logo
NEL Animal Cardiovascular Center Achieves World's First Surgical Correction of Complex VSD in Canine Patient

NEL Animal Cardiovascular Center Achieves World's First Surgical Correction of Complex VSD in Canine Patient

ANYANG, South Korea--(BUSINESS WIRE)--Jun 22, 2025--
NEL Animal Cardiovascular Center, a private 24-hour animal hospital in South Korea, said that its cardiac surgery team has successfully performed the world's first surgical correction of a complex ventricular septal defect (VSD) in a canine patient.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250618427466/en/
NEL Animal Cardiovascular Center's medical staff performing surgical correction of a complex ventricular septal defect (VSD) in a canine patient (Photo: NEL Animal Cardiovascular Center)
This veterinary milestone is highly significant, as it marks the first such case not only in Korea but also globally, with no previous reports of successful surgical treatment for complex VSDs.
The patient was diagnosed with a unique form of VSD—a single, continuous defect extending from the perimembranous to the subarterial region (Perimembranous VSD extending into subarterial region). Given that there had been no prior successful surgical cases even for typical VSDs in veterinary medicine, this breakthrough greatly expands the possibilities for surgical treatment of congenital heart disease in Korea's veterinary cardiac surgery field.
Over the past year, NEL's cardiac surgery team has gained experience through more than 50 open-heart surgeries using cardiopulmonary bypass. Based on this expertise, the team developed a thorough surgical plan. During the procedure, the complex VSD involving both membranous and subarterial regions was confirmed. The team performed incisions in the right atrium and pulmonary artery, successfully closing the defect with a bovine pericardial patch.
Immediately after surgery, the left-to-right shunt was completely resolved, and the risk of progressive regurgitation due to aortic valve prolapse was eliminated. The patient's cardiac function recovered to near-normal levels, and the long-term prognosis is considered highly favorable.
Subarterial VSDs are particularly dangerous due to the risk of aortic valve prolapse and severe regurgitation, making early surgical intervention crucial. The success of this surgery offers new hope for animals with congenital heart defects, demonstrating the potential for a surgical cure.
Dr. Tae-Heum Um, Director of NEL Animal Cardiovascular Center, stated,
'Although this was a complex defect, thorough discussion and preparation among our medical team led to a successful outcome. We will continue our efforts so that more animals with congenital heart disease can lead healthy and normal lives.'
NEL Animal Cardiovascular Center is preparing an academic analysis and official report on this case, and sincerely hopes that this achievement contributes to the advancement of veterinary cardiac surgery not only in Korea, but also across Asia.
View source version on businesswire.com:https://www.businesswire.com/news/home/20250618427466/en/
CONTACT: NEL Animal Cardiovascular Center
Yoon il-yong
+82-31-421-7579
[email protected]
KEYWORD: ASIA PACIFIC SOUTH KOREA
INDUSTRY KEYWORD: CARDIOLOGY VETERINARY BIOTECHNOLOGY PETS SURGERY HEALTH HEALTH TECHNOLOGY CONSUMER
SOURCE: NEL Animal Cardiovascular Center
Copyright Business Wire 2025.
PUB: 06/22/2025 08:00 PM/DISC: 06/22/2025 07:59 PM
http://www.businesswire.com/news/home/20250618427466/en
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

CDC warns travelers about chikungunya cases in China as global infections hit 240,000
CDC warns travelers about chikungunya cases in China as global infections hit 240,000

Yahoo

timean hour ago

  • Yahoo

CDC warns travelers about chikungunya cases in China as global infections hit 240,000

U.S. health officials are cautioning travelers about a mosquito-borne illness being transmitted in parts of Asia, South America, Africa and the Indian Ocean. Across the globe, the chikungunya virus has sparked 240,000 cases and 90 deaths in 2025, according to the European Centre for Disease Prevention and Control. The virus, which is infecting people through bites from Aedes mosquitoes, has been spreading in China's Guangdong province this summer. Health officials reported the area has seen over 7,000 confirmed cases since June. The U.S. Centers for Disease Control and Prevention (CDC) this month issued a travel notice for the Guangdon province in China, encouraging travelers to practice enhanced precautions. The agency issued the same notices for other countries where outbreaks have been reported, including Bolivia, Kenya, Madagascar, Mauritius, Mayotte, Réunion, Somalia and Sri Lanka. The CDC is also asking U.S. residents to exercise caution when visiting the following countries, which have not yet reported an outbreak but are at elevated risk of exposure: Brazil, Colombia, Mexico, India, Pakistan, Philippines, Thailand and Nigeria. According to the World Health Organization (WHO), 5.6 billion people are at risk of arboviral diseases such as chikungunya. Other widespread arboviruses impacting humans include dengue, Zika and yellow fever. What are the symptoms of chikungunya? Symptoms of the disease include fever, joint pain and swelling, headache, muscle pain and rash, according to the CDC. How long does infection last? The illness typically lasts between two to 12 days after infection. Some patients can experience extreme symptoms and the virus can be fatal. Elderly people, newborns and individuals with underlying medical conditions are at higher risk of medical intervention. Severe complications, including cardiovascular, neurological and multiorgan involvement, may require intensive medical care, according to the WHO. However, more than half of patients will experience symptoms commonly associated with a fever. What treatments are available? There are no known antiviral treatments for the illness. Medications can be used to manage pain and fever. Two chikungunya vaccines have received regulatory approval but are not widely available. In May, federal officials recommended pausing a vaccine in the United States after reports of serious adverse events. The illness was first discovered in Tanzania in 1952, with outbreaks being reported in Africa and Asia, according to the WHO. Since then, the virus has been transmitted to 119 countries. Last year, more than 620,000 and 213 deaths were reported globally, according to the European Centre for Disease Prevention and Control. In what was then dubbed the largest documented outbreak of chikungunya, an estimated several hundred thousand people were affected by "explosive" outbreaks of the virus in the Indian Ocean islands and India, according to a 2008 study. It's estimated that about 60 percent of regional populations were exposed. CDC issues travel notice for Americans The CDC issued a travel warning on Friday, Aug. 1, advising U.S. residents to take enhanced precautions when traveling to China. Most of the country's cases have been reported in the city of Foshan. Last month, Chinese officials held a national conference to discuss treatments for and prevention of the illness. Authorities agreed to continue monitoring the situation and issue early warnings through multiple channels to prevent further spreading, according to China's National Health Commission. Michelle Del Rey is a trending news reporter at USA TODAY. Contact her at mdelrey@ This article originally appeared on USA TODAY: Chikungunya virus cases reported in China prompt CDC travel notice Solve the daily Crossword

JAMA Surgery Study Confirms Diagnostic Value of Cizzle Bio's DEX-G2 Blood Test For Early Detection of Gastric Cancer
JAMA Surgery Study Confirms Diagnostic Value of Cizzle Bio's DEX-G2 Blood Test For Early Detection of Gastric Cancer

Yahoo

timean hour ago

  • Yahoo

JAMA Surgery Study Confirms Diagnostic Value of Cizzle Bio's DEX-G2 Blood Test For Early Detection of Gastric Cancer

SAN ANTONIO, Aug. 5, 2025 /PRNewswire/ -- A groundbreaking multicenter clinical study published on July 30 in JAMA Surgery confirms the powerful diagnostic performance of the Destinex assay, a novel liquid biopsy that serves as the foundation for Cizzle Bio's DEX-G2 blood-based assay for early detection of gastric cancer—one of the world's deadliest malignancies. The study's findings validate the clinical utility of DEX-G2 as a minimally invasive, clinically actionable tool to detect gastric cancer at its earliest and most treatable stages, when timely intervention can significantly improve outcomes and save lives. The DESTINEX study, conducted at leading cancer centers in Japan and South Korea, evaluated a signature panel of microRNAs derived from exosomes and cell-free serum. The study analyzed 809 serum specimens from 480 participants, including patients with gastric cancer and matched controls. Using machine learning to refine and validate the assay, researchers demonstrated exceptional diagnostic accuracy for early-stage gastric cancer. The study was led by Ajay Goel, Ph.D., AGAF, an internationally recognized leader in cancer biomarker research and the developer of the Destinex assay. Goel also serves as scientific advisor to Cizzle Bio and is chair of the Department of Diagnostics and Experimental Therapeutics at City of Hope Comprehensive Cancer Center, where he led the development of the Destinex assay into the DEX-G2 blood test that Cizzle Bio is now advancing for near-term commercial launch. "The publication of this study in JAMA Surgery is a critical milestone, not only for our scientific team but also for the future of early gastric cancer detection," said Goel. "By combining the sensitivity of cell-free microRNAs with the specificity of exosomal markers, Destinex—and now DEX-G2—offers a minimally invasive, accessible, and highly accurate method for detecting gastric cancer at a stage when outcomes can be dramatically improved." In the study, the Destinex assay achieved an area under the curve (AUC) of 96.8% in the validation cohort, with a sensitivity of 95.0% for detecting early-stage (pT1) gastric cancer. These findings underscore the assay's strength as a minimally invasive tool for identifying gastric cancer early when it is most curable. The assay achieved high sensitivity and specificity in distinguishing individuals with gastric cancer from those without the disease, confirming its potential not only as a minimally invasive screening tool but also to significantly improve patient outcomes through earlier detection and intervention. A Pressing Clinical Need Gastric cancer is the third leading cause of cancer-related deaths worldwide, mainly due to delayed diagnosis. Globally, more than 60% of gastric cancer cases are diagnosed at advanced stages, when curative treatment is no longer an option and prognosis is poor. Endoscopic screening has helped reduce mortality in high-incidence countries such as Japan and Korea, but its cost, invasiveness, and limited availability make it impractical for widespread use in low-incidence regions. Minimally invasive blood-based tests like DEX-G2 have the potential to fill this gap. The Destinex assay, the scientific basis of DEX-G2, demonstrated outstanding sensitivity and specificity for detecting early-stage (T1) gastric cancer, and its diagnostic performance remained robust across tumor stages and patient subgroups. The study also showed a significant drop in biomarker levels after surgical tumor removal, confirming the assay's tumor specificity. Read the full JAMA Surgery study here: "This study reinforces the scientific credibility and clinical utility of the technology behind DEX-G2," said Bill Behnke, CEO of Cizzle Bio. "We are proud to advance this innovation into clinical practice, where it has the potential to make earlier detection a reality for patients who currently have few options for early detection." From Discovery to Clinical Application Cizzle Bio is advancing its DEX-G2 test, based on the Destinex assay, for near-term commercial deployment in CLIA-certified laboratories. It is intended to support clinicians in detecting gastric cancer earlier, particularly in primary care and gastroenterology settings where endoscopy may not be accessible or practical. The company holds a worldwide exclusive license for DEX-G2 and is actively pursuing commercialization in both U.S. and global markets, with a focus on reaching populations where gastric cancer is often diagnosed too late for curative treatment. About Cizzle Bio Cizzle Bio is a Texas-based biotechnology company dedicated to revolutionizing cancer diagnostics by advancing biomarker-based blood tests, starting with early detection of lung and gastric cancers. Our goal is to empower patients, equip clinicians, and improve outcomes through innovation, compassion, and life-saving solutions. We hold exclusive licensing rights for our groundbreaking CIZ1B biomarker test in the United States, Canada, and the Caribbean and a worldwide exclusive license for our DEX-G2 biomarker gastric cancer test. Cizzle Bio is commercializing both tests for U.S. clinical Media Contact: Yolanda Heibergeryolanda@ View original content to download multimedia: SOURCE Cizzle Bio

Is salmon sperm the secret to amazing skin? We asked derms about the buzzy beauty trend
Is salmon sperm the secret to amazing skin? We asked derms about the buzzy beauty trend

CNN

time3 hours ago

  • CNN

Is salmon sperm the secret to amazing skin? We asked derms about the buzzy beauty trend

Salmon sperm skin care quick picks Serum: Rejuran Advanced Anti-Aging Retinol + c-PDRN Serum Under-eye patches: Abib PDRN Retinal Eye Patch Moisturizer: Gangnam Glow Rejunol Mucin PDRN Facial Cream Sheet mask: Medicube Salmon PDRN Pink Collagen Jelly Gel Mask Neck cream: Valmont V-Lift Neck Cream If salmon sperm skin care is a phrase you've heard before, it was likely within the context of the anti-aging facials celebrities can't seem to get enough of right now. With claims of instantly glowing and youthful skin, it's no wonder the K-beauty ingredient has become a beauty trend in and of itself, spreading beyond in-office treatments into face moisturizers, serums, face masks and beyond. So, what exactly is salmon sperm doing in our skin care, and what are the benefits of this seemingly off-putting ingredient? I consulted four experts, including three dermatologists and a licensed esthetician, to answer the questions on all of our minds as well as share some of their top product recommendations you can try out for yourself. First popularized in South Korea, salmon sperm skin care refers to skin care products that include salmon-derived polydeoxyribonucleotide (PDRN), or purified DNA fragments. 'PDRNs are polynucleotides that are derived from salmon sperm,' Dr. Michelle Henry, board-certified dermatologist and founder of Skin & Aesthetic Surgery of Manhattan, said. 'The products themselves don't contain salmon sperm; they contain fragments that are derived from salmon sperm.' Salmon PDRN has become increasingly popular, particularly in South Korea and parts of Europe, for a couple reasons. 'The DNA extracted is surprisingly rich in protein and nucleic acid,' Dr. Ellen Marmur, board-certified dermatologist and founder of MMSkincare, said. 'These ingredients hold rejuvenating qualities that are perfect for an anti-aging effect.' According to Dr. Dendy Engelman, a board-certified cosmetic dermatologist and Mohs surgeon at the Shafer Clinic, this extracted DNA also closely resembles human DNA, making it effective and well tolerated in skin care products. Benefits include the stimulation of skin regeneration, hydration and collagen production. In-office salmon sperm treatments, such as the buzzy and provocative 'salmon sperm facial,' have a star-studded clientele, with high-profile fans that include Kim Kardashian and Jennifer Aniston. 'Treatments often combine microneedling or lasers with PDRN to drive the ingredient deeper, leading to firmer, healthier, more luminous skin,' Engelman said. The best part is that incorporating salmon PDRN products into your at-home routine won't have to feel like you're ingesting it on an episode of 'Fear Factor' since they can be used topically too. These products, which include everything from sheet masks to serums, combine PDRN with other popular skin care ingredients to target a range of skin concerns from home and without the high price tag associated with in-office treatments. 'Salmon PDRN is used for its ability to stimulate collagen production, accelerate the healing of open skin, deeply hydrate and reduce inflammation,' Engelman said. 'It helps repair the skin barrier, improve elasticity and can even soften fine lines and texture over time.' According to Olga Skydan, a licensed aesthetician with a medical degree in dermatology in Ukraine and medical expert board member at Luvly, many dermatologists use it in an injectable form for post-acne scarring or dull skin, and even after lasering for its anti-inflammatory effect, Henry added. Topical products with salmon PDRN aim to mimic these effects and benefits over time, and they're particularly useful for people who are dealing with sun damage, early signs of aging or compromised skin barriers, Skydan said. 'Because it's highly biocompatible, it integrates well into our skin's natural repair processes, making it a powerful tool for overall rejuvenation,' Engelman said. Rejuran Advanced Anti-Aging Retinol + c-PDRN Serum The most well-known brand when it comes to PDRN products, Rejuran's anti-aging serum is a favorite amongst our experts. 'I'm particularly impressed by this product, which combines salmon DNA with stabilized vitamin C and retinol to target fine lines, texture and pigmentation,' Engelman said. Both she and Marmur recommend it for those in search of a comprehensive anti-aging approach. Medicube PDRN Pink Collagen Exosome Shot For those just dipping their toes into the world of PDRN skin care, both Henry and Marmur recommend this under-$25 spicule serum that enhances your skin care's absorption. It's available in two different parts per million (PPM) formulas of varying concentrations, both of which target a range of skin care concerns, from boosting elasticity to smoothing textured or rough skin to boosting hydration, Henry said. If you have sensitive skin, be sure to start with the gentler option. VT Cosmetics PDRN 100 Essence 'You can get PDRN from salmon, but there are other plant-based sources being studied like rose or ginkgo,' Henry said. This lightweight yet nourishing essence boasts PDRN derived from ginseng, which the brand claims to be more stable and have a lower molecular weight than its animal-derived counterpart. The vegan PDRN alternative also includes a nourishing ceramide complex and soothing panthenol. Genabelle PDRN Vita Toning Ampoule Skydan describes this ampoule — a term generally used to describe highly concentrated and targeted liquid skin care products — as a solid introduction to PDRN skin care. 'It blends salmon DNA with niacinamide and vitamins to brighten, hydrate and improve texture,' she said, adding that it's a great option 'for people dealing with dull or uneven skin and want that 'glass skin' finish without irritating ingredients.' She recommends applying two to three drops of the product after cleansing but before your moisturizer, both in the morning and at night. Abib PDRN Retinal Eye Patch Beauty and fashion editor Sophie Shaw recently added these anti-aging under-eye patches into her routine. They're saturated in a vegan PDRN serum that's derived from cica, ginkgo and bamboo, and the formula also contains caffeine, niacinamide and retinal to help reduce puffiness and fine lines. Gangnam Glow Rejunol Mucin PDRN Facial Cream Salmon PDRN and snail mucin, two K-beauty staples, meet in this face moisturizer. While PDRN is commonly touted for its anti-aging benefits, it's also an effective way to keep your skin hydrated, according to Marmur. 'The DNA strands have a rich network of hydrogen bonds capable of carrying water,' she said, providing deep hydration to your skin for that plump and healthy look. A nourishing cream, such as this option, is also an easy way to maximize your overnight skin care routine. Derma Factory PDRN 4% Ampoule 'This is one of the strongest over-the-counter PDRN products on the market, with a 4% concentration,' Skydan said. 'It's best for people dealing with compromised skin barriers, post-acne inflammation or irritation after treatments like microneedling.' She recommends applying it at night on clean skin and following it up with a gentle moisturizer. 'If your skin is sensitive, start with twice a week and then build up,' she said, adding that it's best to keep it in a cool, dark place to preserve the formula's stability. Centellian 24 360° Shot PDRN Active Serum Shaw also likes this PDRN serum that leaves her skin plump and hydrated. It contains collagen, ginseng root, turmeric and niacinamide to fortify the skin. She likes to use her Medicube Mini Booster Pro to smooth the gel formula over her skin and ensure maximum absorption. Innisfree Retinol Green Tea PDRN Firming and Smoothing Serum Looking for a vegan product? According to Marmur, vegan alternatives to salmon PDRN are worth exploring for their similarly excellent results. One example is this green tea-derived PDRN, which is extracted from patented lactic acid bacteria from green tea. The cruelty-free formulation also includes retinol to help firm skin and smooth the appearance of fine lines. Medicube Salmon PDRN Pink Collagen Jelly Gel Mask Engelman recommends this jelly-textured face mask, which is designed to be left on the skin for about three to four hours. Once your skin has completely absorbed the mask, you'll notice it will transform from opaque to transparent. 'It contains salmon PDRN, hydrolyzed collagen, peptides and niacinamides to hydrate, brighten and plump the skin,' she said. Valmont V-Lift Neck Cream If you're looking for an anti-aging product to target both your neck and face, Marmur recommends this luxury cream from Valmont, a brand that incorporates highly polymerized salmon roe DNA into its V-Lift collection. 'I like this specifically because it's made for your neck, which tends to age faster than the skin on our faces,' she said. 'It absorbs easily and gives quick results.' Genabelle PDRN 3% Hyper Boost Ampoule Ideal for those looking to restore a dewy and resilient complexion, Engelman recommends this 'beautifully formulated intensive treatment that leverages high-concentration PDRN' for improving skin elasticity and hydration. 'It works best incorporated into an evening regimen,' she said, advising clients with sensitive skin to introduce it into their routine gradually to minimize irritation. The following FAQs have been answered by dermatologists Dr. Dendy Engelman, Dr. Michelle Henry, Dr. Ellen Marmur and Olga Skydan. Is salmon sperm good for skin? Is salmon sperm good for skin? 'Salmon sperm supports tissue repair, boosts elasticity and helps calm redness,' Engelman said. 'Many patients notice smoother, stronger, more resilient skin after consistent use.' Skydan calls it a game changer. 'It's gentle, doesn't over-exfoliate or sensitize the skin and suits a range of skin types,' she said. 'But it works best as part of a consistent routine rather than a miracle one-off.' Like most skin care products, consistency is key. Skydan said to think of adding PDRN into your skin care routine as a long-term investment in your skin's recovery and strength as opposed to a quick or instant fix. Salmon PDRN's benefits are said to extend beyond the aesthetic. Marmur notes it has potential to aid in wound healing and overall anti-inflammatory effects, though more research and larger-scale studies are needed. 'There is anecdotal evidence that is very promising,' she said, sharing that she uses salmon PDRN topically on many of her patients after in-office procedures, and they do see good results. 'However, we can't compare these results to what our colleagues are seeing in Europe or Asia, where PDRN is approved for injection and is very popular,' she said. 'In the US, we're still waiting for the pool of data to grow so we can fully understand its full potential and its long-term safety profile.' Are salmon sperm facials FDA approved? Are salmon sperm facials FDA approved? 'No, salmon sperm facials — specifically the injectable forms using PDRN — are not FDA approved in the US at this time,' Engelman said. 'While topical creams or serums with salmon DNA are permitted under cosmetic guidelines, injectable versions still lack formal FDA clearance,' she said. In short, 'anyone considering these treatments should proceed cautiously and always seek trusted, well-trained providers using products that comply with US regulations,' Engelman said. What are the side effects of a salmon sperm facial? What are the side effects of a salmon sperm facial? 'Potential side effects of a salmon sperm (PDRN) facial include temporary redness, swelling, bruising or mild irritation, especially if paired with microneedling or injections,' Engelman said. 'Some people may also notice slight peeling or increased sensitivity as the skin renews.' If you're opting for a topical salmon sperm facial, 'side effects are rare but could include irritation if the formula includes other active ingredients or if your skin is sensitive,' Skydan said. For those allergic to fish, our experts generally advise against salmon-derived PDRN products or facials. 'Because PDRN is derived from salmon, there's a theoretical risk of a reaction if you have a fish allergy,' Engelman said. 'While the DNA is highly purified, we still advise caution. Anyone with a known fish allergy should generally avoid these treatments or discuss them thoroughly with their dermatologist first to minimize any risk.' For this article, we consulted the following skin experts to gain their professional insights. Dr. Dendy Engelman, board-certified cosmetic dermatologist and Mohs surgeon at Shafer Clinic in New York Dr. Michelle Henry, board-certified dermatologist and founder of Skin & Aesthetic Surgery of Manhattan Dr. Ellen Marmur, board-certified dermatologist and founder of MMSkincare Olga Skydan, licensed aesthetician with a medical degree in dermatology in Ukraine and medical expert board member at Luvly CNN Underscored has a team of skilled writers and editors who have many years of experience testing, researching and recommending products, and they ensure each article is carefully edited and products are properly vetted. We talk to top experts when applicable to make certain we are testing each product accurately, recommending only the best products and considering the pros and cons of each item. For this story, contributing writer Noelle Ike spoke to dermatologists about salmon PDRN, or 'salmon sperm' skin care, and its benefits.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store