Watch: 'Hoppers' trailer introduces new Pixar sci-fi film
The trailer released Wednesday introduces viewers to Mabel, (May December's Piper Curda) who learns about a strange new technology "like Avatar" that allows her to transfer her consciousness into an animal robot.
Her conversations with other creatures shows "mysteries within the animal world that are beyond anything she could have imagined," according to an official synopsis.
The voice cast also includes Bobby Moynihan and Jon Hamm, and the film is directed by Daniel Chong.
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Bruce Springsteen joins Zach Bryan for surprise 'Atlantic City' performance: Watch
Even Bruce Springsteen isn't too big for a cameo. The Boss joined musicians Zach Bryan and Caleb Followill of the Kings of Leon for a rendition of his 1982 classic "Atlantic City" at Bryan's July 20 MetLife Stadium show in New Jersey. The Kings of Leon and Jersey-based Rock band Front Bottoms were the openers for the concert, while Springsteen, 75, was a surprise guest, joining later for a quick-lick guitar solo on Bryan's track "Revival" during the encore. "Proud to call him my hero, one of the greatest songwriters to ever live," Bryan said before introducing the legendary rocker. "If you guys will have him, this is Bruce Springsteen!" Why Bruce Springsteen changed his set list to end concerts with this song The pair then moved on to play "Atlantic City," a harmonica-heavy ballad off Springsteen's 1982 album "Nebraska." Followill, Bryan and Springsteen stood at side-by-side mics, passing the lyrics back and forth, before embracing at the end of the track as the crowd coo-ed "Bruuuucee!" Bryan, 29, has followed in Springsteen's singer-songwriter footsteps, often folding angst into his scratchy, smoker's vocals and genre-bending music, which features a cocktail of folk, country and soul. Bruce Springsteen and the E Street Band still rock, quake and shake after 50 years Springsteen joined Bryan on stage last year in Brooklyn and Philadelphia, lending old-school rocker legitimacy to an emerging act. The two also collaborated on the track "Sandpaper" off Bryan's 2024 album, "The Great American Bar Scene." The July 20 show was the third for Bryan this weekend at MetLife, the first time a country artist played three nights in a single stand at the venue. Springsteen is fresh off the release of a previously unheard cache of tracks from years passed. On "Tracks II: The Lost Albums," the Boss treats fans to the musical roads not taken, with mystic, ranchera, and rock music blending on a masterful mix of some 83 songs. Contributing: Anna Kaufman, USA TODAY This article originally appeared on Asbury Park Press: Bruce Springsteen joins Zach Bryan for surprise set: Watch
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Find Your Happy Place: Topgolf Celebrates the Premiere of Happy Gilmore 2 with a Limited-Edition Odyssey Hockey Stick Putter Giveaway at all U.S. Venues
DALLAS, July 21, 2025 /PRNewswire/ -- Golf fans, comedy lovers and Happy Gilmore diehards – get ready to channel your inner Happy. In celebration of the highly anticipated premiere of Happy Gilmore 2 on Netflix July 25, Topgolf has partnered up with the global streaming service to tee up an epic giveaway. Topgolf venues across the U.S. will become the ultimate Happy Gilmore 2 fan zone this summer as Players have the chance to win a new, limited-edition Odyssey Hockey Stick putter made by Odyssey – the very same putter used by Happy in the new movie – Sunday, July 27, and August 1-3. How It Works:During game play on July 27 and again the weekend of August 1–3, Players who dispense a golden ball will win the Happy Gilmore 2 limited-edition Odyssey Hockey Stick putter and a tube sock headcover on the spot. Venues will give away two putters total – one per weekend – making this a seriously exclusive prize. That's just two Players per Topgolf venue that will be lucky enough to take home this epic piece of golf movie history! Crafted by Odyssey, the number one putter on every major Tour for over 25 years, the Hockey Stick putter was specifically for Happy Gilmore 2. The unique design is as bold as Happy's backswing – and there are only a limited number that exist. Note: While Topgolf is our happy place, Happy Gilmore-style swings are not permitted. For official rules, please visit: What They Said Rodney Ferrell, Topgolf's Vice President Global Partnerships: "Happy Gilmore is a cult classic that disrupted how popular culture views the game of golf. Similarly, Topgolf has been doing the same thing since day one – redefining the game to be accessible for all to play and enjoy. With the highly anticipated sequel on the horizon, this partnership is a perfect match for anyone who loves to swing big, laugh loud, and find their happy place on or off the tee line." Whether you're a die-hard Happy fan, a casual moviegoer or just someone looking for a good time, come take a swing. You just might go home with more than bragging rights. About Topgolf A Topgolf Callaway Brands Corp. (NYSE: MODG) brand, Topgolf is the ultimate instigator of play. Thanks to our 100+ venues around the globe, powered by industry-leading Toptracer technology, we're leading the charge of modern golf. We offer a variety of tech-driven games, a top-tier food and drink menu, space to host large events, and a vibe focused on more play for all. To learn more, plan an event, or make plans to come play around, visit About Topgolf Callaway Brands Topgolf Callaway Brands Corp. (NYSE: MODG) is an unrivaled tech-enabled Modern Golf and active lifestyle company delivering leading golf equipment, apparel and entertainment, with a portfolio of global brands including Topgolf, Callaway Golf, TravisMathew, Odyssey and OGIO. "Modern Golf" is the dynamic and inclusive ecosystem that includes both on-course and off-course golf. Learn more at ABOUT THE FILMHappy Gilmore returns!RELEASE DATE: July 25, 2025DIRECTOR: Kyle NewacheckWRITERS: Tim Herlihy & Adam SandlerPRODUCERS: Adam Sandler, Tim Herlihy, Jack Giarraputo, Robert SimondsEXECUTIVE PRODUCERS: Judit Maull, Kevin Grady, Dennis Dugan, Barry Bernardi, David Bausch, Dan BullaCAST: Adam Sandler, Julie Bowen, Chris McDonald, Benny Safdie, Ben Stiller, Benito Antonio Martínez Ocasio, John Daly, Haley Joel Osment, Jackie Sandler, Sadie Sandler, Sunny Sandler, Maxwell Jacob Friedman, Philip Schneider, Ethan Cutkosky, Conor Sherry, Kevin Nealon, Lavell Crawford, Kym Whitley, John Farley, Eric André, Martin Herlihy, Margaret Qualley, Keegan Bradley, Bryson DeChambeau, Tony Finau, Rickie Fowler, Brooks Koepka, Rory McIlroy, Collin Morikawa, Jack Nicklaus, Xander Schauffele, Scottie Scheffler, Jordan Spieth, Justin Thomas, Bubba Watson, Will Zalatoris, Verne Lundquist, Austin Post, Marcello Hernandez, Travis Kelce, Eminem, Blake Clark, Oliver Hudson, Reggie Bush, Nikki Garcia, Becky Lynch, Tim Herlihy, Nelly Korda, Nancy Lopez, Boban Mfarjanovic, Paige Spiranac, Dan Patrick, Stephen A. Smith, Ken Jennings, Cam'ron, Scott Mescudi press@ View original content to download multimedia: SOURCE Topgolf Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
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Could cancer drugs be the future of Alzheimer's treatment?
With few treatments available to stop or reverse Alzheimer's disease, scientists have turned to cancer drugs as a potential means of walking back cognitive decline. Alzheimer's cases are rising in the United States and worldwide due to an aging population, but there is no cure for the disease. Attempts to develop new treatments that slow the disease's progress, rather than lessen symptoms, have frequently failed. Only two drugs — the antibody therapies Leqembi and Kisunla — are currently approved by the Food and Drug Administration to slow the progression of early Alzheimer's, and scientists say their benefits are limited. Some pharmaceutical companies have halted or abandoned their Alzheimer's drug development programs because of unsuccessful trials. Others are trying to use existing medications, including popular weight loss drugs, to combat Alzheimer's. With that in mind, researchers at the University of California, San Francisco conducted a broad search for drugs that could be repurposed to treat the condition — in theory, reducing the time in which the drugs could be made available to patients. They scoured a database of more than 1,300 drugs of various classes, including antipsychotics, antibiotics, antifungals and chemotherapy drugs. Then, they looked at how those drugs affected gene expression. Their new study, published Monday in the journal Cell, identified two cancer drugs as the best candidates to lower Alzheimer's risk in patients. When combined, the drugs seemed to slow or reverse Alzheimer's symptoms in mice. One of the drugs is normally used to treat breast cancer, while the other is effective against colon and lung cancer. Alzheimer's disease is associated with significant changes in the way genes are expressed in the brain, leading to the increased production of certain proteins and the decreased production of others. These imbalances may disrupt brain function and contribute to symptoms like memory loss. Fewer than 90 drugs in the researchers' database reversed the expression of signature Alzheimer's-related genes in human brain cells. And five drugs in particular seemed to lower the risk of Alzheimer's in actual patients, based on electronic medical records. The authors ultimately selected two of those drugs, both approved by the FDA to treat cancer, to test in mice. 'We didn't expect cancer drugs to come up' as the most promising, said Marina Sirota, a co-author of the study and interim director of the UCSF Bakar Computational Health Sciences Institute. The authors said the breast cancer drug letrozole seemed to change gene expression in nerve cells. And the colon and lung cancer drug irinotecan seemed to change gene expression in glial cells, which support the nervous system. Alzheimer's can destroy nerve cells and cause glial cells to proliferate, creating inflammation in the brain. In a 2020 study, breast cancer patients who received letrozole were less likely to develop Alzheimer's than patients who did not receive the drug. Colorectal cancer survivors treated with irinotecan also had a decreased Alzheimer's risk, according to a 2021 study. After testing the drugs in mice, the study authors found that the two-drug combo reversed brain degeneration and improved memory in mice that had developed hallmarks of Alzheimer's as they aged. Because results in mice often don't translate to humans, the researchers hope to test the drugs in a clinical trial with Alzheimer's patients. 'Developing a new drug can take hundreds of millions, or even billions, of dollars, on average take more than 10 years. For this repurposed drug, usually it just takes two or three years, and then you can go to the clinical trial and the cost is much, much lower,' said Dr. Yadong Huang, a co-author of the study and professor of neurology at UCSF. 'We still haven't generated or produced any very effective drugs that can really slow dramatically the cognitive decline,' he added. Part of the difficulty in developing drugs for Alzheimer's is the complexity of the disease. Its exact cause is largely unknown. For now, the authors said, it's unclear exactly why the cancer drugs seem to work against Alzheimer's. One theory is that the breast cancer drug blocks the production of estrogen, a hormone that controls the expression of a large number of genes. The colon and lung cancer drug may also block inflammation in the brain by preventing the proliferation of glial cells — though Huang said there are other possibilities. Dr. Melanie McReynolds, an assistant professor of biochemistry at Pennsylvania State University, who was not involved in the study, offered another theory. Her research has suggested that a different type of cancer drug could help treat Alzheimer's by regulating glucose metabolism, the process by which cells make energy. McReynolds said the process is necessary for various brain cells to communicate with each other. 'With aging, with stress, with diseases, that line of communication is disrupted,' she said. McReynolds said the drug combo tested in the new study might reverse metabolic decline — what she called 'the secret for contributing to better outcomes with Alzheimer's.' But assessing how Alzheimer's patients tolerate the combination of cancer drugs will be important. Letrozole can cause hot flashes and irinotecan can cause severe diarrhea. Both drugs can lead to nausea and vomiting. 'These drugs have huge side effects, so you need to always balance and figure out whether those types of side effects would be amenable to somebody with Alzheimer's,' Sirota said. 'It's not that it's a slam dunk.' This article was originally published on Solve the daily Crossword
