume this product with the lot codes shown below." Fortunately, the issue was discovered before anyone had an allergic reaction and suffered health consequences. Customers who bought the affected items are now being urged to return them to the place where they were purchased to obtain a full refund. The impacted candies were sold in a plastic tub and include items with the following lot codes: 55021 BEST BY: DEC 28, 202555031 BEST BY: DEC 29, 202555491 BEST BY: FEB 13, 202655501 BEST BY: FEB 14, 202656061 BEST BY: APR 11, 202656071 BEST BY: APR 12, 2026 You can find your lot code and best by date on the left side of the candy tub. In 2024, 2,454 product recalls had already occurred in the United States across five key industries by the third quarter of the year, according to Sedgwick. These recalls affected a total of 580.4 million products. The five industries include medical devices, food, pharmaceuticals, consumer products, and automotive. Related: TSA issues stern warning forbidding popular summer item Food saw a 112.7% increase in recalls in 2024 year, a disturbing number for those who expect and hope the products they consume will be safe. Consumers should monitor the FDA for news of recalls to make sure they do not have affected products. The FDA has a searchable database of safety alerts online to help make that easier, with Wegman's chocolate products currently topping the list as the most recent recall. More Retail: Walmart CEO sounds alarm on a big problem for customersTarget makes a change that might scare Walmart, CostcoTop investor takes firm stance on troubled retail brandWalmart and Costco making major change affecting all customers Hopefully, consumers with serious milk allergies will see the news of the chocolate recall and return the items before any harm is done. Related: Veteran fund manager unveils eye-popping S&P 500 forecast The Arena Media Brands, LLC THESTREET is a registered trademark of TheStreet, Inc.
Yahoo
an hour ago
- Yahoo
If Most People Get HPV at Some Point, Do You Need to Tell Partners You Have It?
The sexually transmitted infection human papillomavirus (HPV) is really, really, ridiculously common. Roughly 13 million people get it each year, according to CDC data, and it's safe to assume that if you're sexually active, you will likely have it at some point in your life—giving it the dubious honor of being the most common STI. There are many strains of the virus, most of which aren't dangerous and have no symptoms, so you can get it and get over it (your body fights and clears it on its own) without ever knowing. It also means you can unknowingly give it to someone else—which is a big part of the reason it's seemingly everywhere. Indeed, it might seem like since HPV is all around us, there's no real need to inform your sexual partners if you have it. They either have it, too, or are bound to at some point, right? So why make it awkward? "It's a bit of a quandary—there are so many different strains of HPV that most people have had at least one," Idries Abdur-Rahman, MD, a board-certified ob-gyn, tells SELF. Plus, you can only get tested for the virus if you have a vagina, so depending on who you're telling, they may not even be able to find out whether they have it, too, Dr. Abdur-Rahman explains (more on that later). Those factors combined with the fact that HPV is often harmless means it's natural to wonder if speaking up is worth it, he says. But the truth is that, although HPV is common, certain strains of the virus can be dangerous. And as with any STI, there's a certain amount of honesty you owe to a partner if you know that you may pass something along to them—even if it seems like it's probably NBD. Here's what you need to know before you give yourself permission to keep mum. Many of the 200-plus viruses that fall under the HPV umbrella won't harm you at all, and you'll never know you had one because they often clear from your system all on their own, Antonio Pizarro, MD, an ob-gyn, urogynecologist, and female pelvic medicine expert in Shreveport, LA, tells SELF. But there are several strains—usually types 6 and 11—that cause genital warts, or little clusters of flat or raised bumps you can pass to a partner. Wart-causing strains are considered 'low-risk,' because they rarely cause cancer but in some cases, they might. And there are 12 'high-risk' types of HPV that can cause cancer of the vagina, vulva, penis, anus, head, and neck. Of those, types 16 and 18 are to blame for most HPV-related cases of cancer, including cervical cancer. If you know that you are HPV positive, chances are it's one of these higher-risk strains: HPV tests don't screen for every 200-plus virus; they only look for a dozen or so strains that are more likely to cause cancer. But having one of these types doesn't automatically mean you'll develop any health issues. In fact, chances are, you'll still clear the infection and be HPV-free with no lingering effects. "Unless it causes untreated cancer, HPV is not lethal, and it's very likely to simply go away on its own," Dr. Pizarro reiterates. However, "even if a person—male or female—who's been exposed doesn't develop cancer, HPV can be passed on to subsequent partners and lead to cancer for them. This needs to be disclosed the way any other STD needs to be disclosed," Dr. Pizarro says. An HPV test is done as part of routine cervical cancer screening…which means you have to have a cervix to ever learn if you do, in fact, have HPV. For the test, your ob-gyn will swab the inside of your vagina and way up into the cervix, collecting a sample of secretions, and sending it to a lab. A Pap smear, which is done the same way, tests for changes in cervical cells and not the HPV virus specifically—but typically, an abnormal result is highly suggestive of HPV. The recommendations for when to get which test are a little confusing, but the most likely guideline your ob-gyn will follow is that of the U.S. Preventive Services Task Force (USPSTF), which advises anyone with a cervix aged 21 to 29 is screened with a Pap every 3 years, and then from age 30 to 65, with an HPV test every 5 years. Alternative options include getting a Pap every 3 years or getting a combined HPV/Pap (called a co-test) every 5 years. But there's no commercially available HPV or HPV-adjacent test for people with penises, Dr. Lew notes. 'They have done studies on HPV in [cis] men, so a test must exist, but it's not a test you could go into a doctor's office and ask for,' Dr. Lew says. Since HPV is asymptomatic until it progresses to the point of causing cancer—unlike other STIs that might cause pain during urination or discharge, prompting someone to seek medical care—if you aren't subject to cervical cancer screening, you'll likely go your entire life never knowing you have or had it. The exception: 'If you genital warts, then you can assume you have some version of HPV,' says Dr. Lew. The wart-causing strains of the virus are not usually the same ones that cause abnormal Pap smears and cancer, but it's still good to know and important to disclose to your partner that you have a form of HPV that causes genital warts. (Because reminder: In some situations, these strains can turn into cancer, which is why they are called 'low-risk' and not 'no-risk.') Although people with penises are often none the wiser if a partner gives them HPV, they can also still end up getting cancer: About 40% of HPV-related cancers happen in cis men. If you have one of the higher-risk strains, it could put your partner at risk for several types of cancer, and telling them gives them the chance to talk to their doctor and keep a closer eye on their health. It also lets them know that they might be at risk of passing that scarier strain on to future partners. To be honest, safe sex isn't guaranteed to fully prevent you getting any STIs (though it's certainly better than doing nothing). But since HPV is transmitted through skin-to-skin contact, barriers like dental dams and condoms don't protect you from getting it during sex as much as they do against STIs passed via mucous membranes and bodily fluids, like syphilis and gonorrhea. 'Condoms do help protect against HPV infection,' Jennifer Lew, MD, an ob-gyn at Northwestern Medicine Regional Medical Group, tells SELF. 'But like all STIs, they can't offer complete protection because they are only covering a small section of the body parts that come in contact [during sex],' she explains. Ultimately, though, 'it's the best we have for protecting yourself or your partner,' so it's always a good idea to use protection, despite its imperfections. So, how can you protect yourself and others? Well, abstinence is always an option (albeit an impractical one). Because HPV can infect multiple areas of the body, this would mean not having vaginal, oral, or anal sex…ever. Limiting your sexual partners can also reduce your exposure. The best way to avoid any of the risky types of the virus is by getting the HPV vaccine, which protects against the two low-risk wart-causing strains and seven of the ones that cause the majority of cancers. It's approved for all genders, FYI. The vaccine is most effective when taken before you're sexually active and exposed to HPV, but is approved for people up to 45. If you weren't vaccinated earlier in life, talk to your doctor about whether it's a good option for you. So many people have HPV. 'It's not a badge of shame,' Dr. Pizarro says, so telling someone doesn't need to be a huge production. 'I would just bring it up as saying you've tested positive for HPV, it's super common, and a lot of people have it," he says. Dr. Lew is a proponent of always disclosing HPV to your partner, if you know you have it. 'It brings honesty to the relationship,' she says. It can also bring up some sticky feelings—including guilt on one partner's part, if they could have been the one to give it to the other unknowingly. It's important to remember, and perhaps communicate to your partner, that the majority of people have had HPV and it's almost impossible to track who gave it to whom and when…so it's likely just counterproductive to focus on that. Talking to your partner about an HPV diagnosis may also prompt a larger conversation about STIs and encourage you both to get a full panel done. It's never a bad idea to check in and get a test every now and then to make sure everyone is healthy and safe. If you're apprehensive, scared, angry, or feeling any other emotion after an HPV diagnosis, lean on your ob-gyn for assurance and guidance. Figuring out what HPV means for your health and sex life can be immensely confusing, thanks in large part to the fact that there are so many different strains. If you're not totally sure what to make of all this information, you're not alone. Even ob-gyns have different ways of thinking about the potential risks, so be sure to bring up any questions or concerns with your own doctor who can discuss your specific diagnosis. Related: Is There an Age Limit for the HPV Vaccine—and How Effective Is It for Adults? You Can Absolutely Get an STI From Oral Sex These Are the Only Kinds of Birth Control That Also Protect Against STIs Get more of SELF's great service journalism delivered right to your inbox. Originally Appeared on Self


CNN
2 hours ago
- CNN
Best bug sprays in 2025, tried and tested
The best bug sprays we tested Best bug spray: Proven Insect Repellent Spray Best DEET-free bug spray: Coleman SkinSmart DEET-Free Insect Repellent Best DEET bug spray: Cutter Backwoods Insect Repellent Nothing ruins time spent outdoors while camping, hiking or relaxing in the backyard like an entourage of pesky mosquitoes chowing down on your arms and legs. Sure, bug spray is great, but between the various active ingredients and concentrations, it's hard to know what truly works, let alone find a repellent that doesn't smell like a chemistry lab or make you feel like you took a dip in a vat of oil. Since insect repellents are one of the best ways to repel mosquitoes, I went hands-on with 13 bug repellents to test how they feel, how they smell and everything else you'd want to know before you use one. I also consulted multiple experts to ensure I included repellents that are effective at, well, repelling bugs. I only tested bug repellents with active ingredients approved by both the Centers for Disease Control and Prevention (CDC) and Environmental Protection Agency (EPA): DEET, picaridin, oil of lemon eucalyptus, p-Menthane-3,8-diol (which is in oil of lemon eucalyptus), IR3535 and 2-Undecanone. DEET was the resounding favorite among the experts I interviewed, but they also praised the effectiveness of the other ingredients, especially picaridin and oil of lemon eucalyptus. Notably, I didn't include any essential oils like peppermint oil or vanilla extract. To be clear, I didn't test each spray for its efficacy at repelling bugs; there are just too many external variables that go into that. Instead, I conducted extensive research, leaned on my expertise and referenced the opinions of experts to choose a pool of repellents that science has proven to be effective. Then, I tested each of the products for things like ease of use, smell and feel. After months of testing, here are the three bug sprays that stood out above the rest. Proven Insect Repellent Spray So nice and light, you might forget you're wearing it, though bugs won't. Picaridin, Proven's active ingredient, comprising 20% of its formula, is one of the best at repelling bugs. Coleman SkinSmart DEET-Free Insect Repellent A 30% IR3535 spray in an aerosol bottle, Coleman SkinSmart delivered a consistent, wide spray, dried instantly and didn't leave any greasy residue on my skin. Cutter Backwoods Dry Insect Repellent Cutter Backwoods is a 25% DEET formula, the gold standard in insect repellents. It's very effective, and it had the mildest scent and least greasy texture of the DEET repellents I tested. This picaridin formula from Proven is one of the most portable options, perfect for hikers or for simply stashing in your bag so you're always prepared. The nozzle, despite its small design, is incredibly consistent and applies evenly. It isn't an aerosol can, but it's equipped with a long pump, so spraying felt nice and easy, even though it gets harder when you spray it upside down (since, thanks to gravity, the straw may no longer be submerged). Despite that fact, it didn't take me long at all to spray myself. With an average application time of just over 21 seconds, it was the fastest pump spray I tested. Proven's scent is largely, well, nonexistent. In the first round of testing for this story, each bug repellent went through two separate testers, and both testers who used Proven said they could barely smell anything. No wafting, tear-inducing chemical odor. The Proven bug spray also wasn't greasy and had a nearly perfect score for the way the spray felt on each of the testers' skin. It was easy to forget that I even applied this spray — besides the fact that no bug would dare come near me — making it one of the best sprays for clothes and skin The Proven repellent was also remarkably portable, thanks in part to its slim bottle. It can fit in any bag, but it's not so small that you'll easily lose it. (If you do prefer a travel-size spray, this repellent is available in a smaller, 2-ounce spritzer.) The bottle also comes with a simple cap to protect from any leaks, which held up well during some stress testing. While it doesn't provide perfect protection because it can fall off, when one of our testers threw it in a bag and went for a bike ride, it stayed completely secure. I love the way Proven's spray disappears on my skin, not to mention its nearly scentless formula. If you're looking for an insect repellent that's easy to use and easy to forget, you can't get much better than the Proven Insect Repellent Spray. One of the better bug sprays for skin and coming in just shy of first place in my ratings, was the Coleman SkinSmart DEET-Free Insect Repellent Spray. It was one of the best sprays in the performance category (which covered tests such as spray smell, feel, quality and others), falling just a little short in portability due to its slightly bulky bottle. The IR3535 repellent had a wide, even spray that made application a breeze. And since it's an aerosol can rather than a pump spray, I didn't have the problem of the pump not being submerged in the spray when applying it upside down. Instead, the aerosol pushes the repellent out, which made spraying my entire body a super-fast process. Just be careful of spraying upside down too often because, like all aerosol products, if you do it too much, the aerosol will escape. (I had this happen with a different aerosol spray when I used it upside down too many times, which resulted in repellent stuck in the can with no way to get out. Bummer.) The feel of the Coleman SkinSmart wasn't greasy or sticky at all. The formula uses a drying technology that makes it disappear almost instantly on your skin. The only issue I had with this spray was its smell. It's marketed as odorless, and while that rang true for one of our testers in the first round, another said it had a smell of chemicals that could easily make you cough when you spray it, and that the harsh scent lingered for a while. Another highlight of the Coleman IR3535 formula is the bottle it comes in. It's equipped with a locking switch to keep it secure. It was right in the middle in terms of size, not big and bulky, but also not slim and packable like some of the other options I tested. If you want an aerosol repellent with similar performance to my top pick, and you're fine giving up portability, the Coleman SkinSmart DEET-Free Insect Repellent is what you seek. During my research, I found the consensus was that DEET is the gold standard when it comes to insect repellents. But despite its reputation, sprays containing DEET didn't score as well overall in our tests as other options. If you don't care as much about the smell and feel of the spray and want the science-backed, best-in-class ingredient for repelling bugs, DEET is the way to go. Out of the multiple DEET-based repellents I tested, the Cutter Backwoods Dry Insect Repellent edged out the competition. It really came down to the Cutter and the ever-popular OFF! Deep Woods Insect and Mosquito Repellent, but the OFF! cap popped off during testing, and was the aerosol can that left had repellent stuck in the bottle I mentioned before. So, even though it performed well, I had to knock off some points. The Cutter had a solid spray, though it came out slightly wet and cold at times. The nozzle is larger than the others I tested, resulting in a wide area of application. This, plus its ability to spray upside down, made for ultra-fast application times, clocking in at an average of under 13 seconds for mostly full-body coverage. The spray wasn't too offensive but was still a little harsh, as it has that classic chemical smell you expect from bug spray. The repellent also left a light residue that took quite a while to fully dry, but it didn't feel too greasy. Another feature of this spray I loved is the size of the bottle. In the original round of testing, the Cutter was a bit bulky, but now its bottle is slim, making it much easier to handle and pack. Its thin shape makes it easy to grasp, and its cap is comfortable to hold down while applying. It isn't as small as the Proven bottle, but it's still super easy to stuff into basically any bag or backpack. If you're looking for a DEET repellent, willing to sacrifice some comfort in terms of the spray's feel and smell, and you don't mind carrying around a larger can, Cutter Backwoods Dry Insect Repellent should top your list. I ran each bug repellent through the same tests to measure both performance and portability. I did not test each spray's ability to physically repel bugs, but instead relied on our extensive research and the opinions of experts I interviewed to create criteria that all the repellents I tested met. The performance ratings, on the other hand, were based on tests that examined the physical quality of spray, smell and feel, among other things. Since many of these tests are subjective, I had at least two testers evaluate each repellent during the first round of testing and took the average of both results. Here's a full breakdown of every test I ran. Performance Spray quality: I tested how wide, even and consistent the spray was by applying it multiple times on myself. Spray smell: I smelled the spray whenever I applied it and noted how strong or weak it was, as well as if it was a pleasant or harsh smell. Spray feel: I noted how the spray felt on my skin whenever I applied it and if it was greasy or sticky. Spray difficulty: I tested how hard it was to spray myself with each repellent, noting how hard it was to hold each bottle and if I could spray it upside down. Spray time: In the first round of testing, each tester timed and sprayed themselves three times with each repellent, and calculated the average time it took to spray themselves. I then averaged the results from both testers to come up with an average spray time. Spray durability: After conducting all other tests, I observed how the bottle held up and if the quality of the spray was affected. Portability Leaks: I examined each bottle and looked for any sort of locking mechanism or cap and judged how likely it would be to leak in a bag. Size: I noted how large each bottle was and threw it in a bag to see if it took up a lot of space. Size options: I researched how many size options are available for each repellent. I tested 13 bug repellents after thoroughly researching the most effective ingredients and talking to several experts to find the best at repelling flying and biting insects. I chose only repellents with an active ingredient that is both CDC and EPA approved, which are DEET, picaridin, oil of lemon eucalyptus, p-Menthane-3,8-diol (which is a component of oil of lemon eucalyptus, but they are regulated separately), IR3535 and 2-Undecanone. The experts I talked to largely echoed the CDC and EPA, praising the effectiveness of all these ingredients, but heralded DEET above all else as the industry standard. 'DEET is still the gold standard to many in the public health profession,' said Elmer Gray, entomologist at the University of Georgia Cooperative Extension Service. Many of his peers also agree. 'The gold standard for insect repellents is still DEET-based products sold under a whole host of brand names,' said Jerome Goddard, extension professor of medical entomology at Mississippi State University, with a doctorate in entomology. 'Many studies through the years have demonstrated its effectiveness against a variety of flying insects and (somewhat) against ticks.' While some may harbor concerns over DEET's safety and its toxicity, all the experts I talked to said those worries are largely unfounded. 'The first law of toxicology is that everything is toxic,' said Jeffrey G. Scott, professor of insect toxicology at the department of entomology at Cornell University. 'It's just the dose that determines the effect,' he said. The EPA has concluded that DEET is safe, and many of the worrying stories of people getting seizures or even dying came after ingestion or 'dermal applications not consistent with label directions,' according to the EPA. That's why, whether you're using a spray, a wipe or lotion, you should carefully follow the directions on the label. The EPA has been testing DEET for decades and found that if used as directed, it is completely safe for everyone, even pregnant women and children over 2 months of age. However, repellents with the active ingredient oil of lemon eucalyptus and p-menthane-3,8-diol aren't recommended for children under the age of 3 because the dangers of applying them to kids under that age haven't been thoroughly explored. The CDC recommends using products with an active ingredient concentration of more than 10% for limited protection and says that the effectiveness of DEET plateaus after 50%. The experts I talked to agree. 'In general, higher concentrations of an active ingredient provide longer duration of protection, regardless of the active ingredient,' said Eva Buckner, assistant professor and state extension specialist at University of Florida's Institute of Food and Agricultural Sciences Medical Entomology Laboratory. 'However, concentrations above around 50% do not offer a marked increase in protection time. Products with less than 10% active ingredient may offer only limited protection, often from one to two hours.' Following that guidance, all the repellents I tested have between a 10% and 40% concentration of their active ingredients. Even with regular repellent application, you may occasionally be bitten — and if you consider yourself a mosquito magnet, you're probably very aware of when you are. If you're the kind of person who seems to attract mosquito bites, I've found that the viral suction-based Bug Bite Thing can provide relief, as long as you keep it on hand and use it immediately. Otherwise, a variety of topical applications, ranging from hydrocortisone creams to treatments like After Bite may help. Sawyer Picaridin Insect Repellent Lotion This lotion took longer to apply than any other repellent in my testing pool and left a sticky feeling on my skin. When applying this lotion, I got a strong whiff of chemicals, but that scent soon went away as I rubbed the lotion in. However, a few minutes after application, my skin felt sticky, especially my hands. I didn't love the application process or the feel of this repellent, and it took longer to apply than a typical spray — not to mention the lid doesn't have any locking mechanism, so it could also accidentally leak into your bag. Repel Sportsmen Max 40% DEET Bug Spray This 40% DEET spray from Repel sprays quickly, but it smelled bad and felt wet on my skin. Repel's 40% DEET concoction is sure to keep bugs at bay, but I found it quite unpleasant to apply. The repellent comes out thick and wet, with the harsh smell you probably think of when you hear the words 'bug spray.' Once dried, the repellent felt sticky on my skin, and I wanted to wash it off. Plus, the bottle doesn't have a lock. If you want a high DEET percentage and only need to apply it to your clothes, this might be a good option, but I much preferred my other winners. Ranger Ready Picaridin Insect Repellent Spray With a subtle, pleasant smell, this picaridin formula is a solid option. However, it went on a little wet and has a leaky applicator. When the Ranger Ready repellent arrived in the mail, one corner of the box was soaked with leaked spray. After opening it up, I saw a lock on the applicator of the spray bottle set to 'on' instead of 'off,' so I chalked the leak up to faulty packaging. However, once I tested the spray, I noticed that even with the lock set to the 'off' position, some repellent would still squirt out if I pressed on the trigger. Besides the potential for some leaks, this repellent had a similar performance to the winning Proven spray and is worthy of consideration. OFF! Deep Woods Insect Repellent, 2-Pack If you're careful with a slightly more delicate can and avoid spraying it upside down too much, then the OFF! Deep Woods repellent is a top-notch pick. This spray was one of the leaders early on in the testing process, but it dropped in the rankings after some durability issues. The cap popped off in a bag during a day of hiking, and after some serious spraying (much of it upside down), the aerosol in the bottle ran out, resulting in a can that still has bug repellent in it with no way to get it out. Ben's Tick and Insect Repellent Ben's has an incredibly strong, unpleasant and chemical smell that most people may not like. It also goes on thick with a wet feel that had our testers antsy for a shower. This bug spray from Ben's has a spraying mechanism that mimics the distribution you'd get from an aerosol can without actually using any of the gas. However, the spray came out extremely dense and sticky, which outweighed any of its other benefits. Sawyer SP544 Premium Insect Repellent This spray can be frustrating to use as it doesn't cover a large area when you try to apply it. I did like, however, that it dried quickly and that the spray bottle features a double-locking lid. The pump spray on the Sawyer repellent provided short little spritzes that didn't cover much area, so I found myself spraying a lot to get even coverage. Its small size makes it a little difficult to hold and spray all around, but it doesn't have a strong smell. It dried quickly, but the pump also got clogged quite a bit during testing. The highlight was the double-locking lid, which ensured a leak-free experience. OFF! FamilyCare Insect and Mosquito Repellent Spritz This picaridin option from OFF! impressed our testers with a wide aerosol spray and a fast-drying feel. One tester of this OFF! FamilyCare spray said she didn't smell anything when she applied it and another smelled orange peel, so even if you do smell anything, it's not a harsh, eye-watering scent. This repellent scored highest in the performance category, but its aerosol version doesn't have a cap or lock and is a little bulky, which knocked off some points. Only one point behind our runner-up, Coleman SkinSmart spray, it's still a high-quality option. OFF! Botanicals Insect Repellent This repellent is made with p-menthane-3,8-diol, but its tiny size and small pump make it hard to apply. This spray from OFF! doesn't apply particularly evenly and sometimes just squirts a jet of spray instead of a mist. However, it didn't have a scent at all, which was a huge bonus. It's also available in one of the smallest size options (2 ounces), so if you want a truly tiny spray you can fit in your pocket, this one could be for you. Repel Plant-Based Lemon Eucalyptus Insect Repellent The scent of this lemon eucalyptus spray was polarizing for our testers. One loved the natural, herby tones and the other was left coughing because of its strong and pungent smell. This lemon eucalyptus spray from Repel was the hardest for our testers to agree on. Some couldn't stand the smell, while others thought it smelled amazing. Even if you enjoy the scent, I'd recommend applying it outside, as it is quite strong. This repellent was also extremely greasy and took a while to dry. Similar to Ben's spray, the first thing I wanted to do after applying it was take a shower. Coleman Botanicals Insect Repellent Coleman's Botanicals Insect Repellent is oilier than other options, and the spray dripped around the nozzle, making it a little messy. This spray had a pleasant smell due to its oil of lemon eucalyptus base, although it was strong at times. The pump worked well, but it took too long to apply and the bottle is a bit stubborn: You can't spray it upside down due to its pump function, and it's easy for your finger to slip off the small nozzle. The following questions were answered by Jerome Goddard, extension professor of medical entomology at Mississippi State University; Elmer Gray, entomologist at the University of Georgia Cooperative Extension Service; and Karthikeyan Chandrasegaran, assistant professor in the entomology department at the University of California, Riverside. Does bug spray expire? Does bug spray expire? 'Yes, bug spray can expire, and its effectiveness may diminish over time. Most insect repellents have a shelf life of approximately three to five years, depending on the active ingredients and how the product is stored. The longevity of the active compounds — such as DEET, picaridin or essential oil derivatives — is a key factor in determining shelf life,' Chandrasegaran said. 'Although not all bug sprays are required to carry expiration dates, it is generally recommended to replace them after three years to ensure reliable protection. Signs that a repellent may no longer be effective include changes in smell, color or texture, or visible separation of the ingredients.' What is DEET in bug spray? What is DEET in bug spray? 'Previously called N,N-diethyl-m-toluamide, DEET remains the gold standard of currently available insect repellents,' Goddard said. 'The chemical was discovered by USDA scientists and patented by the US Army in 1946. It was registered for use by the public in 1957. Twenty years of empirical testing of more than 20,000 other chemical compounds has not resulted in another marketed product with the duration of protection and broad-spectrum effectiveness of DEET.' How does bug spray work? How does bug spray work? 'They all generally work to disrupt the mosquitoes' ability to locate humans in the environment or to make a potential host and their skin less attractive to bite,' Gray said. 'The precise details are still somewhat unclear. DEET seems to have an irritant effect on the mosquito's sensory system. Other products seem to make it more difficult for mosquitoes to sense their prey in the environment, and others mask our scent or produce avoidance-type signals.' Can you bring bug spray on a plane? Can you bring bug spray on a plane? 'Yes, you can bring bug spray on a plane, but it must comply with specific airline and Transportation Security Administration (TSA) regulations,' Chandrasegaran said. 'In carry-on baggage, insect repellents — whether in aerosol or pump spray form — are permitted as long as each container holds 3.4 ounces (100 milliliters) or less and fits within the quart-sized clear plastic bag used for liquids under the TSA's 3-1-1 rule. This ensures that the repellent is treated like any other liquid or gel when passing through airport security.' Does bug spray work on ticks? Does bug spray work on ticks? 'Yes, the CDC recommends the use of a product with 20% or higher concentration of DEET, picaridin or IR3535. Repellents containing the active ingredient permethrin can be used on clothing only,' Gray said. 'In today's world of widespread tick-borne diseases and populations, this is a very important aspect. The best tick prevention starts with wearing light-colored pants; tuck them into your socks and apply a high-concentration repellent to your shoes, socks, pants and waistline. If possible, tuck in your shirt and apply repellents above the waistline. It is also advised to avoid walking where grass, brush and vegetation brush against your legs. Using these precautions is highly effective in preventing ticks from contacting our skin.' 'DEET is more effective in repelling mosquitoes than ticks,' Goddard said. 'One study demonstrated that DEET on military uniforms provided between 10% and 87.5% protection against ticks, depending on species and life stage of the tick. There was an average of 59.8% protection against all species of ticks. Protection levels in the 50% range are less than desirable because just one tick can transmit a tick-borne disease.' For this article, we consulted the following experts to gain their professional insights. Eva Buckner, assistant professor and state extension specialist at University of Florida's Institute of Food and Agricultural Sciences Medical Entomology Laboratory Karthikeyan Chandrasegaran, assistant professor in the entomology department at the University of California, Riverside, with a doctorate in evolutionary ecology Jerome Goddard, extension professor of medical entomology at Mississippi State University, with a doctorate in entomology Elmer Gray, public health extension entomologist for the University of Georgia Cooperative Extension Service Jeffrey G. Scott, professor of insect toxicology at the department of entomology at Cornell University, with a doctorate in entomology CNN Underscored editors thoroughly test most of the products we cover and provide full transparency about how we test them. We have an experienced team of writers and editors with many years of testing experience who ensure each article is carefully edited and products are properly vetted. The author of this guide, Kai Burkhardt, tested and reviewed each bug spray and repellent included in this piece. He sprayed the repellents and noted how easy they were to apply, how they felt, smelled and more. Burkhardt also interviewed multiple experts to figure out what ingredients are effective and safe in bug sprays.